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Sodium Pyrithione CAS 3811-73-2

Molecular Formula: C5H6NNaOS

Formula Weight: 151.16

ZSpharmac: Sodium Pyrithione Raw Material Supplier

Product Name: Sodium Pyrithione
CAS No: 3811-73-2
Purity: 99%

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Basic Info

Product Name:Sodium Pyrithione
Other Names:Sodium Omadine
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Very Deep Brown Solution
EINECS No.:223-296-5
Provide:Sodium Pyrithione MSDS;
Sodium Pyrithione COA

What is Sodium Pyrithione?

Pyrithione Sodium, chemically known as N-methyl-N-cyclohexyl-4-thiopyridinium sodium salt, is an organic sulfur compound with broad-spectrum antimicrobial properties.

Pyrithione Sodium exerts its antimicrobial effect by interfering with the metabolic process of microorganisms, especially by inhibiting zinc ion-dependent enzymes in fungi and bacteria, such as alcohol dehydrogenase in yeast, thereby destroying the function of cell membranes and the production of cell energy, leading to the stunting of microbial growth or death. This mechanism of action gives it a broad-spectrum antimicrobial activity against a variety of microorganisms, including fungi, bacteria and some viruses.

Sodium Pyrithione Property

Melting point -25 °C
Boiling point 109 °C
density 1.22
vapor pressure 0-0Pa at 25℃
refractive index 1.4825
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility H2O: 0.1 M at 20 °C, clear, faintly yellow
form Solution
color very deep brown
Water Solubility 54.7 g/100 mL


Sodium Pyrithione Uses

1. Personal care products
Anti-dandruff shampoo: Sodium pyrithione can effectively inhibit the growth of fungi on the scalp, such as Malassezia, and is a common ingredient in the treatment and prevention of dandruff.
Skin care: It is used to treat and prevent skin diseases caused by bacteria and fungi, such as acne, tinea pedis, etc., and is widely accepted for its good skin compatibility.
Oral care: As an ingredient in toothpaste and mouthwash, it helps reduce bacteria in the mouth and prevent gingivitis and bad breath.

2. Household hygiene and cleaning products
Disinfectants: Used for cleaning and disinfection in homes, hospitals and public places, effectively killing bacteria and fungi and maintaining environmental hygiene.
Mold inhibitors: Added to paints, wallpapers, plastic products, etc., to prevent mold growth and extend the service life of products.
Laundry and detergents: Improve the cleaning effect of clothing and hard surfaces, inhibit bacterial growth, and maintain cleanliness and hygiene.

3. Water treatment and industrial applications
Water treatment: Used as a microbial control agent in cooling towers, swimming pools and industrial circulating water systems to prevent the formation of biofilms and keep water clean.
Oil extraction: As a drilling fluid additive, it prevents microbial corrosion and ensures equipment safety and operating efficiency.
Paper and textile industry: As a preservative and mildew-proof agent, it protects paper and textiles from microbial damage and extends the shelf life of products.

4. Agricultural field
Seed treatment: Used for seed disinfection, preventing seed-borne diseases, and improving crop emergence rate and growth quality.
Crop protection: As a spray, it prevents and controls crop diseases such as leaf spot and rust caused by fungi, and ensures the healthy growth of crops.

5. Medical and veterinary applications
Medical device disinfection: Used for disinfection of surgical instruments, catheters, etc. to ensure the safety of medical operations.
Veterinary care: Used in pet bathing products to prevent skin diseases and parasitic infections and keep pets healthy

Sodium Pyrithione Prominent Applications in Cosmetics

1. Anti-dandruff shampoo products
Core function: Sodium pyrithione can effectively inhibit fungi that cause dandruff on the scalp, such as Malassezia, reduce the formation of dandruff, and relieve scalp itching and redness caused by fungal infections. It is the core ingredient of most anti-dandruff shampoos.
Advantages: Compared with traditional antifungal agents, sodium pyrithione has better skin compatibility and lower irritation, and is suitable for long-term use.

2. Anti-acne and skin care products
Acne control: In facial cleansers, skin care gels or creams, sodium pyrithione can reduce the number of Propionibacterium and other bacteria that cause acne, helping to control the formation of acne and blackheads.
Skin barrier protection: By reducing the excessive reproduction of microorganisms and maintaining the balance of skin microecology, it helps to maintain the health of the skin barrier and reduce skin inflammation and sensitivity.

3. Preservation and preservation
Cosmetic preservation: As a preservative, sodium pyrithione can effectively prevent the growth of microorganisms in cosmetics and extend the shelf life of products. It is suitable for all kinds of water-based cosmetics, such as lotions, emulsions and masks.
Auxiliary of preservative-free system: In cosmetics that pursue low irritation or preservative-free system, sodium pyrithione can be used as an auxiliary antibacterial ingredient to reduce the risk of microbial contamination.

4. Sensitive skin care
Mildness: For products designed for sensitive skin, sodium pyrithione is used to reduce skin irritation and allergic reactions caused by microorganisms due to its mild antibacterial properties, thereby improving the safety and comfort of the product.

5. Oral care products
Oral health: In oral care products such as toothpaste and mouthwash, sodium pyrithione can help control the growth of bacteria and fungi in the mouth, reduce plaque formation, and prevent gingivitis and bad breath.


National Center for Biotechnology Information. “PubChem Compound Summary for CID 19658, Sodium Omadine” PubChemhttps://pubchem.ncbi.nlm.nih.gov/compound/Sodium-Omadine. Accessed 15 June, 2024.

As a company specializing in the production and supply of Palm Kernel Oil raw materials, we are committed to providing customers with high-quality products and preferential prices. We have rich experience and technology to ensure the quality and stable supply of our products. No matter where you are, we can provide you with the Palm Kernel Oil raw materials you need to support your production and research and development.

We always adhere to the principle of honest operation, strictly control product quality, and serve every customer with a customer-first attitude. Over the years, we have established good cooperative relations with domestic and foreign customers and won their trust and praise.

If you have any needs or are interested in our products, please contact our service staff directly, and we will wholeheartedly provide you with the best service and products. Looking forward to cooperating with you and developing together!

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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