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Tetrandrine CAS 518-34-3

Molecular Formula: C38H42N2O6

Formula Weight: 622.75

ZSpharmac: Tetrandrine Supplier

Product Name: Tetrandrine
CAS No: 518-34-3
Purity: 99%

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Basic Info

Product Name:Tetrandrine
Other Names:D-Tetrandrine
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Off-White Solid
EINECS No.:683-095-7
Provide:Tetrandrine MSDS;
Tetrandrine COA

What is Tetrandrine?

Tetrandrine (Tet), additionally referred to as Tetrandrine, is a sort of bisbenzylisoquinoline alkaloid extracted from the bulb root of Tetrandrine (Stephamiatetrandra S. Moore), belonging to bisbenzylisoquinoline It is a brand-new kind of calcium antagonist, which is the primary energetic component of Fangji; it has anti-inflammatory, analgesic, antihypertensive, anti-silicosis, hypoglycemic, anti-free extreme damage, anti-hepatic fibrosis and also various other anti-tumor medicinal impacts; It is scientifically used for straightforward silicosis and coal silicosis. It is also made use of for early light high blood pressure, rheumatic pain, arthralgia, neuralgia, etc. It is additionally utilized in the therapy of liver cancer, lung cancer, colon cancer, bladder cancer cells and also leukemia.

Tetrandrine Property

Melting point 219-222 °C(lit.)
alpha 285 º (c=1, CHCl3)
Boiling point 662.81°C (rough estimate)
density 1.1528 (rough estimate)
refractive index 1.5300 (estimate)
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly, Heated)
form solid
color Off-White


The Main Function of Tetrandrine

In the field of cosmetics, the main functions of tetrandrine are anti-allergic and anti-inflammatory, analgesic and swelling, redness and itching, regulation and restoration of skin immune system, mainly used for the repair of various sensitive skin, and for the treatment of various allergic factors. Redness, swelling, itching, infantile rash, eczema, and hormone face all have a good repair effect.

Tetrandrine’s core function is to regulate the skin’s immune system: the root cause of skin allergies is that the skin’s own immune system is destroyed and the skin’s barrier function is lost. Tetrandrine can restore the normal immune function of the skin and enhance its resistance to external stimuli. The resistance ability can fundamentally solve the problem of skin sensitivity.

Tetrandrine has a significant inhibitory effect on allergic symptoms such as itching, redness, and inflammation caused by various sensitizers. After using 0.5% tetrandrine for 30 minutes, the above symptoms can be significantly relieved; using 2% tetrandrine A element has obvious immediate analgesic and antipruritic effects.

Pharmacological Actions of Tetrandrine

1. Avoidance as well as treatment of liver fibrosis Tet can substantially reduce lotion type procollagen, product as well as liver HA, and also decrease intrahepatic collagen deposition, recommending that Tet can be utilized to deal with liver fibrosis in chronic liver illness.
2. Result on hypoxic pulmonary hypertension In pets with hypoxic pulmonary hypertension, Tet can considerably reduce raised lung arterial pressure and also lung vascular resistance, and improve carbon monoxide as well as oxygen transport capacity, but has no substantial result on systemic circulation and blood gas levels. Influence. Tet primarily prevents the proliferation of collagen fibers in lung arterioles as well as prevents the enlarging and also muscularization of pulmonary vessels caused by hypoxia, to ensure that the constriction of pulmonary arterioles can be dramatically reduced, and also the pulmonary artery stress can be minimized, thereby partially preventing the growth of lung hypertension.
3. Restorative effect on silicosis Based upon the prep work of Proα1() and Proα1() collagen cDNA probes, the impact of Tet on the mRNA of kind and also collagen genes in silicosis tissues was observed by utilizing spot and sitting molecular hybridization methods. Influence. Consequently, it is thought about that the collagen buildup in silicosis tissue is caused by the improved expression of collagen genetics caused by quartz dust, as well as TET can straight or indirectly prevent the transcription of collagen genetics, thereby decreasing the synthesis of collagen in infected tissue.
4. Healing result on high blood pressure Tet has a substantial antihypertensive effect and can considerably decrease blood lipid peroxide (LPO) and also thromboxane (TXB2) levels in hypertensive patients, as well as significantly boost turf, prostacyclin (6-keto-PGF1α) levels and also decreased TXB2/6-keto-PGF 1α ratio. The antihypertensive system of Hanfang Chemicalbook hexamethasone is caused by obstructing the voltage-dependent calcium channel of myocardial as well as vascular smooth muscle mass as well as raising the level of 6-keto-PGF1α.
5. The restorative result on angina pectoris Tet can substantially lower the myocardial oxygen consumption index, compared with nifedipine, there is no substantial difference. Therefore Tet is an effective medication for treating angina pectoris, protecting against myocardial infarction as well as decreasing myocardial ischemia-reperfusion injury.
6. The healing effect on ophthalmic diseases (1) The therapeutic result on experimental uveitis: Tet inhibits experimental uveitis, along with its anti-inflammatory effect, it is also associated with its restraint of humoral and cellular immune feedbacks. (2) Result on former uveitis: The mechanism of Tet’s resistance to former uveitis may be connected to its decrease in cells. (3) The effect on retinoblastoma: Tet has no straight repressive result on Rb44 cells at a low dosage (0.1 μg/ mL), however it can significantly boost the murder impact of radiation on Rb44 cells. With the increase of medication concentration, the cell killing price increased, as well as there was no substantial distinction before and after radiation management. Tet enhances the effectiveness of radiotherapy mainly by hindering the repair work of potentially dangerous damages to cells.
7. To improve the result of anticancer medicines MTT method was utilized to find the poisoning of daunorubicin (DNR) as well as homoharringtonine (HHT) on leukemia cells, as well as observe the result of Tet on the cytotoxicity of both chemotherapeutic medications. Outcomes Tet can dramatically boost the toxic results of DNR and HHT on drug-resistant cells (K562/AO2, K562/HHT).

Extraction and Separation of Tetrandrine

1. Extraction of total alkaloids and separation of lipophilic and hydrophilic alkaloids
Tetrandrine is an alkaloid, and the plant raw material is Tetrandrine (root). The principle of extraction and separation is the higher content or the main component and the difference in dissolution, which is called acid water percolation. The separation method is as follows:
2. Separation of tetrandrine and B by low-pressure column chromatography
Low-pressure column chromatography is used under low pressure (0.5-3kg/cm2, generally 0.3-1.2kg/cm2) for thin-layer chromatography with a particle diameter between classical column chromatography (100-200μm) and HPLC (~37μm). Silica gel (or alumina) H or G (50-75μm) is used as a column chromatography column as a filler. Its basic principle is the same as that of HPLC, and its separation effect is also between that of classical columns and HPLC. It is packed by vacuum dry method. The layer is compact and uniform, and the chromatographic bands are uniformly distributed. At the same time, the optimal separation solvent system of thin-layer chromatography can be directly used in low-pressure column chromatography. It is a kind of separation effect, simple equipment, convenient operation, fast Methods. Suitable for constant preparative separation of natural products.
(1) Column packing
Vacuum dry installation method, column specifications: column length 30cm, inner diameter 2cm, a total of about 30g of silica gel (about 22cm in height). Add it to 1.5g of silica gel with a dropper, mix well, evaporate to dryness on a water bath, grind it finely, carefully add it to the top of the column through a long-necked funnel, and tap it vertically until the surface of the sample is flat and does not stir , Cover it with blank silica gel about 1-2cm high, and then cover it with a circular filter paper, and press it tightly.
(2) Elution
First check whether the valves and pipelines from the air compressor to the chromatography column are normal, close each valve tightly, and start the air compressor to the rated pressure (5.8kg/cm2) for use. Use a dropper to carefully add a small amount of eluent (cyclohexane-ethyl benzylate-diethylamine/6:2:0.8) along the column wall of the chromatography column. When the liquid level reaches a certain height, add the rest of the eluent again. (About 250ml in total), quickly install a glass plug connector on the top of the column, press it tightly with an iron clip (to prevent the connector from being flushed when pressurized), carefully open the air compressor valve, and then open the needle valve and air filter to reduce the pressure. Pressure device, (note: the pressure is too high. The glass column will explode, generally 2kg is safe, and a protective mask can be worn if necessary) to adjust the required pressure, 0.6~1.2kg/cm2, it will flow out after about 40 minutes, control the flow rate 1ml/cm2 Divide into one tube every 10 minutes, collect 12-15 copies, and the whole process of elution takes about 3 hours.
(3) Check
Each fraction was transferred into a small glass evaporator, concentrated on a water bath, and checked by TLC respectively. Adsorbent: silica gel G, developer: cyclohexane-ethyl acetate-diethylamine/6:3:1, modified iodine Bismuth Potassium Reagent was sprayed for color development, with Tetrandrine and B as the standard control, the same components were combined to obtain crude A and B respectively, recrystallized with acetone, and determined.

About Products:
If you need Tetrandrine as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Tetrandrine manufacturer and supplier, ZSpharmac will provide Tetrandrine raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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