Zhishang Chemical

Welcome to Zhishang Chemical      +86-176 5311 3209     Simon@sdzschem.com

Zhishang Chemical

Sucralose Powder CAS 56038-13-2

Molecular Formula: C12H19Cl3O8

Formula Weight: 397.63

ZSpharmac: Sucralose Powder Supplement

Product Name: Amrinone 
CAS No: 56038-13-2
Purity: 99%

Basic Info

Product Name:Sucralose Powder
Other Names:Amrinon
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Food Additives
Appearance:White Powder
EINECS No.:259-952-2
Provide:Sucralose Powder MSDS;
Sucralose Powder COA

What is Sucralose Powder?

Sucralose Powder is a white powder product that is conveniently soluble in water, ethanol as well as methanol. It is currently the only useful sugar created from sucrose. Its sweet taste is 600 times that of sucrose, and its sweet taste is pure. The sweetness characteristic is really comparable to sucrose, with no bitter aftertaste; no warmth, no tooth decays, good stability, especially in aqueous solution. After a lasting toxicological test, it has actually been proved that it is very risk-free and also is currently the most effective functional sweetener.Today, Sucralose Powder has actually been extensively made use of in beverages.

Sucralose Powder Properties:

Melting point 115-1018°C
alpha D +68.2° (c = 1.1 in ethanol)
Boiling point 104-107 C
density 1.375 g/cm
storage temp. 2-8°C
solubility Do you have solubility information on this product that you would like to share
form Powder
color White
PH6-8 (100g/l, H2O, 20°C)
optical activity[α]/D 86.0±2.0°, c = 1 in H2O
Water Solubility Soluble in Water.


Sucralose Powder Uses

  1. Sucralose Powder is a non-nutritive sugar, extensively used in beverages, food, medicine, cosmetics and also other sectors. Given that sucralose is a brand-new sort of non-nutritive sweetener, it is a perfect food additive for patients with obesity, cardiovascular disease and also diabetes., as a result, its application in natural food as well as medicine remains to increase. In recent times, some medical investigates have actually utilized it as a tracer particle for the resolution of colonic leaks in the structure, primarily by gas chromatography. Sensitivity and also specificity are for refresher course. This product is the most perfect strong sugar today and can be taken in by kids, teenagers, youth, middle-aged, elderly and also individuals with various diseases without any nutritional uncertainties.
  2. Sucralose Powder is used as a food sweetener, dietary supplement, one of the important amino acids.
  3. Sucralose Powder is commonly used in processed foods such as drinks, eating gum, milk items, maintains, jelly puddings, breads, breads, biscuits, ice cream and jams.
  4. Sucralose Powder is a newly approved sweetener in my country. my country stipulates that it can be used in pickles, compound seasonings, prepared wine, beverages, ice cream, popsicles, cakes, canned fruits, biscuits and bread, with a maximum usage of 2.5g/kg; in candied fruit and modified chewing gum, the maximum usage amount is 1.5g/kg ; Can also be used as table sweetener, the maximum dosage is 0.05g/packet.

Sucralose Powder Production Method

The synthetic routes of sucralose can be roughly divided into three categories: monoester method, chemical-enzymatic method and group migration method.

6 group protection method This method was developed by Tate-Lyle Company. Firstly, Bacillus strains were used to ferment glucose at 30 °C to generate glucose-6-acetic acid. The highest concentration of glucose-6-acetic acid could reach 15 g/L, and the yield could reach 85% of the theoretical yield. Glucose-6-acetic acid was then purified by a combination of methanol extraction and silica gel column chromatography separation, and the purification yield was 80% to 85%.

Under the action of β-fructosyltransferase produced by Bacillus subtilis, the mixed reaction of glucose-6-acetic acid and Sucralose Powder produces sucrose-6-acetic acid, and the concentration of sucrose-6-acetic acid can reach 120 g/L. The yield of this step is 58%. 70% pure sucrose-6-acetic acid can be obtained by chromatography. 4,1′,6′,-Trichloro-4,1′,6′-trideoxygalactosucrosepentaacetic acid is obtained by reacting Sucralose Powder -6-acetic acid with Vilsmeier’s reagent made of phosphorus pentachloride and DMF , the yield of this step was 39%. Sucralose Powder can be obtained after sucralose pentaacetic acid is removed from the acetate group, and the yield of deacetic acid is 90%. In this method, the fermentation cost of glucose-6-acetic acid is high, and the purification of Sucralose Powder -6-acetic acid is difficult, and the total yield is about 20%. The synthetic route is as follows:

This method is also developed by Tate-Lyle Company to synthesize raffinose as raw material. Raffinose sugar beet, cottonseed and other plants are currently not available in large quantities. They can be synthesized from a saturated solution of galactose and sucrose at 30°C under the action of galactosidase, and the product concentration can reach 7.5g/L.

Raffinose is chlorinated with thionyl chloride in the presence of triphenylphosphine to form 4,1′,6′,6”-tetrachloro-4,1′,6′,6”-tetradeoxygalactose cotton Subsaccharide heptanoic acid. After the latter is deacetic acid, 4,1′,6′,6”-tetrachloro-4,1′,6′,6”-tetradeoxygalactose raffinose (TCR), calculated as raffinose , the yield of TCR was 32.6%. Under the action of α-galactosidase at 30°C, TCR was hydrolyzed for 24 hours to generate Sucralose Powder with a hydrolysis yield of 80% to 90%. The total yield was 26% to 29%. Monoester method The method was proposed by KhanRA and MuytiKS in 1982. Using the reaction principle of alkyd esterification, we try to shield a certain hydroxyl group in the sucrose molecule, and by controlling the conditions, we can obtain as high monoester content as possible. Then it is separated, chlorinated, de-esterified and purified to obtain the product. This method is difficult to control the position and degree of esterification, and the yield is only 5% to 7%.

base transfer method
Using sucrose as raw material, it is obtained by tritylation (shielding three primary hydroxyl groups), acetylation (shielding five secondary hydroxyl groups), detritylation, acetyl transfer, chlorination, deacetylation and other steps. Sucralose.

Tritylation and Acetylation At 50°C, 50 g of sucrose and 60 g of N-methylmorpholine were dissolved in 100 mL of dimethylformamide. After half an hour, 141.8 g of trityl chloride (purity 97%) was added in three times, and the heating was continued for 3.5 h. Then 42.7g of sodium bicarbonate was added, and the temperature was kept at 50°C for 1h. The solution was vacuum-dried, then dissolved in 96.6 mL of acetic anhydride, then 15.6 g of potassium acetate was added, heated to 115° C. and kept at a constant temperature for 3 hours. After cooling, 400 mL of ethanol was added to obtain 183.2 g of crystalline material, which contained 124.6 g of 6,1,6′-trioxy-trityl-pentaacetyl sucrose (TRISPA), with a yield of 68.6%.

Detrityl group 200g TRISPA was dissolved in 800mL toluene, cooled to 0°C, and 1.7g of hydrogen chloride gas was passed through, and a precipitate was formed after 4.5h. It was purged in nitrogen for 1 h to remove residual hydrogen chloride gas, filtered and washed with 65 mL of toluene to form particles, re-dissolved in 120 mL of 1% triethylamine toluene solution, the mixture was filtered again, and washed with 65 mL of toluene, After drying, 81 g of 2,3,3′,4,4′-pentaoxy-acetylsucrose (4-PAS) was obtained, and the yield was 80%.

Acetyl Migration 50 g of 4-PAS was dissolved in 100 mL of water, heated to 60°C, filtered while hot, and cooled to room temperature. 2.5 mL of pyridine was added and stirred at room temperature for 2.5 h. The solution was acidified with 2.5 mL of concentrated hydrochloric acid and extracted with dichloromethane (2 x 125 mL). The extract was concentrated to 50 mL, and heptane (3×50 mL) was added and stirred to precipitate crystals. After 20 min, filter, rinse the crystal with 30 mL of heptane, and dry under vacuum for 16 h to obtain 34 g of 2,3,3′,4′,6-pentaacetylsucrose (6-PAS) with a yield of 58%.

Chlorination 50g 6-PAS and 50.3g triphenylphosphorus oxide (TPPO) were stirred into 150mL toluene solution to make a slurry, 32.8mL thionyl chloride was added at room temperature, the solution was refluxed for 2.5h and then cooled to 40°C. Then 200 mL of water was added to further cool to 0 °C, the mixture was vigorously stirred for 1 h, filtered, and rinsed with 75 mL of toluene: water (1:2) to obtain crude 4,1′,6′-trichloro-4,1′ , 6′-trideoxy-acetyl-galactosucrose (TOSPA). It was dissolved in 200 mL of hot methanol, stirred at 20 °C for 1 h, recrystallized and filtered again to obtain 40 g of pure TOSPA with a yield of 75%.

Deacetylation Dissolve 50 g TOSPA and 0.5 g sodium methoxide in 125 mL methanol, and stir under vacuum for 1.5 h. After adding Amberlite IRC50 (H+) resin, the solution was stirred and neutralized again, filtered, and the filtrate was decolorized with 2 g of activated carbon and 2 g of diatomaceous earth and concentrated. 100 mL of ethyl acetate was added, and the Sucralose Powder was crystallized out. After washing and drying, the product weighed 26 g and had a purity of 92%.

Health Problems of Sucralose Powder

Some claim that Sucralose Powder alters the quantity and quality of the beneficial flora in our gut. These claims are largely based on a 2008 study by Abou-Donia et al. It has also been suggested that Sucralose Powder limits the body’s absorption of certain therapeutic drugs, making them less effective. It has also been suggested that Sucralose Powder breaks down during baking and releases the potentially toxic compound chloropropanol.

However, many, including a panel of experts, have exposed the myths in the Abou-Donia et al (2008) paper, which is flawed in several key areas. The findings of Abou-Donia et al and Schiffman & Rother (2013) (both in the same journal) used mice, not humans, and they were fed large amounts of Sucralose Powder based on their weight . In fact, the study used a Sucralose Powder product under the Splenda brand, which also contains maltodextrin and dextrose used as bulking agents, so any poor results are likely due to these high glycemic index carbohydrates, not Sucralose Powder itself. Other studies have shown no changes in gut function, including the gut microbiome, after Sucralose Powder intake.

There is also a claim (which also questions some other non-caloric sweeteners) that consuming Sucralose Powder can affect insulin response, blood sugar levels, and appetite. It has been suggested that this is a sensory learning response, where the body associates the sweet taste of sucralose with sugar, leading to an insulin response. It is known that high sugar intake only leads to short-term satiety, followed by increased appetite, and they claim the same happens with Sucralose Powder. However, this is not the case, the production of appetite is very complex, involving many hormones as well as the nervous system. In fact, studies have shown that neither insulin nor appetite increases after ingesting Sucralose Powder.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Sucralose Powder Quotation