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Trifluoroacetic Anhydride CAS 407-25-0

Molecular Formula: C4F6O3

Formula Weight: 210.03

ZSpharmac: Trifluoroacetic Anhydride Supplement

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Product Name: Trifluoroacetic Anhydride
CAS No: 407-25-0
Purity: 99%

Basic Info

Product Name:Trifluoroacetic Anhydride
Other Names:Trifluoroacetic Anhydride, 99+%
CAS:407-25-0
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical Raw Materials
Appearance:Clear Liquid
EINECS No.:206-982-9
Storage:Warehouse Ventilation Low Temperature Drying 2-8 ° C
Provide:Trifluoroacetic Anhydride MSDS;
2,2,2-Trifluoroacetic anhydride COA

What is Trifluoroacetic Anhydride?

Trifluoroacetic anhydride (TFAA) is made use of as a solvent, driver, dehydration condensation representative and also maintaining representative in the synthesis of numerous polymers and also great chemicals. It is commonly made use of in dyes, photosensitive products, fluid crystal screen materials, aerospace technology, pesticides, pharmaceuticals, polymeric materials, etc, to boost the rate of polymerization as well as product return, and also as a derivatized chemical reagent used in gas chromatography as well as high performance fluid chromatography for pet meat, vegetables and fruits. The discovery of harmful metabolites and also bacteriocin has great development and application potential customers.

Trifluoroacetic Anhydride Properties:

Melting point -65 °C (lit.)
Boiling point 39.5-40 °C (lit.)
density 1.511 g/mL at 20 °C (lit.)
vapor pressure 6.28 psi ( 20 °C)
refractive index n20/D 1.3(lit.)
Fp -26 °C
storage temp. 2-8°C
solubility Miscible with benzene, dichloromethane, diethyl ether, dimethylformamide, terahydrofuran and acetonitrile.
form Liquid
color Clear
Specific Gravity1.487
Water Solubility Hydrolysis

 

Trifluoroacetic Anhydride Uses

  1. Trifluoroacetic anhydride is made use of as logical reagent, solvent, catalyst, dehydration condensing representative, protective representative for carboxyl as well as amino trifluoroacetylation; resources for preparing organic fluorine fine chemicals, medications and chemicals.
  2. Trifluoroacetic anhydride Gas Chromatography Analysis of Biologically Active Compounds. Protective agent for primary and secondary amines. Also used in the oxidation of aldehydes to acids, esters and amines.
    Derivatized grades are used to protect primary and secondary amines. Derivatives are more volatile.
  3. Trifluoroacetic anhydride is an intermediate of chlorfenapyr.
  4. Trifluoroacetic anhydride is used as a pesticide intermediate.

Trifluoroacetic Anhydride Laboratory Common Reagents

Trifluoroacetic anhydride is a commonly used reagent in chemical laboratories. Because there are two strong electron-withdrawing groups, trifluoromethyl, in its structure, it is a relatively strong organic acid anhydride, and its chemical properties are relatively active. Therefore, trifluoroacetic anhydride has a great use in organic synthesis. For example, trifluoroacetic anhydride can react with carboxylic acid to form the corresponding mixed acid anhydride (ie, activated ester), which enhances the electrophilicity of the carbonyl group of the carboxylic acid and makes it more difficult to be attacked by nucleophiles. Since trifluoroacetic anhydride is hygroscopic, it can be used as a dehydrating reagent for some reactions. A mixture of trifluoroacetic anhydride and sodium iodide can be used as the reducing agent. A mixture of trifluoroacetic anhydride and dimethyl sulfoxide can be used as the oxidizing agent. In addition, trifluoroacetic anhydride has several other uses in synthetic organic chemistry.

Chemical Reactions Related to Trifluoroacetic Anhydride

react with carboxylic acid Trifluoroacetic anhydride can react with carboxylic acid to generate activated acid anhydride, which greatly improves the electrophilic properties of carboxylic acid. For example, the Friedel-Crafts acylation of the activated anhydride generated by the reaction of trifluoroacetic acid with benzoic acid and methoxybenzene was carried out in a yield of up to 98% (Equation 1).

dehydration reaction In the presence of a weak base, trifluoroacetic anhydride can be used as a dehydrating agent to dehydrate amides, oximes, hydroxy ketones or hydroxy acid esters to generate corresponding nitrile and unsaturated ketone or carboxylic acid ester; And ortho-hydroxy acid derivatives are oxidized to ortho-diketones. Commonly used weak bases include triethylamine, pyridine, 2,6-lutidine (formula 2) and the like.

三氟乙酸酐 相关化学反应

Production Process of Trifluoroacetic Anhydride

Weigh 200 kilograms of phosphorus pentoxide with a content of 98.20% (mass percentage, the same below), put 189.7 kilograms of them into a clean, dry 500-liter reactor, and introduce 250 kilograms of metered content 98.5% trifluoroacetic acid into High drop in the tank. Check that the joints are well sealed, and the emptying pipelines at the top of the distillation column and the receiving tank are unobstructed. Open the deep well water pump and let the condensed water into the condenser to circulate, and start to drip phosphorus pentoxide at a rate of 0.15 liters/min. After 10 minutes, adjust the dripping rate to 0.4 liters/min. After 10 minutes, adjust to 1.2 liters/min, 10 minutes later to 1.8 liters/min, 10 minutes later to 2.8 liters/min, 10 minutes later to 3.8 liters/min, until the dripping is completed, close the dripping pipeline valve. At this time, the temperature of the gas phase in the kettle was 82°C. After 20 minutes, the temperature of the kettle was 65°C, and the jacket of the kettle began to be fed with steam. After 15 minutes, the temperature of the kettle rose to 72°C, and the steam was turned off. After 16 minutes, the temperature of the kettle was 80°C, the kettle boiled, and there was reflux at the bottom of the tower. At this time, the tower body was heated to 35°C with a pressure regulator, raised to 45°C after 5 minutes, and the reflux reaction was maintained for 80 minutes at a kettle temperature of 80 to 90°C and a tower temperature of 40 to 45°C. After the reflux reaction is completed, while maintaining the above-mentioned kettle temperature, tower temperature and reflux state, observe that the temperature at the top of the tower is 39.2 ° C, and open the product tank receiving valve to start collecting the product. Control the feeding speed at 1.0-1.2 liters/min, and keep the temperature at the top of the tower between 39-40.5°C. After 2 hours, 132 liters of finished products have been received. At this time, the temperature at the top of the distillation column rose to 40.6 °C, and the closing valve was closed to allow the system to fully reflux. The temperature of the kettle was raised to 100°C, the temperature of the tower body was raised to 50°C, and the temperature of the tower was 40.1°C after 10 minutes, the receiving valve was opened, and the finished product was continued to be collected at a speed of 0.6 liters to 0.8 liters/min. After 20 minutes, the top of the tower was The temperature rises to 40.6 °C again, close the receiving valve, continue full reflux until the temperature at the top of the tower drops to 40.2 °C, open the receiving valve and continue to collect the finished product at a speed of 0.2 liters to 0.4 liters/min. When the temperature rises to 40.8°C, the finished product receiving valve is closed, and the finished product is stopped. Open the collection valve of the back distillation tank, and change the collection of the back fraction. At this time, the collection valve is fully opened, and there is no need to control the collection speed. After 10 minutes, the temperature at the top of the column has risen to 56°C, and there is no more reflux, and the end-distillate collection valve is closed. Close the valve at the bottom of the tower and turn off the heating of the tower body. Turn off the steam in the jacket of the kettle, discharge the waste heat from the jacket of the kettle, and cool it with water in the deep well. When the temperature in the kettle dropped to 40°C, the water measuring tank was opened, and 148 kg of recovered steam condensed water measured in advance was dripped into the kettle at a rate of 0.2 liters/min, and the jacket cooling water was kept circulating. After 20 minutes, the water droplet acceleration was adjusted to 0.6 liters/min, and after 20 minutes, it was adjusted to 1.8 liters/min until the addition was complete. It was observed that when all the materials in the kettle became liquid and the temperature was lower than 35°C, the by-product phosphoric acid was released. Drain the condensed water from the jacket of the kettle, enter a small amount of steam, open the vent valve of the kettle, and dry the water vapor in the kettle for use. In this process (1), 142 liters × 1.51 = 214.42 kilograms of product trifluoroacetic anhydride were obtained, the purity was 99.2%, and the yield was 85.8% in terms of trifluoroacetic acid, and 16.8 liters (25.64 kilograms) of back fraction and tail gas condensed mixture were obtained. ), 366 kg of by-product phosphoric acid was obtained, and the content was 75.2%. Then, 16.8 liters (25.64 kg) of the recovered fraction and the condensed mixture of tail gas were introduced into the high-level dropping tank, and the remaining 10.3 kg of phosphorus pentoxide was put into a 50-liter dry and clean reaction kettle. . Pass the deep well water into the condenser for circulation, and start to drip the recovered mixture at a rate of 0.2 liters/min. After 10 minutes, change the dripping rate to 1.8 liters/min. Until the dripping is completed, close the dripping pipeline valve. At this time, the temperature in the autoclave was 70°C, and it was allowed to react spontaneously. After 10 minutes, steam was introduced into the jacket of the kettle to raise the temperature of the kettle to 76°C, and the steam was turned off. After 5 minutes, the temperature of the kettle reached 81°C, the kettle boiled, and there was reflux at the bottom of the tower. At this time, the tower body was heated to 35°C with a pressure regulator and gradually increased to 45°C, and the reflux reaction was maintained for 60 minutes at a kettle temperature of 80 to 90°C and a tower temperature of 40 to 45°C. After the reflux reaction was completed, while maintaining the above-mentioned kettle temperature, column temperature and reflux state, the temperature at the top of the column was observed to be 39.4°C, and the product was collected. Control the feeding speed at 0.2 to 0.4 liters/min, and keep the temperature at the top of the tower between 39 and 40.5 °C. After 20 minutes, the temperature at the top of the tower rose to 40.7°C, and the back-distillation collection valve was closed to allow the system to fully reflux. The temperature of the kettle was raised to 100°C, the temperature of the tower body was raised to 50°C, and the temperature of the top of the tower was 40.8°C after 10 minutes. At this time, the receiving valve is fully opened. After 5 minutes, the temperature at the top of the tower has risen to 55 ° C, and there is no more reflux. Close the back-distillation receiving valve, close the bottom valve, and turn off the heating of the tower body. Close the jacket of the kettle and discharge the waste heat side by side, and enter the deep well water for cooling and circulation. When the temperature in the kettle dropped to 40°C, the water metering tank was opened, and 12 kg (liter) of recovered steam condensed water was added dropwise to the kettle at a speed of 0.2 liters/min, and the jacket cooling water was kept circulating for 60 minutes. added later. It was observed that when all the materials in the kettle became liquid and the temperature was lower than 35°C, the by-product phosphoric acid was released. Drain the condensed water from the jacket of the kettle, enter a small amount of steam, open the vent valve of the kettle, and dry the water vapor in the kettle for use. In this process (2), 7.4 liters (11.18 kilograms) of product were obtained with a purity of 99.1%, and 0.12 liters (0.18 kilograms) of the last fraction was obtained, and 16 kilograms of by-product phosphoric acid were obtained with a content of 75.4%. In this process, a total of 214.42+11.18=225.6 kg of trifluoroacetic anhydride is obtained, with a purity of 99.2% and a yield of 90.24% calculated as trifluoroacetic acid.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

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* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

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FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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