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Tocopherol Oil CAS 1406-18-4

Molecular Formula: C29H50O2

Formula Weight: 430.71

ZSpharmac: Tocopherol Oil Supplier

Product Name: Tocopherol Oil
CAS No: 1406-18-4
Purity: 99%

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Basic Info

Product Name:Tocopherol Oil
Other Names:Tocopherol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance: Colorless Liquid
EINECS No.:215-798-8
Provide:Tocopherol Oil MSDS;
Tocopherol Oil COA

What is Tocopherol Oil?

Tocopherol is also called vitamin E. In natural vitamin E, there are 7 well-known isomers, 4 of which prevail, namely α-, β-, γ-, δ-, and also the frequently called vitamin E describes the α-type. The α-type has the greatest activity and also the δ-type has the most affordable task.
α-type has 3 optical isomers. The synthetic product is dl-body. Pale yellow thick oily transparent fluid. Happens naturally in vegetable oils. The loved one molecular mass is 430.69. The family member density is 0.950 (25 ° C). The melting point is 2-3 ° C. The boiling point is 350 ° C(decay), 140 ° C(0.800 × 103Pa ~ 1.333 × 103Pa). The refractive index is 1.5045 (25 ° C). Insoluble in water, conveniently soluble in ethanol, ether, acetone, chloroform and also oil. In the lack of air, it is secure to warmth and also alkali, does not react with acid listed below 100 ° C, however is conveniently oxidized, and also can be oxidized to quinone in the air as well as under light or with chemical reagents. This effect will be accelerated in the visibility of iron salts and silver salts. Rat dental LD5010000mg/kg.
Tocopherol is a solid antioxidant, which can effectively prevent the rancidity of fats in food as well as digestion tract, and protect cells from hazardous materials generated by the oxidation of unsaturated fatty acids. Vitamin E is a superb complimentary radical scavenger that shields biofilms from cost-free extreme assault and is an efficient anti-aging nutrient. This item can enhance the body’s resistance; keep the honesty of red blood cells as well as advertise the biosynthesis of red blood cells; it is an essential element for advertising cell respiration, which can safeguard lung cells from air pollution; stop heart diseases.

Tocopherol Oil Property

Melting point 292 °C
storage temp. 0-6°C
OdorTypical vegetable oil
LogP10.962 (est)


Tocopherol Oil Skincare Benefits

Tocopherol Oil has a lipophilic and also hydrophobic structure, which can go into the biological membrane layer having unsaturated fats, as well as can straight catch complimentary radicals in the lipid stage medium, properly terminating the chain reaction of cost-free radicals resulting in lipid peroxidation, thus preserving the membrane without Stability of saturated fatty acid make-up, which is just one of the crucial systems to shield cells from damages. Consequently, vitamin E is among one of the most important biological free radical scavengers and antioxidants in the human body.

Lasting ultraviolet radiation can trigger skin cells to generate reactive oxygen types (ROS). Under typical circumstances, the ROS generated by ultraviolet radiation can be gotten rid of by the antioxidant system in the cells in time, yet extreme ROS will certainly ruin the balance of oxidation and also antioxidant systems in the body. Thus setting off a collection of harmful biological effects.

Tocopherol Oil can recover the proliferation task of cells after UVA (long-wave ultraviolet) irradiation, minimize the intracellular ROS degree after UVA irradiation, secure the morphological framework of cells after UVA irradiation, and slow down the destruction rate of intracellular collagen ColI and ColIII.

Hinders tyrosinase task
Some researchers removed tyrosinase from fresh Sydney, and respectively used catechol and levodopa as substratums to observe the result of vitamin E-β cyclodextrin incorporation complicated on tyrosinase task. The outcomes revealed that low focus of vitamin E-β cyclodextrin addition complicated had a repressive effect on tyrosinase. When catechol was used as the substrate, the inhibition price of tyrosinase by 0.5% vitamin E-β cyclodextrin incorporation complex got to 48.98%.

Tocopherol Oil Pharmacological Actions

Tocopherol Oil can be split right into 4 types: α, β, γ, and also δ, amongst which α-tocopherol has the toughest anti-sterility activity. The role of vitamin E is to:
(1) Keep normal reproductive feature, promote gonad growth, promote conception as well as shield against abortion, and so forth. It can also promote the regular development of fish reproductive system, specifically the growth of fish eggs, and likewise lower the event of saprolegniasis as well as also the death of broodstock.
( 2) Vitamin E is an important anti-oxidant in the body, which can prevent the manufacturing of complimentary radicals as well as preserve the routine feature of muscular tissue cells. Throughout the metabolic rate of fats, it can stay clear of the generation of a huge amount of unsaturated fatty acid peroxides, so it can keep the honesty of cell membrane layer layers with function. The antioxidant effect of vitamin E can furthermore reduce carp thin back health problem set off by fatty acid deterioration, lower the fatality cost of adolescent fish, and stay clear of the build-up of fat.
( 3) Safety and security of epithelial cells as well as likewise anti-aging effects. Vitamin E can shield epithelial cells from the damages of oxidized lipids, boost skin capillary resistance, maintain regular leakages in the framework, increase blood flow in addition to anti-aging outcomes.
( 4) Enhance immune feature, high-dose vitamin E can promote the manufacturing of immunoglobulin, boost resistance to illness, and also enhance anti-stress result.
( 5) Improve the use of vitamin A, and also advertise the typical growth as well as advancement of pets and keep muscular tissue tone.
( 6) Secure the liver.
( 7) Controling breathing function in tissues, participating in various enzymes and biochemical reactions.

Tocopherol Oil Test Method

Vitamin E is mainly tocopherol, including four forms of α, β, γ, and δ. Fat-soluble vitamins include retinol, alpha-tocopherol, beta-tocopherol, gamma-tocopherol, and delta-tocopherol. A method for simultaneous detection of 5 fat-soluble vitamins is as follows:

Step 1. Solution configuration and calibration

(1) Preparation of standard products

Take 200 µL of α-tocopherol at a concentration of 5 mg/mL, 20 µL of β-tocopherol at a concentration of 50 mg/mL, 200 µL of γ-tocopherol at a concentration of 1 mg/mL, 20 µL of δ-tocopherol at a concentration of 50 mg/mL, and 560 µL BHT chromatographic methanol with a concentration of 0.1%, mixed evenly to obtain a 1mg/mL vitamin E standard;

Take 50 μL of retinol with a concentration of 1 mg/mL, 500 μL of vitamin E standard with a concentration of 1 mg/mL, and 450 μL of BHT chromatographic methanol with a concentration of 0.1%, vortex and mix well to obtain a solution containing 50 μg/mL vitamin A and 500 μg/mL Mixed standard of vitamin E.

Store at -80°C in the dark for 3 months and avoid repeated freezing and thawing.

(2) Calibration of standard products

Draw 20 μL of a mixed standard substance containing 50 μg/mL vitamin A and 500 μg/mL vitamin E, put it in a 5 mL volumetric flask, and after constant volume with absolute ethanol, calibrate the concentration of the standard substance with an ultraviolet spectrophotometer, respectively in retinol, Measure the UV absorbance value of α-tocopherol, β-tocopherol, γ-tocopherol and δ-tocopherol at the UV absorption wavelength, calculate the actual concentration of the standard according to the formula (1) and (2), and avoid light during the whole process Operation, where C is the actual concentration of the standard to be calibrated in g/100mL, A is the average absorbance of the standard measured at the ultraviolet absorption wavelength, and E is the 1% standard specific absorptivity of the sample to be tested.

C=A/E×dilution factor (1)

Dilution factor=10000×5mL/20μL(2)

(3) Dilution of standard

The standard was serially diluted with 0.1% BHT methanol solution to obtain standard solutions with concentrations of 0.5 μg/mL, 1 μg/mL, 2 μg/mL, 5 μg/mL, 10 μg/mL, 20 μg/mL and 50 μg/mL. Store at -80°C in the dark for 3 months and avoid repeated freezing and thawing.

(4) Configuration of internal standard working solution

Accurately weigh 2 mg of pentadeuterated retinol, place it in a 10 mL volumetric flask, and dilute to 10 mL with absolute ethanol to obtain a 200 μg/mL pentadeuterated retinol solution; accurately weigh 2.5 mg of hexadeuterated α-tocopherol Phenol was placed in a 5mL volumetric flask, and the volume was adjusted to 5mL with absolute ethanol to obtain a 500 μg/mL hexadeuterio-α-tocopherol solution. The calibration method is the same as that of the standard product.

Step 2. Sample pretreatment

Add the internal standard working solution containing 0.125 μg/mL pentadeuterated retinol and 1.25 μg/mL hexadeuterated α-tocopherol to the sample to be tested, dilute with pure water or aqueous formic acid, add ethanol, methanol or acetonitrile solution, vortex Vortex and mix at high speed to remove protein, add n-hexane for extraction, vortex mix and centrifuge to get the supernatant, dry the supernatant with nitrogen at room temperature, add reconstitution solution, vortex mix and centrifuge to obtain the supernatant is the pretreated sample.

Step 3, liquid chromatography-mass spectrometry analysis

Add 7 μL of the pretreated sample into the injection bottle of the liquid chromatography-mass spectrometry instrument. The chromatographic column uses a Shimadzu C18 column with a specification of 5 μm×2.1 μm×50 mm. The temperature of the chromatographic column is 25 ° C. The chromatographic column adopts a gradient Elution method, the mobile phase of gradient elution adopts ammonium formate-acetonitrile mixed solution, the flow rate of mobile phase is 0.5mL/min, the time of gradient elution is 6min, wherein, the condition of gradient elution is as shown in Table 1, specific It is: within the first 0-0.3min, the mobile phase is constant at 50% ammonium formate and 50% acetonitrile; within the first 0.3-0.6min, the volume percentage of ammonium formate is continuously reduced from 50% to 5%, and the volume percentage of acetonitrile is from 50% % continuously increased to 95%; within 0.6-1.8min, the mobile phase was constant at 5% ammonium formate and 95% acetonitrile; within 1.8-2min, the volume percentage of ammonium formate decreased continuously from 5% to 2%, acetonitrile The volume percentage of ammonium formate continuously increases from 95% to 98%; within the first 2-5min, the mobile phase is constant at 2% ammonium formate and 98% acetonitrile; within the first 5-5.2min, the volume percentage of ammonium formate continuously increases from 2% To 50%, the volume percentage of acetonitrile continuously decreased from 98% to 50%; in the first 5.2-6min, the mobile phase was constant at 50% ammonium formate and 50% acetonitrile.

Step 4. Linear relationship and limit of quantitation

The standard solutions with concentrations of 0.5 μg/mL, 1 μg/mL, 2 μg/mL, 5 μg/mL, 10 μg/mL, 20 μg/mL and 50 μg/mL were analyzed by liquid chromatography-mass spectrometry, and the chromatographic peak area is the ordinate, with the concentration of the analyte as the abscissa, draw the standard curve, the linear weight is 1/x,

Target Regression equation R
Retinol y=3.45129x+-0.00506 0.999
a-tocopherol y=0.17573x+-0.00284 0.999
β-tocopherol y=0.05136x+0.01238 0.999
γ-tocopherol y=0. 32888x+0.01578 0.996
Delta-tocopherol y = 0.05501x+0.02208 0.993
The results showed that the concentration of retinol, α-tocopherol, β-tocopherol, γ-tocopherol, and δ-tocopherol showed a good linear relationship with the corresponding chromatographic peak areas, and the linear range obtained was the same as the clinical reportable range : Linear range and clinically reportable range of 0.05-5 μg/mL for retinol, linear range and clinically reportable range of 0.1-10 μg/mL for γ-tocopherol, α-tocopherol, β-tocopherol and δ-tocopherol The linear and clinically reportable range of tocopherol is 0.5-50 μg/mL.

Step 5. Recovery and precision

The internal standard working solutions of vitamin A and vitamin E were taken respectively, and three concentrations of samples were prepared for the sample recovery and precision experiments.

About Products:
If you need Tocopherol Oil, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Tocopherol Oil manufacturer and supplier, ZSpharmac will provide Tocopherol Oil raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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