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Solvent Red 43 CAS 15086-94-9

Molecular Formula: C20H8Br4O5

Formula Weight: 647.89

ZSpharmac: Solvent Red 43 Supplier

Product Name: Solvent Red 43
CAS No: 15086-94-9
Purity: 99%

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Basic Info

Product Name:Solvent Red 43
Other Names:Tetrabromofluorescein
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Red Liquid
EINECS No.:239-138-3
Storage:Inert Atmosphere,Room Temperature
Provide:Solvent Red 43 MSDS;
Solvent Red 43 COA

What is Solvent Red 43?

According to the 2015 edition of the “Safety and Technical Specifications for Cosmetics”, the varieties of bromofluorescein cosmetic dyes include 4′,5′-dibromofluorescein, 2′,4′,5′,7′-tetrabromofluorescein, 2′,4′,5′,7′-tetrabromo-4,7-dichlorofluorescein, 2′,4′,5′,7′-tetrabromo-4,5,6,7-tetrachlorofluorescein white. These four dyes and their respective disodium salt dyes or lakes are allowed for the coloring of cosmetics. Among them, 2′, 4′, 5′, 7′-tetrabromofluorescein is solvent red 43, also known as 2′, 4′, 5′, 7′-tetrabromo-3′, 6′-dihydroxyspiro[iso Phenylpropane-1(3H), 9′(9H)-xanthene]-3-one, which is a dye and pigment

Solvent Red 43 Property

Melting point 300 °C
Boiling point 640.3±55.0 °C(Predicted)
density 1.02 g/mL at 20 °C
refractive index 1.5000 (estimate)
storage temp. Inert atmosphere,Room Temperature
solubility H2O: 0.1 g/mL, dark red
form Liquid
Colour Index 45380:2
color White to Light yellow to Red


Solvent Red 43 Uses

Solvent Red 43 is made use of as an organic stain. Adsorption sign, determination of fluoride ion, quantitative analysis and also titration of bromide ion and also iodide ion. Azure B was prepared from red supply solution.

Preparation of Solvent Red 43

Solvent Red 43 is prepared as complies with: Add in a 250mL four-necked flask, include 61.0 g of sodium hypochlorite service (10%, 86mmol), position an outside ice-water bath, start mixing, include concerning 36g of water, 24.3 g of 32% fluid caustic soda, and the temperature of the product to 0 ~ After 5 ° C, 13.9 g of bromine (99%, 86mmol) was slowly added dropwise, as well as the reaction temperature was managed below 15 ° C. Action the content (readily available bromine is about 20%) and also establish it aside. Add 250g of acetic acid into a 500mL four-neck flask, start mixing, include 13.6 g of fluorescein (97.5%, 40mmol), warm up to 50-60 ° C, as well as mix quickly (300-400rpm) for 30min. The temperature was lowered to 25-30 ° C, and 134.0 g of the above-mentioned sodium hypobromite solution (20%, 168 mmol) was slowly included dropwise within 3-4 hrs, throughout which the response temperature was regulated at 25-30 ° C. Insulated and also mixed for another 2 hours, a sample was taken to discover the end point of bromination by fluid phase. Include proper quantity of salt bisulfite to remove recurring hypobromous acid. Cool off to 15 ° C and also filter with suction to obtain an unrefined filter cake. The unrefined filter cake was beaten equally in about 100mL of water down hydrochloric acid liquid service (1 +500), and filteringed system with suction, and also desalted by doing this for 3 times. The filter cake was dried at 100 ° C. to obtain 25.0 g of the light pink target product Solvent Red 43 (HPLC purity 97.8%, material 97.8%, 37.7 mmol), return 94.3%.

Solvent Red 43 With Color Changing Lipstick

Eosin, a coloring color commonly used in color-changing lipsticks, is an acid dye with a typical name of solvent red 43, additionally referred to as tetrabromofluorescein or tetrabromofluorescein in English. It will certainly produce a color change according to the adjustment of pH worth. When the pH value is above 4, the solvent red 43 in the color-changing lipstick becomes crimson.

Although the lips are neutral, saliva is normally weakly alkaline. When saliva touches the lips, the lips also end up being weakly alkaline, that is, the pH worth is above 7. The color-changing lipstick constructed from eosinic acid pigment has a pH value of 3. When the lipstick including solvent red 43 is applied on the lips, it will transform color. Eosin pigment serves as an acid-base sign!

Friends who have used PH test paper know that when the PH value is evaluated on the PH test paper, the colors generated by different PH values are different. Place on a color-changing lipstick, as well as the make-up result will be different.

Why can color-changing lipsticks change into multiple colors?
For example, there are several different color-changing lipsticks, including pink and orange. This is because the coloring dye eosin, also known as tetrabromofluorescent yellow or tetrabromofluorescein, has different molecular structures, so the colors produced are also different. , but it only changes in the color system of red.

Does color-changing lipstick have anything to do with temperature?
Many manufacturers who sell color-changing lipsticks on the market claim that color-changing lipsticks are temperature-changing lipsticks, that is, they have different colors according to different temperature changes. In fact, the main principle is the pH value, but it also has a certain relationship with the temperature. But it’s just a matter of time. The higher the temperature, the faster the discoloration will be, but the final color will be the same. For example, if black turns pink, it takes 30 seconds if the temperature is high, and it takes 1 minute if the temperature is low.

About Products:
If you need Solvent Red 43 as a cosmetic raw material, please contact our service personnel directly, and we will provide you with high-quality products at the best price.
As an experienced Solvent Red 43 manufacturer and supplier, ZSpharmac will provide Solvent Red 43 raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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