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Ubidecarenone CAS 303-98-0

Molecular Formula: C59H90O4

Formula Weight: 863.34

ZSpharmac: Ubidecarenone Supplement

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Product Name: Ubidecarenone
CAS No: 303-98-0
Purity: 99%

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Basic Info

Product Name:Ubidecarenone
Other Names:coenzyme Q10
CAS:303-98-0
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Light Orange to Dark Orange Neat
EINECS No.:206-147-9
Storage:-20°C
Provide:Ubidecarenone MSDS;
Ubidecarenone COA

What is Ubidecarenone?

Ubidecarenone is one of the important physiologically active substances that are indispensable for human health. It has functions such as improving human immunity, enhancing antioxidant capacity, and delaying aging. According to reports, the annual demand for Ubidecarenone raw materials in the world market in 2005 has reached about 400t, and it is still growing at an annual rate of 10%. Japan is the first country to develop coenzyme Q10, and its production ranks first in the world. Currently, most of the world’s products come from Japan. In recent years, Ubidecarenone has been widely used in the pharmaceutical, health care and cosmetic markets in Western Europe, the United States, Australia and Japan. In my country, Ubidecarenone was initially mainly limited to the application in the field of medicine, and now it is gradually expanding into the fields of food, health care products and cosmetics, and the market demand is growing. The international market is in short supply and the domestic market is in short supply. Coenzyme Q10 has become one of the important raw materials in the international market.

Coenzyme Q10 (coenzymeQ10) is also known as ubiquinone (named for the quinone substances widely present in the mitochondrial respiratory chain of living cells), molecular formula: C59H90O4, molecular weight: 863.36. The chemical name is 2,3-dimethoxy-5-methyl-6-decabenyl-benzoquinone. Ubidecarenone is yellow or light yellow crystalline powder, odorless, tasteless, easily soluble in chloroform, benzene, carbon tetrachloride, soluble in acetone, petroleum ether and ether; slightly soluble in ethanol, insoluble in water and methanol. It is easily decomposed into a red substance when exposed to light, and is stable to temperature and humidity, with a melting point of 49°C. Ubidecarenone is a lipid-soluble electron carrier between NADH dehydrogenase, succinate dehydrogenase and BC complexes in the respiratory chain, an ATP generating element, and plays an important role in the proton transfer and electron transfer of the respiratory chain in the cell mitochondria. Activator of respiration and cellular metabolism, also an important antioxidant and non-specific immune enhancer. Because Ubidecarenone can enhance physical strength and energy, protect cardiovascular, reduce the side effects of lipid-lowering drugs, protect the skin and other functions, it also has important application value for improving immunity, delaying aging, health care and beauty.

Ubidecarenone Properties:

Melting point 49-51 °C
Boiling point 715.32°C (rough estimate)
density 0.9145 (rough estimate)
refractive index 1.4760 (estimate)
storage temp. -20°C
solubility Soluble in chloroform.
form neat
color Light Orange to Dark Orange

 

Ubidecarenone Uses

  1. Ubidecarenone is a coenzyme medication. Likewise an important antioxidant as well as immune booster.Additionally, it is additionally tried for main and also second hyperaldosteronism, cerebrovascular disorders and hemorrhagic shock. Nausea or vomiting, tummy discomfort, anorexia nervosa, and so on may happen during use, and periodically urticaria and transient palpitations might happen.
  2. Ubidecarenone can be extensively made use of in food, cosmetics, dietary supplements as well as other industries. Coenzymes are additionally vital antioxidants and also immune enhancers.
  3. Ubidecarenone can activate the nutrients of human cells and cellular power, which can boost human resistance, boost anti-oxidation, hold-up aging and also boost human vigor. On top of that, researches in the last few years have revealed that this item likewise has anti-tumor results, as well as has a specific professional result on advanced metastatic cancer. It can avoid coronary heart problem, alleviate periodontitis, deal with duodenal abscess and also gastric abscess, as well as enhance human immune feature. as well as has a significant result in eliminating angina pectoris.

Ubidecarenone Production Method

Preparation of APIs
Technique 1. Alcohol-alkali saponification technique
Prep work of saponification remedy Take pig heart deposit, press completely dry and also consider, add 300g/L industrial pyrogallic acid according to the weight of the dry deposit, stir well, add alcohol-alkali solution (3-3.5 times the quantity of ethanol, 320g/L of the completely dry deposit) Salt hydroxide), warmed as well as mixed to reflux for 25-30min, rapidly cooled to area temperature to acquire a saponified remedy. Pig heart deposit [NaOH] → [Pyrogallic acid, ethanol] Preparation of saponification liquid concentrate Take the saponification fluid, promptly add 1/10 of its volume of petroleum ether or 120 # fuel to extract 3-4 times, mix, layer, get the essence. Clean with water until virtually neutral, concentrate to 1/10 of the initial volume at listed below 40 ° C, amazing, allow stand overnight below -5 ° C, as well as filter to get a focused remedy. Saponification option [oil ether] → extraction remedy [< 40 ℃] → concentrate Ubidecarenone Preparation of refined items The concentrate went through silica gel column chromatography, eluted with oil ether and 10% ether-petroleum ether together, and the eluate was collected, The solvent was recovered to obtain a yellow oil. Dissolve in outright ethanol by heating, filter, stand the filtrate, crystallize by cooling, and dry in vacuum to acquire Ubidecarenone refined product Concentrate [silica gel column, ether-petroleum ether] → eluent [absolute ethanol] → Ubidecarenone refined item.

Approach 2, alcohol-ether mixed solvent extraction method
Preparation of Ubidecarenone Crude item Take the pig heart residue,add 1.5 times the amount of V ethanol: V ether = 3:1 mixed solvent, add Chemicalbook to heat for 3-4 times, each 15-20min, cool to room temperature, filter, and extract together liquid. Concentrate, add appropriate amount of water, add petroleum ether for extraction, concentrate the extract, and the concentrate is a yellow oily product, namely Ubidecarenone crude product. Preparation of Ubidecarenone Finished Ubidecarenone Take the crude Ubidecarenone product, dissolve it in acetone, set it to below -10°C to separate out impurities, filter, evaporate the filtrate to remove acetone, add a small amount of petroleum ether to dissolve, separate it by silica gel column chromatography, add anhydrous ethanol to crystallize, and obtain coenzyme Q10 finished product. Ubidecarenone crude product [silica column] → [acetone, anhydrous ethanol] Coenzyme Q10 finished product

Method 3. Use beef heart slag as raw material
Beef heart dregs [10%NaOH-80% ethanol]→brown black solution [extraction]→gasoline extract [washing]→orange butter layer [concentration]→Ubidecarenone crude product [fat separation]→clear oil layer [column chromatography]→ Ubidecarenone eluent [frozen, concentrated] → orange-yellow oil [crystal dry] → coenzyme Q10 finished product injection Properties This product is a yellow and clear liquid, with the prolongation of storage time, there will be orange-yellow precipitation, which can be heated in hot water A few minutes, shake to dissolve, does not affect the curative effect. The stability of this crystal is poor. When placed for 3-6 months, the content decreases by about 3%-5%, and the highest is more than 8%. However, the rate of decrease of the content becomes slower with the passage of time. Preparation This product is a sterile aqueous solution made of Ubidecarenone and Tween-80 or other cosolvents.

Ubidecarenone Indications

1. Therapy of cardiac arrest and also dilated cardiomyopathy: Ubidecarenone has an exceptional repairing effect on myocardial cell problems triggered by ischemic (hypoxic) heart problem, as well as considerably boosts myocardial hypertrophy and dilated cardiomyopathy.
2. Impacts of lowering high blood pressure and blood lipids: A 12-week double-blind test on 46 men as well as 37 women with hypertension discovered that clients that took in 120 mg each day (in two divided dosages) had an average drop in blood pressure of concerning 17 mm mercury shot (mmHg).
3. Antioxidative residential or commercial properties, application of cardio system: avoidance of arteriosclerosis, myocardial infarction and also apoplexy, Ubidecarenone, as a strong antioxidant, can resist the oxidation of low-density lipoprotein in the blood, reduce the formation of arteriosclerosis, and also avoid heart attack and also thrombosis.
4th, the treatment of heart disease: In 1970, the scientist Folkers verified by medical tests that compared to standard medicine, 2/3 of the clients who took in 100 mg of Ubidecarenone a day for 2 consecutive months had substantially improved cardiac feature.
5. For the treatment of heart disease after surgery: The healing time of Ubidecarenone is substantially reduced than that of people that have not used it.
6. Postpone the advancement of heart failure as well as minimize the mortality price: It can treat upper body discomfort triggered by coronary stenosis. Boost heart beating capability, hypoxia tolerance.
7. Charm and anti-aging: Assist the skin stop oxidative damage to DNA, withstand photoaging, and lower creases. It is additionally frequently made use of in numerous anti-wrinkle, fixing as well as skin tightening solutions. However, extensive research study believes that exogenous Ubidecarenone is far much less reliable than endogenous Ubidecarenone to resist human aging.
8. Anti-fatigue: It has the function of protecting and bring back the honesty of the biofilm structure as well as stabilizing the membrane layer potential. It is a non-specific immune booster of the body, so it shows a superb anti-fatigue result as well as keeps the cells in a great and also healthy and balanced state.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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