Zhishang Chemical

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Zhishang Chemical

Ursolic Acid CAS 77-52-1

Molecular Formula: C30H48O3

Formula Weight: 456.71

ZSpharmac: Ursolic Acid  Supplement

Product Name: Ursolic Acid
CAS No: 77-52-1
Purity: 99%

Basic Info

Product Name:Ursolic Acid
Other Names:Ursolic Acid Reddit
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to off-White Crystalline Powder or Needles
EINECS No.:201-034-0
Provide:Ursolic Acid MSDS;
Ursolic Acid COA

What is Ursolic Acid ?

Ursolic acid, furthermore described as ursolic acid as well as additionally ursolic acid, is a pentacyclic triterpenoid substance gotten rid of from the evergreen creeping bush bearberry of the Rhododendron family members. It has an unique odor and also is large as well as also glossy in outright ethanol. Prisms, however terrific hair-like needles in weaken ethanol. insoluble in water as well as petroleum ether.Recently, it has been located that it has anti-carcinogenic, anti-cancer, causing F9 teratoma cell distinction and anti-angiogenesis results, in addition to it is extremely most likely ahead to be a new anti-cancer medication with decreased poisoning along with high efficiency. On top of that, ursolic acid has obvious antioxidant attribute along with is a solid antioxidant. The antioxidant impact of ursolic acid has desirable effects on the body’s anti-aging, skin blemish as well as pigment elimination, so it is extensively used as a Drug as well as likewise all-natural lightening cosmetic basic materials, experiments have revealed that ursolic acid can prevent the tasks of 5-lipoxygenase as well as likewise cyclooxygenase in the process of arachidonic acid metabolic process, and additionally prevent the manufacturing of prostaglandins in addition to leukotrienes, which may be ursolic acid Stops inflammatory response, prevents the origin of lipid peroxides.

Ursolic Acid Properties:

Melting point 292 °C (dec.) (lit.)
alpha 59 º (c=0.3, pyridine)
Boiling point 502.79°C (rough estimate)
density 1.0261 (rough estimate)
refractive index 1.4940 (estimate)
storage temp. 2-8°C
solubility Soluble in DMSO (up to 25 mg/ml with warming)
form Crystalline Powder or Needles
color White to off-white
Water Solubility insoluble


Ursolic Acid Uses

  1. Ursolic acid can additionally show its anticancer activity by causing apoptosis, hindering cell cycle progression, preventing cell proliferation, inhibiting metastasis, and lowering tumorigenesis through different signaling pathways. Current experimental studies have shown that ursolic acid inhibits a variety of cancers, including bladder cancer, colon cancer, breast cancer, cervical cancer, gastric cancer, glioma, neuroblastoma, fibrosarcoma, liver cancer, leukemia, multiple myeloma , lung cancer, ovarian cancer, pancreatic cancer, thyroid cancer, melanoma and prostate cancer, etc. In order to further understand and study the role of ursolic acid in cancer and open up a new chapter in chemotherapy, scientists have conducted a variety of in vivo and in vitro studies.
  2. The antioxidant result of Ursolic Acid has favorable impacts on the body’s anti-aging, skin blemish as well as pigment elimination. As a cosmetic, ursolic acid has secure homes, and its shade and smell do not transform with time, and also there are It has a great touch, so it is widely utilized in beauty and skin treatment items, as well as is a natural bleaching cosmetic resources.

Determination of Ursolic Acid Content in Plants

(1) Chromatographic problems: silica gel G thin-layer plate; cyclohexane-chloroform-ethyl acetate (20:5:8) is the developing representative, which is developed up; the dispersing distance is 12-18 cm; 5% sulfuric acid ethanol solution, warmed at 110 ° C 5min color advancement.
( 2) Preparation of the reference compound solution: Exactly evaluate a suitable quantity of the ursolic acid referral material, include a mixed option of outright ethanol: ethanol (3:2) to make a service including 1 mg per milliliter as the reference substance remedy.
( 3) Preparation of sample remedy: Precisely weigh 20 g of a shattered example of gardenia (the fried gardenia is taken after the return is converted), placed it in a Soxhlet extractor, add 300 ml of ether for reflux removal till colorless, and also recoup the solvent to dryness. The residue was soaked in petroleum ether for 2 times, 15ml each time, concerning 2min, and also the oil ether was poured out, and also the mix of absolute ethanol-diethyl ether (2:3) was somewhat warmed to liquify as well as ready to a 5ml volumetric flask as a sample remedy.
( 4) Determination: Precisely draw 2 μl of the sample solution as well as the referral remedy, as well as place them on the exact same thin-layer plate. According to the above chromatographic problems, develop color. Scan according to the thin-layer scanning method, λS=520nm, λR=700nm; double-wavelength reflection method sawtooth scanning; SX=3.0; slit: 1.20 mm × 1.2 mm; paper rate: 20mm/min. Step the absorbance essential worth of the example as well as the recommendation compound, and also determine the ursolic acid content.

In Vivo Study of Ursolic Acid

At present, scientists have detected the chemosensitizing effect of ursolic acid in animal models, and research reports have shown that ursolic acid exhibits significant chemosensitizing effects on a variety of cancer types. In addition, ursolic acid sensitizes the therapeutic drug capecitabine by inhibiting multiple biomarkers related to inflammation, proliferation, invasion, angiogenesis, and metastasis, and has the potential to improve the efficacy of traditional drugs. Therefore, preclinical studies suggest that combining ursolic acid with other natural compounds, conventional drugs or radiation may be an effective combination for the treatment of cancer.

Fruits, vegetables, and herbs that are sources of ursolic acid are commonly consumed by humans and are considered safe. To date, no toxic effects associated with the use of ursolic acid have been identified in animal or human studies. In addition, the U.S. Food and Drug Administration and the European Food and Safety Administration recommend that the specific composition of rosemary extract (one of the sources of ursolic acid) is safe for human health and for use as an antioxidant additive in food, which This suggests that UA has potential as an adjunct to cancer therapy.

Many experimental systems have reported that UA has various biochemical and pharmacological effects such as anti-inflammatory, antioxidant, anti-proliferative, anti-cancer, anti-mutation, anti-atherosclerosis, anti-hypertensive, anti-leukemia and anti-virus; UA can not only enhance cancer The chemosensitivity of cells can also enhance the effects of other chemotherapeutic agents on liver injury, glucose intolerance and insulin resistance, acne vulgaris, hyperlipidemia, biofilm formation, myocyte differentiation, depression and neurodegenerative diseases. Although some clinical studies have confirmed the safety and efficacy of ursolic acid, more clinical studies with more and more patients are still needed to validate the existing findings.

Therefore, the use of new and safe drugs, such as ursolic acid, in conjunction with the original chemotherapy drugs, reduces the burden on patients, reduces the side effects of chemotherapy, increases the efficacy of drugs, prolongs the life and quality of life of cancer patients, and is also very important for the prognosis of cancer treatment. .

Although ursolic acid has no firm evidence so far in cancer treatment, as a natural ingredient from food sources, both in vitro and in vivo studies have shown antitumor potential, and it may be used as a safe adjunct drug for research.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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