record one, ( 1) preparing a salt water including a minimum of 150 g/l Usp Sodium Chloride by dissolving a resource of Usp Sodium Chloride in water; ( 2) Cooling the resulting brine to a temperature level listed below 0 ° C yet above the eutectic temperature of the resulting salt water by indirect air conditioning in a self-cleaning fluidized bed heat exchanger/crystallizer to create a Usp Salt Chloride-containing dihydrate The slurry and also mommy liquor of the item, the brine does not have any kind of solid Usp Sodium Chlorideaccording to the judgment of the naked eye; ( 3) separating the sodium chloride dihydrate developed symphonious (2) at the eutectic temperature so that a stream abundant in Usp Sodium Chloride dihydrate is developed; ( 4) Usp Sodium Chloride dihydrate is fed into a recrystallizer to form Usp Sodium Chloride and also mom alcohol. record 2, An aliquot of 1,200 g of a 26 wt% NaCl solution (prepared by liquifying pharmaceutical quality salt in demineralized water at space temperature level) was placed in a jacketed glass vessel as well as cooled using Syltherm 800 for air conditioning. Listed below 0 ° C, Usp Sodium Chloride dihydrate starts to take shape. Cooling was quit at -19 ° C. Just one solid phase is formed. When mixing was stopped, crystals settled to the bottom of the vessel. The crystals formed were separated by filtering off the mommy alcohol. The mommy liquor was examined for NaCl content (weight) and located to contain 23.6 wt% NaCl. The Usp Sodium Chloride dihydrate crystals were put in a buoy and the temperature level was elevated to 10 ° C. The crystals began to recrystallize into anhydrous Usp Sodium Chloride. Part of the sodium chloride item liquifies in the released water of crystallisation, so some saturated brine is formed. The crystals were divided from the brine by filtering through a glass filter and were of high purity. report three. At space temperature level, 20 ml of ethanol was added to 50 ml of saturated aqueous Usp Sodium Chloride solution, and after mixing for 2 minutes, 50 ml of 31% focused hydrochloric acid was added, and also the option was permitted to settle for half a hr. The micron-scale superfine Usp Sodium Chloride powder was gotten. The fragment dimension of the crystals prepared in this instance was observed with an optical microscope: when the amount of ethanol was 20 ml, the bit dimension of sodium chloride was 8-10 μm; the crystallization return was 86%. report four. At room temperature level, 742 g of calcium chloride and also 1000 mL of saturated Usp Sodium Chloride solution were completely blended for 2 hours, then kept in a mixing state, as well as experienced for filtration., include 1 mg of potassium ferrocyanide, stir for 0.5 h, filter, clean the filter cake with 300 mL of saturated Usp Sodium Chloride solution three times, accumulate the solid, as well as ultimately completely dry it in a vacuum drying stove to get micron-sized sodium chloride at a temperature level of 80 ° C. The calcium ion concentration in the filtrate was spotted by the same approach as well as discovered that C=117.74 g/L, the filtrate was 1800mL, and also 731.73 g of sodium sulfate was added to the filtrate with mixing and also proceeded stirring. Filter, gauge the calcium ion concentration C=0.56 g/L in the filtrate, filter, wash the filter cake with 100 mL of water, gather the strong, and also ultimately dry it in a vacuum cleaner drying out oven to get micron-scale calcium sulfate at a temperature of 120 ° C. record 5. At space temperature level, include 50 ml of ethanol to 50 ml of saturated liquid Usp Sodium Chloride solution, without adding modifier, stir for half an hour, promptly filter to gather crystals, and completely dry in a vacuum drying out stove at 80 ° C. The surface morphology was scanned with a scanning electron microscopic lense (SEM) and the particle dimension was determined. When making use of various percentages of ethanol as anti-solvent to prepare ultrafine NaCl, the fragment dimension distribution of NaCl is around a couple of microns. When the amount of ethanol is 50 ml, the fragment size of Usp Sodium Chloride is 7.07 μm; the primary condensation return is 41.4%.
