Zhishang Chemical

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Zhishang Chemical

Sodium Lauroylsarcosinate CAS 137-16-6

Molecular Formula: C15H28NO3.Na

Formula Weight: 293.38

ZSpharmac: Sodium Lauroylsarcosinate Supplement

Product Name: Sodium Lauroylsarcosinate
CAS No: 137-16-6
Purity: 99%

Basic Info

Product Name:Sodium Lauroylsarcosinate
Other Names:N-Lauroylsarcosine sodium salt
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:205-281-5
Storage:Room Temp
Provide:Sodium Lauroylsarcosinate MSDS;
Sodium Lauroylsarcosinate COA

What is Sodium Lauroylsarcosinate?

Salt Lauroylsarcosinate is a white to pale yellow fluid with a special odor. Soluble in water, ethanol or glycerol. Under typical conditions, it is relatively steady to warm, acid and alkali. It is less bothersome to the skin as well as has a weaker degreasing impact. It is used as lathering representative, cleaning agent, anti-enzyme, bactericide as well as emulsifier in different cosmetics, and it can protect against dental caries when utilized in toothpaste. Salt laurylsarcosinate is an amino acid surfactant. Along with its exceptional surface task, it likewise has the characteristics of anti-bacterial and antiseptic, corrosion as well as corrosion inhibition as well as excellent biodegradability, so it is extensively utilized in detergents and also cosmetics., food and drink, steel rust, mineral flotation, pesticides as well as biomedicine and also many various other areas.

Sodium Lauroylsarcosinate Properties:

Melting point 46 °C
density 1.033 g/mL at 20 °C
vapor pressure 0.02 hPa (20 °C)
RTECS MC0598960
Fp 267℃
storage temp. room temp
solubility H2O: 1 M at 20 °C, clear, colorless
form Powder
color White
Specific Gravity1.03 (20/4℃)
PH7.0-9.0 (25℃, 1M in H2O)
Water Solubility Soluble in water (293 g/L).


Sodium Lauroylsarcosinate Uses

  1. Salt Lauroylsarcosinate is an amino acid surfactant. In addition to its excellent surface activity, it likewise has the qualities of antibacterial as well as antiseptic residential or commercial properties, deterioration and rust inhibition, and excellent biodegradability. rust, mineral flotation protection, chemicals and also biomedicine and several other fields.
  2. Salt Lauroylsarcosinate is used in biochemical study. Anionic surfactants. Hexokinase preventions. Anionic detergent. Yeast RNA seclusion. It can be utilized for RNA and also DNA seclusion, as a solubilizer in cell purification, as an additive when dividing DNA from human serum, and it can additionally increase the nitrogen-fixing capability of vegetable rhizobia by adding this product. It additionally has many applications in immunochemistry.
  3. Salt Lauroylsarcosinate is an anionic surfactant. Because it does not create extreme foam, it can be utilized for cell lysis in RNA extraction methods.

Sodium Lauroylsarcosinate Other Applications

Fang Ningtao and others tried to use Salt Lauroylsarcosinate as a decellularization reagent to prepare acellular tissue engineering scaffolds and analyze their biological properties. Methods: The porcine valved conduits were decellularized with 0.25% Salt Lauroylsarcosinate and nuclease, and the contents of DNA and soluble protein were determined, HE and Movat staining, electron microscope observation and biomechanical test were carried out. ; Biocompatibility analysis of rat subcutaneous embedding assay. Results After decellularization, the DNA content in the valve leaflets and the wall of the valve conduit was only 1.35% and 2.81% of the normal, the soluble protein content was only 8.46% and 12.65% of the normal, and the cellular components were almost completely removed. HE and Movat staining and electron microscope observation showed that the tissue structure was complete, the cell structure completely disappeared, and the main matrix components such as collagen, elastic fibers and proteoglycans were fully retained; the biomechanical properties of the valve were not statistically different from those of the normal valve; the scaffold biocompatibility good, with low immunogenicity and degradability. Conclusion: Salt Lauroylsarcosinate is an ideal new decellularization reagent, which can establish a low-toxicity, high-efficiency decellularization method without damage to tissue structure, and prepare decellularized products with excellent biological properties. Cell scaffold material.

CN201710937850.8 discloses a descaling agent for drainage pipes. The present invention is composed of the following raw materials in parts by weight: 8-16 parts of Salt Lauroylsarcosinate, 5-11 parts of sodium hydroxide, 7-15 parts of polyacrylamide, 4-10 parts of polymaleic anhydride, hydroxy 3-7 parts of ethyl acid, 3-9 parts of gallic acid, 7-11 parts of hydroquinone, 2-5 parts of hypochlorite, 2-4 parts of citric acid. The raw material cost of the invention is low, the preparation method is simple, the dirt formed in the drainage pipeline can be effectively removed, the scale removal ability is strong, the secondary damage to the pipeline is not caused, and the bacterial growth in the drainage pipeline is reduced.

CN201210162646.0 discloses a gram-positive bacterial nucleic acid extraction method. The invention provides a reagent for breaking the cell wall of Gram-positive bacteria, which is composed of extracting solution A and extracting solution B; it is composed of extracting solution A and extracting solution B; the extracting solution A is prepared according to the following method: Tris, EDTA , SDS, Tween-80, Triton-X-100, Brij-58, 3-[(3-cholesterylaminopropyl)dimethylamino]-1-propanesulfonic acid, sodium lauryl sarcosinate, β -Mercaptoethanol and water are mixed to obtain extract A; the extract B is prepared according to the following method: water-saturated phenol, ethanol and pyrrolidone are mixed to obtain extract B. Experiments of the present invention prove that the present invention provides a method for efficiently extracting gram-positive bacterial nucleic acid, which is simple to operate, very low in cost, and has good extraction effect, especially in extracting RNA, which is better than currently widely used commercially available kits.

Synthesis of Sodium Lauroylsarcosinate

1) Synthesis of Sodium Lauroylsarcosinate: add a certain amount of lauric acid in a dry three-necked flask equipped with a reflux condenser, heat and melt, control the temperature at 60-70 e, slowly add phosphorus trichloride dropwise under full stirring, and react for 2 h. The layers were left to stand, and the phosphorous acid in the lower layer was removed to obtain the upper layer of lauroyl chloride.
2) Synthesis of N-Sodium Lauroylsarcosinate: add a certain amount of sodium sarcosinate solution and solvent tetrahydrofuran to a four-necked flask with an electric stirrer and a reflux condenser, and add lauroyl chloride and hydrogen dropwise by Chemicalbook under stirring. Sodium oxide aqueous solution, the pH value of the reaction system is controlled in the range of 9~11, after the dropwise addition, the reaction is continued for 3h to recover the solvent, and the pH value is adjusted to 1~2 with dilute acid to convert N-Sodium Lauroylsarcosinate into insoluble N-lauroyl sarcosine in water, so as to be separated from water-soluble inorganic salt impurities. The product was extracted with ether, the upper oil layer was washed with water until neutral, dried over anhydrous sodium sulfate, evaporated to remove the solvent, and recrystallized with petroleum ether to obtain white needle-like crystals.

Sodium Lauroylsarcosinate Safety

Sodium Lauroylsarcosinate can be found in the cosmetic database as a moderately dangerous ingredient, mainly because it may contain the impurity nitrosamine (a well-known carcinogen), and because it is considered a penetration aid Agents that alter the skin’s structure and help other chemicals penetrate deep into the skin. CosmeticsInfo.org believes that Sodium Lauroylsarcosinate should not be used in cosmetic and personal care products because of the potential for the formation of nitroso (N-nitroso) compounds. Sodium Lauroylsarcosinate does not have the potential toxicity and harm expected, and it is oral low toxicity. It was not found to be mutagenic, irritating and sensitizing. But as mentioned earlier, it helps other ingredients penetrate the skin.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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