Span 60 can be used as an emulsifier in the preparation of creams, emulsions and ointments, such as the preparation of behenicol cream, the emulsifier is composed of Span-60, Tween-60 and glycerol monostearate. The best composition of the three is the weight ratio of glycerol monostearate: Span-60: Tween-60=1:2:3, by using Span-60, Tween-60, monostearic acid Glycerides and other excipients with a wide range of sources, stable quality and low price constitute a compound emulsifier, which has achieved good results. The quality of the preparation is stable and controllable, and the production cost is greatly reduced, which is very beneficial to the industrialized production and popularization of the product.
Span 60 can prepare stable water-in-oil emulsion or microemulsion when used alone; if used in combination with different proportions of hydrophilic emulsifier Tween, various water-in-oil and oil-in-water emulsions can be prepared Or cream; can also be used as solubilizer, wetting agent, dispersing agent, suspending agent, etc. It can be used to prepare inhalants, intramuscular injections, oral liquids, ophthalmic preparations, topical preparations and vaginal preparations, such as cefoperazone sodium tazobactam sodium microsphere injection is composed of cefoperazone sodium, tazobactam sodium, PLA, Span 60 , Glycerol monostearate and glucose. In particular, from 4-8 parts by weight of cefoperazone sodium, 1-2 parts of tazobactam sodium, 2.5-5 parts of PLA, 1.25-2.5 parts of Span 60, 1-2 parts of glycerol monostearate, 1 to 2 parts of glucose.
In addition, studies have shown that Span 60 can significantly improve the absorption of Coptis alkaloids by animals. Adding 0.001~20 times the amount of Span-60 to the drug containing Coptis alkaloids can improve the absorption of Coptis alkaloids by animals by more than 35%.