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Tartrazine CAS 1934-21-0

Molecular Formula: C16H13N4NaO9S2

Formula Weight: 492.41

ZSpharmac: Tartrazine Supplier

Product Name: Tartrazine
CAS No: 1934-21-0
Purity: 99%

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Basic Info

Product Name:Tartrazine
Other Names:Food Yellow No. 4
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Orange Powder
EINECS No.:217-699-5
Storage:Room Temp
Provide:Tartrazine MSDS;
Tartrazine COA

What is Tartrazine?

Tartrazine is amongst the three primaries of food man-made pigments, and also it is likewise one of one of the most extensively made use of artificial pigment on earth for food coloring. Chemical name: 1-(4-sulfonic acid phenyl)-4-(4-sulfonic acid phenylazo)-5-pyrazolone-3-carboxylic acid trisodium salt. It is a brilliant yellow powder or granule with an azo-heterocyclic framework, along with can be securely utilized for coloring in food, beverage, medication, cosmetics, feed, cigarette and also numerous other fields.

Tartrazine Property

Melting point 300 °C
Boiling point 909.54℃[at 101 325 Pa]
density 2.121[at 20℃]
vapor pressure 0Pa at 25℃
storage temp. room temp
solubility DMSO (Sparingly, Heated), Water (Slightly)
Colour Index 19140
form Powder
color Orange
Water Solubility 260 g/L (30 ºC)


Application of Tartrazine

As a tinting rep, Tartrazine is typically made use of in food, beverage, medication, everyday needs in addition to cosmetics, and additionally has a lengthy history. In 1884, H. J. Ziegler first created tartrazine from the condensation response of phenylhydrazine to sulfonic acid and likewise dihydroxytartaric acid. Ziegler not just established the structure of tartrazine, yet additionally suggested the tautomerism in between the azo-azo sorts of tartrazine fragments. The U.S.A. has actually used tartrazine to food considering that 1916. Tartrazine is now taken advantage of in more than 60 nations worldwide. Traces of it can be found in beverages, gelato, sherbet, jelly, yogurt, soft drinks, containers and confectionery layers.

Although there is no definitive proof of tartrazine’s carcinogenicity, tartrazine is known to trigger allergic and other reactions. In 1959, Lockey initially reported the adverse response of individuals with a history of urticaria after swallowing tablet computers having tartrazine. Later on, allergies brought on by tartrazine were reported one after another. In August 1979, the United States FDA specified that all foods and also prescription medicines having tartrazine ought to detail tartrazine active ingredients on the tag.

In September 2007, the British Food Requirements Agency appointed the College of Southampton to conduct a research study on the influence of edible artificial coloring on children’s growth. It was discovered that 6 pigments, Tartrazine, Sunset Yellow, Azorubin, Carmine, Quinoline Yellow, as well as Allura Red, would certainly affect youngsters’s development. Kid’s knowledge can result in a 5.5 factor decrease in youngsters’s intelligence worth in extreme situations, and it can also result in behavioral disorders such as ADHD in children. Consequently, the British Food Requirements Company proposed to the government to use much less food additive in food. Several European customer protection organizations likewise prompted the EU to outlaw making use of these 6 pigments. The scientists will likewise carry out further research on the hazards of salt benzoate, an additional food preservative.

Symptoms of an allergic reaction to Tartrazine generally consist of: anxiousness, migraine, anxiety, blurred vision, hissing, itching, weakness of limbs, hives, suffocation, etc. Hatred tartrazine is more usual in individuals who dislike aspirin. Research estimates the total variety of people in the United States with tartrazine hatreds be about 360,000, or about 0.12% of the populace.

Content Analysis Method of Tartrazine

A method for accurately analyzing the content of Tartrazine, specifically carried out according to the following steps:

(1), take the Tartrazine sample (accurate to 0.0002 gram) of m gram (about 2 gram) in 250ml Erlenmeyer flask, add 50ml mass fraction and be 65% concentrated nitric acid, shake well, cook on electric furnace, keep slightly Boiling state for 2 hours, m≤2;

(2) Take off the Erlenmeyer flask and cool to room temperature, add 55ml of a mixed strong acid solution with a mass fraction of 65% concentrated nitric acid and a mass fraction of 71% perchloric acid with a volume ratio of 10:1, shake well, cook on an electric stove, and keep slightly Boiling state 1 hour, until the solution in the Erlenmeyer flask is light green; if not, add 65% concentrated nitric acid and 71% perchloric acid with a mass fraction of 10:1 mixed strong acid solution 22ml, Continue to heat and boil slightly until the solution is digested and turns light green;

(3) Take off the Erlenmeyer flask and cool it to room temperature, add 100ml of distilled water, and boil on an electric stove to remove excess acid in the solution until the remaining 30ml of the solution;

(4) Take off the Erlenmeyer flask, rinse the mouth of the bottle and the wall of the bottle with a small amount of distilled water, add 60ml of barium chloride solution with a concentration of 60g/L and shake well, put it on an electric stove and boil it, remove it, and cool it to room temperature. There will be white barium sulfate precipitate at the bottom of the Erlenmeyer flask. Finally, filter it with a 30ml glass sand core crucible with a known weight m0 and wash it with distilled water for 10 times until the filtrate is tested with silver nitrate and there is no white precipitate. And the pH is 6-7, otherwise continue to rinse with distilled water;

(5) Place the cleaned and precipitated glass sand core crucible in an oven at 100-105°C for 2 hours, take it out and place it in a desiccator to cool to room temperature, then weigh the total weight m1 of the crucible and the precipitate;

(6) Weigh m grams (about 2 grams) of Tartrazine sample (accurate to 0.0002 grams) into a 300ml beaker, add 150ml of distilled water, stir with a glass rod to completely dissolve the tartrazine, then add 20 grams of activated carbon, and add nitric acid Mix 1ml of nitric acid solution with a volume ratio of 1:1 to water, stir evenly, let it stand for 30 minutes, and filter it with dry filter paper. If there is still color, replace the activated carbon and re-operate;

(7) Collect all the colorless filtrates in step (6), add 30ml of barium chloride solution with a concentration of 60g/L and shake them well, put them on an electric stove and boil them, take them off, and cool them down to room temperature. White barium sulfate precipitate appears, and finally use a 30ml glass sand core crucible that has been washed and dried in advance and has a known weight m2 to suction filter, wash the precipitate with distilled water for several times, until the filtrate is tested by silver nitrate and has no white precipitate and the pH is 6‑ 7, otherwise continue to rinse with distilled water;

(8) Bake the glass sand core crucible with the cleaned sediment in step (7) in an oven at 100-105°C for 2 hours, take it out and place it in a desiccator to cool to room temperature, then weigh the total weight of the crucible and the sediment m3;

(9) Calculation: The main content of tartrazine% = {(m1‑m0)‑(m3‑m2)}×100/(0.8736×m)%

Wherein: 0.8736 is the quality of the barium sulfate that the sulfonic acid group that 1 gram 100% Tartrazine contains forms.

Purification Method of Tartrazine

S1. Adjust the pH of the Tartrazine aqueous solution to 0.8-3, the Na on the tartrazine is replaced by H, and precipitate 1-(4-sulfonic acid phenyl)-4-(4-sulfonic acid phenylazo)-5-pyridine Azolinone-3-carboxylic acid is filtered to obtain a filter cake; due to the impurity salts such as sodium chloride will not be separated into precipitates, and 1-(4-sulfonic acid phenyl)-4-(4-sulfonic acid phenyl Nitrogen)-5-pyrazolone-3-carboxylic acid has a certain hydrophobicity, so that the amount of solution remaining in the filter cake is significantly reduced, and the by-products introduced with the solution are also significantly reduced. Use hydrochloric acid, sulfuric acid aqueous solution to adjust the pH of lemon yellow aqueous solution.

S2, add water to the filter cake, add dropwise an aqueous sodium hydroxide solution to adjust the pH to 6-8, and obtain a lemon yellow concentrate. The Tartrazine concentrated solution can be directly used, spray-dried or used for crystallization to obtain tartrazine products.

S3. The Tartrazine concentrated solution is cooled to precipitate and precipitate, filtered and dried to obtain the pure tartrazine. After the filter cake is dissolved in water, it is neutralized with alkali to become tartrazine in the form of trisodium salt again, and then crystallized and filtered to obtain the product. This process is equivalent to the effect of a recrystallization, but due to most of the by-product chlorine in the product Sodium chloride has been removed in the previous filtration step, and only a small amount of water needs to be added at this time, so the yield is high.

About Products:
If you need Tartrazine, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Tartrazine manufacturer and supplier, ZSpharmac will provide Tartrazine raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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