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Sodium Monofluorophosphate CAS 10163-15-2

Molecular Formula: FH3NaO3P

Formula Weight: 123.98

ZSpharmac: Sodium Monofluorophosphate Supplier

Product Name: Sodium Monofluorophosphate
CAS No: 10163-15-2
Purity: 99%

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Basic Info

Product Name:Sodium Monofluorophosphate
Other Names:Disodium Monofluorophosphate
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:233-433-0
Provide:Sodium Monofluorophosphate MSDS;
Sodium Monofluorophosphate COA

What is Sodium Monofluorophosphate?

Salt monofluorophosphate (“MFP” for quick) is a white powdery solid with a melting point of worrying 626 ° C. It is promptly soluble in water as well as has strong hygroscopicity. Its solubility in water at 25 ° C is 42%.There is no rusting result, the pH worth of 2% liquid choice is 6.5-8.0, as well as likewise the fluid choice embarks on slow-moving hydrolysis when boiling, which can trigger a decline in blended fluorine as well as also an increase in cost-free fluorine, so the pureness is minimized.

Sodium Monofluorophosphate Property

Melting point 625 °C
vapor pressure 0Pa at 20℃
solubility H2O: slightly soluble(lit.)
form Powder
color white
Water Solubility Soluble in water. Insoluble in ethanol and ether.


Applications of Sodium Monofluorophosphate

1. Application in tooth paste
Sodium monofluorophosphate is one of the most extensively utilized toothpaste additive on the planet. It is an exceptional anti-caries representative and also tooth desensitization representative. The mass fraction in toothpaste is 0.7% to 0.8%. According to the ingredients contained, it is mainly split into two categories: nursing toothpaste and organic tooth paste.

1) Nursing tooth paste: Nursing toothpaste has anti-caries, desensitization, anti-inflammation, anti-calculus and other functions, as well as the established grass coral full-effect nursing tooth paste has this multi-effect feature. One of the most crucial thing for the reliable avoidance as well as treatment of teeth and also periodontal illness is to remove the germs in the mouth that are hazardous to the wellness of the teeth, and also herbal plant removes have been commonly recognized in the prevention and elimination of general swelling of the periodontals as well as dental mucosa. The fluoride in Grass Reefs Total Amount Treatment Tooth paste has anti-bacterial and also antiseptic impacts. According to relevant research, reduced concentration of fluoride ions (0.8% salt monofluorophosphate in lawn coral) has far better anti-bacterial impact. Fluoride is utilized as an additive to stop cavities. It not just has a healthcare impact on tooth acid desensitization, but likewise communicates with enamel to develop fluorapatite on the surface of enamel, which improves the hardness of enamel.

2) Biological tooth paste: Biological tooth paste is to add materials that have particular active functions on biological organisms to toothpaste. Currently, organic toothpaste mainly includes enzyme prep work, antibody prep work and also various other biologically active prep work. Toothpastes including enzymes mostly consist of protease and also dextranase. Proteolytic enzyme toothpaste can promote the fast hydrolysis and breakage of the lengthy polypeptide chain of the healthy protein, making the food deposit connected to the tooth surface area soft, very easy to cleanse the mouth, and has the function of softening blood vessels, which can make the swelling as well as edema of the periodontals diminish, and the blood loss phenomenon of the teeth is obvious improve or remove.

Contains glucanase to aid remove tartar. Tooth paste consisting of antibody preparations is normally divided right into: toothpaste containing milk antibodies and also toothpaste consisting of genetically customized prep work. Milk antibody tooth paste is to extract the antibody in milk, which can be included in tooth paste to fight against specific illness. The toothpaste containing the transgenic antibody prep work is to add the item of human oral disease injection gene in the transgenic potato root to the toothpaste, which can generate the corresponding result of preventing dental illness. The fluorine in salt monofluorophosphate is stable, and also the fluorine in salt monofluorophosphate is preserved at 84.4% within one year, which can effectively make sure the anti-caries result; its pH worth is 5.5-6.5, which is neutral; as well as it has good compatibility with abrasives. These benefits determine monofluorophosphoric acid. Salt is extremely suitable as a tooth paste additive and has actually been mass-produced in our country. The Beijing Division of Stomatology observed the anti-caries result of fluoride tooth paste for 2 as well as a fifty percent years, and also the cavities decrease was 42.95%.

2. Application in food
1) Used as an artificial additive: According to long-lasting professional experiments, salt monofluorophosphate as a resource of fluorine is better than other common fluoride raw materials (such as sodium fluoride). Salt monofluorophosphate can be used as a food additive to boost food nutrition, but if it goes beyond the requirement, it is hazardous. Sodium monofluorophosphate is contributed to food, and 0.25-5mg of fluorine can be added daily, which amounts the consumption of 2.5-16mg sodium monofluorophosphate. According to the data, it is unsafe to consume fluoride-containing sodium salt (1.7-14mg) as well as phosphate (1.1-8.8 mg) everyday. In Europe, the degree of additives in food is usually listed below the optimum limit. For grownups, eating 2mg of fluoride-containing food each day will certainly not surpass the criterion. Therefore, while taking notice of the dietary value of food boosted by sodium monofluorophosphate, we should likewise pay attention to its safety.

2) Utilized as chewing periodontal basic material: chewing gum tissue has actually constantly been preferred by the public. But present eating periodontal does not possess the health care features such as cavities prevention, desensitization, anti-bacterial sanitation, anti-cold. Although basic medicated tooth paste has several impacts, it can not change the chewing function and also mouthfeel of chewing gum. In 1998, Li Guohua established a chewing periodontal with numerous functions. 0.5% salt monofluorophosphate was added to this chewing gum, so it has a great anti-caries effect.

3. Application in clinical therapy
1) For regulation of menopause: women blood lipid and lipoprotein metabolic process Salt monofluorophosphate can be made use of to control blood lipid as well as lipoprotein metabolic process of postmenopausal ladies.

2) To boost bone mass and alleviate osteoporosis: Sodium monofluorophosphate promotes the differentiation as well as expansion of osteoblasts, and also at the same time advertises the boost of bone mass. This effect is caused by the fluorine in acid phosphatase hindering growth elements. MFP can apply its function via other signaling mechanisms. Although salt fluoride also has the function of raising bone mass, eating the very same amount of MFP and also NaF, MFP increases bone mass a lot more. Salt monofluorophosphate can raise bone mass and also alleviate weakening of bones, yet it can not transform the mineralization of bone cells.

4. Made use of as a corrosion prevention: When steel bars corrode, a collection of defense and also repair work methods can enhance the concrete structure, and deterioration preventions are one of the most attractive replacements. As a rust prevention, MFP can slow down the rust of steel bars.

The Content of The Invention of Sodium Monofluorophosphate

The objective of today innovation is to get rid of the deficiency of existing manufacturing approach, provide a type of production approach of sodium monofluorophosphate with reduced power usage, easy to get resources, much less impurities in the item introduced in the production procedure, and reduced item manufacturing cost.

The item of the present development is accomplished by the complying with technological options: with phosphoric acid and alkali (soda ash or caustic soda) as resources, the ratio of the two is sodium/phosphorus (Na/P) mol proportion= 1: 1 ± 0.005, through neutralization, drying Polymerization, polymer polymeric sodium phosphate and salt fluoride are combined as well as thawed to acquire monofluorophosphate sodium product, the proportion of polymeric salt phosphate to salt fluoride is: phosphorus/fluorine (P/F) molar ratio= 1.000 ± 0.005. There is no demand to prepare monosodium metaphosphate, and salt fluoride is used as the fluorinating agent for continuous manufacturing.

Its manufacturing technique consists of the adhering to processes: 1. Polymerized phosphate preparation: feed antacids (soda ash or caustic soda) and phosphoric acid into a straight stirred wall scuffing activator, regulate the response temperature level to be less than 95 ° C, as well as make use of the warmth of response to vaporize a part of the water. After the neutralization is finished, the jacket of the reactor is heated up for dehydration as well as polymerization, and the temperature of the catalyst rises to 250 ° C to 350 ° C and is maintained for 45 to 60 mins. The gotten polymerized salt phosphate is in the type of acid pyrophosphate as well as a small part of metaphosphate Existence, dampness< 0.2%.

2. Combining of sodium fluoride: polymerized sodium phosphate and salt fluoride are fed into the pulverizer at the same time for squashing and blending, the molar ratio of polymerized sodium phosphate and sodium fluoride is regulated to be 1-10:10 -1, and also the pulverized material enters a mixer Homogenize.

3. Melting reaction: After homogenization, the blend is continually fed into the upper part of a carbonaceous activator heated up by power frequency, as well as the product is squeezed out from all-time low by the gravity of the upper product with the melting reaction. The house time of the melting reaction is 14 to 18 minutes. The melt in the discharge pipe is strengthened as well as blocked, and the discharge pipe is also equipped with a power frequency heating resource. Control the temperature of the product at the outlet to 680 ° C to 730 ° C, feed the mixture constantly, as well as release the product continuously.

4. The melt is cooled as well as created right into flakes, smashed and also sieved to get the item.

Compared to the previous art, today innovation has the complying with advantages: 1. The raw products of phosphoric acid and also alkali (soda ash or caustic soda) are very easy to get as well as the expense is reduced.

2. Compared with sodium metaphosphate as raw material, the energy intake is low, contaminations are not easily presented in the manufacturing procedure, as well as the product brightness is high.

3. Compared with the neutralization method, there is no corrosion trouble, as well as the investment in production tools is tiny.

4. Compared to the fluorination method, there is not a problem of gas therapy and also environmental pollution, and also it is a clean production process.

5. The manufacturing approach of today creation is very easy for constant manufacturing, as well as the manufacturing control is basic.

Summary of the illustrations:
Fig. 1 is the manufacturing process flowchart of the here and now creation.

About Products:
If you need Sodium Monofluorophosphate as a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Sodium Monofluorophosphate, ZSpharmac will provide Sodium Monofluorophosphate raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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