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Tetraethyleneglycol Monododecyl Ether CAS 78-98-8

Molecular Formula: C3H4O2

Formula Weight: 72.06

ZSpharmac: Tetraethyleneglycol Monododecyl Ether Supplement

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Product Name: Tetraethyleneglycol Monododecyl Ether
CAS No: 78-98-8
Purity: 99%

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Basic Info

Product Name:Tetraethyleneglycol Monododecyl Ether
Other Names:Tetraethylene Glycol Monododecyl Ether, 98%
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Colorless Transparent Liquid
EINECS No.:226-097-1
Provide:Tetraethyleneglycol Monododecyl Ether MSDS;
Tetraethyleneglycol Monododecyl Ether COA

What is Tetraethyleneglycol Monododecyl Ether?

Tetraethyleneglycol Monododecyl Ether belongs to polyether defoamer. Polyether defoamer is a large variety of defoamer at present. It is non-toxic, odorless, non-irritating, resistant to hard water, acid and alkali, and has good compatibility with the system. Compared with another large type of silicon-containing antifoaming agent, although its defoaming performance is not high, its antifoaming performance is quite excellent.

Tetraethyleneglycol Monododecyl Ether is used as an antistatic agent and also emulsifier in cosmetics, yet it must be kept in mind that there is a high possibility of triggering skin irritation and acne.

Tetraethyleneglycol Monododecyl Ether Properties:

Melting point 14°C
Boiling point 185°C/0.2mmHg(lit.)
density 0.946 g/mL at 20 °C(lit.)
refractive index n20/D 1.453
Fp >230 °F
storage temp. 2-8°C


Applications of Tetraethyleneglycol Monododecyl Ether

  1. Tetraethyleneglycol Monododecyl Ether is used as an antistatic agent and emulsifier in cosmetics. It should be noted that there is a high possibility of causing skin irritation and acne.
  2. CN201811249391.5 discloses a makeup-removing composition and a preparation method and application thereof, wherein, by weight percentage, the makeup-removing composition is mainly made of the following raw materials: 20%-60% vegetable oil, 10%-30% lauryl alcohol Ether sulfate, 15%-30% laureth-4, 5%-25% emollient, 1%-10% foam stabilizer and 0-1% vegetable acne-removing agent. The makeup-removing composition has good makeup-removing effect, does not require secondary cleaning, is mild and non-irritating to the skin, and has a good moisturizing effect.
  3. CN201911332927.4 discloses a bubble bath oil and a preparation method thereof, which comprises the following components by weight percentage: almond oil: 30-55%, cocamide DEA: 1-4%, laureth Sulfate TIPA Salt: 15-25%, Propylene Glycol: 3-8%, Tetraethyleneglycol Monododecyl Ether: 20-35%, PEG-7 Glyceryl Cocoate: 1-4%, Auxiliary Ingredients: 0.5%-1%, this The invented bubble bath oil can not only remove the dirt and excess sebum on the skin, but also can maintain the oil balance of the skin, improve the itchy and dry skin condition, increase the lubricating feeling of the skin, and also have the effect of nourishing while cleaning. To a true wash and care 2-in-1.

Preparation of Tetraethyleneglycol Monododecyl Ether

General synthesis method: under argon protection, add iodoalkane (1 eq.) to a solution of DMF (40 mL) containing triethylene glycol or tetraethylene glycol (1 eq.), cool the mixture to 0 °C, add Sodium hydride (1.5eq.60% in mineral oil), stirred for 2h, quenched with water, extracted with ethyl acetate (20mL×2), combined with ethyl acetate phases, washed with saturated brine, and then dried over anhydrous sodium sulfate , concentrated to obtain the crude product, which was purified by silica gel column chromatography (ethyl acetate-n-hexane), and the obtained sample was immediately used for the next reaction.

Synthesis of Tetraethyleneglycol Monododecyl Ether Using the general synthesis method above, tetraethylene glycol (2 mL, 11.59 mmol) was reacted with 1-iodododecane (4.42 g, 11.59 mmol) and sodium hydride (0.70 g, 17.38 mmol) to obtain Tetraethyleneglycol Monododecyl Ether (2.18 g, 6.02 mmol, 52% yield) as a colorless oil; Rf=0.41 (ethyl acetate-n-hexane 3:2).

Electrosorption of Tetraethyleneglycol Monododecyl Ether at the Water Interface

The adsorption of Tetraethyleneglycol Monododecyl EtherC12E4 was investigated by measuring the electrocapillary curves at the polarized interface between 0.1 mol dm-3 tetraphenylboronic acid in nitrobenzene solution and 0. 0. C12E4 adsorbs on the interface over the entire polarization potential range of 250 mV. Although C12E4 itself is a neutral molecule, its surface activity is greatly affected by changes in the interfacial potential drop; an increase in the potential of the aqueous phase significantly enhances the adsorption relative to the potential in the nitrobenzene phase. The adsorption of C12E4 molecules to form complexes with Li+ suggests that the ions on the water side of the interface play a decisive role in determining the dependence of adsorption on the interfacial potential difference. The proposed model of interfacial complex formation based on the Gouy-Chapman bilayer theory well explains the observed trend in the Gibbs energy of adsorption when the potential drop across the interface changes.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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