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Sodium Pyrithione CAS 3811-73-2

Molecular Formula: C5H6NNaOS

Formula Weight: 151.16

ZSpharmac: Sodium Pyrithione Raw Material Supplier

Product Name: Sodium Pyrithione
CAS No: 3811-73-2
Purity: 99%

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Basic Info

Product Name:Sodium Pyrithione
Other Names:Sodium Omadine
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Very Deep Brown Solution
EINECS No.:223-296-5
Provide:Sodium Pyrithione MSDS;
Sodium Pyrithione COA

What is Sodium Pyrithione?

Salt pyrithione, also referred to as salt pyrithione, salt omedin, pyrithione, and sodium α-pyridine-N-oxide, is a pyridine derivative fungicide. It appears like a yellow, light-tangy transparent fluid with a melting point of 250 ℃, a little specific smell. Quickly soluble in organic solvents such as water and ethanol, solubility (in mass section): water 53%, ethanol 19%, polyethylene glycol (PEG400) 12%. The excellent pH array is 7 to 10, and the mass portion is 2% liquid remedy with a pH well worth of 8.0. Unsteady to light, oxidants and solid lowering agents. Non-ionic surfactants will somewhat inactivate it, and it can chelate with heavy metals. The key application areas include: daily chemical items, adhesives, papermaking, medication, chemicals, leather products, disinfection items, and so on.

Sodium Pyrithione Property

Melting point -25 °C
Boiling point 109 °C
density 1.22
vapor pressure 0-0Pa at 25℃
refractive index 1.4825
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility H2O: 0.1 M at 20 °C, clear, faintly yellow
form Solution
color very deep brown
Water Solubility 54.7 g/100 mL


Sodium Pyrithione Uses

1. Has antibacterial result
Research study released in the Journal of Skin-related Medications shows that bits in Salt Pyrithione involve with area fungal and bacterial cells to manage their populaces. By taking care of the development of these invaders, ZPT improves problems affecting the skin and scalp.

2. Function as an antifungal agent
Salt Pyrithione is one of one of the most commonly taken advantage of part in medicated hair shampoos and soaps as a result of its effective antifungal results. Research shows that zinc pyrithione is supplied in microparticle kind to the cellular lining of the skin, preventing fungal activity and improving inflammatory skin problem such as fungal acne and dandruff

3. Decrease dandruff.
A 2018 research study launched in Scientific Information uncovered that ZPT protected against the growth of M. restricta, a fungus that generally sets off dandruff. The scientists uncovered that zinc pyrithione treatment substantially reduced the expression of enzymes that assist these fungis endure on human skin.
ZPT has really similarly been revealed to improve dandruff by increasing mobile zinc levels.

4. May advertise hair growth
A regulated examination released in the British Journal of Dermatology discovered that day-to-day use 1% zinc pyrithione hair shampoo for 26 weeks enhanced hair development. The scientists believe this might be due to ZPT’s antifungal and anti-bacterial impacts.

5. Eliminates skin inflammation and itchiness
Investigates reveal that Salt Pyrithione avoids the growth of fungi and antibacterial agents that set off skin inflammation. It help alleviate itching, swelling, and inflammation that often go along with inflammatory conditions such as fungal acne, dandruff, psoriasis, and seborrheic dermatitis.

6. Adjust “oil” manufacturing
Problems like seborrheic dermatitis can develop entirely dry and oily skin at the same time. By impeding the advancement of the yeast that activates this condition, ZPT aids take care of the skin’s oil manufacturing and improve the greasiness connected with it.

Preparation Method of Sodium Pyrithione

The important intermediate in the synthesis of Sodium Pyrithione is 2-chloropyridine nitrogen oxide (2-PCL-N-oxide), which can be prepared by responding 2-chloropyridine (2-PCL) with hydrogen peroxide under the catalysis of tungstic acid and phosphoric acid. Obtained, the stimulant needs to be recovered with a minor extra of calcium hydroxide, and afterwards sodium carbonate is contributed to speed up the remaining calcium ions. Ultimately, the solid calcium salt is removed to acquire a clear 2-chloropyridine nitrogen oxide option, which is then remedied through a distillation tower. The unreacted raw material 2-chloropyridine is gotten rid of to get competent products that fulfill company criteria.

1 Basic material and tools
2-Chloropyridine (2-PCL, 99.5%), Jiangsu Hengsheng Chemical Co., Ltd.; hydrogen peroxide (H2O2, 50%), Shanghai Arkema Gaoyuan Chemical Co., Ltd.; tungstic acid (H2WO4, 98%), phosphoric acid (H3PO4, 85%), Jiangyin Chengxing Industrial Group Co., Ltd.; salt hydrosulfide (NaSH, logical grade), sodium carbonate (Na2CO3, analytical quality), calcium hydroxide (Ca( OH) 2, logical quality), Changshu Hongyu CALCIDE LIMITED. Eurostar digital display screen 60 electric mixer, IKA, Germany; S20K pH meter, METTLER TOLEDO; PFX195 colorimeter, Lovibond; JB-30 research laboratory distillation gadget, Deda Tianyi.

2 Synthesis methods
According to the response route in Number 1, include 100 g2-PCL, 5 g tungstic acid, 1 g phosphoric acid, and 50 mL water into a 250 mL four-necked flask equipped with an electrical stirrer, thermostat, round condenser and constant pressure going down funnel. Stir and raise the temperature. When the temperature reaches 65 ° C, start adding 65 mL of H2O2 dropwise. Control the temperature level in between 65 and 75 ° C with a water bathroom. After the reaction is completed, take samples for analysis. When the recurring quantity of H2O2 is less than 2%, amazing 2-PCL. -N-oxide option to 50 ℃, then include concerning 4.5 g (about 3% of the weight of the nitrogen oxide remedy) Ca(OH) 2 powder, adjust the pH to in between 9. 5 and 10. 5, and stay for 3 hours. At this time, there is a mild extra of Ca (OH) 2. Include an ideal amount of Na2CO3, stir for thirty minutes, filter through a filter press tool to obtain a 2-PCL-N-oxide solution, and ultimately go into the correction tool for purification. Subsequently, 95 mL of 38% NaSH solution was included dropwise to the extract at 80 ° C, and 32% salt hydroxide was made use of to neutralize the hydrogen chloride created by the response. The pH of the solution was regulated between 9.0 and 11.5 to completely react. Ultimately, the end product Salt Pyrithione service is acquired.

Including sodium carbonate to the intermediate 2-chloropyridine nitrogen oxide remedy can significantly minimize the calcium ion web content; the calcium ions in the nitrogen oxide remedy can maintain it steady throughout the distillation process; the enhancement of sodium carbonate will cause nitrogen oxides and The shade of salt pyrithione worsens. The greater the quantity of sodium carbonate added, the even worse the color of nitrogen oxides and Salt Pyrithione. For the sake of thorough factor to consider of the final product, the amount of sodium carbonate added is 0.4% (about The quantity of nitrogen oxides) is the amount.

Contact Us

About Products:
If you need the cosmetic raw material Sodium Pyrithione, please contact our service staff directly and we will provide you with high-quality products at the best price.
Our company, as an experienced Sodium Pyrithione manufacturer and supplier, ZSpharmac will provide Sodium Pyrithione raw materials to customers around the world for a long time.
Over the years, the company has adhered to the spirit of “integrity management, strict quality control, and customer first” and has won unanimous praise from customers at home and abroad.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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