Sodium Monofluorophosphate CAS 10163-15-2

Sodium monofluorophosphate is the most widely used toothpaste additive in the world. It is an excellent anti-caries agent and tooth desensitization agent. The mass fraction in toothpaste is 0.7% to 0.8%. According to the ingredients contained, it is mainly divided into two categories: nursing toothpaste and biological toothpaste.

1) Nursing toothpaste: Nursing toothpaste has anti-caries, desensitization, anti-inflammation, anti-calculus and other functions, and the developed grass coral full-effect nursing toothpaste has this multi-effect function. The most important thing for the effective prevention and treatment of teeth and periodontal diseases is to eliminate the bacteria harmful to the health of the teeth in the oral cavity, and herbal plant extracts have been widely recognized in the prevention and elimination of general inflammation of the gums and oral mucosa. The fluoride in Grass Coral Total Care Toothpaste has antibacterial and bactericidal effects. According to relevant research, low concentration of fluoride ions (0.8% sodium monofluorophosphate in grass coral) has better antibacterial effect. Fluoride is used as an additive to prevent dental caries. It not only has a health care effect on tooth acid desensitization, but also interacts with enamel to form fluorapatite on the surface of enamel, which improves the hardness of enamel.

2) Biological toothpaste: Biological toothpaste is to add substances that have specific active functions on biological organisms to toothpaste. At present, biological toothpaste mainly contains enzyme preparations, antibody preparations and other biologically active preparations. Toothpastes containing enzymes mainly contain protease and dextranase. Proteolytic enzyme toothpaste can promote the rapid hydrolysis and breakage of the long polypeptide chain of the protein, making the food residue attached to the tooth surface soft, easy to clean the mouth, and has the function of softening blood vessels, which can make the inflammation and edema of the gums subside, and the bleeding phenomenon of the teeth is obvious improve or eliminate.

Contains glucanase to help remove tartar. Toothpaste containing antibody preparations is generally divided into: toothpaste containing milk antibodies and toothpaste containing genetically modified preparations. Milk antibody toothpaste is to extract the antibody in milk, which can be added to toothpaste to fight against certain diseases. The toothpaste containing the transgenic antibody preparation is to add the product of human oral disease vaccine gene in the transgenic potato tuber to the toothpaste, which can produce the corresponding effect of preventing oral diseases. The fluorine in sodium monofluorophosphate is stable, and the fluorine in sodium monofluorophosphate is maintained at 84.4% within one year, which can effectively ensure the anti-caries effect; its pH value is 5.5-6.5, which is neutral; and it has good compatibility with abrasives. These advantages determine monofluorophosphoric acid. Sodium is very suitable as a toothpaste additive and has been mass-produced in our country. The Beijing Department of Stomatology observed the anti-caries effect of fluoride toothpaste for two and a half years, and the caries reduction was 42.95%.

1) Used as a food additive: According to long-term clinical experiments, sodium monofluorophosphate as a source of fluorine is better than other common fluoride raw materials (such as sodium fluoride). Sodium monofluorophosphate can be used as a food additive to increase food nutrition, but if it exceeds the standard, it is unsafe. Sodium monofluorophosphate is added to food, and 0.25-5mg of fluorine can be added every day, which is equivalent to the intake of 2.5-16mg sodium monofluorophosphate. According to the data, it is unsafe to ingest fluoride-containing sodium salt (1.7-14mg) and phosphate (1.1-8.8mg) every day. In Europe, the level of additives in food is generally below the maximum limit. For adults, eating 2mg of fluoride-containing food per day will not exceed the standard. Therefore, while paying attention to the nutritional value of food enhanced by sodium monofluorophosphate, we should also pay attention to its safety.

2) Used as chewing gum raw material: chewing gum has always been favored by the public. But present chewing gum does not possess the health care functions such as caries prevention, desensitization, antibacterial sterilization, anti-cold. Although general medicated toothpaste has one or more effects, it cannot replace the chewing function and mouthfeel of chewing gum. In 1998, Li Guohua developed a chewing gum with multiple functions. 0.5% sodium monofluorophosphate was added to this chewing gum, so it has a good anti-caries effect.

1) For regulation of menopause: female blood lipid and lipoprotein metabolism Sodium monofluorophosphate can be used to regulate blood lipid and lipoprotein metabolism of postmenopausal women.

2) To increase bone mass and alleviate osteoporosis: Sodium monofluorophosphate promotes the differentiation and proliferation of osteoblasts, and at the same time promotes the increase of bone mass. This effect is caused by the fluorine in acid phosphatase inhibiting growth factors. MFP can exert its function through other signaling mechanisms. Although sodium fluoride also has the function of increasing bone mass, eating the same amount of MFP and NaF, MFP increases bone mass more. Sodium monofluorophosphate can increase bone mass and alleviate osteoporosis, but it cannot change the mineralization of bone tissue.

4. Used as a corrosion inhibitor: When steel bars corrode, a series of protection and repair methods can strengthen the concrete structure, and corrosion inhibitors are the most attractive substitutes. As a rust inhibitor, MFP can slow down the corrosion of steel bars.