Regardless of its potent anti-amyloid homes, curcumin (Cur) has limited utility for the therapy of Alzheimer’s disease (AD) due to its reduced bioavailability. An even more secure metabolite, tetrahydrocurcumin (THC), was found in Cur-treated cells. We contrasted the anti-amyloid and neuroprotective buildings of curcumin, bisdemethoxycurcumin (BDMC), demethoxycurcumin (DMC), as well as THC using molecular docking/dynamics, in silico, as well as artificial insemination research studies. We determined the binding fondness and also H-bonding ability of these substances to amyloid beta (Aβ). Dot blot evaluation, photo-induced cross-linking of unmodified proteins (PICUP), and transmission electron microscopy (TEM) were carried out utilizing these substances to keep an eye on Aβ aggregation restraint. The neuroprotective effects of these by-products were reviewed in N2a, CHO and also SH-SY5Y cells using Aβ42 (10 µM) as the toxin. Finally, Aβ binding capability was compared in mind tissue stemmed from a 5 × craze mouse version of advertisement. We observed that THC had similar binding capability and also Aβ gathering inhibition, such as keto/enol Cur, as well as was greater than BDMC and DMC. All of these by-products showed comparable levels of neuroprotection artificial insemination as well as classified Aβ-plaques in vitro. In general, ECur and also THC revealed stronger anti-amyloid residential properties than other by-products. For that reason, compared to other turmeric by-products, THC is a more stable and also bioavailable metabolite that may offer better therapeutic effect in advertisement. We observed that THC had similar binding ability and Aβ aggregation inhibition, such as keto/enol Cur, as well as was more than BDMC as well as DMC. Every one of these by-products showed similar degrees of neuroprotection in vitro and labeled Aβ-plaques in vitro. On the whole, ECur as well as THC showed more powerful anti-amyloid residential properties than various other by-products. For that reason, compared with other turmeric by-products, THC is a much more steady as well as bioavailable metabolite that might provide better restorative impact in AD. We observed that THC had comparable binding capacity and also Aβ aggregation inhibition, such as keto/enol Cur, and was higher than BDMC and DMC. All of these by-products revealed comparable levels of neuroprotection in vitro and also labeled Aβ-plaques in vitro. Generally, ECur and also THC revealed stronger anti-amyloid residential or commercial properties than other derivatives. Consequently, compared to other turmeric by-products, THC is an extra stable and bioavailable metabolite that might supply higher therapeutic effect in AD.