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Tetrahydrolinalool CAS 78-69-3

Molecular Formula: C10H22O

Formula Weight: 158.28

ZSpharmac: Tetrahydrolinalool Supplier

Product Name: Tetrahydrolinalool
CAS No: 78-69-3
Purity: 99%

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Basic Info

Product Name:Tetrahydrolinalool
Other Names:Linalool Tetrahydride
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Colorless Liquid
EINECS No.:201-133-9
Storage:Room Temperature
Provide:Tetrahydrolinalool MSDS;
Tetrahydrolinalool COA

What is Tetrahydrolinalool?

The taxonomic name of tetrahydrolinalool is 3,7-dimethyl-3-octanol, which has a more pleasurable floral aroma than linalool, with a boiling point of 197-198.5 ° C. Tetrahydrolinalool is much more steady to oxidation than linalool, as well as can be utilized in a variety of day-to-day chemical scent formulas, with a dosage of approximately 30%, and also there is no restriction by IFRA. There are very few reports on the synthesis of tetrahydrolinalool. Early foreign literature reported the full hydrogenation process of fragrant alcohols under the catalysis of decreasing nickel, the addition response of allo-ocimene and also hydrogen chloride, and afterwards the synthesis of tetrahydro linalool by hydrolysis and also Ni-catalyzed hydrogenation reaction. Linalool Refine. Synthesis of tetrahydrolinalool with allo-ocimene as basic material has significant devices corrosion, tough procedure and also no commercial development value. Making use of the discerning hydrogenation of dehydrolinalool to manufacture linalool vacuum purification raffinate as raw material, the complete hydrogenation reaction was accomplished with palladium carbon catalyst, as well as the dehydrolinalool, dihydrolinalool as well as linalool in the raffinate were Camphor alcohol was transformed to tetrahydrolinalool with a reaction return of > 96%.

Tetrahydrolinalool Property

Melting point 

-1.53°C (estimate)

Boiling point 

71-73 °C/6 mmHg (lit.)


0.826 g/mL at 25 °C (lit.)

vapor pressure 

11.1Pa at 19.6℃

refractive index 

n20/D 1.434(lit.)


169 °F

storage temp. 

Sealed in dry,Room Temperature





Specific Gravity



Clear colorless


at 100.00 %. fresh sweet citrus lime floral lily

Odor Type


Water Solubility 

320mg/L at 25℃


Tetrahydrolinalool Uses

  1. Tetrahydrolinalool is an edible seasoning allowed in GB 2760-1996. It is primarily used to prepare flavors such as flavors and berries.
  2. Tetrahydrolinalool is typically made use of as a mixing resources for various man-made crucial oils.

Tetrahydrolinalool Application

Tetrahydrolinalool is much more stable to oxidation than linalool. It can be used in an option of daily chemical taste options, along with can in addition be made use of as a pharmaceutical synthesis intermediate. Examples of its applications are as follow:

1. Synthesis of aprepitant intermediate 2- [( R) -1- [3,5-bis( trifluoromethyl) phenyl] ethoxy] -4- benzylmorpholin-3-one.
( R) -2- [( R) -1- [3,5-bis( trifluoromethyl) phenyl] ethoxy] -4- benzylmorpholin-3-one is the synthesis of aprepitant A crucial intermediate, the synthesis of (R) -2- [( R) -1- [3,5-bis( trifluoromethyl) phenyl] ethoxy] -4- benzyl by crystallization-induced chiral plan conversion Morpholin-3-one, where ether as well as tetrahydrolinalool system is taken advantage of. The specific activities are: after liquifying 2- [( R) -1- [3,5-bis( trifluoromethyl) phenyl] ethoxy] -4- benzylmorpholin-3-one, cool to- 5-0 ° C, after that add tetrahydrolinalool potassium tetrahydrolinalool and also ether choice, respond for 2h, afterwards include petroleum ether to promote development, after that add 25ml hydrochloric acid for neutralization, as well as ultimately add saturated sodium bicarbonate option to change After the pH got to 7.5-9.5, the layers were divided, the temperature degree was lowered and also taken shape, along with (R) -2- [( R) -1- [3,5-bis( trifluoromethyl) phenyl] ethoxy] -4 was managed suction filtration -Benzylmorpholin-3-one. The reaction is less complicated to complete; the reaction cost is accelerated, and additionally the manufacturing cycle is considerably shortened; the manufacturing expenditure is decreased, the discharge of waste liquid is reduced, as well as additionally the atmosphere manages while lowering the cost; it has high return, quick response time, and likewise atomic usage. It has the advantages of high performance and a lot less waste discharge, as well as additionally is an effective as well as eco-friendly synthesis technique.

2. Preparation of a laundry detergent taste included with tricyclodecenyl n-butyrate.
It is composed of the adhering to components according to the pointed out mass percent: methyl dihydrojasmonate 4%; 2-tert-butylcyclohexanol acetate 0.6%; gepone ester 1.3%; benzyl salicylate 1.4%; linalyl acetate 4.7%; styroyl acetate 2.7%; amyl acetate 0.5%; phyllyl acetate 0.4%; benzyl acetate 10%; Raw ester 1.3%; methyl hexyl cinnamaldehyde 4%; privet aldehyde 0.1%; tetradecaldehyde 0.9%; ethyl damascenone 0.2%; 0.5%; Dimethylbenzyl Alcohol 1.5%; Terpineol 1.6%; Vanillyl Alcohol 1.8%; Kara Musk 18%; Kunlun Musk 0.5%; Linalool 4%; ethyl linalool 1.2%; 2,6 di-tert-butyl-p-cresol 1%; D-limonene 0.5%; dipropylene glycol 24.5%. It is customized with tricyclodecenyl n-butyrate, a fruity raw material, to offer a protected fruity fragrance for the scent, also after cleansing, the scent is still long-lasting, clearing up the charm of apples in this formula.

Tetrahydrolinalool Preparation

Step 1: Hydrogenation response procedure actions
In a 0.5 L autoclave, add the linalool rectification raffinate where the hefty components have actually been removed and also the driver according to the process needs, switch on the mechanical mixing, and also control the mixing rate at 400-500 r/min. The autoclave was replaced three times with 0.5 MPa nitrogen gas and three times with 0.51 VIPa hydrogen gas respectively. Fill up the autoclave with hydrogen, set the temperature and pressure according to the process requirements, and start the hydrogenation reaction. After the reaction gets to completion factor, the feed liquid is cooled to space temperature, and the feed is released after pressure release. The stimulant was recuperated by centrifugation, and also the make-up of the item was evaluated by gas chromatography.

Step 2: Vacuum distillation of tetrahydrolinalool
The set rectification procedure is adopted, the internal diameter of the glass rectification column is 25 mm, the size of the column is 700 mm, the bottom of the rectification column has a ring-shaped expansion tube, and also the within is full of mm earring-type stainless-steel packing, and also the decompression vacuum system is obtained by a 2ZX.4 rotary vane air pump. Dissipation is controlled by readjusting the voltage of the transformer linked to the sleeve thermostat, the tower top condenser is cooled down with faucet water at room temperature level, and the reflux ratio controller controls the tower leading reflux flow. The stress at the top of the vacuum purification system is 1.3 kPa, the temperature of the tower bottom is managed at 105-115 ° C, and also the back distillation ratio is 10:1. 1. Collect tetrahydrolinalool fractions with a leading temperature of 88-92 ° C/1.3 kPa.

Making use of 5% Pd/C as stimulant, making use of batch hydrogenation response process, 90 ~ 92 ℃, 2.0 MPa, and also response time 4 h, the linalool and also dihydrolinalool in the linalool vacuum cleaner purification raffinate The mass portions were 59.2%, 38.3%, specifically, m (stimulant): (raffinate)=1.2:100, the response yield of synthesizing tetrahydrolinalool from linalool vacuum purification raffinate was 96.3%, and tetrahydrolinalool in the reaction liquid The mass fraction of camphor is 96.5%. Tetrahydrolinalool items with a mass portion higher than 99% as well as a chroma APHA less than 25 can be obtained by rectification under minimized pressure, and also the correction return is 79.2%. The two dual bonds in the linalool particle have different activities throughout the hydrogenation response of 5% Pd/C catalyst system to create tetrahydrolinalool. Methyl-6-octene-3-alcohol, and then more hydrogenation reaction to produce tetrahydrolinalool. In the response process, linalool can form spin-off 2,6-dimethyloctane, P.2-mentene, P. 1( 7 )-mentene, p-mentanol-1, as well as the temperature level of reaction is higher than At 100 ° C, side reactions are considerably accelerated. Tetrahydrolinalool will certainly form oxidized tetrahydrolinalool in contact with air, and also the item must be secured by nitrogen during storage.

About Products:
If you need Tetrahydrolinalool this cosmetic raw material, please contact our service personnel directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Tetrahydrolinalool, ZSpharmac will provide Tetrahydrolinalool raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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