Spermidine CAS 124-20-9

Molecular Formula: C7H19N3

Formula Weight: 145.25

ZSpharmac: Spermidine Supplier

Product Name: Spermidine

CAS No: 124-20-9

Purity: 99%

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Basic Info

Product Name:	Spermidine
Other Names:	SPERMIDINE FREE BASE
CAS:	124-20-9
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	Clear Colorless Liquid After Melting
EINECS No.:	204-689-0
Storage:	Room Temp
Provide:	Spermidine MSDS； Spermidine COA

What is Spermidine?

Spermidine is a reduced molecular weight aliphatic carbide consisting of 3 amine groups, in addition to it is just one of the natural polyamines present in all microbes. It is a necessary raw material for pharmaceutical synthesis in addition to is commonly made use of in the synthesis of pharmaceutical intermediates. Spermidine signs up with lots of natural treatments in bacteria, such as taking care of cell expansion, cell aging, organ development, resistance and also cancer along with numerous other physical as well as pathological processes. Existing research studies have exposed that spermidine plays a crucial obligation in managing synaptic plasticity, oxidative stress and autophagy in the nerve system.

Spermidine Property

Melting point	23-25 °C
Boiling point	128-130 °C (14 mmHg)
density	1.00 g/mL at 20 °C
refractive index	n20/D 1.479(lit.)
Fp	>230 °F
storage temp.	room temp
solubility	H₂O: 1 M at 20 °C, clear, colorless
form	Liquid After Melting
pka	10.53±0.19(Predicted)
Specific Gravity	0.925
color	Clear colorless
PH	12.0-13.5 (25℃, 1M in H2O)
Odor	Ichtyal, ammoniacal
Water Solubility	Miscible with water, ethanol and ether.

Spermidine Application

Spermidine and Synaptic Plasticity
Synaptic plasticity of neurons is the ability of the nervous system to change the structure and function of synapses to adapt to changes in the external environment, which can be divided into structural plasticity and functional plasticity. Long-term potentiation (longtime potential, LTP) is one of the main manifestations of synaptic plasticity. A large number of studies have confirmed that the synaptic plasticity of neurons is closely related to learning and memory, and most researchers believe that the cellular basis for the formation of learning and memory is LTP. Therefore, regulating synaptic plasticity, especially increasing LTP is an important way to improve learning and memory. There are a large number of N-methyl-D-aspartate (NMDA) receptors on the synapse, which participate in the regulation of synaptic plasticity in the central nervous system, especially the regulation of LTP .

It has been reported that the activation of NMDA receptors can promote the influx of calcium ions and generate LTP, thereby achieving the purpose of improving learning and memory. Studies have shown that the reduction of spermidine levels in the brain impairs the specific spatial learning and associative memory abilities of rats in the water maze test. Systemic administration and amygdala injection of spermidine significantly improved the performance of mice in inhibitory avoidance behavior, fearful episodic memory, and social recognition tasks, and facilitated and reconsolidated fear memory.

Spermidine and oxidative stress
There are oxidation system and anti-oxidation system in the body, and the two are in a state of dynamic balance under normal circumstances. When the body is subjected to various harmful stimuli, excessive polymer active substances such as oxygen free radicals and lipid peroxides are produced in the body, and the oxidation capacity exceeds the antioxidant capacity, which breaks the balance between oxidation and anti-oxidation, leading to oxidative stress , causing damage to cells and tissues. After the brain tissue of the body is damaged, a strong oxidative stress reaction may occur, a large number of oxygen free radicals gather, and neurons are damaged. Spermidine is considered a free radical scavenger and antioxidant in the body. At present, the research on the anti-oxidative stress of spermidine mainly focuses on the urinary system and endocrine system, and there are relatively few reports on the nervous system. Some researchers used the thiobarbituric acid reactant produced in mice as an index to measure free radicals and lipid peroxides, and observed that spermidine can effectively inhibit the thiobarbituric acid reaction in the brain of Wistar rats. The production of substances can reduce oxidative stress damage and protect the nervous system.

Spermidine for Hypopigmentation

1. Spermidine therapy boosts melanin manufacturing
In order to research the impact of spermidine on melanin production, the research group dealt with melanin in MNT-1 cells with various concentrations of spermidine, and discovered that spermidine treatment raised melanin production with quantitative analysis.

2. Spermidine can manage the protein deterioration system related to melanin
In order to show that spermidine can manage genetics associated with protein destruction, the research study group found that 181 genes were down-regulated as well as 82 genetics were up-regulated with organized discovery of spermidine-treated cells, excluding genes connected to melanin manufacturing For more proof, the research study group assessed the result of spermidine on the expression levels of the tyrosinase gene household TYR, TRP-1 and also TRP-2, which are genes that firmly manage melanin manufacturing. mRNA expression levels validated that spermidine did not change the expression of genes associated with melanogenesis. But the task of several genetics was modified by spermidine and also was associated with protein deterioration, and also a number of altered genes were associated with ubiquition, a healthy protein destruction system connected with melanin production.

3. Spermidine regulates healthy protein stability and promotes melanin manufacturing.
Melanin production is regulated by the balance of synthesis as well as degradation of melanogenesis-related healthy proteins. Spermidine deals with TYR, TRP-1 and TRP-2 genes, with the action of transporter genetics SLC3A2, SLC7A1, SLC18B1 as well as SLC22A18, it increases the degree of intracellular polyamines, therefore raising the security of proteins related to melanin production to advertise the manufacturing of melanin in vivo produce.

In recap, this research study reveals that the natural substance spermidine has a prospective function in the treatment of hypopigmentation, as well as has certain application worth in the field of cosmetics as well as health care products in the future.

Preparation of Spermidine

A method for preparing spermidine. The method includes the following steps:

a, using compound I aminopropanol and butyrolactone as raw materials to react in a solvent, and concentrating after the reaction to obtain a crude compound II;

b. Dissolving the crude product of compound II in a solvent, and then adding lithium tetrahydrogen aluminum to react, the reaction is completed, and the crude product of compound III is obtained after post-processing;

c. Dissolve the crude compound III in a solvent, add alkali and di-tert-butyl dicarbonate to react, after the reaction is completed, the crude compound VI is obtained after post-processing;

d. Dissolve the crude product of compound VI in a solvent, protect it with an inert gas, add a ligand and phthalimide, and then add a condensing agent to react. After the reaction is completed, concentrate to obtain the crude product of compound V;

e. The crude compound V is dissolved in a solvent, and reacted by adding hydrazine hydrate. After the reaction is completed, the crude compound VI is obtained after post-processing; the crude compound VI is rectified to obtain the pure spermidine.

About Products:
If you need Spermidine, a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced Spermidine manufacturer and supplier, ZSpharmac will provide Spermidine raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.