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Zhishang Chemical

Sodium Pyrithione CAS 3811-73-2

Molecular Formula: C5H6NNaOS

Formula Weight: 151.16

ZSpharmac: Sodium Pyrithione Supplier

Product Name: Sodium Pyrithione
CAS No: 3811-73-2
Purity: 99%

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Basic Info

Product Name:Sodium Pyrithione
Other Names:Sodium Omadine
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Very Deep Brown Solution
EINECS No.:223-296-5
Storage: -20°C Freezer
Provide:Sodium Pyrithione MSDS;
Sodium Pyrithione COA

What is Sodium Pyrithione?

Salt pyrithione, additionally referred to as pyrithione salt, omadine sodium, pyrithione sodium, α-mercaptopyridine-N-oxide salt, comes from pyridine derivative fungicides, the appearance is yellow and light rice-colored clear fluid, melting point 250 ° C, a little characteristic odor. Soluble in natural solvents such as water and also ethanol, solubility (by mass portion): water 53%, ethanol 19%, polyethylene glycol (PEG400) 12%. The maximum pH array is 7-10, and the mass portion is 2% aqueous remedy with a pH worth of 8.0. Unstable to light, oxidizing representatives and also solid lowering agents. Non-ionic surfactants will a little inactivate it, and it can chelate with heavy metals. The major application areas include: everyday chemical items, adhesives, papermaking, medication, pesticides, natural leather items, disinfection supplies, and so on.

Sodium Pyrithione Property

Melting point -25 °C
Boiling point 109 °C
density 1.22
vapor pressure 0-0Pa at 25℃
refractive index 1.4825
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility H2O: 0.1 M at 20 °C, clear, faintly yellow
form Solution
color very deep brown
Water Solubility 54.7 g/100 mL


Sodium Pyrithione Uses

  1. Sodium Pyrithione can be utilized in steel cutting liquid, antirust liquid, latex paint, adhesives, leather products, textile products, coated paper and also other fields.
  2. Sodium Pyrithione is used in various antifungal medications and hair shampoo as well as skin care items in the pharmaceutical and chemical market. It not only avoids putridity and mildew of products, yet additionally eases itching and also dandruff, which is very effective.
  3. Salt Pyrithione can be utilized as a reliable fungicide for fruit trees, peanuts, wheat, veggies as well as various other crops, as well as is additionally an excellent anti-bacterial for silkworms.
  4. Salt Pyrithione can be used to formulate products such as disinfectants, creams as well as medical broad-spectrum antifungal dermatology medicines.
  5. Sodium Pyrithione Applied chemical researches of 2-mercaptopyridine-N-oxides; esterification of carboxylic acids with the N-oxides using the decarboxylation radical domino effect pathway.

Embodiments of the Invention of Sodium Pyrithione

The following examples will be provided to particularly describe the here and now invention. The copying are for illustration and also do not restrict the scope of the present development.

Add 3.0 g of copper sulfate (II) 5 hydrate and also 1.5 g of ammonium sulfate to 40 mL of water included in a beaker, and also better add 5% sulfuric acid to prepare a copper sulfate (II) ammonium sulfate facility salt service (A). Next off, 8.85 g of a 40% liquid option of pyrithione salt (certain gravity 1.20) was included in 50 mL of water in a beaker to prepare a watered down sodium pyrithione aqueous solution (B). The temperature was preserved at 25 ° C., and (B) was gone down right into (A) over 30 minutes while stirring. In order to make the pH not exceed 3 throughout this duration, include 5% sulfuric acid suitably. Filter the resulting eco-friendly copper pyrithione slurry, repeat 3 times, placed the filter deposit back right into 100mL of water, stir and after that filter, dry the obtained strong, as well as grind it in a mortar to get 3.6 g of eco-friendly granular.

The median diameter of the material acquired by distributing the eco-friendly granular material in a 0.1% DEMOL N (Demol N) (Kao Firm) aqueous remedy was “LA-920” by a laser diffraction bit dimension circulation analyzer, Horiba Manufacturing Co., Ltd. The result of the dimension was 10.6 μm. In addition, the median diameter after applying the ultrasonic function of this device for 1 min was 9.5 μm. The propensity of the mathematical value to reduce as a result of the rise of the ultrasonic application time is the same as that of the commercially available Salt Pyrithione.

In order to observe the inner state of the fragments, photographs of 6,000 times (FIG. 2) as well as 30,000 times (FIG. 3) were taken with an electron microscope. Consequently, it was evaluated to be an accumulation of ellipsoidal and rod-shaped Salt Pyrithione substances having a length of 0.1-1.0 μm inside.

Next off, in order to research the chemical composition of the aggregate, X-ray diffraction analysis was executed. Because of this, the peak positions of the green granular accumulations and also the commercially available copper pyrithione (made by Kolon Life Sciences Co., Ltd.) were exactly the exact same in the graphs (Numbers 4 and 5), so it was validated that the nature of the environment-friendly granular aggregates was Sodium Pyrithione.

Further disperse the Sodium Pyrithione granular accumulations right into water, and also mix at 80 ° C for thirty minutes. After stirring, there is a weak ammonia odor, and the aggregates are destroyed by regarding 10s of percent. This circumstance suggests that the accumulation has water-soluble ammonia substances. Thinking about the process of creating Sodium Pyrithione from copper sulfate (II) ammonium sulfate facility salt and sodium pyrithione, it is speculated that the ammonium sulfate dissociated during the response is adsorbed by Sodium Pyrithione. Link between Salt Pyrithione. That is, it is thought about that a facility is created. Nonetheless, no trace of it was found in the X-ray diffraction pattern, so it is assumed that the web content of ammonium sulfate is a trace quantity.

The Preparation Method of Sodium Pyrithione

The important intermediate for the synthesis of Sodium Pyrithione is 2-chloropyridine nitrogen oxide (2-PCL-N-oxide), which can be prepared by reacting 2-chloropyridine (2-PCL) with hydrogen peroxide under the catalysis of tungstic acid and phosphoric acid. The catalyst needs to be recovered with a slight excess of calcium hydroxide, then sodium carbonate is added to precipitate the residual calcium ions, and finally the solid calcium salt is filtered to obtain a clear 2-chloropyridine nitrogen oxide solution, which is then rectified by a rectification tower The unreacted raw material 2-chloropyridine was removed to obtain a qualified product meeting the enterprise standard.

1 Raw materials and instruments
2-chloropyridine (2-PCL, 99.5%), Jiangsu Hengsheng Chemical Co., Ltd.; hydrogen peroxide (H2O2, 50%), Shanghai Arkema Gaoyuan Chemical Co., Ltd.; tungstic acid (H2WO4, 98%), phosphoric acid (H3PO4, 85%), Jiangyin Chengxing Industrial Group Co., Ltd.; Sodium Hydrosulfide (NaSH, Analytical Pure), Sodium Carbonate (Na2CO3, Analytical Pure), Calcium Hydroxide (Ca(OH) 2, Analytical Pure), Changshu Hongyu Calcium Ltd. Eurostar digital display 60 electric stirrer, IKA, Germany; S20K pH meter, METTLER TOLEDO; PFX195 colorimeter, Lovibond; JB-30 laboratory distillation device, Deda Tianyi.

2 Synthetic roadmap

3 synthesis method
According to the reaction route in Figure 1, add 100 g of 2-PCL, 5 g of tungstic acid, 1 g of phosphoric acid, and 50 mL of water into a 250 mL four-neck flask equipped with an electric stirrer, a thermometer, a spherical condenser and a constant pressure dropping funnel. Stir and heat up. When the temperature reaches 65 °C, start to add 65 mL of H2O2 dropwise. Control the temperature between 65 and 75 °C through a water bath. After the reaction, take samples for analysis. When the residual amount of H2O2 is less than 2%, cool the 2-PCL -N-oxide solution to 50 °C, then add about 4.5g (about 3% of the weight of the nitrogen oxide solution) Ca(OH) 2 powder, adjust the pH to 9.5-10.5, stay for 3 hours, At this time, Ca (OH) 2 is slightly excessive, add an appropriate amount of Na2CO3 and stir for 30 minutes, then filter through a filter press device to obtain a 2-PCL-N-oxide solution, and finally enter a rectification device for rectification. Subsequently, 95 mL of 38% NaSH solution was added dropwise to the rectified liquid at 80 °C, and at the same time, 32% sodium hydroxide was used to neutralize the hydrogen chloride generated by the reaction, and the pH of the solution was controlled between 9.0 and 11.5 to fully react Finally, the final product Sodium Pyrithione solution is obtained.

The addition of sodium carbonate to the intermediate 2-chloropyridine nitrogen oxide solution can significantly reduce the calcium ion content; the calcium ion in the nitrogen oxide solution can keep it stable during the rectification process; the addition of sodium carbonate will make the nitrogen oxide and The chromaticity of Sodium Pyrithione becomes worse, the higher the amount of sodium carbonate added, the worse the chromaticity of nitrogen oxides and Sodium Pyrithione, for the comprehensive consideration of the final product, the added amount of sodium carbonate is 0.4% (relative to nitrogen oxide The amount of material) is the optimal amount.

About That Product:
If you need Sodium Pyrithione as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Sodium Pyrithione, ZSpharmac will provide Sodium Pyrithione raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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