Zhishang Chemical

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Zhishang Chemical

Tetrahydrocurcumin CAS 36062-04-1

Molecular Formula: C21H24O6

Formula Weight: 372.41

ZSpharmac: Tetrahydrocurcumin Supplement

Product Name: Tetrahydrocurcumin
CAS No: 36062-04-1
Purity: 99%

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Basic Info

Product Name:Tetrahydrocurcumin
Other Names:Tetrahydrocurcuminoids
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Light Yellow to Yellow Powder
EINECS No.:609-201-3
Storage:Inert Atmosphere,Room Temperature
Provide:Tetrahydrocurcumin MSDS;
Tetrahydrocurcumin COA

What is Tetrahydrocurcumin?

Tetrahydrocurcumin (THC for short), as the energetic as well as major metabolite of curcumin in vivo, is hydrogenated from curcumin separated from the rhizome of turmeric extract. Tetrahydrocurcumin is the main bleaching energetic component in all-natural turmeric origin remove, not only has the greatest tyrosinase repressive activity, however also has outstanding chemical security, as well as the look is an odor-free white powder, which gets over the Common turmeric extracts are chemically unstable and also prone to skin-staining defects. Ordinary turmeric remove is yellow, has bad chemical security, and also has photosensitivity.

Tetrahydrocurcumin Property

Melting point 95-97 ºC
Boiling point 564.1±45.0 °C(Predicted)
density 1.222
Fp 196℃
storage temp. Inert atmosphere,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly, Heated)
form powder


Tetrahydrocurcumin Uses

Tetrahydrocurcumin is a natural functional whitening resources with solid activity of hindering tyrosinase. Free radicals, have obvious antioxidant, prevent melanin, repair work blemish, anti-inflammatory activity, block the inflammatory process, etc. Additionally, the restraint of totally free radicals, the inhibition of numerous inflammatory aspects lipoxygen and enzymes, collagenase, hyaluronidase, mirrors the prospective anti-aging effect of tetrahydrocurcumin.

  1. UV defense
    Hinders sunburn triggered by UVB; avoids inflammatory responses brought on by UV radiation.
  2. Free extreme scavenging
    Free radicals externally of the skin are generated by the militarized aging of the skin by UV rays, chemicals or other stressors.
  3. The molecular structure of tetrahydrocurcumin contains both phenolic hydroxyl team as well as β-diketone structure, which is a natural antioxidant. It can not only remove the produced cost-free radicals, however also inhibit the further generation of complimentary radicals, therefore damaging the chain reaction of free radicals as well as obstructing their damages to the skin and also body.
  4. Hinder tyrosinase
    It can effectively prevent tyrosinase, slow down the manufacturing of melanin, as well as is more effective than whitening agents such as kojic acid, arbutin, and also vitamin C. At the same time, the effective antioxidant task of tetrahydrocurcumin can also delay the production of melanin, therefore lightening up the skin and also achieving a lightening impact.
  5. block inflammation
    Tetrahydrocurcumin has broad-spectrum anti-inflammatory as well as antibacterial impacts, can repair skin inflammation and skin damage triggered by UVB, and also can better soothe pain and swelling. It has a considerable effect on the therapy of moderate burns, skin inflammation and also acne scars.

In Vitro Activity Study of Tetrahydrocurcumin

Regardless of its potent anti-amyloid homes, curcumin (Cur) has limited utility for the therapy of Alzheimer’s disease (AD) due to its reduced bioavailability. An even more secure metabolite, tetrahydrocurcumin (THC), was found in Cur-treated cells. We contrasted the anti-amyloid and neuroprotective buildings of curcumin, bisdemethoxycurcumin (BDMC), demethoxycurcumin (DMC), as well as THC using molecular docking/dynamics, in silico, as well as artificial insemination research studies. We determined the binding fondness and also H-bonding ability of these substances to amyloid beta (Aβ). Dot blot evaluation, photo-induced cross-linking of unmodified proteins (PICUP), and transmission electron microscopy (TEM) were carried out utilizing these substances to keep an eye on Aβ aggregation restraint. The neuroprotective effects of these by-products were reviewed in N2a, CHO and also SH-SY5Y cells using Aβ42 (10 µM) as the toxin. Finally, Aβ binding capability was compared in mind tissue stemmed from a 5 × craze mouse version of advertisement. We observed that THC had similar binding capability and also Aβ gathering inhibition, such as keto/enol Cur, as well as was greater than BDMC and DMC. All of these by-products showed comparable levels of neuroprotection artificial insemination as well as classified Aβ-plaques in vitro. In general, ECur and also THC revealed stronger anti-amyloid residential properties than other by-products. For that reason, compared to other turmeric by-products, THC is a more stable and also bioavailable metabolite that may offer better therapeutic effect in advertisement. We observed that THC had similar binding ability and Aβ aggregation inhibition, such as keto/enol Cur, as well as was more than BDMC as well as DMC. Every one of these by-products showed similar degrees of neuroprotection in vitro and labeled Aβ-plaques in vitro. On the whole, ECur as well as THC showed more powerful anti-amyloid residential properties than various other by-products. For that reason, compared with other turmeric by-products, THC is a much more steady as well as bioavailable metabolite that might provide better restorative impact in AD. We observed that THC had comparable binding capacity and also Aβ aggregation inhibition, such as keto/enol Cur, and was higher than BDMC and DMC. All of these by-products revealed comparable levels of neuroprotection in vitro and also labeled Aβ-plaques in vitro. Generally, ECur and also THC revealed stronger anti-amyloid residential or commercial properties than other derivatives. Consequently, compared to other turmeric by-products, THC is an extra stable and bioavailable metabolite that might supply higher therapeutic effect in AD.

Cancer Chemopreventive and Therapeutic Potential of Tetrahydrocurcumin

Cancer cells has actually turned into one of the leading causes of death worldwide in current decades. Regardless of advances in recognizing the molecular basis of tumorigenesis, diagnosis, as well as medical therapy, the exploration as well as advancement of efficient medicines is an active as well as important location of cancer research study. Tetrahydrocurcumin, the significant curcuminoid metabolite of curcumin, occurs normally in turmeric extract. Research study rate of interest in tetrahydrocurcumin is enhancing since it transcends to curcumin in water solubility, chemical stability, bioavailability, as well as antioxidant activity. Many artificial insemination and in vivo studies have shown that THC puts in anticancer effects through several devices, including modulation of oxidative tension, exogenous cleansing, inflammation, expansion, metastasis, set cell death, as well as immunity. Although the pharmacology of tetrahydrocurcumin as well as curcumin are similar, the structure of tetrahydrocurcumin establishes its special as well as certain molecular device, therefore making it a prospective candidate for the avoidance as well as treatment of cancer cells. Nonetheless, the energy of tetrahydrocurcumin has yet to be assessed, as just minimal pharmacokinetic as well as oral bioavailability research studies have been conducted. This review sums up research studies on the anticancer residential properties of tetrahydrocurcumin and also describes its device of action. The utility of tetrahydrocurcumin has not been examined as only minimal pharmacokinetic and also oral bioavailability research studies have been conducted. This review summarizes researches on the anticancer homes of tetrahydrocurcumin and defines its mechanism of action. The utility of tetrahydrocurcumin has not been reviewed as just limited pharmacokinetic and oral bioavailability researches have actually been performed. This evaluation sums up researches on the anticancer buildings of tetrahydrocurcumin as well as explains its device of action.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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