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Troxerutin CAS 7085-55-4

Molecular Formula: C33H42O19

Formula Weight: 742.68

ZSpharmac: Troxerutin Supplier

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Product Name: Troxerutin
CAS No: 7085-55-4
Purity: 99%

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Basic Info

Product Name:Troxerutin
Other Names:Troxerutin, 95%
CAS:7085-55-4
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Light Yellow to Yellow Neat
EINECS No.:230-389-4
Storage:Sealed in Dry,Store in Freezer, Under -20°C
Provide:Troxerutin MSDS;
Troxerutin COA

What is Troxerutin?

Troxerutin (troxerutin)It can hinder the gathering of red cell and platelets, boost blood oxygen content, enhance microcirculation, and also promote the formation of new members vessels. It is a far better medicine for dealing with occlusive analytical capillary, protecting endothelial cells, as well as treating acute ischemic brain injury; It additionally has the effects of anti-radiation damage, anti-inflammation, anti-allergy, and also anti-ulcer. It is the primary part of Vinaorutong, often made into tablet computers as well as shots.

Troxerutin Property

Melting point 181°C
Boiling point 1058.4±65.0 °C(Predicted)
density 1.65±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Freely soluble in water, slightly soluble in ethanol (96 per cent) and practically insoluble in methylene chloride.
form neat
pka5.92±0.40(Predicted)
color Light Yellow to Yellow

 

Troxerutin Anti-Blue Light Sunscreen Artifact

Light belongs to visible light, next to the ultraviolet band. Although it is not as good as ultraviolet rays, blue light has a wavelength band between 400 and 500nm, which is the highest energy band in visible light.

Blue light can penetrate deeper into the skin causing oxidative damage to cellular DNA.

Paris famous dermatologist Marie-Estler Lu said: Blue light can cause melanin pigmentation for up to 3 months, especially in the epidermal granular layer and deeper skin layer.

Troxerutin is extracted from Sophora japonica, which is a natural plant-derived component. It is one of the flavonoid rutin derivatives. Troxerutin has better water solubility and better efficacy than rutin. Troxerutin has a strong absorption effect on blue light, and at the same time has a good anti-oxidation effect, reducing various damages to the skin caused by free radicals, and can achieve the effect of anti-blue light.

Troxerutin Safety – HaCaT Cytotoxicity HaCaT cells (4×104 cells) were seeded into 96-well plates and pre-incubated with indicated concentrations of Troxerutin for 4, 8 and 12 hours. After pretreatment, HaCaT cells were exposed to 50 mJ/cm², and cell viability was measured by the water-soluble tetrazolium salt (WST-1) assay. Results are presented in triplicate and expressed as mean ± SE of percent optical density (OD) of the control. Asterisks indicate significant differences compared to HaCaT cells treated with UVB alone (*p<0.05)

1. Troxerutin scavenges free radicals and protects cells from oxidative stress-induced damage

Studies have found that after cells are irradiated by blue light, active oxygen free radicals are generated in mitochondria, and these highly active oxygen free radicals can damage mitochondria and DNA. Troxerutin absorbs blue light, reduces the damage of blue light to cells, and achieves the effect of preventing blue light.

2. Troxerutin reduces the damage of blue light to the skin by absorbing blue light

3. Troxerutin anti-blue light-reduces the damage of blue light to the skin by scavenging free radicals

Studies have found that after cells are irradiated by blue light, active oxygen free radicals are generated in the mitochondria, and these highly active oxygen free radicals can

Damage mitochondria and DNA. Troxerutin reduces the generation of oxygen free radicals through anti-oxidation, and achieves the effect of preventing blue light.

Effect of troxerutin on scavenging oxygen free radicalsComparison of troxerutin and VC on scavenging oxygen free radicals

Troxerutin UV protection – protecting cells from UVB-mediated growth arrest

Troxerutin prevented UVB-mediated growth arrest in a dose-dependent manner.

Troxerutin (5 μM) effectively shields cells from UVB-mediated growth apprehension. Especially, pretreatment with 5 μM troxerutin for 8 h enhanced cell feasibility by 20.27% compared to unattended HaCaT cells exposed to UVB (Fig. 2).

Overall, pretreatment with troxerutin safeguarded cells from UVB-mediated growth apprehension.

Troxerutin safeguards versus UV rays—- changes miRNA expression in UVB HaCaT cells
Troxerutin alters miRNA expression accounts in UVB-exposed HaCaT cells As explained in the Introduction, miRNAs play key functions in UVB responses with details binding to target genes.

We utilized a miRNA genetics microarray consisting of 1,368 probes representing 1,205 human miRNAs. Overall RNA labeled with Cy3 (an environment-friendly fluorescent dye) was removed from HaCaT cells treated with or without troxerutin and afterwards revealed to UVB radiation. Each Cy3-labeled example was hybridized to the miRNA microarray. Utilizing evaluation software (GeneSpring GX version 11.5; Agilent), we initially stabilized the data for every sample making use of worldwide normalization.

In previous researches, troxerutin-induced DNA repair work improved its protection versus gamma rays. Troxerutin enhanced DNA repair work activity in HaCaT cells.

Moreover, using miRNA microarray evaluation and also bioinformatics tools, we determined teroxetine-induced miRNAs and also found web links between teroxetine-induced miRNAs, along with anti-apoptosis, improved migration, and DNA repair work effects. In HaCaT cells exposed to UVB, troxerutin changed the expression of 68 miRNAs, which were upregulated or downregulated ≥ 2-fold.

The Preparation Method of Troxerutin

A kind of preparation method of high-purity troxerutin is characterized in that comprising the following steps:

(1) the synthesis of troxerutin, put into autoclave after rutin and catalyzer are mixed uniformly, pour ethylene oxide into methanol and pour in autoclave again, close autoclave, control reaction pressure Not higher than 0.5MPa, the reaction temperature is 50-80°C, stop the reaction when the content of trihydroxyethyl rutin is the highest when monitored by HPLC sampling, adjust the pH of the reaction solution to 5-6 with hydrochloric acid, then cool and crystallize with suction filtration or rotary evaporation Methanol is obtained troxerutin, and described catalyst is sodium methylate or sodium ethylate, and the mass ratio of rutin and catalyst is 10-15:1, and the mass ratio of rutin and ethylene oxide is 3-4:1, and methanol The volume dosage is 3-5 times of rutin quality;

(2) Refining of troxerutin, the troxerutin obtained by cooling crystallization suction filtration or rotary steaming of methanol is moved into the extraction crystallization reaction kettle so that it is at the lower end of the crystallization frame, and the outlet valve is closed at a rate not higher than 2L/min. Feed CO2 into the extraction and crystallization reactor at a flow rate of 1 to 3 hours until the pressure reaches 6-10MPa, set the temperature at 50-80°C, stir at a speed of 350r/min, release CO2 after 1-3h, and crystallize the plate with the reduction of CO2 High-purity troxerutin was separated out.

Identification of Troxerutin

(1) Take about 20mg of this product, add 20ml of water, 1ml of hydrochloric acid and a small amount of zinc powder, put it on a water bath and heat it, and it will show a continuous red color.

(2) Take about 20mg of this product, add 20ml of water and a small amount of aluminum trichloride, and the solution will be bright yellow.

(3) Take this product, add water to make a solution containing 20 μg per 1 ml, and measure it according to the spectrophotometric method (Appendix IVA of Part Two of the Chinese Pharmacopoeia 2000 Edition), there are maximum absorptions at the wavelengths of 254nm and 347nm, and the maximum absorption at the wavelength of 283nm Has minimal absorption.

About Products:
If you need Troxerutin as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Troxerutin manufacturer and supplier, ZSpharmac will provide Troxerutin raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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