Zhishang Chemical

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Zhishang Chemical

Tranexamic Acid Bnf CAS 1197-18-8

Molecular Formula: C8H15NO2

Formula Weight: 157.21

ZSpharmac: Tranexamic Acid Bnf Supplement

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Product Name: Tranexamic Acid Bnf
CAS No: 1197-18-8
Purity: 99%

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Basic Info

Product Name:Tranexamic Acid Bnf
Other Names:TranexaMic Acid
CAS:1197-18-8
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Crystalline Powder
EINECS No.:214-818-2
Storage:2-8°C
Provide:Tranexamic Acid Bnf MSDS;
Tranexamic Acid Bnf COA

What is Tranexamic Acid Bnf?

Tranexamic Acid Bnf has recently attracted widespread attention because it is added to Yunnan Baiyao toothpaste. This medicine is a good medicine widely used in clinical practice. Of course hemostasis is probably the least of the reasons many toothpastes add to their hope of having an effect. The discovery of Tranexamic Acid Bnf is legendary. In the 1950s, Japanese pharmacologist Utako Okamoto discovered tranexamic acid, also known as tranexamic acid (a well-known whitening and freckle-removing product) in the process of searching for a hemostatic agent. Utako Okamoto was born in 1918 and has been engaged in brain research since 1942. Japan was defeated in 1945, and the research materials were extremely scarce. Her original research work was unsustainable, and she was forced to study hemostatic drugs. The reason is: she has blood on her body, and as a woman, she will bleed every month, which is a good sample for self-study. .

Tranexamic Acid Bnf is a synthetic by-product of lysine and also is a typically utilized hemostatic medicine in medical practice. It applies hemostatic effect by hindering the dissolution of fibrin. Tranexamic Acid Bnf can highly adsorb to the lysine binding site (POUND) of the fibrin affinity website on plasmin and plasminogen, inhibit the binding of plasmin, plasminogen as well as fibrin, as well as hence strongly Additionally, in the visibility of anti-plasmin such as macroglobulin in product, Tranexamic Acid Bnf has more apparent anti-fibrinolytic impact. Its bioavailability is 34% as well as its half-life is 3.1 h.

Tranexamic Acid Bnf Property

Melting point >300 °C (lit.)
Boiling point 281.88°C (rough estimate)
density 1.0806 (rough estimate)
refractive index 1.4186 (estimate)
storage temp. 2-8°C
solubility Freely soluble in water and in glacial acetic acid, practically insoluble in acetone and in ethanol (96 per cent).
form Crystalline Powder
pkapKa 4.3 (Uncertain);10.6 (Uncertain)
color White
Water Solubility 1g/6ml

 

Tranexamic Acid Bnf Function and Application

  1. injury
    Researches have actually revealed that Tranexamic Acid Bnf can safely and reliably decrease death in people with stressful bleeding. In view of this, tranexamic acid, a cost-effective, common medication, has actually been included in the that Crucial Medicines Listing and will certainly be commonly used in high, center and also low-income nations around the globe.
  2. stressful mind injury
    Studies have actually revealed that craniocerebral people getting Tranexamic Acid Bnf are much less most likely to develop dynamic hemorrhage and have a tendency to have a reduced death rate.
  3. Although neither study concerned very clear verdicts, it still recommended that tranexamic acid has the possible to boost the prognosis of stressful brain injury, which will certainly lay the structure for follow-up studies, such as the upcoming execution and also employment of up to 10,000 cranial The CRASH-3 study in clients with brain injury will provide reliable evidence for the efficacy of tranexamic acid in improving death and also morbidity.
  4. heavy menstrual bleeding
    Tranexamic Acid Bnf can considerably minimize blood loss in ladies with menorrhagia. A Cochrane methodical testimonial of antifibrinolytics (largely tranexamic acid) in the therapy of menorrhagia located that antifibrinolytics lowered blood volume more in ladies with menorrhagia than sugar pill or various other therapies loss without raising the occurrence of side reactions. On November 13, 2009, the U.S. Fda authorized oral tranexamic acid as a treatment for females with severe menorrhagia.
  5. postpartum hemorrhage
    Researches have actually revealed that Tranexamic Acid Bnf substantially reduces postpartum hemorrhage. Nevertheless, there is currently no evidence from high-quality researches to support making use of antifibrinolytics in postpartum hemorrhage because of the somewhat low technical high quality of the three consisted of randomized tests. Presently, a randomized, double-blind, placebo-controlled trial called WOMAN (The World Maternal Antifibrinolytic Trial) is underway, which will sign up 15,000 individuals worldwide, to evaluate the early use tranexamic acid for death, hysterectomy in clients with postpartum hemorrhage supply trusted proof of improvements in rates, and so on.
  6. Surgical treatment
    A Cochrane organized review of 65 randomized controlled trials discovered that Tranexamic Acid Bnf decreased the risk of postoperative blood transfusions by practically one-third (RR 0.61, 95% CI 0.53 to 0.70) and also decreased intraoperative and also postoperative problems. Bleeding quantity, while the incidence of thromboembolic events did not boost.
  7. Other therapeutic impacts
    Tranexamic Acid Bnf is likewise made use of as a second-line regimen for the adjuvant therapy prior to and after surgical treatment in hemophiliacs with aspect VIII shortage. As well as can likewise be utilized for hereditary angioedema.
  8. bleaching result
    Its smudging and spot getting rid of result is about 50 times higher than that of vitamin C, as well as virtually 10 times that of fruit acid.

Clinical Application of Tranexamic Acid Bnf in Dermatology

Chloasma is a typical gotten skin hyperpigmentation identified by boosted skin and/or dermal pigment as well as raised facial blood vessels, made up of epidermal melanocytes, keratinocytes, facial fibroblasts, as well as vascular endothelial cells. The intricate interactions in between both are related to elements such as hormones, genes and UV radiation. Clients with melasma have a raised variety of pole cells in the lesioned skin. Tranexamic acid minimizes mast cell task, anti-angiogenic and melanogenesis, and also help in the treatment of melasma.

Medical researches have confirmed that basic dental management of Tranexamic Acid Bnf 250 mg twice a day begins to take effect in regarding 2 months. After 3 to 4 months of therapy, 89.7% of the individuals are enhanced compared to those prior to the drug, and the recurrence rate of chloasma after drug withdrawal is 27.2%. %9. After 3 months of ongoing therapy, the melasma Location and Extent Index (mMASI) improved by 57.5%. The reappearance rate three months after discontinuation was 6.2%.

After 12 weeks of topical 2% tranexamic acid option covering treatment, 95.7% of clients had a considerable decline in mMASI.

Topical 2% ~ 3% tranexamic acid combined with 1064 nm Q-switched Nd: YAG laser or extreme pulsed light (IPL) has a collaborating therapeutic effect on melasma, and also can successfully stop and decrease pigmentation after phototherapy.

It is a sequelae of inflammatory or post-traumatic responsive hypermelanosis (solar sunspots). Adhering to treatment with a 532 nm Q-switched Nd: YAG laser in such individuals, a solitary intradermal shot of tranexamic acid (50 mg/mL) reduced the incidence of post-inflammatory hyperpigmentation by 12% after 4 weeks.

Incidence of post-inflammatory hyperpigmentation in people with sunspots treated with 532 nmQ-switched Nd: YAG in mix with dental Tranexamic Acid Bnf 1500 mg/d, versus 532 nmQ-switched Nd: YAG alone, at week 6 There was no distinction, however dermoscopic examination after 12 weeks showed a considerable renovation in skin pigmentation in the mix team.

It is generally a gray-brown coloring of the face and neck. The professional study results revealed that dental Tranexamic Acid 250 mg twice a day as well as compound glycyrrhizin tablet computers 50 mg three times a day were treated for 3 months, and afterwards adjusted to dental Tranexamic Acid Bnf 250 mg twice a day as a monotherapy for 3 In March, the patients were reviewed as well as checked with a skin detector. The melanin index (MI) and erythema index (EI) of 70% of the patients were minimized by 51% to 75% compared with those prior to therapy, indicating that the illness was substantially improved.

Associated post-inflammatory erythema, a common sequelae that happens after acne inflammation, is associated with raised proinflammatory cytokines as well as neovascularization. Daily and nightly topical 5% Tranexamic Acid Bnf solution can work within 6-8 weeks, and also it is easy to use, has no damaging responses, and is cost-efficient. It is an excellent therapy for those people that can not manage the price of laser.

Describes the dilation of small capillary between 0.50 and 1 mm in diameter near the skin or mucosal surface. Medical therapy found that with 3 consecutive intralesional injections of Tranexamic Acid Bnf with a 1-week period between treatments, partial vascular regression was observed in both within 1 week after the initial dose, however no further after 2 subsequent treatments. improve.

It is an usual chronic inflammatory skin disease of the face, and its pathogenesis includes abnormal innate immunity, inflammatory feedback of the skin to microorganisms, UV damages as well as vascular hyperresponsiveness. Tranexamic acid can improve the signs and symptoms of roseola by anti-inflammatory, hindering angiogenesis, fixing the skin barrier, and also inhibiting the activation of protease-activated receptors by serine proteases. Scrubing 10% Tranexamic Acid Bnf solution two times a day in people with steroid-induced telangiectatic rosettes significantly enhanced erythema, telangiectasia as well as burning sensation within 4 to 6 weeks. After 6 weeks of therapy with 10%% tranexamic acid option wet compress alone, the severity rating (IGA-RSS) decreased by 2 points compared with before treatment, as well as the extent rating of 10%% tranexamic acid option wet compress integrated with microneedling therapy was substantially lower than that before treatment. Before treatment, it was lowered by 3 points, as well as the alleviative results of both were preserved for more than four months, verifying that the symptoms of all individuals were significantly boosted.

Chronic urticaria describes recurrent urticaria with or without angioedema long-term 6 weeks or more, the extent of which is associated with plasma thrombin generation, fibrinolysis, and also elevated plasma focus of inflammatory pens, suggesting Tranexamic Acid Bnf has a potential healing result on this condition. In individuals with refractory chronic urticaria, reduced molecular weight heparin incorporated with oral tranexamic acid 1 g 3 times a day, 2 weeks later. In 50% of individuals, illness task decreased by 90% to 100%. It recommends that the symptoms of the illness are considerably improved, but it is very easy to relapse after quiting the drug.

Angioedema is a self-limiting localized edema that occurs in subcutaneous or mucosal cells. After first aid with Tranexamic Acid Bnf IV mixture alone, 81% of clients experienced significant renovation, with 39% attaining quick enhancement within an hour, but the remaining 19% had just partial improvement. Oral tranexamic acid 1– 3 g/d as maintenance regimen in people with hereditary angioedema and also idiopathic nonhistaminergic angioedema resulted in a 75% decrease in assault frequency in 27% of individuals after 6 months.

In pet experiments, dental administration of Tranexamic Acid Bnf option (12 mg/kg) 3 times a week resulted in greater skin moisturization and also less creases in animals after 2 years, as well as the improvement of creases was extra apparent in women pets.

In the animal experiment making use of UVA regional irradiation to induce photoaging in the eyes, the experimental animals were given dental tranexamic acid option (750 mg/kg) 3 times a week. Collagen enhances and wrinkles decline.

In the photoaging animal experiment induced by UVB irradiation on the back skin, 3%, 4%, and also 5% tranexamic acid lotion 0.1 g/cm2 was applied on the back of the animals, respectively, once a day for 10 consecutive weeks. Compared to the animals, the skin thickness of the buttocks in the experimental team was raised, and also the level of facial flexible tissue deterioration was reduced.

The above pet experiments all reveal that tranexamic acid has a positive result on the all-natural aging and photoaging of the skin. The application of tranexamic acid in skin aging is still in the stage of pet experiments, and also its effectiveness and also safety and security need to be more verified in scientific tests.

For people with hereditary hemangioma complicated with hemorrhage, the hemorrhage can be promptly and effectively controlled after external use Tranexamic Acid Bnf integrated with neighborhood compression bandaging.

In patients with Steven Johnson disorder or poisonous skin necrolysis (TEN), intraoral positioning of sterilized gauze soaked in a 5% tranexamic acid remedy can successfully regulate dental mucosal blood loss.

After applying gauze soaked with tranexamic acid as well as epinephrine option on the medical incision for surgical people, intraoperative blood loss can be efficiently decreased.

For skin surgery individuals, intradermal injection of 10% tranexamic acid injection as well as 2% lidocaine injection watered down 1:1 can efficiently reduce intraoperative blood loss before skin surgery. Hemostasis was better in people with coagulants.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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