Spans emulsifiers can be used as emulsifiers when preparing creams, emulsions and ointments. When used alone, they can prepare stable water-in-oil emulsions or microemulsions; if used in combination with different proportions of hydrophilic emulsifiers, Tween , then various water-in-oil, oil-in-water emulsions or creams can be prepared; it can also be used as a solubilizer, wetting agent, dispersant, suspending agent, etc. It can be used to prepare inhalants, intramuscular injections, oral liquids, ophthalmic preparations, topical preparations and vaginal preparations. Medicinal Span 85 is an excellent non-ionic surfactant, which can be used as emulsifier, solubilizer, suspension agent, moisturizing agent, etc. It is widely used in the pharmaceutical industry.
Span 85 has been used as emulsifier, solubilizer, suspending agent and lubricant in aerosol, liniment, injection, ointment and other dosage forms in China. The literature points out that surfactants can act as protective agents and stabilizers in suspensions, and non-ionic surfactants with an HLB value of less than 10 are the most effective. Span 85 is the most commonly used liquid that can be dissolved or dispersed in the liquid phase. The concentration is 0.25~1% of the total weight, and it is also useful to more than 5%. In a British patent for the manufacture of medical powder aerosols, it is stated that the suspension powder is insoluble and well dispersed in a mixture of liquefied propellant and a liquid non-ionic surfactant, among the 38 formulations listed 36 use Span series, of which 33 use Span 85 (prescriptions contain hydrocortisone, phenylephrine, etc.) In the aerosol formulations such as glycerol, guaiacol glycerol ether), sodium cromoglycate, chlorpheniramine, hexylamine, ethoxycoumarin, triple bacterin, etc. It is also widely used in Shanghai, Chongqing, Wuxi and other pharmaceutical factories. As a valve system lubricant, it has low friction resistance and quick spring recovery. It is far better than using mineral oil in the valve with less residue and less odor. It does not affect the color of the aerosol and improves the amount after spraying. After comparison, Span 85 is better than Span-80 (both have a certain anti-rust effect on the spring). Wuxi Pharmaceutical No. 1 Factory used Span 85 as a solubilizer for burn aerosol and burn liniment to increase the solubility of chlorhexidine acetate in sesame oil. Compared with Span-80, it has good solubilization performance and low viscosity. The finished product Transparent, easy to filter and use.
For the emulsion droplets prepared by Span 85, 95% of the oil droplets have a particle size of less than 5μ. Some fat-soluble vitamins, such as A, D, and E, are often formulated into oil injections. If you want to prepare aqueous injections or aqueous suspension injections, dispersants must be added. Such as Span-85, it has the effect of solubilizing the micelles of the main drug. The Vidin glue calcium injection in Jiangsu, Guangdong and Zhejiang contains Span-85 0.22% and Tween-80 0.88%. For stability test, after 4000rPm for 15 minutes, there is no delamination phenomenon. The disc 85 can increase the solubility and release of the drug in the ointment base and reduce the viscosity. It is also used in tablet coating formulations abroad, and has anti-humidity and other effects. Span series have been used as food additives in Japan and other countries, used in ice cream, bread, cakes, chocolate, throwing sugar, etc. as emulsifier and dispersant, as stabilizer and suspending agent for emulsified food, and also as a dispersant. Foaming agent.