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Unveiling Dipeptide-2

Introduction >>>

In today’s society, with the improvement of living standards and the continuous advancement of science and technology, people’s pursuit of eternal youth and delayed aging is increasing. The anti-aging market has flourished, and various skin care products and health products have emerged in an endless stream. Among them, scientific and effective active ingredients have become the key to success. In this blue ocean full of hope and competition, a chemical raw material called “dipeptide-2” is gradually emerging. With its unique physiological functions and significant anti-aging effects, it has become a star ingredient in the new generation of anti-aging.

Dipeptide-2, chemical name L-valyl-L-tryptophan, is a short-chain peptide composed of two amino acids, valine and tryptophan. Unlike a single amino acid or protein in the traditional sense, dipeptide-2, with its unique molecular structure, can penetrate deep into the bottom layer of the skin and exert a series of positive physiological effects. In recent years, with the in-depth study of it, dipeptide-2 has shown excellent performance in promoting lymphatic circulation, stimulating collagen synthesis, anti-oxidation and anti-inflammation, especially in the field of eye care and anti-wrinkle and skin firming, its application value has been widely recognized.

Chemical Properties and Synthesis of Dipeptide-2

Molecular properties and stability
The molecular properties of dipeptide-2, including its molecular weight, solubility, and stability, are important considerations for its use as a cosmetic raw material. Dipeptide-2 is typically a white powder with good water solubility, which means it can be easily dispersed and dissolved in water-based formulas for easy application in skin care products. Its stability is affected by pH and temperature, so these conditions need to be controlled during production and storage to maintain its activity and effectiveness.

Chemical synthesis route
The synthesis of dipeptide-2 usually involves solid phase peptide synthesis (SPPS) or liquid phase peptide synthesis (LPS) technology. Solid phase peptide synthesis is the most commonly used peptide synthesis method currently. It uses resin as a carrier to gradually build the amino acid sequence on the resin, and then releases the complete peptide chain by cleavage. During the synthesis process, the first amino acid is first fixed on the resin, and then the subsequent amino acids are added one by one to form peptide bonds through chemical reactions. Each time an amino acid unit is added, deprotection and washing steps are required to ensure the correct assembly of the peptide chain.

The specific synthesis process is as follows:
Resin preparation: Select an appropriate resin as a carrier, such as polystyrene resin, which contains active functional groups on the surface that can react with the carboxyl group of the amino acid to form a stable chemical bond.
First amino acid fixation: Protect the amino group of L-tryptophan, and react the carboxyl group with the functional group on the resin and fix it on the resin.
Deprotection and washing: Remove the amino protecting group of the amino acid and wash the resin to remove by-products.
Subsequent amino acid addition: Add L-valine and repeat the deprotection and washing steps until the complete dipeptide is formed.
Cleavage and Purification: Finally, dipeptide-2 is chemically cleaved from the resin and purified by high-pressure liquid chromatography (HPLC) to ensure the purity and quality of the final product.

Physiological Functions and Anti-aging mechanisms of dipeptide-2

Application of Dipeptide-2 in Cosmetics Industry

Eye Care Products
Dipeptide-2 is best known for its use in eye care products, especially eye creams and eye serums. It effectively improves blood circulation in the area around the eyes and promotes lymphatic circulation, thereby reducing the formation of eye bags and lightening dark circles. In addition, dipeptide-2 can increase skin firmness and smooth fine lines and wrinkles around the eyes, bringing significant anti-aging effects to this sensitive area.

Anti-aging Products
In the anti-aging range, dipeptide-2 is widely used in a variety of facial skin care products, including creams, serums and masks. By stimulating collagen synthesis, dipeptide-2 helps improve skin elasticity, reduce the appearance of wrinkles, and make the skin look younger and more vibrant.

Lymphatic Circulation Enhancer
Given its positive effects on lymphatic circulation, dipeptide-2 is also used as an ingredient in body care products to help detoxify and reduce puffiness. This function is particularly useful for leg and abdominal care to improve the appearance and texture of the skin.

Other Uses of Dipeptide-2

Pharmaceutical field
Pharmaceutical intermediates: Dipeptide-2 can be used as an intermediate in the pharmaceutical industry and participate in the synthesis process of drugs, although the specific application details may be limited to specific drug development and research.

Scientific research
Experimental reagents: In biochemical and pharmacological studies, dipeptide-2 can be used as an experimental reagent to study its effects on cell functions, such as collagen synthesis.

Food industry
Functional food additives: In theory, some physiological functions of dipeptide-2 (such as antioxidant properties) may make it a potential ingredient in functional foods or dietary supplements, but its current application in the food industry is not widespread and must comply with food safety regulations.

Animal research
Growth promoter: Animal studies have shown that topical application of dipeptide-2 can be used as a growth promoter to enhance skin protein synthesis and amino acid absorption, which has potential applications in the study of skin repair and regeneration.

Formulation additives
Cosmetic formulas: In cosmetic formulas, dipeptide-2 can work synergistically with other active ingredients, such as hyaluronic acid, vitamin C or E, to enhance the comprehensive skin care effect of the product.

Research and Development
New Ingredient Research: The versatility of dipeptide-2 makes it a hot spot for researchers to study new skin care ingredients and mechanisms, promoting the development of cosmetics and dermatology.

Lymphatic Circulation Promotion
Body Care: In addition to eye care, dipeptide-2 can also be used in body care products to help promote lymphatic circulation and reduce edema and water accumulation in other parts of the body.

Are the Ingredients of Dipeptide-2 Raw Materials Safe?

Source and properties of ingredients:
Dipeptide-2 is composed of two naturally occurring amino acids, valine and tryptophan, both of which are common components in the normal metabolism of the human body, and therefore have high biocompatibility.

Cosmetic raw material database:
Dipeptide-2 has been included in the Yaozhi Data Cosmetic Raw Material Database, indicating that it has been confirmed as a used raw material, that is, it is approved for use in cosmetics.

Safety information:
According to the classification of WGK Germany:3, the safety level of dipeptide-2 is medium, which means that under normal conditions of use, its impact on the environment is considered to be limited, but this usually refers to the safety assessment of direct use on the environment rather than on the human body.

Scope and restrictions of use:
Dipeptide-2 is widely used in eye creams and other skin care products, indicating that it is relatively safe for skin contact and has no significant irritation or toxicity.

Regulatory compliance:
As a cosmetic raw material, dipeptide-2 must comply with the cosmetic regulations of various countries and regions, such as the EU’s COSING list and China’s Cosmetic Safety Technical Specifications, which require safety assessments of cosmetic raw materials.

Clinical studies:
Multiple clinical studies have supported the effectiveness and safety of dipeptide-2, especially in anti-aging and improving eye bags, with no serious adverse reactions reported.

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