Zhishang Chemical

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Zhishang Chemical

Tripeptide CAS 49557-75-7

Molecular Formula: C14H24N6O4

Formula Weight: 340.38

ZSpharmac: Methylglyoxal Miel Supplement

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Product Name: Tripeptide
CAS No: 49557-75-7
Purity: 99%

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Basic Info

Product Name:Tripeptide
Other Names:Copper Peptide
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Off-White Solid
EINECS No.:1592732-453-0
Storage:Under Inert Gas (Nitrogen or Argon) At 2–8 °C
Provide:Tripeptide MSDS;
Tripeptide COA

What is Tripeptide?

Copper Peptide, also called copper peptide, GHK-Cu, is a complicated of GHK (tripeptide-1) as well as copper ions, and GHK is a fragment of kind I collagen. Dr. Lauren Picart is the innovator of copper peptide. In 1973, he uncovered that human blood consists of Copper Peptide, as well as the copper peptide web content in the blood of youngsters is 2.5 times that of the senior. At the same time, he found that Copper Peptide has a good injury repair function. After more study, it was found that Copper Peptide can activate cells remodeling.

Peptide is a little molecule protein, likewise referred to as polypeptide or peptide. It is made up of amino acids with a certain sequence linked by amide bonds. The two amino acids are called dipeptides, and also the 3 amino acids are called Copper Peptide. example. Nearly all physical procedures in the human body are managed by polypeptides or healthy proteins composed of particular amino acid series. Peptides play a vital duty in the natural aging process of skin, such as cell expansion, swelling, angiogenesis, pigmentation, as well as protein synthesis as well as regulation. The peptides are used in cosmetics to achieve the features of promoting collagen manufacturing, anti-free radical oxidation, anti-inflammatory fixing, anti-edema, lightening, breast enhancement and also weight-loss.

The genuine elegance peptide starts with copper peptide (described as copper peptide or blue copper peptide, CAS: 89030-95-5, Copper peptide GHK-Cu). Copper peptide is among the earliest and most extensively utilized cosmetic peptides in the peptide collection. GHK was originally separated from human plasma in 1973, and also was found to have actually wound repair work function in 1985. In 1999, scientists thought that GHK as well as its copper facility could be used as an activator of cells makeover, which is likewise a signal peptide., Promote the destruction of a multitude of collagen accumulations outside the mark, the synthesis of regular skin collagen, the production of elastin, proteoglycans and glycosaminoglycans, the development rate and movement of various cell kinds, anti-inflammatory, antioxidant responses.

Tripeptide Properties:

Melting point >144°C (dec.)
Boiling point 831.0±65.0 °C(Predicted)
density 1.324
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility Aqueous Acid (Slightly), DMSO (Slightly)
form Solid
color Off-White


What Are The Functions of Tripeptide?

It seems yes, many in vitro experiments have shown that Tripeptide can induce collagen production in fibroblasts. Other studies have found that it has a stronger ability to stimulate the synthesis of collagen precursors than anti-aging ingredients such as retinoic acid and vitamin C.

Does this mean that Tripeptide is more anti-aging than retinoid and vitamin C?
This may not be the case. Although research by Abdulghani et. al. shows that blue copper peptide stimulates collagen synthesis more than retinoid and L-vitamin C, no studies have shown that it can improve skin texture as well as the latter two.

Although the exact mechanism is not yet known, it is certain that Tripeptide is involved in the synthesis of some key enzymes in maintaining skin health, such as the powerful antioxidant-superoxide dismutase SOD, and the key enzyme of elastin and collagen cross-linking-lysin. Aminoacyl oxidase. Therefore, blue copper peptides may achieve the effect of youthful skin by increasing collagen synthesis.

The idea is that “copper can be metabolized by the body and is therefore less toxic than other heavy metals”.

A 1999 study by Nature found that Tripeptide activates matrix metalloproteinase-2, an enzyme that degrades collagen. But this activation only occurs when the broken skin wound is healing. The study found that some tissue components degraded by matrix protease-2 may play a role in this repair process. But in Maquart’s 1993 study, the use of copper on broken skin increased damage repair. There is no evidence that matrix metalloproteinase-2, which degrades collagen, is activated in intact skin. I am personally intrigued by Tripeptide and I believe these experiments show that it is safe and effective regardless of skin damage.

Structure and Mechanism of Action of Biologically Active Tripeptide

Bioactive Tripeptide is confirmed wound therapist, can aid hair growth, as well as has been made use of in skin as well as hair care products for the past twenty years. Today, they are taken into consideration one of one of the most efficient skin restoring actives. Copper is a component present in our cells and its exhaustion has been linked to several degenerative illness. Among copper’s main effects is anti-inflammatory, which functions by hindering inflammatory cytokines, and there is an expanding idea that relentless infection brings about aging.

Tripeptide mechanism of action
Bioactive Tripeptide can be made use of as an activator of cells improvement, promoting the degradation of a great deal of collagen aggregates outside the mark, advertising the production of typical skin collagen, elastin, and proteoglycans, promoting the growth of various cell kinds and anti-inflammatory as well as antioxidant actions, Boost skin elasticity, firmness as well as minimize the deepness of wrinkles, coloring as well as other skin issues. It also enhances capillary growth and antioxidant capability, aiding the skin restore its natural ability to repair itself. Therefore, it is recommended by dermatologists as well as plastic surgeons as one of the most non-irritating anti-aging and also anti-wrinkle components in the 21st century.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Tripeptide Quotation