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Sodium Laureth Sulfoacetate CAS 1847-58-1

Molecular Formula: C14H29NaO5S

Formula Weight: 332.43

ZSpharmac: Sodium Laureth Sulfoacetate Supplement

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Product Name: Sodium Laureth Sulfoacetate
CAS No: 1847-58-1
Purity: 99%

Basic Info

Product Name:Sodium Laureth Sulfoacetate
Other Names:Sodium Lauryl Sulfoacetate
CAS:1847-58-1
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Pharmaceutical Raw Materials
Appearance:Colorless Liquid
EINECS No.:217-431-7
Storage:Inert Atmosphere,Room Temperature
Provide:Sodium Laureth Sulfoacetate MSDS;
Sodium Laureth Sulfoacetate COA

What is Sodium Laureth Sulfoacetate?

Sodium Laureth Sulfoacetate is an adduct of New Houttuyniacin and Sodium Bisulfite. Since Sodium Laureth Sulfoacetate is an oily substance, it is insoluble in water, and its solubility is increased after the addition. During the storage process of sodium in solution state, it is easy to precipitate out, which causes an increase in adverse reactions during clinical application. In addition, the Sodium Laureth Sulfoacetate is sensitive to light, which can cause drug deterioration.
From the natural Houttuynia cordata, the active ingredient houttuyniacin with antibacterial activity is extracted, and its chemical name is Decanoy aceta Ldehyde. This pharmaceutical prep work has been commonly used in scientific method. The Salt Laureth Sulfoacetate synthesized by chemical techniques in China, the chemical name is sodium dodecanoylacetaldehyde salt bisulfite, and also the pharmacological activity as well as medicinal result of decanoylacetaldehyde are basically comparable. Medically, it is mostly made use of for respiratory system illness, gynecological diseases, gastrointestinal system conditions, surgical conditions, and also ENT conditions.The medicine prepared with the Sodium Laureth Sulfoacetate is currently only the Sodium Laureth Sulfoacetate injection, and there are also literature reports of the new houttuycin sodium intravenous infusion (Chinese Patent Application No.: 02135030.2, main classification number: A61k31/185 ), but its products have not been marketed, (and the preparation method is different from the present invention). Therefore, the dosage form of Sodium Laureth Sulfoacetate is not rich enough, which affects the scope of use of the drug.

Sodium Laureth Sulfoacetate Properties:

storage temp. Inert atmosphere,Room Temperature
CAS DataBase Reference1847-58-1
EPA Substance Registry SystemAcetic acid, sulfo-, 1-dodecyl ester, sodium salt (1847-58-1)

 

Sodium Laureth Sulfoacetate Applications

Sodium Laureth Sulfoacetate is a chemical composition of an aldehyde component in the volatile oil of the whole plant of Trichosanthes chinensis. Clinically, it is mainly utilized for breathing system diseases, gynecological illness, digestion system conditions, surgical illness, and also ENT illness. Sodium Laureth Sulfoacetate has obvious inhibitory result on Streptococcus pneumoniae, Bacillus typhi, Staphylococcus aureus, Escherichia coli and also Sporothrix.
Salt Laureth Sulfoacetate Shot is mainly utilized for adnexitis, pelvic inflammatory illness, chronic cervicitis and various other gynecological inflammations, along with for upper respiratory system infection, chronic bronchitis, pneumonia, and so on.

Preparation of Sodium Laureth Sulfoacetate

At present, the synthetic methods of Sodium Laureth Sulfoacetate mainly include the following three categories:
The first type of method: the mixture of calcium laurate and calcium acetate is obtained by the reaction of lauric acid, glacial acetic acid and slaked lime, and then the calcium salt mixture is reacted under high temperature conditions to obtain dodecyl ketone, which is then condensed with ethyl formate to obtain dodecyl ketone. Acetaldehyde, and then added with sodium bisulfite to obtain Sodium Laureth Sulfoacetate.
In the process of preparing dodecaketone by the synthetic method, the temperature requirements are relatively high, the conditions are harsh, and the production cost is high, which is not conducive to large-scale industrial production.
The second type of method: using 1-bromo-n-decane and ethyl acetoacetate as raw materials, alkylation and decarboxylation to obtain 2-tridecone, and condensation with ethyl formate through ester ketone to obtain dodecanoylacetaldehyde, and finally Addition of dodecanoylacetaldehyde and sodium bisulfite to obtain Sodium Laureth Sulfoacetate.
The synthesis method is found in “Qilu Pharmaceutical Affairs” 2006.8, Synthesis of Sodium Laureth Sulfoacetate . The synthetic route is complicated, the total yield is not high, and it is only suitable for laboratory preparation.
The third type of method: use methylundecanone as raw material to react with metal sodium and toluene as solvent, extract sodium dodecanoylacetaldehyde from toluene with distilled water, and finally combine sodium dodecanoylacetaldehyde with sulfurous acid Sodium hydrogen is added in a weakly acidic environment to obtain sodium a-hydroxydodecanoylethylsulfonate, namely Sodium Laureth Sulfoacetate .
The synthesis method refers to the three-step synthesis method of the synthesis process of Houttuyniacin sodium, which is found in “Anhui Medicine” 2004.2 New Synthesis Research of Sodium Laureth Sulfoacetate . This process has harsh production conditions and high cost, and is not suitable for large-scale production.
specific method:
(1) get coconut oil 3500g, put in an enamel container, add sodium hydroxide 750g and sulfuric acid 250g respectively, after saponification and acidification; Put in the vacuum fractionation device, at 150 DEG C, under the condition of pressure 120mmHg, vacuum fractionation, Preparation of dodecanoic acid;
(2) Preparation of calcium salt
Take 1800g of sieved lime and add 2500ml of water and stir it into a paste, and heat 500g of dodecanoic acid in a 10,000ml porcelain bucket to dissolve it completely, mix it with 2500g of glacial acetic acid, pour it into the lime paste, and keep stirring to form calcium salt , placed overnight (to make calcium salt);
(3) Mixed ketone preparation:
The obtained calcium salt was put into a cracking tank, and heated under direct fire for 10 hours to crack to obtain about 750ml of mixed ketones;
(4) Preparation of tridecone-2 (fractionation)
Take 1000ml of mixed ketone, pour it into a round-bottomed flask, add 2 to 3 glass beads to prevent waterfall boiling, connect a fractionation device, and then heat (the temperature is controlled at 150°C and the pressure is controlled at 120mmHg) under reduced pressure distillation. The fractions within the range are weighed to obtain tridecone-2;
(5) preparation of dodecanoylacetaldehyde sodium salt:
Take 200 g of tridecone-2, 750 g of ethyl formate, and 1000 ml of anhydrous benzene, mix them in a 5000 ml conical flask, and then take 125 g of sodium metal, chop them, put them into the mixed solution in stages, and shake them thoroughly. The conical flask is for external use. Cooling with ice water, keeping the reaction solution at 25°C and leaving it at room temperature, to obtain sodium dodecanoylacetaldehyde;
(6) Addition of sodium dodecanoylacetaldehyde sodium bisulfite
Take the above reactant and extract it with water 4 times: 2000ml×2, 1000ml×2, combine the 4 water extracts, take another 750g NaHSO3 dissolve in 1500ml water, mix with 250ml glacial acetic acid, add the above water extract, and immediately generate a lot of white precipitates, Stir well, place the liquid, filter, filter dry, place the liquid, pour the precipitate into a porcelain bucket, heat and boil in a water bath with 50% ethanol 8000ml, filter, heat and boil the filtrate in a water bath and place overnight for reconstitution. After crystallization, suction-filtered to dryness, washed with about 1500ml of ether in different times, then washed with water, washed with ether until white, drained, and dried at 80°C to obtain new houttuyniacin sodium.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Our Mission
Help China Chemicals to benefit the happiness of human life
Our Vission
Become the most trusted chemical supplier in the world
Our Business Philosophy
Striver – oriented, enrich employees, customer first, deep service, seek development
Our Values
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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