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Stigmasterol Sigma CAS 83-48-7

Molecular Formula: C29H48O

Formula Weight: 412.7

ZSpharmac: Stigmasterol Sigma Supplier

Product Name: Stigmasterol Sigma
CAS No: 83-48-7
Purity: 99%

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Basic Info

Product Name:Stigmasterol Sigma
Other Names:Stigmasterol
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:201-482-7
Provide:Stigmasterol Sigma MSDS;
Stigmasterol Sigma COA

What is Stigmasterol Sigma?

Stigmasterol Sigma is an all-natural phytosterol. All-natural phytosterols are similar in framework to animal sterols such as cholesterol. They are an active component in plants. They exist in different veggie oils and are extensively made use of in medication, food, cosmetics and other sectors. The primary parts of phytosterols include campesterol, β-sitosterol, stigmasterol and brassicasterol. Brassinolide is a plant environment-friendly development regulatory authority, and also its market ability in 2017 will certainly be about 1 billion. Because of its architectural features, stigmasterol can be made use of as a raw material for the synthesis of brassinolide, and also has been preferred by residential and international markets. substantial focus. At the same time, because of its special physiological functions, Stigmasterol Sigma can be made use of as a synthetic sex hormone, adrenocortical hormone (prednisone anti-inflammatory rheumatic drug), steroidal birth controls, menopausal treatment drugs, diuretics, antineoplastic medications, anabolic hormones and also energizers. The moms and dad substance of many medicines such as hormones.

Stigmasterol Sigma Property

Melting point 165-167 °C (lit.)
alpha -50 º (c=2, CHCl3)
Boiling point 472.07°C (rough estimate)
density 0.9639 (rough estimate)
refractive index 1.5000 (estimate)
storage temp. -20°C
solubility chloroform: soluble50 mg/ml
form Powder
color White
Water Solubility insoluble


Stigmasterol Sigma Uses

  1. Stigmasterol Sigma is made use of as a resources for the synthesis of steroid hormonal agents as well as also as a basic material for the production of vitamin D3.
  2. Stigmasterol Sigma is a plant sterol with a chemical structure comparable to cholesterol. It has anticancer, antipyretic, anti-inflammatory and immunomodulatory buildings.
  3. Stigmasterol Sigma is made use of in biochemical research study to produce progesterone, and it is also the raw material for producing progesterone in medication.

Extraction of Stigmasterol Sigma Method in Plants

Today, the main techniques for removing Stigmasterol Sigma from blended phytosterols in your home and also abroad are: solvent approach as well as solvent formation approach.
Directly utilize the solubility difference of each element in the blended phytosterols, pick an ideal natural solvent for multi-step removal, recrystallization and separation; use natural acids to react with the alcoholic hydroxyl teams contained in the mixed phytosterols to create matching phytosterol derivatives, to enhance the difference in physical residential properties, and then utilize recrystallization and other techniques to separate; use the halogen addition response on the sterol ring and the double bond on the branch chain to raise the distinction in physical parameters of the created by-products, and then pick an appropriate organic solvent Extraction, recrystallization as well as separation.
1. Solvent approach,
Making use of soybean blended phytoalcohol as basic material, by changing the ratio of solid to liquid and formation temperature level, it was verified that after 2-3 stages of fractional crystallization, the purity > 60% of phytoalcohol can be obtained. Via 4-5 quality formation, the pureness can get to more than 85%.
2. Solvent crystallization technique
From the process contrast of the separation of mixed phytosterols by solvent crystallization, it is located that the visibility of a small amount of water can not just greatly increase the yield of sterols, yet likewise enhance the selectivity of stigmasterol in a certain array, which is handy to get high-purity Stigmasterol Sigma as well as sitosterol items.
2.1 Multi-stage fractional crystallization method. The reaction steps of the technique are as follows: the very first step, include solvent absolute ethanol, n-propanol or n-butanol to the phytosterol, heat up and liquify, after that slowly cool off and also take shape, filter, and also repeat those concentration actions 0 to 1 for the crystals acquired After that, centrifugal splitting up as well as vacuum cleaner drying out are performed; the 2nd step is to include a separation solvent to the phytosterol concentrate acquired in the very first step, warm up as well as liquify, then gradually cool off to crystallize, filter, as well as repeat the above splitting up steps 2 to 3 for the acquired crystals Below par. The creation considerably boosts the pureness and return of Stigmasterol Sigma via two different actions of basic material focus and also splitting up as well as filtration, and has no contamination to the setting.
2.2 Polar solvent crystallization technique Very first enrich Stigmasterol Sigma to 90% with a non-polar solvent, and after that take shape with a polar solvent to obtain high-purity stigmasterol. The procedure is to liquify the raw products in toluene to acquire a 25% option, cool to 25 ° C, keep the temperature level for 1 hr, take shape, as well as repeat 6 times to get stigmasterol with a purity of 92%. When the purity of stigmasterol is more than 90%, it can no longer be improved by crystallization. At this time, the gotten stigmasterol is dissolved in acetone under anhydrous problems at a proportion of 1:20, gradually cooled, taken shape, as well as the pureness can be lowered. boosted to 98%.
2.3 Organic solvent condensation approach Wang Yaqiong et al. used mixed phytosterols as resources to examine the separation as well as crystallization qualities of stigmasterol in 3 solvents: toluene, toluene methanol as well as toluene acetone. It was revealed that using toluene (90%) and acetone (10%) as Mixed solvent, after 5 times of crystallization, Stigmasterol Sigma content > 70%, complete yield of stigmasterol > 50%. Gao Yuying et al. made use of n-butanol as a solvent to improve stigmasterol from blended soybean phytosterols, with a solid-to-liquid ratio of 1:4, placed in a constant temperature water bathroom at 20 ° C to 30 ° C, crystallized for 1 to 2 hrs, and also filteringed system or centrifuged at a constant temperature for 4 Stigmasterol Sigma with a material of more than 85% can be obtained by ~ fifth grade condensation.

Preparation of Stigmasterol Sigma

About That Product:
If you need Stigmasterol as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Stigmasterol manufacturer and supplier, ZSpharmac will provide Stigmasterol raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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