Zhishang Chemical

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Zhishang Chemical

Span 85 CAS 26266-58-0

Molecular Formula: C60H108O8

Formula Weight: 957.49

ZSpharmac: Span 85 Supplement

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Product Name: Span 85
CAS No: 26266-58-0
Purity: 99%

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Basic Info

Product Name:Span 85
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Colourless to Pale Yellow Thick Oil
EINECS No.:247-569-3
Storage:Store Below +30°C.
Provide:Span 85 MSDS;
Span 85 COA

What is Span 85?

Span 85 is not a solitary substance, but a combination of numerous comparable make-ups, with sorbitol as the main body. It has low thickness and also the tiniest HLB worth, so it has the greatest lipophilicity. It is a superb water-in-oil (w/O) emulsifier as well as an O/w kind auxiliary emulsifier.

Span 85 Properties:

Melting point -23°C(lit.)
density 0.94 g/mL at 20 °C
vapor pressure <1.4 hPa (20 °C)
refractive index n20/D 1.476(lit.)
Fp >230 °F
storage temp. Store below +30°C.
solubility chloroform: soluble50mg/mL, clear, faintly to light yellow
form Oil
color Colourless to Pale Yellow Thick


Span 85 Uses

  1. Span 85 is utilized as emulsifier, solubilizer and rust prevention in pharmaceuticals, cosmetics, textiles, paints, petroleum items, and also oil removal.
  2. Span 85 is utilized as an emulsifier, lubricating substance, moistening representative, dispersant, thickener, etc.
  3. Span85 has been used in research to develop a new bottom-up process for the production of protein- and peptide-containing nanoparticles for HFA propellants in suspension chemicals. It has also been used to investigate the application of analytical liquid chromatography in polymer nonionic antistatic additives.

Span 85 production Method

Put 1 mol of sorbitol into the response kettle, after vacuuming and also dehydration, the preheated refined oleic acid is poured into the pot, and the quantity of oleic acid included is 3 mol, and then a suitable quantity of sodium hydroxide is included as a driver. After that, the temperature was progressively raised to regarding 210 ° C under vacuum, and the response was maintained for 8 h. Sampling and also measuring the acid value of 14-15 mgKOH/g esterification reaction was completed. After representing stratification, the lower layer fluid is thrown out, as well as the upper layer liquid is poured into a decolorizing pot.

Application of Span 85

Spans emulsifiers can be used as emulsifiers when preparing creams, emulsions and ointments. When used alone, they can prepare stable water-in-oil emulsions or microemulsions; if used in combination with different proportions of hydrophilic emulsifiers, Tween , then various water-in-oil, oil-in-water emulsions or creams can be prepared; it can also be used as a solubilizer, wetting agent, dispersant, suspending agent, etc. It can be used to prepare inhalants, intramuscular injections, oral liquids, ophthalmic preparations, topical preparations and vaginal preparations. Medicinal Span 85 is an excellent non-ionic surfactant, which can be used as emulsifier, solubilizer, suspension agent, moisturizing agent, etc. It is widely used in the pharmaceutical industry.

Span 85 has been used as emulsifier, solubilizer, suspending agent and lubricant in aerosol, liniment, injection, ointment and other dosage forms in China. The literature points out that surfactants can act as protective agents and stabilizers in suspensions, and non-ionic surfactants with an HLB value of less than 10 are the most effective. Span 85 is the most commonly used liquid that can be dissolved or dispersed in the liquid phase. The concentration is 0.25~1% of the total weight, and it is also useful to more than 5%. In a British patent for the manufacture of medical powder aerosols, it is stated that the suspension powder is insoluble and well dispersed in a mixture of liquefied propellant and a liquid non-ionic surfactant, among the 38 formulations listed 36 use Span series, of which 33 use Span 85 (prescriptions contain hydrocortisone, phenylephrine, etc.) In the aerosol formulations such as glycerol, guaiacol glycerol ether), sodium cromoglycate, chlorpheniramine, hexylamine, ethoxycoumarin, triple bacterin, etc. It is also widely used in Shanghai, Chongqing, Wuxi and other pharmaceutical factories. As a valve system lubricant, it has low friction resistance and quick spring recovery. It is far better than using mineral oil in the valve with less residue and less odor. It does not affect the color of the aerosol and improves the amount after spraying. After comparison, Span 85 is better than Span-80 (both have a certain anti-rust effect on the spring). Wuxi Pharmaceutical No. 1 Factory used Span 85 as a solubilizer for burn aerosol and burn liniment to increase the solubility of chlorhexidine acetate in sesame oil. Compared with Span-80, it has good solubilization performance and low viscosity. The finished product Transparent, easy to filter and use.

For the emulsion droplets prepared by Span 85, 95% of the oil droplets have a particle size of less than 5μ. Some fat-soluble vitamins, such as A, D, and E, are often formulated into oil injections. If you want to prepare aqueous injections or aqueous suspension injections, dispersants must be added. Such as Span-85, it has the effect of solubilizing the micelles of the main drug. The Vidin glue calcium injection in Jiangsu, Guangdong and Zhejiang contains Span-85 0.22% and Tween-80 0.88%. For stability test, after 4000rPm for 15 minutes, there is no delamination phenomenon. The disc 85 can increase the solubility and release of the drug in the ointment base and reduce the viscosity. It is also used in tablet coating formulations abroad, and has anti-humidity and other effects. Span series have been used as food additives in Japan and other countries, used in ice cream, bread, cakes, chocolate, throwing sugar, etc. as emulsifier and dispersant, as stabilizer and suspending agent for emulsified food, and also as a dispersant. Foaming agent.

The Production of Span 85 in Various Aspects

CN201810861427.9 discloses a slurry for recycled yarn sizing and a preparation method thereof, belonging to the technical field of the textile industry. The present invention adopts raw materials: starch, cowhide cream, sodium peroxide, sodium chloride, dicyandiamide, oleate, sorbitan trioleate, polyoxyethylene sorbitan monostearate, dodecyl Sodium benzenesulfonate and distilled water; first put the distilled water into the mixing bucket, turn on the mixer, then put in oleate, Span 85, polyoxyethylene sorbitan monostearate and stir evenly, then put in Leather paste, sodium chloride, dicyandiamide and sodium dodecyl benzene sulfonate and stir evenly, then add starch and stir evenly, then heat and simmer. The invention develops a special weaving sizing process formula for the regenerated yarn, so that the regenerated yarn is sizing by using a special sizing agent, thereby enhancing the breaking strength of the single yarn, meeting the requirements of the weaving production process, and solving the problem of the single yarn breaking strength of the recycled yarn. The problem of not being able to weave normally.

CN201310178151.1 provides an emulsified oil composition, comprising: 67-72 parts by mass of No. 25 mechanical oil; 2-2.5 parts by mass of chlorinated paraffin; 3-6 parts by mass of sodium petroleum sulfonate; 7-10 parts by mass of OP-10 ; Octylphenol polyoxyethylene ether 3~5 mass parts; Span 85 6~9 mass parts; Potassium hydroxide 0.2~3 mass parts; Oleic acid 1~3 mass parts; Water 0.5 mass parts. Among them, sodium petroleum sulfonate has strong hydrophilicity, inhibits metal corrosion, and has good anti-rust effect; OP-10 and octylphenol polyoxyethylene ether have good emulsifying and cooling effects; Alkylphenol polyoxyethylene ether can also be used as a reducing agent to remove copper oxide, thereby inhibiting copper rod oxidation; chlorinated paraffin makes emulsified oil have good fluidity and good cooling performance; oleic acid has the effect of polishing and rust removal; 25 No. mechanical oil has a certain cooling effect.

CN201610849978.4 discloses a water-containing ethanol gasoline micro-emulsifier. The micro-emulsifier of the present invention is composed of a lipophilic emulsifier and a hydrophilic emulsifier: the volume ratio of the lipophilic emulsifier is 5-6.5:0.5-1.5 : 0.5~1.8 sorbitan monooleate, Span 85 and polyoxyethylene sorbitan monostearate are compounded; the volume ratio of the hydrophilic emulsifier is 0.5~1.5: 0.5~1.5: 4.5~6: 2~4 is compounded by octylphenol polyoxyethylene ether with a polymerization degree of 10, octylphenol polyoxyethylene ether with a polymerization degree of 4, isobutanol and isopropanol. Using the micro-emulsifier of the invention to prepare the water-containing ethanol gasoline can significantly improve the low-temperature stability of the micro-emulsion water-ethanol gasoline.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Span 85 Quotation