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Span 60 CAS 1338-41-6

Molecular Formula: C24H46O6

Formula Weight: 430.62

ZSpharmac: Span 60 Supplement

Product Name: Span 60
CAS No: 1338-41-6
Purity: 99%

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Basic Info

Product Name:Span 60
Other Names:Sorbitan Monostearate
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Cream Coloured Flakes Solid
EINECS No.:215-664-9
Storage:Store Below +30°C.
Provide:Span 60 MSDS;
Span 60 COA

What is Span 60?

Sorbitol is a polyol that can be used to produce foods such as vitamin C. It is non-toxic and sweet. Stearic acid is obtained by hydrogenation and hydrolysis of palm oil. Sorbitan monostearate (Sorbitan monostearate), trade name Span 60 (Span 60) is a non-ionic surfactant with HLB value of 4.7, with emulsifying, dispersing, wetting and other properties, high emulsifying efficiency, It can be used in combination with other emulsifiers. It is a good water-in-oil (W/O) emulsifier. It is non-toxic and non-irritating to the skin. It is a pollution-free food additive recognized by all countries in the world. When sorbitol reacts with stearic acid, traditional production technology has problems such as high reaction temperature, incomplete reaction and low yield. Although the products obtained from traditional sorbitan monostearate meet the requirements of GB13481-2011, they are still far from the requirements of the cosmetic industry, pharmaceutical industry and food industry.

Span 60 Properties:

Melting point 

54-57 °C(lit.)

Boiling point 

464.84°C (rough estimate)



vapor pressure 

<1.4 hPa (20 °C)

refractive index 

1.4593 (estimate)


>230 °F

storage temp. 

Store below +30°C.


Practically insoluble, but dispersible in water, slightly soluble in alcohol.




Cream coloured flakes

Span 60 Uses

  1. Span 60 country specifies that it can be utilized for instant coffee, dry yeast, cream and also hydrogenated grease, as well as the maximum use amount is 10.0 g/kg; it can be utilized in veggie healthy protein, fruit juice drinks, strong beverages, ice cream, milk, toffee, delicious chocolate, bread as well as cakes. The amount is 3.0 g/kg.
  2. Span 60 is utilized as gas chromatography fixed fluid, emulsifier and also thickener.
  3. Span 60 is made use of in medicine, cosmetics, food, pesticide, paint, plastic sector as emulsifier, stabilizer, fabric market as antistatic agent, softening and also oiling representative.
  4. Span 60 is an outstanding water/oil emulsifier with strong emulsification, diffusion as well as wetting impacts. Can be mixed with numerous types of surfactants.

Span 60 Production Method

one action
Include equimolar fat, sorbitol as well as an ideal quantity of stimulant sodium hydroxide right into the reaction kettle, and also under the security of nitrogen flow, heat to 190 ° C to begin dehydration and also esterification; when remaining to warmth to 230 ~ 250 ° C, one side ester After the response is finished, it is cooled to 85-95 ° C, and an ideal amount of hydrogen peroxide is included for decolorization for thirty minutes to acquire the product. Anhydride initially and then esterification
Location 320kg of 50% sorbitol in a dehydration pot, add a suitable quantity of phosphoric acid, decompress at 100 ~ 150 ° C( 5332.9 Pa) and dehydrate to generate sorbitan; additionally, put 290kg of stearic acid in the esterification pot, warm as well as thaw, mix, and also include sorbitan as well as a proper quantity of 50% salt hydroxide option, react at 170 ~ 210 ° C for about 4 h, when the acid worth of the response service is less than 5, the response is ended; amazing to 110 ° C, add 30% of salt hydroxide 2kg of hydrogen oxide is decolorized (Te can be decolorized with triggered carbon), and finally, the product is discharged while it is still warm, as well as it is developed into pieces in an air conditioning tray, as well as pulverized to get a fine-grained product of concerning 395kg.
Esterification to anhydride
At 200 ~ 260 ℃, equimolar stearic acid, sorbitol and also an ideal amount of alkaline stimulant sodium hydroxide are used for esterification. When the acid worth is less than 10, an acidic stimulant phosphoric acid is included, and then dried out at 180 ~ 240 ℃ to develop a Anhydride is Span 60.

Span 60 Other Applications

Span 60 can be used as an emulsifier in the preparation of creams, emulsions and ointments, such as the preparation of behenicol cream, the emulsifier is composed of Span-60, Tween-60 and glycerol monostearate. The best composition of the three is the weight ratio of glycerol monostearate: Span-60: Tween-60=1:2:3, by using Span-60, Tween-60, monostearic acid Glycerides and other excipients with a wide range of sources, stable quality and low price constitute a compound emulsifier, which has achieved good results. The quality of the preparation is stable and controllable, and the production cost is greatly reduced, which is very beneficial to the industrialized production and popularization of the product.

Span 60 can prepare stable water-in-oil emulsion or microemulsion when used alone; if used in combination with different proportions of hydrophilic emulsifier Tween, various water-in-oil and oil-in-water emulsions can be prepared Or cream; can also be used as solubilizer, wetting agent, dispersing agent, suspending agent, etc. It can be used to prepare inhalants, intramuscular injections, oral liquids, ophthalmic preparations, topical preparations and vaginal preparations, such as cefoperazone sodium tazobactam sodium microsphere injection is composed of cefoperazone sodium, tazobactam sodium, PLA, Span 60 , Glycerol monostearate and glucose. In particular, from 4-8 parts by weight of cefoperazone sodium, 1-2 parts of tazobactam sodium, 2.5-5 parts of PLA, 1.25-2.5 parts of Span 60, 1-2 parts of glycerol monostearate, 1 to 2 parts of glucose.

In addition, studies have shown that Span 60 can significantly improve the absorption of Coptis alkaloids by animals. Adding 0.001~20 times the amount of Span-60 to the drug containing Coptis alkaloids can improve the absorption of Coptis alkaloids by animals by more than 35%.

Span 60 Preparation

A preparation method of Span 60 with low energy consumption, high yield and excellent product quality, the specific preparation steps are:

1) Ingredients: in parts by weight, 400-500 parts of sorbitol with a mass concentration of 30%, 700-900 parts of stearic acid with an acid value of 210 mgKOH/mg, 2.0-3.0 parts of dehydrating agent, and 4-6 parts of esterification catalyst for standby use ; Wherein, the dehydrating agent is orthophosphoric acid;

2) Dehydration: put sorbitol and dehydrating agent into a closed reactor, heat to 120 ℃ ~ 125 ℃ under heat preservation reaction for 20 ~ 35min, and generate intramolecular dehydration to generate sorbitan;

3) Esterification: after the dehydration is completed, put stearic acid into the reactor, when the temperature reaches 135 ℃ ~ 140 ℃, then put the esterification catalyst into the reactor; then heat up to 200 ℃ ~ 210 ℃, under nitrogen environment The vacuum degree in the reactor was kept at 0.090~0.10MPa, the esterification reaction took place for 5~8h, and the slices were cooled, and the acid value of the obtained Span 60 was less than 5mgKOH/mg.

The normal dehydration reaction of sorbitol can be realized only by high temperature conditions. When sorbitol is above 130 ℃, it will spontaneously undergo internal water loss reaction to obtain Span 60. The use of a dehydrating agent that is too acidic will lead to the uncertainty of sorbitol dehydration, and it is impossible to accurately cyclize to obtain sorbitan monostearic anhydride, resulting in many impurities that cannot be separated, reducing the yield. If other weak acid is used, it will not have sufficient dehydration capacity.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Span 60 Quotation