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Zhishang Chemical

Tributyl Citrate CAS 77-94-1

Molecular Formula: C18H32O7

Formula Weight: 360.44

ZSpharmac: Tributyl Citrate Supplier

Product Name: Tributyl Citrate
CAS No: 77-94-1
Purity: 99%

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Basic Info

Product Name:Tributyl Citrate
Other Names:Tri-n-Butyl Citrate
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Liquid
EINECS No.:201-071-2
Storage:Store Below +30°C.
Provide:Tributyl Citrate MSDS;
Tributyl Citrate COA

What is Tributyl Citrate?

Tributyl citrate (TBC) is an excellent ecological plasticizer and also lube. It is a non-toxic, fruity aromatic, colorless and also transparent oily fluid at space temperature level. The boiling point is 170 ° C(133.3 ), and also the flash point (open mug) is 185 ° C. Soluble in a lot of organic solvents. Low volatility, excellent compatibility with resin, high plasticizing effectiveness, it is enabled to be made use of in food packaging and medical as well as sanitary products in Europe and also the USA, along with youngsters’s soft playthings, pharmaceuticals, clinical products, tastes and also fragrances, cosmetics producing as well as other sectors. It can enhance products with good cold resistance, water resistance and mold resistance. After plasticized by this item, the resin exhibits great transparency as well as reduced temperature bending performance, as well as has reduced volatility and also low extractability in various media, great thermal security, and also does not change color when heated up. Lubing oil prepared with this product has excellent lubricating residential properties.

Tributyl Citrate Property

Melting point ≥300 °C(lit.)
Boiling point 234 °C (17 mmHg)
density 1.043 g/mL at 20 °C (lit.)
refractive index n20/D 1.445
Fp 300 °C
storage temp. Store below +30°C.
solubility Miscible with acetone, ethanol, and vegetable oil; practically insoluble in water.
form Liquid
color Clear
Water Solubility insoluble


Tributyl Citrate Uses

Tributyl citrate (TBC), as one of the new generation of environmentally friendly plasticizers, has actually attracted attention from all over the globe. The US Food and Drug Administration (FDA) has actually approved its use in clinical gadgets, food product packaging products, kids’s toys and also personal hygiene items. TBC is a naturally degradable plasticizer with excellent compatibility, low volatility as well as high plasticizing efficiency. Additionally, it additionally has outstanding cool resistance, light resistance, water resistance as well as mildew resistance.

Tributyl citrate is widely used. In terms of food, medicine and instrument packaging, because TBC has the advantages of good compatibility with polyvinyl chloride (PVC) and high plasticizing efficiency, the PVC film plasticized with TBC has a good performance. The air permeability and water permeability can keep meat fresh and prolong the freshness period of vegetables; in the pharmaceutical industry, adding TBC as a carrier to medicine can make the outer surface of the medicine strong and not easy to break, and its existence can make the medicine in the It can be slowly released in the body at a certain rate within a certain period of time to maintain the effective concentration of the drug in the blood and achieve the purpose of effective treatment; in terms of biodegradation, adding appropriate TBC to the degradable polymer material can make the polymer change from rigid chain to It is a flexible chain and gives it machinability.

In addition, tributyl citrate can also be used as a raw material for the production of another environmentally friendly plasticizer, acetyl tributyl citrate (ATBC). The synthesis of TBC and dioctyl phthalate is obtained by the esterification reaction of acid and alcohol under the action of a catalyst. Traditional esterification reactions generally use concentrated sulfuric acid as a catalyst, which can fully contact with the reactants. And the catalytic activity is high, and the cost is relatively low; however, concentrated sulfuric acid has many disadvantages as a catalyst, such as difficulty in separating from the product, many side reactions, corrosion of equipment and environmental pollution. Therefore, the research and development of new environmentally friendly catalysts has become the focus of attention.

Compared with liquid acid catalysts, solid acid catalysts have their outstanding advantages: (1) easy to separate from the product after the reaction; (2) easy to regenerate and reusable; (3) easy to achieve continuous production; (4) The equipment is non-corrosive; (5) easy to store and handle; (6) green and pollution-free. Based on the above advantages, people continue to develop new solid acid catalysts and catalytic processes to meet the needs of laboratories and industries, and solid acid catalysts have also been widely used.

At the same time, solid acid catalysts also have some disadvantages: (1) The catalytic activity of solid acid is not as good as that of liquid acid catalysts such as sulfuric acid; (2) The thermal stability of solid acid is poor, and it is easy to deactivate during the reaction, making the catalytic The life is shortened; (3) For some specific reactions, solid acids cannot meet the demand because of their different acid strengths; (4) The price is higher. For example, the above-mentioned problems have been encountered during the use of strongly acidic cation exchange resins. On the one hand, their catalytic activity is not high enough;

On the other hand, it is heat-resistant and stable. The use temperature is limited below 120°C. When the temperature is higher than this temperature, the catalyst is easy to collapse, and it is easy to lose the catalytic sulfonic acid group, resulting in catalyst deactivation. These deficiencies limit the application of solid acid catalysts. In order to make full use of the unparalleled advantages of solid acid, it is necessary to develop new methods and new routes, overcome the shortcomings and shortcomings of solid acid, and improve it to expand its industrial application.

Preparation of Tributyl Citrate

Production Method of Tributyl Citrate

1. Citric acid and n-butanol (feeding ratio 1:1) are refluxed at 150°C for 4 to 5 hours under the action of sulfuric acid (feeding amount is 0.3% of the total mass of citric acid and n-butanol), when the acid value of the reactant drops When it reaches below 1mgKOH/g, it is the end point of esterification. The product is decolorized by activated carbon, filtered, neutralized, washed with water, and distilled under reduced pressure, and the still liquid is the finished product.
Refining method: Contains impurities such as free acids and alcohols. When refining, it is dried with anhydrous potassium carbonate or sodium sulfate and then rectified under reduced pressure.

2. Preparation method: Add 315g (1.0mol) of citric acid (2), 500g (6.7mol) of n-butanol, and 1.5mL of concentrated sulfuric acid into a 1L round bottom flask. Install a 60cm fractionation column and a water separator, heat the reaction dehydration, and dehydrate 115-120mL in about 4 hours, and the temperature of the reaction liquid reaches 130°C. Continue heating to the reaction liquid temperature of 155° C., and recover butanol. Then cool to 50°C, add 4g of solid sodium carbonate in batches to neutralize the sulfuric acid until the pH is 5-6. Stand overnight, filter, and distill under reduced pressure to collect fractions at 198-200°C/0.8-0.9kPa to obtain 460g of product (1) with a yield of 85%.

About That Product:
If you need Tributyl Citrate as a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Tributyl Citrate, ZSpharmac will provide Tributyl Citrate raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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