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Zhishang Chemical

Terbinafine Bnf CAS 91161-71-6

Molecular Formula: C21H25N

Formula Weight: 291.43

ZSpharmac: Terbinafine Bnf Supplement

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Product Name: Terbinafine Bnf
CAS No: 91161-71-6
Purity: 99%

Basic Info

Product Name:Terbinafine Bnf
Other Names:Terbinafinehydrochloride
CAS:91161-71-6
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Medical Raw Materials
Appearance:White Crystal
EINECS No.:618-706-8
Storage:2-8°C
Provide:Terbinafine Bnf MSDS;
Terbinafine Bnf COA

What is Terbinafine Bnf?

Terbinafine hydrochloride for the treatment of skin, hair and also nail infections triggered by Trichophyton, Microsporum canis, and also Epidermophyton floccosum. It can likewise treat various ringworm illness, in addition to skin yeast infections caused by Candida, and also onychomycosis triggered by mold and mildew.Terbinafine hydrochloride is an allylamine antifungal drug, which inhibits squalene epoxidase in the process of ergosterol synthesis in fungal cells, and makes squalene accumulate in cells to play a bactericidal effect.

Terbinafine Bnf Properties:

Melting point 203-205 °C
Boiling point 417.9±33.0 °C(Predicted)
density 1.007±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka6.92±0.50(Predicted)

 

Terbinafine Bnf Uses

  1. Terbinafine Bnf Oral administration is suitable for the treatment of: ① by Trichophyton (T. rubrum, Trichophyton mentagrophytes, Trichophyton verruciformis, Trichophyton officinalis and Trichophyton purpura, etc.), Microsporum and Epidermophyton floccosum, etc. Infections of the skin, hair and toenails. ② all kinds of ringworm and skin yeast infection caused by Candida. ③ Onychomycosis (onychomycosis) caused by mold.
  2. Allylamine antifungal drugs have a broader antibacterial spectrum and higher antifungal activity than naftifine. It can hinder the fungal squalene epoxidase with high selectivity, to make sure that the squalene epoxidation response throughout the formation of the fungal cell membrane layer is obstructed, and also the development of the fungal cell membrane is ruined, so as to eliminate or hinder the fungus. Safe, reduced poisoning, tiny side effects, excellent oral and also topical tolerance, no teratogenicity or embryotoxicity. It is scientifically used for numerous skin fungal infections (tinea pedis, jock impulse and tinea corporis) as well as nail fungal infections.

Terbinafine Precautions

1. Those who are allergic to this product, pregnant women and lactating women should not use it.

2. Patients with renal insufficiency should be used with caution; patients with hepatic insufficiency should appropriately reduce the dose.

Use with liver drug enzyme inhibitors such as cimetidine can slow the clearance rate of this product and prolong the plasma half-life; use with liver drug enzyme inducers such as rifampicin can accelerate the metabolism of this product and increase the plasma clearance rate It is accelerated by 1 times, and the excretion half-life is shortened by more than half. When co-administered with the above drugs, appropriate dose adjustment should be considered.

Clinical Application of Terbinafine

Application 1.
Wu Jingyun et al summarized the clinical efficacy of Kushen Qinlian prescription combined with terbinafine hydrochloride in the treatment of onychomycosis. Methods: A total of 108 patients with onychomycosis who were treated in our hospital from August 2015 to May 2019 were selected as the research objects, and they were divided into two groups according to the different admission time of the patients. The control group, 54 patients, was treated with conventional western medicine terbinafine hydrochloride. The 54 cases in the group were treated with Kushen Qinlian prescription on the basis of the treatment, and the curative effects of the two groups were compared. Results: The overall efficient rate of the analysis team was 98.15% (53 instances), which was dramatically higher than that of the control group, 85.19% (46 cases), as well as the difference in between both groups was statistically significant (P < 0.05). The difference was statistically significant (P < 0.05). Conclusion: In the clinical treatment of patients with onychomycosis, Kushen Qinlian prescription combined with terbinafine hydrochloride can achieve satisfactory results, help to improve the patient’s symptom score, and has clinical application value.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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