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Trometamol CAS 77-86-1

Molecular Formula: C4H11NO3

Formula Weight: 121.14

ZSpharmac: Trometamol Supplier

Product Name: Trometamol
CAS No: 77-86-1
Purity: 99%

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Basic Info

Product Name:Trometamol
Other Names:Tris
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Crystalline
EINECS No.:201-064-4
Provide:Trometamol MSDS;
Trometamol COA

What is Trometamol?

Trometamol Chinese name is trihydroxymethyl aminomethane; tromethamine; tromethamine; 2-amino-2-(hydroxymethyl)-1,3-propanediol. It is a white crystal or powder.Soluble in ethanol as well as water, a little soluble in ethyl acetate and likewise benzene, insoluble in ether as well as carbon tetrachloride, destructive to copper in addition to lightweight aluminum, and also annoying chemicals.

Trometamol Property

Melting point 167-172 °C(lit.)
Boiling point 219-220 °C10 mm Hg(lit.)
density 1,353 g/cm3
vapor pressure 0.0267 hPa (20 °C)
refractive index 1.4170 (estimate)
Fp 219-220°C/10mm
storage temp. 20-25°C
solubility H2O: 4 M at 20 °C, clear, colorless
form crystalline
color white
PH10.5-12.0(4 m in water, 25 °C)
PH Range7 – 9
pka8.1(at 25℃)
Water Solubility 550 g/L (25 ºC)


Trometamol Uses

Trometamol is mainly used in pharmaceutical intermediates; it can be used as a biological buffer and a reference substance for acid titration; it is also used as an intermediate for biochemical reagents and fosfomycin; it can also be used as a vulcanization accelerator, cosmetics (cream, lotion, etc.) agent), mineral oil, paraffin emulsifier, biological buffer.

Trometamol Application

Trometamol is widely used in acute metabolic and respiratory acidemia. It is an alkaline buffer and has a good buffering effect on metabolic acidosis and enzymatic activity. The original synthesis method of tris(hydroxymethyl)aminomethane uses nitromethane and aqua formaldehyde as the main raw materials, the price of nitromethane is 11,400 yuan/ton, the consumption of materials is 1.05 tons/ton; the price of water formaldehyde is 12,000 yuan / ton, the material consumption is 1.6 tons / ton; the price of solvent methanol is 2450 yuan / ton, and the material consumption is 2.5 tons / ton. This method consumes a lot of materials, and the manufacturing cost is high, 40,000 to 45,000 yuan / ton. In addition, the product recrystallization adopts traditional methanol refining, the product quality is poor, the content is 99.2%, the absorbance (260nm) is 0.15, and the waste methanol produced in the process of producing tris with the original synthesis method is more, three wastes many.

Trometamol buffer solution is a biological reagent, a buffer solution commonly used in biological preparation and medical preparation. Such as commonly used in peprotech recombinant cytokines and protein solubilization, tris buffer solution is also widely used as nucleic acid, protein solvent, electrophoresis solvent, etc., the amount is large. However, this buffer solution is not easy to store for a long time, the concentration of the stock solution is low, and the number of times of use is also small. Moreover, the preparation of this buffer solution is troublesome, especially when it is necessary to obtain a buffer solution with a specific pH value, it is laborious and time-consuming to adjust the pH value. Generally, the pH meter cannot accurately measure the pH value. The preparation of aminomethane buffer solutions presents difficulties.

The pH value of Trometamol buffer solution varies with temperature, and the variation range is large, which makes the preparation of Tris buffer solution more difficult, and the technology is difficult to master. This patented product is currently not produced in China, and it mainly depends on the import price, which is expensive.

Preparation of Trometamol

About Products:
If you need Trometamol, a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Trometamol manufacturer and supplier, ZSpharmac will provide Trometamol raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, and customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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