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Zhishang Chemical

Tocopheryl Acetate Hlb CAS 7695-91-2

Molecular Formula: C31H52O3

Formula Weight: 472.74

ZSpharmac: Tocopheryl Acetate Hlb Supplement

Product Name: Tocopheryl Acetate Hlb
CAS No: 7695-91-2
Purity: 99%

Basic Info

Product Name:Tocopheryl Acetate Hlb
Other Names:Tocopheryl Acetate
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Yellow Viscous Liquid
EINECS No.:231-710-0
Provide:Tocopheryl Acetate Hlb MSDS;
Tocopheryl Acetate Hlb COA

What is Tocopheryl Acetate Hlb?

Tocopheryl Acetate Hlb of vitamin E can stop the oxidation of vitamin E, boost the security of
vitamin E items, as well as likewise resolve the issue of inadequate water solubility and improve its surface activity.
Vitamin E acetate is a by-product of vitamin E. It has excellent security and also can be commonly utilized in medication, food and cosmetics as a substitute for vitamin E. Vitamin E acetate is a beige or light yellow powder or granule, or a greenish-yellow or yellow thick fluid, nearly odorless, and comes to be darker when revealed to light. After vitamin E comes to be vitamin E acetate, it has other unique impacts. For example, vitamin E acetate can be made use of to prepare medications for the treatment of dental mucosal dryness, vaginal dry skin and irritation, anal, nasal and eye mucosal ulcers, dental mucosal abscess. It can additionally be used in cosmetics, food as well as feed, and so on.

Tocopheryl Acetate Hlb Properties:

Melting point -28°C
Boiling point 224 °C0.3 mm Hg(lit.)
density 0.96 g/mL at 20 °C (lit.)
vapor density 16.3 (vs air)
refractive index n20/D 1.497
Fp >230 °F
storage temp. 2-8°C
solubility Practically insoluble in water, freely soluble in acetone, in anhydrous ethanol and in fatty oils.
form neat
color Clear yellow viscous liquid
Specific Gravity0.962 (20/4℃)
Water Solubility Immiscible with water.


Tocopheryl Acetate Hlb Uses

  1. Tocopheryl Acetate Hlb has the result of preventing the oxidation of cell membranes and also intracellular unsaturated fats as well as other simple oxides in the body’s metabolic rate, therefore protecting the stability of cell membranes as well as avoiding aging, as well as can maintain the regular feature of reproductive body organs. Vitamin E has solid decreasing properties as well as can be utilized as an antioxidant.
  2. Tocopheryl Acetate Hlb serves as an anti-oxidant in the body, eliminates complimentary radicals in the body, as well as decreases the damage of ultraviolet rays to the human body. For skin treatment, hair care, etc.
  3. Tocopheryl Acetate Hlb is made use of as a pharmaceutical, dietary, aesthetic additive.
  4. Tocopheryl Acetate Hlb has solid reducibility, has anti-oxidation as well as anti-aging effects in the process of human metabolic rate, as well as can preserve the normal feature of reproductive organs. Typically, DL-vitamin E can be used as a nutritional fortifier. my nation states that it can be made use of to fortify sesame oil, salad oil, margarine and dairy products in a quantity of 100-180 mg/kg; in prepared baby food, the quantity made use of is 40-70 μg/ kg; The maximum dose in prepared tocopherol drinks is 20-40 mg/Ll; in fortified milk drinks, the maximum dosage is 10-20 μg/ kg. It can additionally be strengthened with D-α-tocopherol, D-α-tocopherol acetate or DL-α-tocopherol, as well as the dose needs to be transformed. Natural vitamin E concentrate functions as an anti-oxidant.

Tocopheryl Acetate Hlb Production Method

The preparation and extraction method of Tocopheryl Acetate Hlb uses C1-C4 low-carbon alcohol or an alcohol-ketone mixture containing (5%-15%) C3-C5 low-carbon ketone as an extracting agent, and extracts from vegetable oil. For example, add 50 mL of methanol to 100 g of crude palm oil, shake and extract at 45 °C, take the methanol phase to freeze overnight at -10 to -20 °C, filter to remove the precipitated sterols and fatty acid crystals, and distill the mother liquor to remove methanol to obtain vitamin E. Concentrated, the content is 11%. The esterification method uses the deodorized distillate in the oil and fat deodorization process as a raw material, esterifies the fatty acid therein with a polyhydric alcohol, and removes the ester by steam distillation to obtain a concentrate. For example, 1000g soybean oil deodorized distillate (acid value 68.8, saponification value 133, iodine value 152) was added with glycerol with an equivalent acid value of 1.1 times (41.4g), and refluxed with xylene (240°C) until the acid value decreased. After the solvent was removed, the esterified product was distilled with steam (at 400Pa), and the acid freed during the distillation was esterified with glycerol. Finally, a concentrate was obtained by distillation, with a content of 56.3% and a yield of 64.8%. Saponification, enzymatic and other methods can also be used. Synthesis of DL-vitamin E 7.8g 2,3,5-trimethylhydroquinone, 6.8g anhydrous zinc chloride and 1mL glacial acetic acid were added to a mixed solvent of 20mL dichloromethane and 5mL diisopropyl ether, Stir evenly at room temperature; 15.6 g of 95% isophytol was added dropwise within 3 h, and then stirred for 30 min; after the reaction was completed, the solvent was removed under reduced pressure, and the obtained russet oil was dissolved in 150 mL of hexane, followed by It was washed with 2% NaOH solution and saturated brine, dried with Glauber’s salt, and then the solvent was removed under reduced pressure to obtain 22.1 g of red-orange oily crude tocopherol with a yield of 99% and a purity of 95%. The crude product was treated with molecular distillation to obtain 18.9 g of colorless oily refined tocopherol, with a yield of 88%. Dissolve 25 g of the above product in 50 mL of acetic anhydride, add 12.5 g of sodium acetate and 1.25 g of sodium metal, and stir at 90-100 °C for 3.5 h. After acetylation, 200 mL of hexane was added for extraction, and the extract was washed with 1% NaOH solution, water, and saturated brine successively. After dehydration with magnesium sulfate, hexane was removed to obtain 26.2 g of crude vitamin E acetate. The crude product was vacuum distilled, and the fractions at 165-170°C were collected to obtain 20.5 g of Tocopheryl Acetate Hlb with a purity of 97.3% and a distillation yield of 78.0%.

Tocopheryl Acetate Hlb Other Applications

Tocopheryl Acetate Hlb, also known as tocopherol, includes 4 kinds, among the various forms of vitamin E compounds, A-tocopherol) has the highest biological activity. Therefore, tocopherol acetate prepared from natural Tocopheryl Acetate Hlb is the most active vitamin E derivative. Its biological activity is three times that of synthetic vitamin E, and it has no chemical pollution and no toxic and side effects on the human body, ensuring the effectiveness of the material. The ingredients are not destroyed, maintaining the pure natural quality of the product. Natural tocopherol acetate has the advantages of high physiological activity, rich nutrition, safety and reliability, and conforms to the trend of human beings to strengthen nutrition, return to nature, and safe consumption, and has been used more and more to replace synthetic vitamin E.

Tocopherol acetate is an essential ingredient for human nutrition, and has significant functions such as anti-oxidation, elimination of free radicals in the body, prevention of cancer, and pre-improvement of immunity.As a feed additive, it can enhance the reproductive function of pets as well as enhance fecundity. In the food sector, it is mostly used as an antioxidant and also dietary fortifier for oily foods; in the pharmaceutical market, it can be utilized as a pharmaceutical raw material for the production of ended up medications, and is useful for the therapy of periodontitis, pachydermia, fatty liver, arteriosclerosis, high cholesterol It has great impacts on blood flow, etc. It can be used in cosmetics to delay skin aging, rise skin flexibility, bring back younger vitality, moisturize the skin, and maintain skin dampness.

In fact, a large part of the use of tocopherol is achieved with Tocopheryl Acetate Hlb. In addition, the natural only tocopherol (or natural tocopherol) produced by some manufacturers is actually its acetate, and the so-called tocopherol is actually tocopherol acetate. Due to the large molecular weight of tocopherol and a longer side chain, it is fat-soluble. This brings unfavorable factors to the products used in feed additives, medicines, food, cosmetics and so on.

When used as a feed additive, it is easy to oxidize, which affects its activity; when used as a drug, because it cannot dissolve in water-soluble media, its application in intravenous injection is limited. This is due to the “allogenic response” in the muscle due to the presence of the oily carrier. When used as a cosmetic, it can only be made into a milky form because it cannot be miscible with water-soluble active ingredients. Such products often have poor surface activity, making it difficult to exert the physiological effects of their active ingredients. The synthesis of water-soluble Tocopheryl Acetate Hlb compensates for these deficiencies. Compared with free tocopherol, tocopherol acetate products have many application advantages in medicine, cosmetics, food and feed.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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