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Tween 80 CAS 9005-65-6

Molecular Formula: C24H44O6

Formula Weight: 428.600006103516

ZSpharmac: Tween 80 Supplier

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Product Name: Tween 80
CAS No: 9005-65-6
Purity: 99%

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Basic Info

Product Name:Tween 80
Other Names:Polysorbate 80
CAS:9005-65-6
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Amber Viscous Liquid
EINECS No.:500-019-9
Storage:-20°C
Provide:Tween 80 MSDS;
Tween 80 COA

What is Tween 80?

Tween 80 is an artificial non-ionic emulsifier, extensively used in cosmetics, food locations in addition to pharmaceutical preparation work. Its commercial production method is: under alkali catalysis, ethylene oxide and sorbitol fat partial ester as well as likewise sorbitan fat partial ester carry out improvement reaction, where every 1 mol of sorbitol or matching sorbitol anhydride is included with 20 mol of ethylene oxide. This kind of emulsifier was first developed by ICI Organization in the USA. Tween is the trade name provided to this type of emulsifier by ICI Firm, as well as various numbers are given according to the different sorts of fatty acids utilized in the synthesis procedure to produce a full occupation name., such as Tween 60, Tween 80, and so on. Due to its broad application along with hassle-free memory, Tween has actually ended up being a typical brand name for polysorbate on the market. It has a characteristic oily odor and additionally a rather bitter taste. Tween has good thermal security. Due to the fact that the prolonged chain of polyoxyethylene comprises a hydrophilic group, the percentage of the hydrophilic team in the whole emulsifier bit is leading. Because of that, Tween has high hydrophilic performance and additionally HLB worth, originating from O/W kind emulsifier. Its surface task is not influenced by ecological pH, as well as likewise can considerably reduce the interfacial stress of soybean oil/water system at a really low emphasis (0.05%). Tween itself is water-soluble, as well as also at the same time, it has an excellent solubilizing impact on lipophilic compounds that are insoluble in water, along with can be made use of to develop emulsified tastes. It also has exceptional oygenation and also mixing frothing cause food. It has a wonderful preserving outcome on certain oil crystals. Utilizes: Tween is generally made use of in the food market. It can be used as an emulsifier, stabilizer along with dispersant in bakery items for bread, cake, ice cream as well as reducing.

Tween 80 Property

Melting point 

-25 °C

Boiling point 

>100°C

density 

1.08 g/mL at 20 °C

vapor pressure 

<1 mm Hg ( 20 °C)

refractive index 

n20/D 1.473

Fp 

>230 °F

storage temp. 

-20°C

form 

viscous liquid

color 

Amber

Specific Gravity

1.080 (25/4℃)

PH

5-7 (50g/l, H2O, 20℃)

PH Range

6

Water Solubility 

5-10 g/100 mL at 23 ºC

 

Tween 80 Uses

  1. Tween 80 is extensively made use of in oil extraction as well as transport, medicine, cosmetics, paint pigments, textiles, food, pesticides. It is utilized as emulsifier, dispersant, stabilizer, diffusing agent, lubricant, conditioner, antistatic representative, corrosion inhibitor, completing representative, viscosity reducer, and so on in detergent manufacturing and metal surface antirust cleaning.
  2. Tween 80 is used as emulsifier, moistening representative, penetrating agent, diffusing representative, and so on. It is additionally made use of as a component of cotton as well as viscose cord tensioning representatives. Used as an emulsifier in the manufacturing of polyurethane foam. The food industry is utilized as an emulsifier for ice cream. The dosage is 0.1% butter, and the basic oil has to do with 1%.
  3. Tween 80 is used as a solubilizer, diffusing agent, antistatic agent, stabilizer, lubricant, etc.
  4. Tween 80 is made use of as a stationary liquid in gas chromatography for the splitting up of alcohols, ketones, esters and also fats and also hydrocarbons.
  5. Tween 80 is used as O/W type food emulsifier, used alone or combined with Span-60, Span-65 and Span-80. my nation states that it can be made use of to emulsify all-natural pigments, and the maximum use is 1. g/kg; the optimum usage in milk is 1.5 g/kg; the maximum use in gelato and also gelato is 1.0 g/kg.
  6. Tween 80 has superb emulsifying, dispersing and wetting properties. In the food market, it is made use of as an emulsifier, dispersant as well as turbidity for sodas such as gelato, bread, cakes, candies, and so on. The dosage is 0.1% to 0.5% to stop velvety food from spraying, food aging, and also to boost high quality, boost gloss, improve preference, as well as boost gentleness. Particularly for velvety chocolate toffee, there is a clear anti-blooming effect. It can be used alone or together with food emulsifiers such as glycerides as well as sucrose esters to put in a synergistic effect. It is also widely used as a solubilizer in innovative cosmetics, light textiles, as well as pharmaceutical sectors. It is additionally widely made use of in textiles, paints, emulsion explosives, chemicals, printing, petroleum and various other sectors as emulsifiers, stabilizers, lubricating substances, softeners, and antistatic agents.

Tween 80 Pharmacological Activity

Intravenous injection of Tween 80-containing injections, such as etoposide injection and docetaxel injection, often produces acute hypersensitivity reactions, especially docetaxel injection, with an early occurrence rate of 5% to 40% (Severe cases are more than the second-class allergy standard set by the National Cancer Institute, which is a minority), which can be effectively improved by giving glucocorticoids and antihistamines before surgery. It is speculated that it is related to the oleic acid released by its hydrolysis in vivo. Studies have shown that oleic acid can promote the release of histamine in dogs and cause acute hypersensitivity reactions. Domestic studies have also been carried out on the allergic reactions caused by traditional Chinese medicine injections containing Tween 80 to dogs.

American scientists have found that Tween 80 may cause the degeneration of cystic cells, thereby causing peripheral neurotoxicity. The cause of this adverse reaction may be the polyol compound in Tween 80. Polyethylenes produced by reaction with ethylene oxide.

P-glycoprotein plays an important role in the active drug transport process. Tween 80 can form giant micelles in blood and body fluids to encapsulate or chimeric protein molecules, inhibiting P-glycoprotein from participating in the drug transport process at the biomembrane interface. 

Tween 80 showed some antitumor activity in model animals, which may be related to the release of oleic acid. Research data show that oleic acid can inhibit the production of peroxides in the body and interfere with the growth of tumor cells.

Medical workers in Switzerland and other countries have reported 28 cases of acute liver injury such as elevated transaminase and jaundice due to rapid intravenous infusion of amiodarone. Among them, 1 patient was given oral administration without Tween 80 due to the need for liver injury after liver injury. The amiodarone tablet showed no damage, so it is presumed to be caused by Tween 80. Domestic studies have also shown that: 3 different dosing regimens were used to give TUW 80 to dogs. Group 1, intramuscular injection of 40 mg·kg-1, once a month, for 6 consecutive months; group 2 , intramuscular injection of 5 mg · kg-1, once every 3 days, a total of 3 times; group 3, continuous infusion of 52 mg · kg-1 · hr-1, for 3 consecutive days. Group 1 dogs developed facial swelling, systemic congestion, and increased water intake. However, the incidence and frequency of these observations decreased significantly from the third dose onwards. One dog was killed with vomiting, recumbency, and rectal bleeding after a single dose. Microscopic examination revealed hyperemia, inflammation, hemorrhage, and necrosis of the gastrointestinal tract. The clinical signs of animals in groups 2 and 3 were similar to those in group 1. Animals in group 3 also developed marked anemia and leukocytosis. Clinical chemical examination found that AST and bilirubin were significantly increased, BUN and creatinine were slightly increased, and serum potassium was significantly decreased.

Gross observation and microscopic examination revealed TU80-related changes in liver, kidney, lung, and skin. Liver changes include vacuolation of hepatocytes, eosinophils in sinusoids, eosinophilic bodies, green/brown staining of bile ducts, necrosis of hepatocytes, vacuolation of epithelial cells of renal convoluted tubules; pulmonary edema, necrosis, acute inflammation; Skin hyperemia, edema, necrosis, inflammation. Sweden reported a case of contact allergy caused by the use of Tween 80 aerosols, and it was believed that Tween 80 had adverse effects on the patient’s lungs.

Analysis of Tween 80

About Products:
If you need Tween 80, a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Tween 80 manufacturer and supplier, ZSpharmac will provide Tween 80 raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, and customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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