Zhishang Chemical

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Zhishang Chemical

Spermidine Drosten CAS 124-20-9

Molecular Formula: C7H19N3

Formula Weight: 145.25

ZSpharmac: Spermidine Drosten Supplement

Product Name: Spermidine Drosten
CAS No: 124-20-9
Purity: 99%

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Basic Info

Product Name:Spermidine Drosten
Other Names:Spermidine
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Colorless Liquid
EINECS No.:204-689-0
Storage:Room Temp
Provide:Spermidine Drosten MSDS;
Spermidine Drosten COA

What is Spermidine Drosten?

Spermidine Droste is a reduced molecular weight aliphatic carbide including 3 amine groups as well as is one of the all-natural polyamines present in all living microbes. It is a crucial sources for pharmaceutical synthesis and also is extensively utilized in the synthesis of pharmaceutical intermediates. Spermidine Droste is associated with many biological procedures in organisms, such as managing cell proliferation, cell senescence, body organ development, resistance, as well as cancer cells and other physical and also pathological processes. Recent researches have actually shown that spermidine plays a vital function in controling synaptic plasticity, oxidative anxiety and also autophagy in the nervous system.

Spermidine Drosten Property

Melting point 23-25 °C
Boiling point 128-130 °C (14 mmHg)
density 1.00 g/mL at 20 °C
refractive index n20/D 1.479(lit.)
Fp >230 °F
storage temp. room temp
solubility H2O: 1 M at 20 °C, clear, colorless
form Liquid After Melting
color Clear colorless
Specific Gravity0.925
OdorIchtyal, ammoniacal
PH12.0-13.5 (25℃, 1M in H2O)
Water Solubility Miscible with water, ethanol and ether.


Applications of Spermidine Drosten

Spermidine Drosten as well as synaptic plasticity
The synaptic plasticity of nerve cells is the ability of the nerve system to change the framework and function of synapses in order to adjust to changes in the outside setting, which can be separated right into architectural plasticity and also useful plasticity. Long-term potentiation (LTP) is among the major indications of synaptic plasticity. A a great deal of studies have confirmed that the synaptic plasticity of nerve cells is closely related to finding out as well as memory, as well as most scientists believe that the cellular basis for the formation of learning as well as memory is LTP. Consequently, managing synaptic plasticity, particularly raising LTP, is an essential method to boost discovering as well as memory. There are a multitude of N-methyl-D-aspartate (NMDA) receptors on synapses, which are involved in the guideline of synaptic plasticity in the central nerve system, specifically the guideline of LTP.

It has actually been reported that the activation of NMDA receptors can promote the influx of calcium ions and produce LTP, thus attaining the function of improving learning as well as memory. Studies have shown that the reduction of spermidine levels in the mind harms details spatial understanding as well as associated memory capabilities of rats in the water maze examination. The systemic management as well as amygdala injection of Spermidine Drosten dramatically enhanced the efficiency of the computer mice in repressive evasion actions, fear episodic memory as well as social acknowledgment jobs, as well as promoted and also re-consolidated anxiety memory.

Spermidine Drosten as well as Oxidative Stress
There are oxidative systems and antioxidant systems in the body, as well as under normal situations, the two remain in a state of dynamic equilibrium. When the body undergoes numerous damaging stimulations, excessive polymer energetic substances such as oxygen complimentary radicals and lipid peroxides are created in the body, and also the oxidative ability goes beyond the antioxidant capability, breaking the balance between oxidation as well as anti-oxidation, resulting in oxidative stress., causing cell and cells damages. After the brain cells of the body is damaged, a solid oxidative stress reaction occurs, a lot of oxygen totally free radicals collect, as well as nerve cells are damaged. Spermidine Drosten is thought about a totally free radical scavenger as well as antioxidant in the body. At present, the research study on spermidine’s anti-oxidative stress mainly concentrates on the urinary system as well as the endocrine system, and there are relatively couple of reports in the field of the nerves. Some scientists used the thiobarbituric acid catalyst produced in rats as an indicator to determine free radicals and lipid peroxides, as well as observed that Spermidine Drosten can efficiently inhibit the thiobarbituric acid catalyst in the mind of Wistar rats. The manufacturing of oxidative tension lowers oxidative stress and also protects the nerves.

Preparation of Spermidine Droste

A method of preparing Spermidine Droste. The method includes the following steps:

A, take compound I aminopropanol and butyrolactone as raw material to react in solvent, and concentrate after the reaction finishes to obtain compound II crude product;

b. Dissolving the compound II crude product in the solvent, then adding tetrahydroaluminum lithium to carry out the reaction, the reaction ends, and after post-processing, the compound III crude product is obtained;

C, compound III crude product is dissolved in solvent, adds alkali and di-tert-butyl dicarbonate and reacts, and the reaction finishes, obtains compound VI crude product through aftertreatment;

D, the compound VI crude product is dissolved in the solvent, inert gas protection, adds ligand and phthalimide, then adds a condensing agent to react, after the reaction finishes, concentrate to obtain compound V crude product;

e. The crude product of compound V is dissolved in a solvent, and hydrazine hydrate is added to carry out the reaction. After the reaction is completed, the crude product of compound VI is obtained after post-treatment; the crude product of compound VI is rectified to obtain pure Spermidine Droste.

Regulatory and Protective Functions of Spermidine Droste in the Nervous System

The synaptic plasticity of neurons is the ability of the nervous system to change the structure and function of synapses in order to adapt to changes in the external environment, which can be divided into structural plasticity and functional plasticity [8-9]. Long-term potentiation (LTP) is one of the main manifestations of synaptic plasticity. A large number of studies have confirmed that the synaptic plasticity of neurons is closely related to learning and memory, and most researchers believe that the cellular basis for learning and memory is LTP [10]. Therefore, regulating synaptic plasticity, especially increasing LTP, is an important way to improve learning and memory. There are a large number of N-methyl-D-aspartate (NMDA) receptors on synapses, which are involved in the regulation of synaptic plasticity in the central nervous system, especially for LTP adjustment. It has been reported that the activation of NMDA receptors can promote the influx of calcium ions and generate LTP, thereby achieving the purpose of improving learning and memory.

Studies have confirmed that the reduction of Spermidine Droste levels in the brain impairs the specific spatial learning and related memory abilities of rats in the water maze test [14]. The systemic administration and injection of spermidine into the amygdala significantly improved the mice’s performance in inhibitory avoidance behavior, fear episodic memory, and social recognition tasks, and facilitated and re-consolidated fear memory. Varun et al. found that memory impairment caused by the expansion of the presynaptic active area (AZ area) with increasing age. After Drosophila was fed spermidine (30dSpd), the core scaffold proteins in the AZ area such as Bruchpilot (BRP) and RIM-binding Protein (RBP) and other expressions no longer increase, and the AZ region no longer expands with age, thereby inhibiting age-related memory impairment [19-20]. This indicates that spermidine has the ability to improve learning and memory, and this ability may be achieved by regulating synaptic plasticity.

There are oxidative systems and antioxidant systems in the body, and under normal circumstances, the two are in a state of dynamic balance. When the body is subjected to various harmful stimuli, excess polymer active substances such as oxygen free radicals and lipid peroxides are produced in the body, and the oxidative capacity exceeds the antioxidant capacity, breaking the balance between oxidation and anti-oxidation, resulting in oxidative stress. , causing cell and tissue damage. After the brain tissue of the body is damaged, a strong oxidative stress response may occur, a large number of oxygen free radicals will accumulate, and neurons will be damaged.

Autophagy is a self-protection mechanism of cells, and the main role of this process is to degrade defective organelles and misfolded proteins in cells. In neuronal cells, autophagy plays an extremely important role in maintaining the stability of the intracellular environment [34]. Basal levels of autophagy have been reported to have protective effects on neural cells.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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