Tremella Polysaccharide CAS 9075-53-0

Molecular Formula: N/A

Formula Weight: 0

ZSpharmac: Tremella Polysaccharide Supplier

Product Name: Tremella Polysaccharide

CAS No: 9075-53-0

Purity: 99%

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Basic Info

Product Name:	Tremella Polysaccharide
Other Names:	Tremella Polysaccharides
CAS:	9075-53-0
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	White Powder
EINECS No.:	N/A
Storage:	2-8°C
Provide:	Tremella Polysaccharide MSDS； Tremella Polysaccharide COA

What is Tremella Polysaccharide?

Tremella polysaccharide is a polysaccharide obtained by deep culture of Tremella basidiomycetes, and it is a polysaccharide composed of acidic heteropolysaccharides. Its composition includes xylose, mannose, fucose, glucose, glucuronic acid, etc., with a sugar content of more than 75%. In addition to polysaccharides, the preparation also contains white powder of spores. Soluble in hot water, insoluble in alcohol, ether and other organic solvents.
Tremella polysaccharide is an immune enhancer, which can improve the body’s immune function and increase white blood cells. It is clinically used for leukopenia caused by tumor chemotherapy or radiotherapy and leukopenia caused by other reasons, and has a relatively obvious effect. It is also used to treat chronic bronchitis, and the effective rate can reach more than 80%. In addition, it also has anti-aging and anti-oxidation effects, so it can be used as a moisturizing and whitening agent in high-end cosmetics. The polysaccharide can be used as a cosmetic additive with moisturizing and anti-oxidation effects, added to milk beverages to act as a stabilizer, added to bread to increase its nutritional value, etc.

Functional Properties of Tremella Polysaccharide

1. Processing characteristics in food production
Tremella polysaccharides contain more homogeneous polysaccharides (about 70%-75% of the total polysaccharides), which can increase the viscosity of the solution and stabilize the emulsification. Therefore, when used in the processing of beverages, dairy products, and cold drinks, it can not only endow the food with good processing characteristics, but also reduce the use of synthetic additives and improve the nutritional value of the food.

2. Processing characteristics in cosmetic production
Tremella polysaccharide has a certain ability to scavenge hydroxyl radicals, and can be used as an anti-aging ingredient in cosmetics. Lipofuscin is a yellow-brown pigment containing fat and protein, and exists in aging cells in granular form. Lipofuscin is deposited in the cells of various tissues and organs of the human body, resulting in a slowdown of cell metabolism and a decrease in activity, resulting in the decline of human organ functions and aging.

3. Efficacy of health care medicine
The composition of tremella polysaccharides is diverse, not only the monomers are diverse, but also the configuration and conformation after forming polymers are also diverse; a variety of polysaccharides are mixed together to make their biological activities diverse. Modern research has fully confirmed that tremella polysaccharide has multiple health care functions, which are summarized as follows:
(1) Immunomodulation and anti-tumor effects: Over the years, scientists have found that tremella polysaccharides participate in the regulation of various life phenomena of cells, such as the transmission and perception of information between immune cells, activation of immune cells and improvement of the body’s immune function. Through this participation, tremella polysaccharide can not only exert anti-tumor effect by enhancing host immune function, but also directly kill tumor cells by directly acting on tumor cells or inducing tumor cell apoptosis.
(2) Hypoglycemic and blood lipid-lowering effects: Studies have shown that tremella polysaccharide can regulate the activity of glucose metabolizing enzymes, promote the secretion of insulin by pancreatic islets, inhibit gluconeogenesis, and promote the utilization of glucose by peripheral tissues, thereby achieving the effect of lowering blood sugar. Tremella polysaccharide can promote the excretion of cholesterol by binding and adsorbing lipids in the blood, blocking its enterohepatic circulation, and achieving the effect of lowering blood lipids.
(3) Prevention and treatment of cardiovascular diseases: Studies have shown that tremella polysaccharide can significantly prolong the formation time of thrombus, reduce the rate of platelet adhesion and blood swelling, and achieve the effect of preventing and treating cardiovascular diseases.
(4) Anti-ulcer effect: Tremella polysaccharide can significantly inhibit the formation of stress-type gastric ulcer in rats, promote the healing of acetic acid-type gastric ulcer, and has no effect on gastric acid secretion and pepsin activity. Using tremella polysaccharide to treat 124 cases of duodenal ulcer curative effect observation, the short-term effective rate reached 98.6%, and the short-term healing rate reached 79.03%.
(5) Anticoagulant, promoting wound healing and effect: tremella polysaccharide can realize anticoagulant effect by affecting endogenous blood coagulation system and prolonging partial thrombin time. In addition, tremella polysaccharides can protect the wound surface and prevent infection in rats, and can make the wound go smoothly along the physiological repair path, so as to achieve the effect of primary healing.

Application and Development of Tremella Polysaccharide

Based on the diverse biological activities of tremella polysaccharides, people have studied its practical production and application from the aspects of food, cosmetics and medicine, and some of the research has been transformed into actual products in the market.
1. Food
Tremella polysaccharide, as a biologically active macromolecular substance, is widely used in food application and development, and can be used as food fortifier, anticoagulant, emulsifier, thickener, etc. For example, instant white fungus jujube soup, instant white fungus milk powder, instant white fungus soybean milk powder and instant white fungus oatmeal developed by using the good rehydration properties of white fungus polysaccharides; white fungus dried noodles and white fungus biscuits developed by using white fungus polysaccharides to thicken and emulsify , tremella yogurt and tremella jelly and other products. These products are foods with certain health functions made by adding tremella polysaccharides as raw materials into the products and made through special techniques and processing methods.
2. Makeup and beauty category
Tremella polysaccharide can not only promote the immune function of the body, but also has anti-aging and anti-oxidation effects, so it is often used in high-end cosmetics as a moisturizing and whitening agent. There are mainly 4 types of cosmetics and beauty products using tremella polysaccharides as raw materials in the market, namely moisturizing facial masks, nourishing facial creams, cosmetic oral liquids and slimming capsules. “Tremella Hydrating Mask” is made of Tremella polysaccharide as raw material, mixed with other active ingredients according to different functional needs, and has the effect of moisturizing and moisturizing; “Tremella Nourishing Cream” is made of Tremella extract and hydrolyzed pearl liquid as main raw materials. It has the effects of moisturizing skin and promoting muscle growth, delaying skin aging and increasing skin cell vitality; Tremella beauty oral liquid is made of tremella polymer isopolysaccharide, which has good effects of laxative, constipation and weight loss.
3. Medicine
Due to the complex structure and variety of tremella polysaccharides, its biological activity mechanism, efficacy factors, dose-effect and structure-effect relationships are not clear enough, which brings many challenges to the specific research and application of tremella polysaccharides in medicine. Therefore, the use of tremella polysaccharides to develop Pharmaceutical products have just started, and there are not many related products on the market. The main related products on the market are “Tremella spore sugar capsules” and “Tremella spore sugar enteric-coated capsules”, which are produced with tremella polysaccharides that have been submerged in fermentation and separated and extracted from Tremella fungus species. They have the functions of increasing white blood cells, anti-radiation Damage and improve the immune function of the body, can be used for leukopenia caused by radiotherapy, chemotherapy or other reasons, and can also be used as an adjuvant treatment for radiation damage; The ratio is matched with the professionally processed tan viscous liquid, which has the effects of nourishing yin and clearing the lungs, promoting body fluid and relieving cough, and can be used for chronic cough due to lung deficiency, polydipsia due to body fluid injury, etc.; It is a prescription drug as a raw material, which can be used for the prevention and treatment of VA and VD deficiency.

Extraction of Tremella Polysaccharide

Tremella polysaccharide can dissolve in water, but it is difficult to dissolve in high concentration organic solvents. The researchers used this feature to extract tremella polysaccharides. At present, there are many ways to extract tremella polysaccharides, including hot water extraction, alkali extraction, enzymatic extraction, ultrasonic-assisted extraction, etc.

Hot water extraction

Alkaline extraction

Enzymatic extraction

Ultrasonic Assisted Extraction

Hot water extraction

Alkaline extraction

Enzymatic extraction

Ultrasonic Assisted Extraction

Separation and Purification of Tremella Polysaccharide

After the tremella polysaccharide is extracted, it is mixed with various impurities such as inorganic salts and proteins. These impurities need to be removed through a series of processes, and finally the components of the tremella polysaccharide are separated to obtain a pure tremella polysaccharide single component. At present, the separation and purification of tremella polysaccharides mostly adopt the following process: low molecular weight organic solvent precipitation, deproteinization, decolorization, separation and purification of tremella polysaccharide components.

Low molecular weight organic solvent precipitation
Using the principle that polysaccharides are almost insoluble in high-concentration organic solutions, soluble impurities and most polysaccharides are separated. Methanol, ethanol and acetone are the most commonly used organic solvents, and polysaccharides with relatively high purity can be obtained through repeated water dissolution and alcohol precipitation.

Deproteinized
Protein is the main impurity in the extraction process of Tremella polysaccharide. In the purification process of tremella polysaccharide, the organic solvent method is often used to deproteinize, so that the polysaccharide activity will not change much. Commonly used organic solvents include trichloroacetic acid, tannic acid, and sevage reagent. In addition, enzymatic combined sevage reagent deproteinization has also been reported.

Decolorize
Part of the pigment will be entrained during the extraction process of tremella polysaccharide. The presence of pigments can affect the structure of polysaccharides and also affect the biological activity of polysaccharides studied. Decolorization methods include hydrogen peroxide method, adsorption method, ion exchange resin method, etc. Hydrogen peroxide decolorization method is easy to inactivate polysaccharides, while adsorption method is easy to introduce small particles of impurities, which will affect the quality of the final product. The decolorization process of the ion exchange resin method only uses water as the solvent, and it has a strong decolorization ability without affecting the activity and yield of polysaccharides. Compared with the hydrogen peroxide method and adsorption method, it has large adsorption capacity, fast adsorption speed, It has the advantages of stable physical and chemical properties, and is a commonly used decolorization method for tremella polysaccharides.

Separation and purification of each component
Tremella polysaccharide is a mixture mainly including five kinds of polysaccharides. In order to better study the biological activity of each component, it is necessary to separate and purify the components of tremella polysaccharide to obtain a homogeneous polysaccharide. Common polysaccharide separation and purification methods include: organic solvent fractional precipitation method, metal complex method, salting out method, quaternary ammonium salt precipitation method, organic salt precipitation method, ion exchange column chromatography, and ultrafiltration method. Among them, the widely used separation method is ion exchange column chromatography. Ion exchange column chromatography often uses cellulose or dextran gel as the stationary phase, and uses acid groups as cationic adsorbents or amino groups as anionic adsorbents. It can not only separate and purify polysaccharides, but also concentrate and desalt polysaccharides. This separation method can not only ensure the activity of polysaccharides, but also save energy and has no pollution, so it is widely used.

About Products:
If you need Tremella Polysaccharide as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Tremella Polysaccharide manufacturer and supplier, ZSpharmac will provide Tremella Polysaccharide raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.