Something Bakuchiol CAS 10309-37-2

Two recent clinical studies have obtained data on the anti-aging efficacy of Something Bakuchiol and its comparison with retinol.

In the first study, published in the International Journal of Cosmetic Science in 2014, researchers used artificial skin and collagen cells to test the anti-aging benefits of Something Bakuchiol. The results show that Something Bakuchiol has properties that affect gene expression and regulate collagen very similar to retinol in artificial skin and disembodied cells. To see how bakuchiol performed in real life, they asked 16 participants to use a 0.5% bakuchiol product twice a day for 12 weeks. Compared with no use, participants improved in every measure, including skin fine lines and wrinkles, roughness, dryness, and elasticity. In addition, the participants did not experience common retinol side effects such as irritation, dryness and peeling.

In 2018, the British Academy of Dermatology published a further clinical study. In a 12-week, double-blind clinical trial, researchers compared the efficacy of Something Bakuchiol with retinol. In this study, 44 participants used a 0.5% bakuchiol product twice daily or a 0.5% retinol product once daily and had their skin condition assessed by a dermatologist. Compared with before the experiment, the two groups of subjects showed improvement in pigmentation, wrinkles and skin redness, and the effect of the two groups was not statistically significant, indicating that the effect of bakuchiol twice a day was better than that of using bakuchiol once a day. Retinol has the same effect. At the same time, the Something Bakuchiol group reported less flaky skin and peeling than the retinol group.
Other studies have looked at combining Something Bakuchiol with other anti-aging ingredients (such as antioxidants), but only these two clinical studies provide the best and only data on Something Bakuchiol as a single ingredient.

Taken together, these studies suggest that Something Bakuchiol may be as effective as retinol, and possibly milder.

In addition, Olga Bunimovic, an assistant professor at the University of Pittsburgh Medical Center and a dermatologist, said: “At the moment, we only know the relationship between Something Bakuchiol and retinol, but not the relationship between it and other retinoids such as retinoids. relation.

Last year, dermatologist Zoe Derelos conducted a clinical evaluation of a natural bakuchiol anti-aging moisturizer for sensitive skin. Studies have shown that bakuchiol-based anti-aging moisturizers are well tolerated and effective in individuals with sensitive skin.

Need to focus on the optimal concentration, formulation application and mechanism of action

There is a consensus among dermatologists on possible ways to slow down skin aging.

“Retinol is our holy grail,” said dermatologist Mona Gohara, an associate clinical professor of dermatology at Yale University. “Retinol is a derivative of vitamin A that increases collagen synthesis. It is known for reducing collagen breakdown. Unfortunately, it also has side effects such as peeling, dryness or redness. It is FDA listed as a Class C drug, and it has potential risks for pregnant women.”

Something Bakuchiol is gaining popularity in the skincare world as a plant-derived retinol alternative. “It has the benefits of vitamin A without the side effects,” Gohara said. “Not only is it clinically comparable to retinol, it’s not irritating, and bakuchiol is safe for most skin types.” Plus, unlike retinol, which breaks down in sunlight, bakuchiol can be used during the day, an advantage for newer products from brand

s like Herbivore Botanicals and Beautycounter.

Something Bakuchiol was first commercially available as a topical drug in 2007, when it was introduced to the market under the name Sytenol A by Sytheon Ltd. While early research has shown promise for bakuchiol, most dermatologists today are sticking with retinoids because dozens of studies have demonstrated their effects. As Gohara said, women want choice, especially women with sensitive skin and pregnant women, and now that they have a choice, Something Bakuchiol is safe to use during pregnancy or breastfeeding.

Something Bakuchiol is not structurally similar to retinol, but it is emerging as an effective anti-photoaging option as a better-tolerated alternative to retinol. But the evidence pales in comparison to many standard skin care ingredients like fruit and ascorbic acid. The clinical research results provide necessary conditions for further expansion of the research population. In the future, it is necessary to focus on the optimal concentration, formulation application and mechanism of action of Something Bakuchiol.