Zhishang Chemical

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Zhishang Chemical

Theaflavin Supplement CAS 4670-05-7

Molecular Formula: C29H24O12

Formula Weight: 564.49

ZSpharmac: Theaflavin Supplement Supplier

Product Name: Theaflavin Supplement
CAS No: 4670-05-7
Purity: 99%

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Basic Info

Product Name:Theaflavin Supplement
Other Names:Theaflavin
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Red to Very Dark Red Neat
Provide:Theaflavin Supplement MSDS;
Theaflavin Supplement COA

What is Theaflavin Supplement?

Theaflavin Supplement is a crucial high quality part as well as practical part in black tea. It has different organic tasks as well as medicinal results such as decreasing blood fat, reducing blood pressure, anti-oxidation, anti-radiation, antibacterial, and also anti-cancer. It is referred to as “soft gold in tea”, The material of theaflavins in black tea is only 0.5%-2.0%.Theaflavin Supplement is also used as a fragrance, moisturizer, skin conditioner and protectant. It belongs to the chemical group of flavonoids. Recommended for formulations of cosmetic products such as oral care.
Theaflavin Supplement is a basic term for a course of compounds that are soluble in ethyl acetate and also have benzophenone ketone formed by the oxidation of polyphenols. Theaflavins have 12 components, including theaflavins (TF), theaflavins-3-gallate (TFMG), theaflavins-3,3′-digallate (TFdiG) as well as theaflavins -3′-gallate (TFM’G) is the 4 essential theaflavins (see the picture over for the chemical framework). The detoxified product of theaflavin is orange-yellow needle crystal, melting point 237-240 ° C, easily soluble in water, methanol, ethanol, acetone, n-butanol and ethyl acetate, hardly soluble in ether, insoluble in chloroform and also benzene. Theaflavin Supplement option is intense orange, and also its aqueous solution is a little acidic, with a pH of concerning 5.7. The color is not impacted by the pH of the tea soup extract, however it has a tendency to auto-oxidize in alkaline option, as well as it is reinforced with the increase of pH.

Theaflavin Supplement Property

Melting point 237-240 °C (decomp)(Solv: water (7732-18-5))
Boiling point 1079.6±65.0 °C(Predicted)
density 1.777±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO (Slightly), Methanol (Slightly)
form neat
color Red to Very Dark Red


Pharmacological Actions of Theaflavin Supplement

Theaflavin Supplement can hinder the proliferation of human nasopharyngeal carcinoma CNE2 cells as well as induce their apoptosis in a time- as well as concentration-dependent manner. The system of activity may be associated with managing the expression of cell expansion and also apoptosis genes.
Theaflavin Supplement can decrease lotion uric acid in computer mice with hyperuricemia. Its effect of lowering lotion uric acid is connected to the inhibition of xanthine oxidase task as well as the policy of associated anion carrier mRNA and also healthy protein expression degrees.
Theaflavin Supplement can enhance the sensitivity of cervical cancer cells to cisplatin, as well as its mechanism may be related to boosting the expression of apoptosis-related healthy proteins Cleaved Caspase 3, Cleaved Caspase 9, and PARP and inhibiting NF-κB signaling pathway-related proteins p-IκBα, p-NF- κB is related to the expression of p-Akt.
Theaflavin Supplement can successfully postpone the inflammatory degeneration process of rat chondrocytes by boosting the task of chondrocyte synthesis variables, weakening the activity of decay factors as well as preventing cell inflammation, as well as has a certain safety effect on inflammatory chondrocytes.

Extraction Method of Theaflavin Supplement

Detection of Theaflavin Supplement

Wu Hanyin and others developed a high performance fluid chromatography (HPLC) method for the decision of theaflavins in milk tea beverages. Approaches Milk tea samples were sped up with 0.1% acetic acid ethanol, centrifuged at 5000 r/min for 5 minutes, and the supernatant was taken for discovery. Utilizing 0.5% acetic acid (A) and also acetonitrile (B) as the mobile stage for gradient elution, the diode array detector was made use of to check at 280 nm, the flow rate was 1.5 mL/min, the column temperature level was 40 ° C, as well as the outside requirement method was used for quantification. Outcomes The method can accomplish the splitting up as well as detection of four target substances, the recuperations of the 4 theaflavins were in the variety of 89.06%-96.51%, and also the family member standard deviation was less than 5% (n=5). Verdict The method has the advantages of brief pretreatment time, easy procedure, great security as well as high precision, and also can be utilized for the determination of theaflavins in milk tea drinks.

About That Product:
If you need Theaflavin, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Theaflavin manufacturer and supplier, ZSpharmac will provide Theaflavin raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Theaflavin Supplement Quotation