Zhishang Chemical

Welcome to Zhishang Chemical      +86-176 5311 3209     Simon@sdzschem.com

Zhishang Chemical
Search
Close this search box.

USNIC ACID CAS 125-46-2

Molecular Formula: C18H16O7

Formula Weight: 344.32

ZSpharmac: USNIC ACID Supplier

Facebook
Twitter
LinkedIn
Pinterest
WhatsApp
Email
Product Name: USNIC ACID
CAS No: 125-46-2
Purity: 99%

Navigation Bar

Basic Info

Product Name:USNIC ACID
Other Names:(+)-Usnic Acid
CAS:125-46-2
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:A Crystalline Solid
EINECS No.:204-740-7
Storage:Under Inert Gas (Nitrogen Or Argon) at 2-8°C
Provide:USNIC ACID MSDS;
USNIC ACID COA

What is USNIC ACID?

Lichen is a type of organic microorganism with high genetic security formed by cooperative germs (ascomycetes or spores) as well as cooperative algae (cyanobacteria or green algae) after a long period of biological evolution, likewise called lichen-type fungi. Lichens are a vital class of organisms in all-natural environments as well as commonly exist in nature, including plateaus, grasslands, forests, arid deserts, rock surfaces, and also even equatorial as well as polar regions. In taxonomy, lichens are regarded as an independent phylum, and also there are presently 522 genera and also more than 13,500 species known. my country’s lichen sources are really rich, involving 232 genera as well as 1766 species, of which greater than 300 lichens are special to my country. Additional metabolites created by lichens have solid organic task. Lichens have been extensively utilized in folk antibacterial therapy for a very long time. Because lots of secondary metabolites generated by lichens have solid antibacterial results, after penicillin, lichens were formally utilized as a screening agent for anti-biotics in 1940-1950. a vital research topic. In fact, a multitude of researches executed in contemporary times have even more verified the anti-bacterial impact of lichen.
USNIC ACID is currently among one of the most crucial and commonly distributed lichenic acids, additionally called lichenic acid, mainly discovered in Usnea, Alectoria, Ramalina, and also Lichen (Evernia), Cetraria, Cladonia, Parmelia, Lecanora, Haematomma as well as various other category, in the Usneaceae, The material in Meiyi family members as well as Lithmus lichen generally accounts for 0.1 to 4% of the completely dry weight of lichen, and the content in Alectoria chromeuca is 8%. USNIC ACID is an effective furan antibiotic with optical activity. It is found in 2 types (+) as well as (-) in lichens. According to records, in the 1960s, the previous Soviet Union made USNIC ACID into various dose forms, which were commonly used in the treatment of injuries, burns, chapped and other conditions. As a result of its solid anti-bacterial, anti-radiation, antibacterial and also other effects, usnic acid has actually been used in medication, fragrance, cosmetics and also various other industries, and it is added as a pure substance to tooth paste, mouth wash, antiperspirant, sun block oil as well as weight reduction products. Products and so on. In recent years, the study on usnic acid has mainly concentrated on antibacterial, antiviral, insecticidal, antitumor, anti-inflammatory and also other elements.

USNIC ACID Property

Melting point 200°C
alpha D16 +509.4° (c = 0.697 in chloroform)
Boiling point 399.43°C (rough estimate)
density 1.2869 (rough estimate)
refractive index 495 ° (C=0.7, CHCl3)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMF:2.5(Max Conc. mg/mL);7.26(Max Conc. mM)
form A crystalline solid

 

USNIC ACID Uses

Usnic acid is a broad-spectrum antibiotic, which has a solid repressive outcome on a lot of Gram-positive bacteria. The focus of 50 μg/ mL can entirely hinder the development of microbes, and it is utilized as a high-efficiency preservative in cosmetics.It has a discerning inhibitory impact on Streptococcus, the major bacteria that create oral diseases as well as dental caries. Usnic acid has medicinal effect on various skin diseases such as burns, infection, psoriasis and so on.
1. Clinical application: Oral administration of 0.1-1.0g usnic acid sodium salt per day can improve some symptoms of pulmonary tuberculosis and intestinal tuberculosis, such as cough, loss of appetite, fever or intestinal tuberculosis diarrhea, and even Make the microscopic examination of Mycobacterium tuberculosis negative. It can also be used for purulent wounds, burns and skin infections.
2. Application in environmental monitoring: Paraquat (a highly toxic herbicide) can transfer electrons to O2 from different transport systems to generate superoxide radicals. Two kinds of lichens, wrinkled and smooth, were treated with paraquat, and then the content of usnic acid in the two lichens was measured by HPLC. As a result, the content of usnic acid in smooth plum skin increased by 36.3%, and that in wrinkled plum skin increased by 13.7%. They believe that the role of usnic acid depends on different lichen species. This study provides direction for the application of usnic acid in the field of pharmaceuticals, cosmetics and environmental biomonitoring.
3. Application in other aspects: In recent years, it has been found that usnic acid has the function of analgesic and antipyretic agent, and its drug effect can be compared with aminopyrine (antipyretic and analgesic), phenylbutazone (anti-inflammatory analgesic) and Hydrocortisone hemisuccinate compared. At the same time, it has been found to have similar effects to antiviral drugs, antiprotozoal drugs, antiproliferative active drugs and anti-inflammatory drugs. Intravenous injection of 10mg/kg Usnenic acid sodium can rapidly and significantly enhance the breathing of anesthetized cats, increase ventilation for a long time, increase oxygen consumption, and increase body temperature. The role, and the toxicity is greater than dinitrophenol. Because of its antibacterial effect, usnic acid can be applied as a preservative.

Pharmacological Action of Usnic Acid

1. Antibacterial impact: Usnic acid can properly inhibit the development of Gram-positive microorganisms such as Staphylococcus aureus, MRSA, acne bacilli, and coryneform bacteria, as well as can prevent the development of Pityrosporum furfur, directly killing Staphylococcus aureus cells, impeding the transduction path of Pseudomonas aeruginosa signal, recommending that Usnea grandis essence as well as Usnea acid can be made use of to deal with acne, rosacea, seborrheic dermatitis and also various other relevant skin diseases; on top of that, Usnea acid can remove sa drug-resistant plasmid, the function of 24h its removal price of 52%, to prolong the action time to 48h, the removal price of approximately 14.6%, might be utilized for clinical treatment of drug-resistant sa infection.
2. Antiviral impact: Research studies have shown that usnic acid has the possible to hinder the spreading of mouse polyomavirus, primarily by hindering the formation of carrier RNA, thus indirectly hindering the duplication of DNA. Usnenic acid in Usnea longus has the task of hindering Epstein-barrvirus (Epstein-barrvirus, EBV), amongst which (+)-usnicic acid showed the highest inhibitory activity (ED501.0 μg/ mL), while (-)-Usnic acid has weak repressive task (ED505.0 μg/ mL).
3. Insecticidal effect: (+)-usnic acid has the activity of killing the promastigotes of Leishmania donovani (Kala-azar), and the artificial insemination active focus of (+)-usnic acid is 25 μg/ mL. The minimum reliable concentration of S-(-) usnic acid to kill trichomoniasis in vitro is 0.4 mg/mL, and there is no significant distinction in the in vitro trichomoniasis killing impact between usnic acid at a focus of 0.4 mg/mL as well as over as well as the same focus of metronidazole. Usnic acid has a development repressive result on trypanosome larvae in 5-30μg/ mL, as well as usnic acid can likewise substantially minimize the quantity of trypanosomes in the blood. Use 40 or 80μg/ mL usnic acid to act as a gigantic infection. Phagocytes can bring about the disintegration of trypanosome mitochondria and Golgi apparatus, as well as the cytoplasm ends up being vacuolated, but has no impact on host cells.
4. Anti-tumor impact: Usnic acid has anti-wild-type P53 breast cancer cells cell line MCF7, non-functional P53 breast cancer cell line MDA-MB-231, lung cancer cells cell line H1299 as well as different cancer cells cell lines L1210, 3LL, DU145, The activity of MCF7, K-562 as well as U251 does not trigger damages to the DNA of typical cells, so it is anticipated to be turned into a new generation of anticancer medicines. Study the inhibitory result of usnic acid drawn out from the fungus Usnea on the spreading of prostate cancer cells PC-3M cells cultured artificial insemination. The results of cell growth restraint experiments reveal that the maximum inhibition price can reach more than 80%, as well as the biological effect is dose-dependent inhibition Partnership, showing that usnic acid has a repressive effect on PC-3M cells cultured in vitro, decreases the proliferation of growth cells, as well as has evident anti-tumor impacts. Yet usnic acid has no repressive impact on 12(S)-LOX cultured with human platelets in vitro. Usnic acid has poor water solubility, and it makes use of 10%HP-β-CD as a solubilizer to examine the effect on 3 type of human deadly cell lines under the problem of pH7.4. -70-fold boost in solubility in CD, with EC50 of 2.9 μg/ mL, 4.3 μg/ mL as well as 8.2 μg/ mL for T-47D, Panc-1 and also PC-3 cells, respectively.
5. Anti-inflammatory task: Usnic acid was studied on the anti-inflammatory activity of rat paw swelling test (intense swelling) as well as rat cotton sphere granuloma test (persistent swelling), and also advil was made use of as a favorable control drug. The outcomes showed that For intense inflammation, at the same dosage as advil (oral 100mg/kg), the anti-inflammatory effect of ibuprofen is far better than that of usnic acid; for persistent inflammation, the anti-inflammatory result of the two is equivalent, and there is a significant difference compared with the control group, It is guessed that the anti-inflammatory system of pinic acid is associated with the restraint of prostaglandin synthesis.
6. Other activities: research the result of sodium usnelate on promoting skin wound healing. The overall experiment reveals that outside application of sodium usnelate can increase the repair service of speculative large skin damages, however the impact of 0.5-8 μg/ mL on the spreading of L929 fibroblasts No assistance. Additionally, the result of salt usnenate on fibroblasts and also its system of promoting injury healing were examined. The outcomes showed that salt usnenate might promote the secretion of TGF-1 and EGF by fibroblasts, and with the boost of medicine focus As well as enhanced, it generates chemotactic effect on repair cells and also inflammatory cells, promotes repair service cell migration as well as deposition of extracellular matrix, as well as promotes injury healing. Furthermore, experimental studies have actually shown that usnic acid has a better stomach protection effect on the stomach ulcer model of rats induced by indomethacin. Compared with the model team, it can substantially boost the degrees of SOD, GSH as well as GPx in rats, reduce the level of LPO, and boost cNOS, decrease iNOS. In regards to anti-radiation, the research study on the absorption of lichen secondary metabolites in the UV region reveals that usnic acid generally absorbs in the UV-B region as well as is fairly steady to light. And the photolysis item of usnic acid still has absorption effect on UV, recommending that usnic acid is a very possible natural sun block agent, which can be used in sun block and also various other cosmetics.

The Preparation Technology of Usnic Acid

1. Antibacterial impact: Usnic acid can properly inhibit the development of Gram-positive microorganisms such as Staphylococcus aureus, MRSA, acne bacilli, and coryneform bacteria, as well as can prevent the development of Pityrosporum furfur, directly killing Staphylococcus aureus cells, impeding the transduction path of Pseudomonas aeruginosa signal, recommending that Usnea grandis essence as well as Usnea acid can be made use of to deal with acne, rosacea, seborrheic dermatitis and also various other relevant skin diseases; on top of that, Usnea acid can remove sa drug-resistant plasmid, the function of 24h its removal price of 52%, to prolong the action time to 48h, the removal price of approximately 14.6%, might be utilized for clinical treatment of drug-resistant sa infection.
2. Antiviral impact: Research studies have shown that usnic acid has the possible to hinder the spreading of mouse polyomavirus, primarily by hindering the formation of carrier RNA, thus indirectly hindering the duplication of DNA. Usnenic acid in Usnea longus has the task of hindering Epstein-barrvirus (Epstein-barrvirus, EBV), amongst which (+)-usnicic acid showed the highest inhibitory activity (ED501.0 μg/ mL), while (-)-Usnic acid has weak repressive task (ED505.0 μg/ mL).
3. Insecticidal effect: (+)-usnic acid has the activity of killing the promastigotes of Leishmania donovani (Kala-azar), and the artificial insemination active focus of (+)-usnic acid is 25 μg/ mL. The minimum reliable concentration of S-(-) usnic acid to kill trichomoniasis in vitro is 0.4 mg/mL, and there is no significant distinction in the in vitro trichomoniasis killing impact between usnic acid at a focus of 0.4 mg/mL as well as over as well as the same focus of metronidazole. Usnic acid has a development repressive result on trypanosome larvae in 5-30μg/ mL, as well as usnic acid can likewise substantially minimize the quantity of trypanosomes in the blood. Use 40 or 80μg/ mL usnic acid to act as a gigantic infection. Phagocytes can bring about the disintegration of trypanosome mitochondria and Golgi apparatus, as well as the cytoplasm ends up being vacuolated, but has no impact on host cells.
4. Anti-tumor impact: Usnic acid has anti-wild-type P53 breast cancer cells cell line MCF7, non-functional P53 breast cancer cell line MDA-MB-231, lung cancer cells cell line H1299 as well as different cancer cells cell lines L1210, 3LL, DU145, The activity of MCF7, K-562 as well as U251 does not trigger damages to the DNA of typical cells, so it is anticipated to be turned into a new generation of anticancer medicines. Study the inhibitory result of usnic acid drawn out from the fungus Usnea on the spreading of prostate cancer cells PC-3M cells cultured artificial insemination. The results of cell growth restraint experiments reveal that the maximum inhibition price can reach more than 80%, as well as the biological effect is dose-dependent inhibition Partnership, showing that usnic acid has a repressive effect on PC-3M cells cultured in vitro, decreases the proliferation of growth cells, as well as has evident anti-tumor impacts. Yet usnic acid has no repressive impact on 12(S)-LOX cultured with human platelets in vitro. Usnic acid has poor water solubility, and it makes use of 10%HP-β-CD as a solubilizer to examine the effect on 3 type of human deadly cell lines under the problem of pH7.4. -70-fold boost in solubility in CD, with EC50 of 2.9 μg/ mL, 4.3 μg/ mL as well as 8.2 μg/ mL for T-47D, Panc-1 and also PC-3 cells, respectively.
5. Anti-inflammatory task: Usnic acid was studied on the anti-inflammatory activity of rat paw swelling test (intense swelling) as well as rat cotton sphere granuloma test (persistent swelling), and also advil was made use of as a favorable control drug. The outcomes showed that For intense inflammation, at the same dosage as advil (oral 100mg/kg), the anti-inflammatory effect of ibuprofen is far better than that of usnic acid; for persistent inflammation, the anti-inflammatory result of the two is equivalent, and there is a significant difference compared with the control group, It is guessed that the anti-inflammatory system of pinic acid is associated with the restraint of prostaglandin synthesis.
6. Other activities: research the result of sodium usnelate on promoting skin wound healing. The overall experiment reveals that outside application of sodium usnelate can increase the repair service of speculative large skin damages, however the impact of 0.5-8 μg/ mL on the spreading of L929 fibroblasts No assistance. Additionally, the result of salt usnenate on fibroblasts and also its system of promoting injury healing were examined. The outcomes showed that salt usnenate might promote the secretion of TGF-1 and EGF by fibroblasts, and with the boost of medicine focus As well as enhanced, it generates chemotactic effect on repair cells and also inflammatory cells, promotes repair service cell migration as well as deposition of extracellular matrix, as well as promotes injury healing. Furthermore, experimental studies have actually shown that usnic acid has a better stomach protection effect on the stomach ulcer model of rats induced by indomethacin. Compared with the model team, it can substantially boost the degrees of SOD, GSH as well as GPx in rats, reduce the level of LPO, and boost cNOS, decrease iNOS. In regards to anti-radiation, the research study on the absorption of lichen secondary metabolites in the UV region reveals that usnic acid generally absorbs in the UV-B region as well as is fairly steady to light. And the photolysis item of usnic acid still has absorption effect on UV, recommending that usnic acid is a very possible natural sun block agent, which can be used in sun block and also various other cosmetics.

About Products:
If you need Usnic Acid, the cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Usnic Acid manufacturer and supplier, ZSpharmac will provide Usnic Acid raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get USNIC ACID Quotation