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Zhishang Chemical

Vitamin b12 Powder CAS 68-19-9

Molecular Formula: C63H88CoN14O14P

Formula Weight: 1355.37

ZSpharmac: Vitamin b12 Powder Supplier

Product Name: Vitamin b12 Powder
CAS No: 68-19-9
Purity: 99%

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Basic Info

Product Name:Vitamin b12 Powder
Other Names:Vitamin B12
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Red to Dark Red Crystalline Powder or Crystals
EINECS No.:200-680-0
Provide:Vitamin b12 Powder MSDS;
Vitamin b12 Powder COA

What is Vitamin b12 Powder?

Vitamin b12 Powder, described as VB12, furthermore called cobalamin, amongst the B vitamins, is a sort of cobalt-containing corrin made complex natural materials, the trivalent cobalt had depend on the center of the corrin ring airplane comparable to porphyrin. It is the greatest along with also most challenging vitamin bit that has actually been uncovered so far, along with it is likewise the only vitamin which consists of steel ions; its crystals are red, so it is additionally called red vitamin. Plants do not consist of VB12 and can not make VB12. Liver is the very best resource of VB12, followed by milk, meat, eggs, fish, and so forth. VB12 is a crucial coenzyme in the synthesis of ribonucleic acid along with deoxyribonucleic acid. VB12 shortage in vivo can trigger pathological adjustments in the nerves such as external nerves as well as in addition major encephalopathy.
Prototypes of a household of natural cobalt sychronisation substances called corrinoids. An analog of Vitamin b12 Powder differs simply in the beta ligand of cobalt, called cobalamin. It is virtually totally synthesized by microorganisms. Nutritional resources contain fish, meat, liver, and also dairy products items; little or no cobalamin in plants. Methylcobalamin as well as cobalamin job as cofactors for enzymes that are changed by the body to their generally energetic forms. Extreme scarcity can create megaloblastic anemia and/or nerve damages. The expedition of Vitamin b12 Powder was first credited to research run in the treatment of a damaging anemia called after British doctor Addison. The damaging anemia was an incurable health issue at the time, along with Minot and also furthermore Murphy were offered the 1934 Nobel Prize in Physiology or Medicine for their expedition in 1926 that the problem could be recuperated by consuming huge amounts of raw liver. Adhering to Minot as well as Murphy’s expedition, this devastating anemia was correctly treated with liver concentrate.
In 1948, Riches in the U.S.A., Smith and Parker in the United Kingdom along with also others separated a red crystal from the liver concentrate and also called it Vitamin b12 Powder. In the exact very same year, R. West of Columbia College in the USA verified that harmful anemia can be efficiently taken care of by instilling Vitamin b12 Powder. Afterwards in 1955, D.Hodgkin et al. determined the crystal structure of vitamin B12 utilizing X-ray examination. He likewise won the Nobel Award in Chemistry in 1964. In 1972, Woodward effectively completed the full synthesis of vitamin B12.

Vitamin b12 Powder Property

Melting point >300°C
Boiling point >300 °C
alpha 23656 -59 ± 9° (dil aq soln)
Fp 9℃
storage temp. 2-8°C
solubility Sparingly soluble in water and in ethanol (96 per cent), practically insoluble in acetone. The anhydrous substance is very hygroscopic.
form Crystalline Powder or Crystals
pkapKa 3.28±0.04(H2O,D2O t=23±0.5 Iunspeci?ed) (Uncertain)
color Red to dark red
Water Solubility Soluble


Vitamin b12 Powder Uses

  1. Vitamin b12 Powder shortage can produce anemia, nerve system disorders. It can be utilized in food for infants and also young kids, and likewise the dose is 10-30 μg/ kg; the dose in prepared alcohol intake fluid is 2-6 μg/ kg.
  2. Vitamin b12 Powder, as a feed nutrition fortifier, has the impact of anti-anemia. The effective dosage for devastating anemia, nutritional anemia and also parasitic anemia is 15-30mg/ t.
  3. Vitamin b12 Powder is a crucial vitamin in the process of human cells metabolic price.A persistent shortage of B12 can create harmful anemia. They can move methyl groups to advertise the synthesis of bases; at the same time, they can boost the synthesis of glycogen, as a result getting rid of the requirement for The role of liver lipids. It is often used scientifically as a drug for the therapy of liver disease. The body requires regarding 21 micrograms of vitamin B121 each day, as well as additionally 2 micrograms can be given in food daily, which can make certain common requirements. Hydroxycobalt in vitamin B12 can respond with cyanide to create cyanocobalt acid, which can get rid of the poisoning of cyanide. Consequently, individuals with vitamin B12 shortage are a lot more mindful cyanide than the fundamental population. Vitamin B12 is generally used for the therapy of pernicious anemia, megaloblastic anemia, anemia caused by antifolate medications as well as polyneuritis.

Vitamin b12 Powder Application

1. Medical and also health care applications
It is generally used to treat numerous VB12 shortage, such as: megaloblastic anemia, anemia caused by medication poisoning, aplastic anemia and leukopenia, and so on; made use of in mix with pantothenic acid, it can prevent pernicious anemia as well as help Absorption of Fe2+ and also secretion of gastric acid; additionally made use of to deal with joint inflammation, facial nerve palsy, trigeminal neuralgia, hepatitis, herpes, bronchial asthma and other allergic reactions, atopic dermatitis, hives, eczema and bursitis; Vitamin b12 Powder It can also be made use of for the treatment of nervousness, impatience, sleeplessness, memory loss, and also anxiety. New research study recommends that vitamin b12 Powder shortage additionally contributes to mental disorders such as depression. VB12 is very safe as a therapeutic representative or health care product, and no poisoning phenomenon was discovered by intravenous or intramuscular shot of VB12 that was several thousand times greater than RDA.
2. Application in feed
Vitamin b12 Powder can advertise the development and growth of fowl and animals, specifically young chicken as well as young livestock, and also boost the usage rate of feed healthy protein, so it can be used as a feed additive. Dealing with fish eggs or fry with VB12 liquid remedy can boost the resistance of fish to harmful compounds in water such as benzene as well as heavy metals, and also lower mortality. Because the “Mad Cow Illness” occurrence in Europe, making use of dietary supplements with clear chemical structures such as vitamins to replace “meat and bone dish” has even more room for development. Most of the VB12 generated in the world is presently made use of in the feed industry.
3. Application in various other facets
In established nations, Vitamin b12 Powder is worsened with various other materials for cosmetics; in the food sector, VB12 can be used as a colorant for ham, sausage, ice cream, fish sauce and also other foods. In family life, VB12 option is adsorbed on triggered carbon, zeolite, non-woven fiber or paper, or made into soap, tooth paste, etc; it can be made use of for deodorization of toilets, fridges, and so on, as well as remove the odor of sulfide and aldehyde; VB12 can also be made use of Dehalogenation of natural halides, typical contaminants in soil as well as surface water in environmental protection.

Vitamin b12 Powder Deficiency and Disease

(1) Anemia
The anemia triggered by Vitamin b12 Powder deficiency is likewise megaloblastic anemia like the absence of folic acid. However, vitamin B12 deficiency was not related to anemia, neither in the elderly nor in those with a reduced intake of animal-derived foods. Vitamin B12 supplementation does not affect complete blood counts in individuals with vitamin B12 shortage.
( 2) Hyperhomocysteinemia
The risk of atherosclerosis as well as venous apoplexy can be boosted when the complete homocysteine focus in the blood surpasses 10 μmol/ L. Vitamin b12 Powder is involved in the methylation metabolic rate of homocysteine and also is a vital cofactor for methionine synthase (the enzyme that militarizes the methylation of homocysteine). The focus of vitamin B12 as well as folic acid is correlated with the focus of homocysteine in blood. A high occurrence of coronary artery disease is related to vitamin B12 shortage in the Indian vegetarian population. In diabetic retinopathy population, vitamin B12 shortage is associated with high homocysteine, and vitamin B12 shortage may be an independent risk factor for diabetic person retinopathy. But vitamin B12 does not decrease the threat of heart disease or diabetes mellitus.
( 3) Neuropsychiatric conditions
Vitamin b12 Powder and folic acid play a crucial duty in keeping the regular function of the main nervous system (CNS). SAM is a vital benefactor of methyl teams in the mind, and also an inequality of methylation is one of the root causes of neurological and psychiatric diseases. Homocysteine is also one of the sources of CNS conditions and is associated with cognitive disability. Vitamin B12 or folic acid deficiency can cause enhanced homocysteine focus as well as hinder methylation condition. Mixed martial arts is likewise hazardous to the nerves. Vitamin b12 Powder and folic acid might have protective effects against CNS lesions, state of mind disorders as well as mental deterioration (including vascular mental deterioration and Alzheimer’s illness mental deterioration) in the elderly, and also various other studies have revealed adverse outcomes. In spite of substantial literary works linking B vitamins to homocysteine, cognitive and state of mind disorders, and also mental deterioration, even if they decrease homocysteine degrees, there is no clear evidence from randomized regulated trials that vitamin B12 supplementation Cognitive problems and also mental deterioration were boosted with folic acid, however not depressive signs.
( 4) Fertility and birth defects
Folic acid is a protective element for neural tube defects (NTD), and also Vitamin b12 Powder, which is carefully pertaining to folic acid metabolic process, is likewise an independent threat variable for NTD. Vitamin B12 deficiency is also one of the risk aspects for very early miscarriage as well as persistent miscarriage. In the neonatal duration, vitamin B12 deficiency can seriously impair the advancement as well as feature of the nerves, and also infants are more likely to provide with development retardation as well as neurological deficiencies than anemia. Once a baby develops a vitamin B12 deficiency, the reduced degrees of vitamin B12 will continue for a minimum of a year. Even with early improvement of vitamin B12 deficiency, these youngsters might provide with long-lasting neurological and cognitive impairment, consisting of irritability, anorexia, development retardation, developing regression, as well as dementia.
( 5) Other
Vitamin b12 Powder shortages may enhance the opportunity of some cancers. Vitamin B12 as well as bone mineral thickness might belong, however the conclusions of different researches are inconsistent.

About Products:
If you need Vitamin B12, a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Vitamin B12 manufacturer and supplier, ZSpharmac will provide Vitamin B12 raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, and customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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