Zhishang Chemical

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Zhishang Chemical

Tetrandrine CAS 518-34-3

Molecular Formula: C38H42N2O6

Formula Weight: 622.75

ZSpharmac: Tetrandrine Supplement

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Product Name: Tetrandrine
CAS No: 518-34-3
Purity: 99%

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Basic Info

Product Name:Tetrandrine
Other Names:D-Tetrandrine
CAS:518-34-3
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Off-White Solid
EINECS No.:683-095-7
Storage:2-8°C
Provide:Tetrandrine MSDS;
Tetrandrine COA

What is Tetrandrine?

Tetrandrine (tetrandrine, Tet), also called tetrandrine, is a bis-benzyl isoquinoline alkaloid extracted from the tuberous root of Stephamiatetrandra S. Moore, which comes from the bis-benzyl isoquinoline substance. As a new kind of calcium antagonist, it is the primary active ingredient of Fangji; it has various pharmacological results such as anti-inflammatory, analgesic, high blood pressure, anti-silicosis, decreasing blood glucose, anti-free radical damages, anti-liver fibrosis as well as anti-tumor; medically used in Simple silicosis and also coal silicosis. It is likewise utilized for early moderate high blood pressure, rheumatic discomfort, arthralgia, neuralgia, etc.

Tetrandrine Property

Melting point 219-222 °C(lit.)
alpha 285 º (c=1, CHCl3)
Boiling point 662.81°C (rough estimate)
density 1.1528 (rough estimate)
refractive index 1.5300 (estimate)
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly, Heated)
pka7.70±0.20(Predicted)
form solid
color Off-White

Application of Tetrandrine

1. Immune system illness Tetrandrine can substantially hinder the development of joint inflammation as well as has a more powerful effect than aspirin, and can be utilized in the treatment of rheumatoid joint inflammation.
2. Cardiovascular system diseases Tetrandrine not just has calcium animosity, yet additionally prevents T-type and also L-type calcium channels in ventricular myocytes, and also connects with M receptors to obstruct calcium-activated potassium networks, becoming a therapeutic array. A therapy for idiopathic supraventricular tachycardia.
3. Gastrointestinal system Tetrandrine has a certain role in shielding liver cells and also resisting liver fibrosis. 4. Ocular diseases Tetrandrine is used for the therapy of ocular swelling, including uveitis, keratitis and the resulting retinopathy.
5. Other Tetrandrine has apparent hostile effect on the acute nephrotoxic result brought on by streptomycin, can minimize the apoptosis and expansion of renal tubular epithelial cells, shield renal function, and have protective effect on intense ischemia-reperfusion renal injury. Considerably lowers lotion creatinine as well as blood urea nitrogen levels, enhances glomerular purification price and renal plasma circulation, and also delays the advancement of glomerulosclerosis. Introduction, physicochemical homes, pharmacological results, applications, etc. of Tetrandrine.

Pharmacological Effects of Tetrandrine

1. Prevention and treatment of liver fibrosis
Tet can significantly decrease lotion kind III procollagen, lotion as well as liver HA, and also minimize the deposition of collagen in the liver, suggesting that Tet can be made use of to deal with liver fibrosis in persistent liver condition.

2. Impacts on hypoxic pulmonary high blood pressure
In canines with hypoxic pulmonary high blood pressure, Tet can considerably lower raised pulmonary arterial pressure and pulmonary vascular resistance, and also can boost carbon monoxide as well as oxygen transportation capacity, yet has no significant impact on systemic circulation and blood gas degrees affects. Tet generally prevents the expansion of collagen fibers in pulmonary arterioles and hinders the thickening as well as muscularization of pulmonary vessels caused by hypoxia, so that the lung arteriolar lumen constriction is significantly reduced, and also the lung arterial stress is decreased, therefore partly hindering the development of lung high blood pressure.

3. Restorative impact on silicosis
On the basis of the preparation of Proα1() and Proα1() collagen cDNA probes, area and sitting molecular hybridization techniques were utilized to observe the impact of Tet on the mRNA of collagen kind I and also type III in silicosis tissue. impacts. As a result, it is believed that the build-up of collagen in silicosis tissue is triggered by the boosted expression of collagen genetics brought on by quartz dust. TET can directly or indirectly hinder the transcription of collagen gene, thereby decreasing the synthesis of collagen in diseased tissue.

4. Healing effect on hypertension
Tet has a considerable antihypertensive effect as well as can significantly lower blood lipid peroxide (LPO) as well as thromboxane (TXB2) levels in hypertensive clients, and also considerably boost SOD, prostacyclin (6-keto-PGF1α) level, reduced TXB2/6-keto-PGF 1α ratio. The antihypertensive device of Tetrandrine is triggered by blocking the voltage-dependent calcium channels in myocardial and also vascular smooth muscle and also increasing the degree of 6-keto-PGF1α.

5. Healing impact on angina
pectorisTet can considerably lower the myocardial oxygen intake index, compared with nifedipine, there is no substantial difference. Therefore, Tet is a reliable medicine for treating angina pectoris, avoiding heart attack and minimizing myocardial ischemia-reperfusion injury.

6. Therapeutic effect on sensory diseases
(1) Healing impact on speculative uveitis: Tet hinders experimental uveitis, in addition to its anti-inflammatory result, it is likewise associated with its restraint of humoral and also cellular immune feedbacks. (2) The effect on pre-uveitis: The device of Tet’s anti-pre-uveitis may be associated with its reduction in intracellular. (3) Result on retinoblastoma: Tet at reduced dosage (0.1 μg/ mL) has no direct inhibitory effect on Rb44 cells, yet can considerably increase the murder impact of radiation on Rb44 cells. With the boost of drug concentration, the cell killing price enhanced, as well as there was no substantial difference in between prior to as well as after irradiation. Tet enhances the efficacy of radiotherapy largely by preventing repair work of possibly deadly damages to cells.

7. Enhance the effect of anticancer medicines.
The MTT assay was made use of to discover the toxic effects of daunorubicin (DNR) and also homoharringtonine (HHT) on leukemia cells, as well as the impacts of Tet on the cytotoxicity of the two chemotherapeutic medications were observed. Outcomes Tet could significantly enhance the toxic results of DNR and HHT on drug-resistant cells (K562/AO2, K562/HHT).

Extraction and Isolation of Tetrandrine

1. Extraction of complete alkaloids and also splitting up of lipophilic as well as hydrophilic alkaloids Tetrandrine is an alkaloid, as well as the plant raw material is fangji (origin). The concept of extraction as well as splitting up is the difference of greater content or primary parts and dissolution, which is called acid water percolation. The separation method is as complies with:
2. Splitting up of Tetrandrine as well as B element by reduced pressure column chromatography. Under low pressure (0.5 ~ 3kg/cm2, typically 0.3 ~ 1.2 kg/cm2), the bit diameter is between classical column chromatography (100 ~ 200μm) as well as HPLC (~ 37μm) slim layer chromatography using silica gel (or alumina) H or G (50 ~ 75μm) as a column chromatography column as a filler, its fundamental principle is the same as HPLC, and also the splitting up result is likewise in between the classic column In between as well as HPLC, the column is packed by dry technique under reduced stress, the layers are portable and also consistent, the circulation of chromatographic bands is concentrated as well as neat, and the ideal separation solvent system of thin-layer chromatography can be straight used for low-pressure column chromatography, which is a sort of splitting up. The effect is much better, the devices is basic, the procedure is convenient, and also the method is quick. Ideal for basic preparative splittings up of natural products.

( 1) Column packing
Dry packing method under reduced pressure, chromatography column specifications: column length 30cm, inner size 2cm, a total of concerning 30g of silica gel (regarding 22cm in elevation) 2.2 Blended samples and also tested to take about 150mg of acetaminophen, include a percentage of acetone to heat-dissolve (simply dissolved Include it to 1.5 g silica gel with a dropper, mix well, evaporate to dry skin on a water bathroom, grind it finely, carefully add it to the top of the column via a long-necked funnel, and also tap it up and down till the surface area of the sample is flat as well as does not stir, and then cover the empty silica gel with a height of about 1 to 2 cm, and afterwards cover with a round filter paper, as well as press it tightly.

( 2) Elution
Initial check whether the shutoffs and also pipelines from the air compressor to the chromatography column are typical, close each valve tightly, and start the air compressor to the rated pressure (5.8 kg/cm2) for usage. Use a dropper to thoroughly include a percentage of eluent (cyclohexane-ethyl formate-diethylamine/6:2:0.8) along the column wall surface of the chromatography column. When the liquid degree reaches a specific elevation, add the remainder of the eluent once more. (total concerning 250ml), quickly set up a glass common plug adapter on the top of the column, press it with an iron clamp (the adapter is punched out when anti-pressurization), very carefully open up the air compressor valve, and after that open the needle shutoff and air filter to minimize the pressure. (Note: the stress is too expensive. The glass column will take off, typically 2kg is safe, use a protective mask if essential) to mobilize the necessary stress, 0.6 ~ 1.2 kg/cm2, flow out after about 40 minutes, control the circulation rate 1ml/ Divide, one tube every 10 minutes, gather 12 to 15 components, and the entire elution process takes concerning 3 hrs.

( 3) Inspect
Each fraction was transferred to a small glass evaporator, concentrated on a water bath, and also checked by TLC. Adsorbent: silica gel G, establishing solvent: cyclohexane-ethyl acetate-diethylamine/6:3:1, changed iodine The bismuth potassium reagent was sprayed to develop color, as well as Tetrandrine and B were used as conventional controls. The exact same elements were integrated to acquire crude An as well as B, specifically, which were recrystallized with acetone and established.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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