Tranexa CAS 1197-18-8

Molecular Formula: C8H15NO2

Formula Weight: 157.21

ZSpharmac: Tranexa Supplier

Product Name: Tranexa

CAS No: 1197-18-8

Purity: 99%

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Basic Info

Product Name:	Tranexa
Other Names:	Tranexamic Acid
CAS:	1197-18-8
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	White Crystalline Powder
EINECS No.:	214-818-2
Storage:	2-8°C
Provide:	Tranexa MSDS； Tranexa COA

What is Tranexa?

Tranexamic acid, an artificial lysine analogue, is a common antifibrinolytic drug that was initially clinically made use of for hemostasis. In the last few years, a lot of extensive research has actually been performed on it in the field of skin elegance, and also it has actually been confirmed that tranexamic acid has the functions of hindering angiogenesis, reducing melanin manufacturing, anti-inflammation, anti-allergic, anti-natural skin aging and photoaging, as well as can be made use of for the therapy of chloasma, inflammation Therapy of different skin conditions such as post-pigmentation, Riehl’s melanosis, urticaria as well as angioedema. In Japan, tranexamic acid has actually been provided in the Pharmacopoeia as a medication sign for chloasma, and also its application prospect in dermatology has actually attracted an increasing number of interest.

Tranexa Property

Melting point	>300 °C (lit.)
Boiling point	281.88°C (rough estimate)
density	1.0806 (rough estimate)
vapor pressure	1.72hPa at 25℃
refractive index	1.4186 (estimate)
storage temp.	2-8°C
solubility	Freely soluble in water and in glacial acetic acid, practically insoluble in acetone and in ethanol (96 per cent).
form	Crystalline Powder
pka	pKa 4.3 (Uncertain);10.6 (Uncertain)
color	White
Water Solubility	1g/6ml

How Tranexa Works and is Used

Trauma
Research studies have actually shown that Tranexa can safely and accurately lower mortality in individuals with stressful blood loss. In view of this, tranexamic acid, an affordable, generic medicine, has actually been included in the WHO listing of essential medicines as well as will certainly be widely made use of in high-, center-, as well as low-income countries around the world.

Traumatic brain injury
Studies have actually shown that mind patients that get Tranexa are less most likely to experience progressive bleeding and also have a tendency to have a reduced mortality price.

Although neither of these two researches has actually gotten to very clear conclusions, it still recommends that Tranexa might boost the prognosis of terrible brain injury, which will certainly lay the foundation for follow-up researches, such as the application and registration of approximately 10,000 stressful mind injury people. The CRASH-3 research study will certainly supply dependable evidence for the efficiency of tranexamic acid in improving mortality and also disability.

Hefty menstruation blood loss
Tranexa had the ability to significantly reduce blood loss in females with hefty menstruation blood loss. A Cochrane arranged testimonial analyzing antifibrinolytics (primarily tranexamic acid) for menorrhagia located that antifibrinolytics reduced blood amount in women with menorrhagia to a much better degree than placebo or other treatments losses without improving the occurrence of unfavorable impacts. On November 13, 2009, the United State Fda approved tranexamic acid dental tablet computers as a treatment for women with serious menorrhagia.

Postpartum hemorrhage
Researches have revealed that Tranexa substantially lowers the quantity of postpartum hemorrhage. Nevertheless, as a result of the low technical high quality of the three included randomized trials, there is no evidence from top notch research study studies to maintain making use of antifibrinolytics in postpartum hemorrhage. Presently, a randomized double-blind placebo-controlled test called female (The Globe Maternal Antifibrinolytic Test) is being carried out, which will definitely hire 15,000 individuals worldwide, in addition to will give very early application of tranexamic acid on mortality in individuals with postpartum hemorrhage, hysterectomy offer trustworthy evidence of improvements in rates, and so forth.

Surgical procedure
A Cochrane methodical evaluation of 65 randomized regulated tests situated that tranexamic acid lessened the danger of postoperative blood transfusion by almost one-third (RR 0.61, 95% CI 0.53 to 0.70) as well as also decreased intraoperative and likewise postoperative The quantity of blood loss, while the event of thromboembolic occasions did not enhance.

Other recovery impacts
Tranexamic acid is in addition utilized as a second-line program for adjuvant therapy prior to and also after procedure in hemophilia people with variable VIII scarcity. And also it can similarly be utilized for hereditary angioedema.

bleaching outcome
Its anti-black as well as also spot-removing impact has to do with 50 times more than that of vitamin C, in addition to almost 10 times that of fruit acid.

Skin Application of Tranexa

1. Melasma
Is a common acquired hyperpigmentation of the skin, the etiology is associated with elements such as hormonal agents, genetics and ultraviolet radiation. Histologically, it is characterized by enhanced skin and/or dermal pigmentation and raised dermal veins, with an increased variety of pole cells at the website of the lesion.

System of Activity: Tranexa has pole cell activity-reducing, anti-angiogenic and also melanogenic residential properties.

2. Post-inflammatory hyperpigmentation
It is a sequela of reactive hyperpigmentation after skin inflammation or injury.

System of activity: Tranexa may lower the release of bradykinin by blocking plasmin, and may also inhibit the launch of leukotrienes and also platelet initiating elements by lowering the number and task of mast cells.

3. Acne-associated post-inflammatory erythema
It is a common sequela that takes place after acne swelling and also is connected with enhanced pro-inflammatory cytokines as well as neovascularization.

Mechanism of activity: Tranexa puts in anti-inflammatory impacts by lowering the expression of proinflammatory cytokines (interleukin 6 and also lump death factor α) and chemokines (CCL10).

4. Telangiectasia
Dilation of small blood vessels on the skin or mucous membrane surface area.

System of action: Tranexa hinders vascular endothelial growth factor-induced overexpression and also activation of vascular endothelial development element receptor in normal human melanocytes as well as human umbilical capillary endothelial cells, consequently preventing skin angiogenesis.

5. Riehl’s melanosis
It is a pigmented disordered skin disease, primarily manifested as gray-brown coloring on the face as well as neck.

System of activity: Tranexamic acid has a comparable chemical framework to tyrosine, which can directly take on tyrosine, interfere with the catalytic impact of tyrosinase on tyrosine metabolic rate, and reduce melanin manufacturing.

6. Rosacea
It is an usual chronic inflammatory skin disease of the face. The pathogenesis includes inherent immune irregularities, inflammatory response of the skin to microbes, ultraviolet light damages, as well as vascular hyperresponsiveness.

Device of action: Tranexa can boost the symptoms of rosacea by anti-inflammation, inhibiting angiogenesis, repairing the skin obstacle, and preventing the activation of protease-activated receptors by serine proteases.

7. Chronic urticaria
It refers to recurring urticaria with or without angioedema lasting for 6 weeks or more, and also its seriousness is connected to the generation of thrombin in plasma, fibrinolysis and also raised focus of inflammatory pens in plasma.

System of activity: Tranexa puts in anti-inflammatory impacts by minimizing the expression of pro-inflammatory cytokines and chemokines. Activation of plasmin turns on the kallikrein-kinin system, which mediates the release of bradykinin, which binds to B2 receptors in the subcutaneous as well as submucosal vasculature resulting in allergic reactions; tranexamic acid may act with Barring plasmin minimizes the release of bradykinin, as well as additionally hinders the launch of leukotrienes as well as platelet-activating factors by minimizing the number as well as activity of mast cells.

8. Angioedema
It is a self-limited local edema that occurs in subcutaneous or mucosal tissues, and its pathogenesis may be associated with mast cell degranulation, moderated by histamine or bradykinin.

9. All-natural skin aging and also photoaging
Device of activity: Tranexa boosts hyaluronic acid synthesis by increasing the variety of skin cells, prevents matrix metalloproteinases by obstructing plasmin, thus reducing the destruction of extracellular matrix in the dermis, and can decrease TNF-α, IL-6 and The degree of active oxygen particles to boost the natural aging of the skin. It is still in the stage of animal experiments, and also clinical tests have not yet been executed.

10. Reduce bleeding
As an antifibrinolytic drug, Tranexa reversibly binds to the lysine binding site on plasminogen, thereby avoiding its conversion into plasmin, inhibiting succeeding fibrinolysis, and also lastly achieving the objective of hemostasis.

Adverse Reactions and Precautions of Tranexa

The negative reaction of taking tranexamic acid is less than that of aminocaproic acid. Frustration, lightheadedness, nausea or vomiting, diarrhea, vomiting, breast rigidity, sleepiness and various other signs might occur, which will gradually go away after quiting the drug. Sometimes, intracranial apoplexy as well as blood loss triggered by drug overdose might take place. Much less typically, menstruation discomfort (menstruation blood coagulation) because of). Due to the fact that this item can get in the cerebrospinal fluid, there might be main nerve system signs and symptoms such as blurred vision, migraine, wooziness, and fatigue after shot, particularly related to the shot speed, but uncommon. Those that need to remain to use this product for a very long time need to go through ophthalmic assessment as well as tracking (such as vision test, vision, visual field as well as fundus). It must be made use of with care in people with thrombosis tendency (such as acute myocardial infarction); it needs to be made use of with caution in people with renal lack as well as postoperative hematuria; in the additional hyperfibrinolytic state triggered by disseminated intravascular coagulation, it must be made use of with care before heparinization. Use this item; if it is used in combination with other coagulation factors (such as factor IX), you should be alert to apoplexy. Tranexamic acid has conflict with thrombolytic representatives such as penicillin or urokinase; contraceptive pills, estrogen or prothrombin facility concentrates incorporated with this product might raise the threat of apoplexy.

About Products:
If you need Tranexa, the cosmetic raw material, please contact our service personnel directly, we will provide you with high-quality products at the best price.
As an experienced Tranexa manufacturer and supplier, ZSpharmac will provide Tranexa raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.