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Wet Ones Benzethonium Chloride CAS 121-54-0

Molecular Formula: C27H42ClNO2

Formula Weight: 448.08

ZSpharmac: Wet Ones Benzethonium Chloride Supplier

Product Name: Wet Ones Benzethonium Chloride
CAS No: 121-54-0
Purity: 99%

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Basic Info

Product Name:Wet Ones Benzethonium Chloride
Other Names:Benzethonium Chloride
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Liquid
EINECS No.:204-479-9
Provide:Wet Ones Benzethonium Chloride MSDS;
Wet Ones Benzethonium Chloride COA

What is Wet Ones Benzethonium Chloride?

Damp Ones Benzethonium Chloride is a brand-new type of quaternary ammonium anti-bacterial representative, which is extensively utilized in day-to-day chemicals as well as cosmetics markets. Additionally, as a bactericidal and anti-bacterial agent, it likewise has essential applications in the field of medicine and also health. For example, it has actually been commonly used in Western countries as an antibacterial element of eye drops or as a bacteriostatic component of injections. In the production of heparin salt products, benzethonium chloride is a necessary crucial intermediate.

Wet Ones Benzethonium Chloride Property

Melting point 162-164 °C (lit.)
Boiling point 162℃[at 101 325 Pa]
density 0.998 g/mL at 20 °C
vapor pressure < 0.001 hPa @ 2°C
refractive index 1.5650 (estimate)
storage temp. 2-8°C
solubility H2O: 0.1 M at 20 °C, clear, colorless
form Liquid
color White
PH5.5-7.5 (25℃, 0.1M in H2O)
PH Range5.5 – 7.5
Water Solubility 1-5 g/100 mL at 18 ºC


Application of Wet Ones Benzethonium Chloride

Damp Ones Benzethonium Chloride is a new kind of quaternary ammonium anti-bacterial agent, which is widely used in daily chemicals and cosmetics sectors. In addition, as an antiseptic antibacterial agent, it also has crucial applications in the field of medication and also health and wellness. For instance, as an anti-bacterial component of eye declines or as a bacteriostatic component of injections, it has actually been commonly made use of in Western countries. In the manufacturing of heparin salt products, benzethonium chloride is an important key intermediate. Benzethonium chloride can be used in numerous hand sanitizers, hand soaps, skin and also hair treatment items, womanly hygiene items, damp wipes and other products and various anti-bacterial solutions, and is also better for dry powder products. Benzethonium chloride is used in the field of cosmetics as well as individual treatment. It is mild and non-irritating to the skin, which is its important benefit. Suggested dosage: 0.01-0.1%.

Wet Ones Benzethonium Chloride is commonly used in the everyday chemical industry for disinfectant wipes. As an antiseptic active ingredient, the marketplace share of Wet Ones Benzethonium Chloride continues to enhance, and the demand for benzethonium chloride in the entire daily chemical industry is quickly increasing, and the intake will increase swiftly. In the field of cosmetics and also environmental disinfection, this item is additionally preferred, as well as the extent of promo as well as application and also the marketplace possibility are extremely broad.

Synergistic Antibacterial Effect of Wet Ones Benzethonium Chloride and PHMB

1. When Wet Ones Benzethonium Chloride and PHMB are used alone, the bactericidal rate is lower than that of mixed use, that is, the two bactericides have a synergistic bactericidal effect. And when the mass fraction of benzethonium chloride was about 50%, the bactericidal rate reached the highest value, the bactericidal rate of the mixed fungicide was close to 80% for Escherichia coli, and the bactericidal rate for Staphylococcus aureus was close to 90%. That is to say, when the two fungicides are configured in a ratio of 1:1, the best synergistic effect can be exerted. The two fungicides showed synergistic bactericidal effect, the possible reason is that both are cationic surfactants, but the relative molecular weights of the two fungicides are quite different. The relative molecular weight of benzethonium chloride is small, and polyhexamethylene biguanide is a polymer with relatively high molecular weight, so the bactericidal mechanism of the two may be different. Therefore, when they are used in combination, they will destroy the bacteria according to their respective bactericidal mechanisms, and the overall death rate of the bacteria will increase.

2. The synergistic effect of the total mass fraction of mixed fungicides of 0.0005% was explored above. When the ratio of benzethonium chloride and PHMB is 1:1, the bactericidal rates of Escherichia coli and Staphylococcus aureus can reach 80% respectively , 90%. In the actual production of hygiene products, the standard of sterilization is 90%. Therefore, it is necessary to explore the synergistic effect of the total mass fraction of mixed fungicides higher than 0.0005%.

3. Wet Ones Benzethonium Chloride and PHMB are configured at a ratio of 1:1 to achieve the best synergy, then the ratio of the two in the mixed fungicide is determined to be 1:1, and the total mass fraction of the tested mixed fungicide is 0.001% and 0.005 %.

When Wet Ones Benzethonium Chloride and PHMB are used alone, the bactericidal rate of both Escherichia coli and Staphylococcus aureus is close to 100% when the mass fraction is 0.02%; the other two have synergistic bactericidal effect, and when the two are 1: When used in a mixed ratio of 1, the best bactericidal effect can be achieved. When the two are in the optimal ratio (1:1), the bactericidal rate of the above two bacteria is close to 100% when the total mass fraction of the mixed fungicide is 0.005%.

Evaluation of the Synergistic Bactericidal Effect of Benzethonium Chloride and PHMB

Wet Ones Benzethonium Chloride and polyhexamethylene biguanide (PHMB) are odorless, non-corrosive, and highly efficient bactericidal organic compounds. Disinfection and other fields have been widely used. Yet fungicide itself has certain toxicity and irritation due to containing chlorine element etc. in its chemical composition, as: have obvious stimulating effect to human skin, eye and upper respiratory tract, can cause asthma and allergic contact dermatitis, also can Cause allergies in some people. Therefore, it is necessary to reduce the amount of fungicide as much as possible under the condition of ensuring the sterilization standard. In view of the fact that the combined use of fungicides may have a synergistic effect, quantitative evaluation of their synergistic bactericidal efficacy will have important practical significance for guiding hygiene product manufacturers to further reduce the amount of fungicides used.

At present, the research on the bactericidal effect of Wet Ones Benzethonium Chloride and PHMB is mainly on the bactericidal effect of single-component and multi-component. For example, most manufacturers use benzethonium chloride with a mass fraction of 0.1% in related hygiene products to ensure a good bactericidal effect on common bacteria such as Staphylococcus aureus and Escherichia coli.

Previous studies have also found that: Wet Ones Benzethonium Chloride mixed with some organic solvents also has a good bactericidal effect, such as: the effective ingredients are benzethonium chloride and isopropanol disinfectant wipes for cleaning the surface of commonly used oral restoration instruments and materials The disinfection effect reaches 100%. The oral disinfectant containing benzethonium chloride and isopropanol can not only kill common bacteria, but also inhibit hepatitis B virus. There are also studies that show that the combined use of fungicides can also enhance their efficacy (i.e. have a synergistic effect), such as: PHMB and chlorhexidine acetate, dialkyldimethylammonium chloride (benzalkonium chloride), didecyl di The bactericidal effect of mixed use of methyl ammonium chloride and polyhexamethylene monoguanidine is better than that of single use. Among them, the compound disinfectant composed of PHMB and didecyldimethyl ammonium chloride or chlorhexidine acetate is used for sterilization The effect is better. Although previous studies have confirmed that compound fungicides have a synergistic effect, quantitative data such as the optimal concentration and ratio of each component in the compound fungicide have not been given. Therefore, it is necessary to conduct in-depth research on this.

About Products:
If you need Wet Ones Benzethonium Chloride this cosmetic raw material, please contact our service personnel directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Wet Ones Benzethonium Chloride, ZSpharmac will provide Wet Ones Benzethonium Chloride raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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