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Zhishang Chemical

Vitamina D3 K2 CAS 67-97-0

Molecular Formula: C27H44O

Formula Weight: 384.64

ZSpharmac: Vitamina D3 K2 Supplement

Product Name: Vitamina D3 K2
CAS No: 67-97-0
Purity: 99%

Basic Info

Product Name:Vitamina D3 K2
Other Names:Vitamin D3
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Food Additives
Appearance:Yellow Powder
EINECS No.:200-673-2
Provide:Vitamina D3 K2 MSDS;
Vitamina D3 K2 COA

What is Vitamina D3 K2?

Vitamina D3 K2, likewise known as cholecalciferol, is a kind of vitamin D that has actually been shown to be the true energetic form of vitamin D in the body. There are at the very least 10 known kinds of vitamin D, yet one of the most essential are vitamin D2 (ergocalciferol) and also vitamin D3 (cholecalciferol). Cholecalciferol, also called vitamin D3, is among one of the most important type of vitamin D, which mostly manages calcium as well as phosphorus metabolism in the body.

Vitamina D3 K2 Properties:

Melting point 83-86 °C(lit.)
alpha 105 º (c=0.8, EtOH 25 ºC)
Boiling point 451.27°C (rough estimate)
density 0.9717 (rough estimate)
vapor pressure 2.0 x l0-6 Pa (20 °C, est.)
refractive index 1.5100 (estimate)
Fp 14 °C
storage temp. -20°C
solubility Practically insoluble in water, freely soluble in ethanol (96 per cent), soluble in trimethylpentane and in fatty oils. It is sensitive to air, heat and light. Solutions in solvents without an antioxidant are unstable and are to be used immediately. A reversible isomerisation to pre-cholecalciferol takes place in solution, depending on temperature and time. The activity is due to both compounds.
form powder
Water Solubility <0.1 g/L (20 ºC)


Vitamina D3 K2 Uses

  1. Vitamina D3 K2 can keep the normal metabolism of calcium and phosphorus, and can advertise the absorption of calcium and also phosphorus by the body. When it is doing not have, children are prone to rickets. my country specifies that it can be used in fortified margarine, as well as the dose is 125-156 μg/ kg; the dosage in fortified dairy items is 63-125 μg/ kg; the dose in fortified baby food is 50-100 μg/ kg; in fortified milk as well as The quantity made use of in milk beverages is 10-40 μg/ kg; the maximum amount made use of in strengthened strong beverages as well as gelato is 10-20 μg/ kg.
  2. Vitamina D3 K2 is a fat-soluble vitamin. There are greater than a dozen compounds recognized to have vitamin D impacts, none of which are steroid derivatives, amongst which vitamin D2 as well as vitamin D3 are of fantastic useful relevance. The globe is controlled by D3, and also the “international basic compound” of vitamin D is likewise a pure crystal of D3. The primary function of vitamin D is the metabolic rate of calcium as well as phosphorus, and it is tough to advertise calcium and phosphorus absorption as well as bone calcification. When the human body lacks D, the capability to absorb calcium as well as phosphorus decreases, and also the degree of calcium and also phosphorus in the blood decreases, to make sure that calcium and also phosphorus can not be deposited in bone tissue, and even bone salts will certainly liquify, which impedes the calcification of bones. Deficiency in children results in rickets, and in grownups, osteomalacia. Japan generally produces and uses D2. Amongst the various needs, medications represent 30%, feed additives account for 65%, as well as artificial additive make up 5%. D2 and D3 as dietary supplements can be made use of in fluid milk, margarine, dairy items and also infant food according to the “Sanitary Common for using Food Nutritional Enhancers (1993 )” promoted by the Ministry of Wellness of my country.
  3. Vitamina D3 K2 is primarily utilized in food, health care products as well as various other related products.
  4. Vitamina D3 K2 acts with a receptor that is a member of a large family of ligand-dependent transcription factors that control the proliferation as well as differentiation of typical and cancer cells, with antiproliferative, Anti-transfer result. Turned on vitamin D receptors in the gut as well as bone likewise keep calcium absorption as well as homeostasis.
  5. Vitamina D3 K2 vitamin medicines, mostly to advertise digestive tract absorption and deposition of calcium and phosphorus, for the therapy of rickets as well as osteomalacia.

Vitamina D3 K2 Preparation

1KG of 7-dehydrocholesterol with a content of 95% was heated to 40 ℃ in 22L methanol+11L n-hexane at a concentration of 3wt.% to dissolve, dubbed 7-dehydrocholesterol solution, and the photochemical water cooler, nitrogen, circulating water pump, High-pressure mercury lamp, turn on the magnetic pump to pass the 7-dehydrocholesterol solution into the photochemical reactor, control the reaction temperature to 40°C, carry out the photochemical reaction at a flow rate of 0.5L/min, collect the photochemical reaction solution to detect the conversion rate of 14%, and carry out decompression recovery n-hexane and methanol, control the temperature at about 30 ℃ to distill 80%, after centrifugation, 0.75 kg of 7-dehydrocholesterol was obtained, which was reapplied.

The solution of a large amount of vitamin P3, the filtrate is all recovered, to obtain the oily solid containing 75% vitamin P3, 5% vitamin D3, 12% tachysterol, 3% 7-dehydrocholesterol of 200 grams by weight, add 500 milliliters of n-hexane to All of it was dissolved and added to a silica gel chromatography column with an inner diameter of 10 cm, a height of 2 m, and a 10 kg interior. After the flow was completed, elution was carried out with n-hexane, collected in sections, followed by high-performance liquid chromatography. The pure vitamin P3 component was evaporated to dryness under reduced pressure, then the temperature was raised to 40°C, and the vitamin P3 was converted into vitamin D3 by thermal isomerization at ‑0.095Mpa for 6 hours, and 150 ml of crystallization solvent methyl formate was added, and it was frozen at ‑8°C Crystallization for 12 hours, filtration, and vacuum drying to obtain 85 g of acicular vitamin D3 crystals with a purity of 99.9%, an optical rotation of +112 degrees, and an absorption coefficient of 475.

Vitamina D3 K2 is so Important!

Below we generally speak about vitamin D3. It is primarily manufactured by the human body itself, and also the human skin consists of a type of cholesterol, which becomes vitamin D3 when revealed to sunshine. As a result, if you can totally obtain direct sunshine on the skin for more than 4 to 6 hrs, the vitamin D3 manufactured by itself can primarily be satisfied. Nonetheless, intoxicated of air contamination and also climate adjustments in different places, the time individuals get sunlight is reducing, so there is an extensive lack of vitamin D around the globe. There are additionally issues that require to be considered, such as the feasible boost in skin cancer brought on by UV direct exposure.

Under conditions of insufficient or absence of sunshine direct exposure, vitamin D in food becomes the major source of vitamin D in the body. Nevertheless, regular plant foods, fruits as well as dried out fruit foods have very little vitamin D. Although animal foods have a small amount of vitamin D, the web content of normal diet regimens can not meet the requirements of the body in all.

Inadequate sunlight direct exposure or nutritional vitamin D deficiency, coupled with less sunshine in pleasant as well as cold regions, particularly in winter or rainy and unclear areas, not enough sunshine direct exposure or dietary vitamin D deficiency, so we need to deal with vitamin D directly absence of danger. Vitamin D deficiency, which shows up as a bone disease called rickets in youngsters and osteomalacia and also osteoporosis in grownups.

It is hard to supplement adequate vitamin D required by the human body in real life. In order to ensure well balanced nutrition and better rise immunity, you can ask nutritional supplements of multivitamins and also minerals to help.

The bones are in a dynamic balance every day. Around the age of 35, the mineral density of the bone reaches the peak, that is, the peak bone mass, and then the bone mass gradually decreases with age. According to statistics, the low bone mass population of men and women over the age of 50 in my country reached 57.6% and 64.6% respectively, which means that a large number of middle-aged and elderly people are at risk of osteoporosis. As a relatively hidden disease, osteoporosis often has a long accumulation period. At this stage, the bone strength will become lower and lower. For example, middle-aged and elderly people often experience some waist and leg pains, cramps, muscle weakness, etc. Unsteady standing and easy falling are all signs of osteoporosis and should be paid attention to in time. Although many middle-aged and elderly people have healthy living habits and actively come to the sun to bask in the sun, it is difficult for the middle-aged and elderly people to synthesize enough vitamin D even if they are exposed to a lot of sunlight due to the reduced ability of their skin to synthesize Vitamina D3 K2 and supplement additional vitamins. D nutrients are essential.

The answer is yes, vitamin D is not only a preventive measure for osteoporosis, but also a treatment measure for osteoporosis. Patients with osteoporosis are in a state of deficiency of vitamin D and calcium, and they need to be actively supplemented. While taking anti-osteoporosis drugs, taking vitamin D can maintain the balance of bone calcium and blood calcium, and protect vitamin D to activate the metabolic system. Of course, vitamin D supplementation is a long-term process. Many people stop taking the vitamin D after taking the amount for a few days or a few weeks every day and find that the effect is not good. This is absolutely not advisable. Adhere to supplementation, in order to completely avoid osteoporosis. The Guidelines for the Diagnosis and Treatment of Primary Osteoporosis (2017 Edition) also recommends that 800-1200 IU of vitamin D should be supplemented every day for the prevention and treatment of osteoporosis.

It is well known that the role of vitamin D is to promote intestinal calcium and phosphorus absorption and bone calcification, and maintain the balance of blood calcium and blood phosphorus. When the concentration of vitamin D in human blood is high, it can promote the differentiation of monocytes into mature macrophages, so that the immune function is also at a high level. (“Progress in Research on the Relationship between Vitamin D and Immune Regulation and Human Diseases”) At the same time, some studies have found that in people with vitamin D deficiency (25(OH)D<25nmol/L), vitamin D supplementation has a more significant protective effect on respiratory infections, and daily or weekly supplementation is more significant than occasional supplementation Sexual high-dose supplementation is better. This analysis revealed from the side that vitamin D has a role in regulating the immune function of the body, especially for people with vitamin D deficiency, the effect will be better.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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