Zhishang Chemical

Welcome to Zhishang Chemical      +86-176 5311 3209     Simon@sdzschem.com

Zhishang Chemical
Close this search box.

Sodium L-Pyroglutamate CAS 28874-51-3

Molecular Formula: C5H6NNaO3

Formula Weight: 151.1

ZSpharmac: Sodium L-Pyroglutamate Supplier

Product Name: Sodium L-Pyroglutamate
CAS No: 28874-51-3
Purity: 99%

Navigation Bar

Basic Info

Product Name:Sodium L-Pyroglutamate
Other Names:Sodium PCA
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Clear Colorless to Pale Yellow Oil
EINECS No.:249-277-1
Provide:Sodium L-Pyroglutamate MSDS;
Sodium L-Pyroglutamate COA

What is Sodium L-Pyroglutamate?

Salt L-Pyroglutamate is a sodium salt of the amino acid glutamic acid. It is an odorless along with likewise anemic crystal that degenerates along with thaws at 232 ° C. Salt glutamate has fantastic water solubility, and also 74 grams of salt glutamate can be liquified in 100 ml of water. The emphasize of monosodium glutamate is to increase the umami choice of food. It is made use of the majority of in Chinese cuisine in addition to can in addition be utilized in soups as well as sauces. MSG was located as well as patented by the Japanese Ajinomoto Organization in 1909. Pure monosodium glutamate appears like a white crystalline powder. When MSG liquifies in water (or saliva), it will swiftly ionize right into cost-free salt ions as well as additionally glutamate ions (glutamate ions are the anion of glutamic acid, which is a natural amino acid). It requires to be noted that if monosodium glutamate is used at a heat over 100 ° C, the umami agent salt glutamate will definitely be ended up being salt pyroglutamate, which is cancer cells developing to human beings. Also, if in an alkaline setup, monosodium glutamate will certainly react chemically to produce a substance called disodium glutamate. So utilize in addition to in addition store suitably. MSG is a kind of flavor, the foundation is Salt L-Pyroglutamate. It ought to be kept in mind that if monosodium glutamate is utilized at a warm over 100 ° C, the umami representative salt glutamate will certainly be transformed right into salt pyroglutamate, which is carcinogenic to people.Likewise, if in an alkaline environment, monosodium glutamate will certainly react chemically to develop a product called disodium glutamate. So make use of as well as conserve properly. Extreme consumption might cause stand cancer cells as well as various other human all-natural disease. Normal consumption of salt pyroglutamate is safe to individuals, consisting of as a chemical (ie oral management). Salt pyroglutamate is not dangerous to humans when utilized usually, consisting of as a skin treatment in addition to hair care product (ie skin penetration). Nevertheless, it has been reported in the compositions that if pyroglutamic acid is instilled straight into the mind of mice, it will definitely develop neurotoxicity. But there is no document concerning pyroglutamic acid in human brain.

Sodium L-Pyroglutamate Property

Melting point 125°C
Boiling point 313.7℃[at 101 325 Pa]
density 1.45
vapor pressure 5.4hPa at 20℃
storage temp. Refrigerator
solubility Methanol (Sparingly), Water
form Oil
pka9.94[at 20 ℃]
color Clear Colorless to Pale Yellow
Water Solubility 613g/L at 20℃


Salt L-Pyroglutamate Applications

1. Cosmetics
Cosmetics is among the most widely used location of Salt L-Pyroglutamate, which can be used in aesthetic solutions, powders, skin therapy lotions, hair conditioners as well as furthermore hair fixatives, and so on. Skin care cosmetics are focused on stopping extreme skin in addition to preserving the skin soft. Simply lately, based upon the understanding that moisturizing impact is very important, it is specifically fascinating to obtain cosmetics with high moisturizing result. When a water-in-oil emulsified cosmetic is connected to the skin, it establishes an oily flick that is tough to evaporate water, to ensure that the skin remains in an exceptional moisturizing state.

However, standard emulsifiers have actually been made use of in cosmetics to create conventional water-in-oil emulsions. When the water material is high, the emulsion will absolutely be uncertain. As a result, from the point of view of storage space safety, the water product need to be decreased as well as also the oil material should be rather large., Such a lotion will absolutely have a sticky and unwanted experience. If salt pyroglutamate emulsifying aid is consisted of in the solution, a brand-new type of water-in-oil visual solution with high water internet material, oily sensation yet not sticky, and excellent storage room protection can be gotten.

One formula of this cream is as follow: (1) 2 parts stearic acid, (2) 4 parts cetyl alcohol, (3) 8 parts liquid paraffin, (4) 2 elements polyoxyethylene stearate, (5) 1 part of triethanolamine, (6) 3 parts of salt pyroglutamate, (7) suitable amount of tastes along with likewise chemicals, (8) 81.5 parts of water. In the regular blend composed of (1 )-( 4 ), gradually add the mix composed of (5 )-( 8) which has truly been heated up to 20 ° C, in addition to emulsify to acquire a water-in-oil emulsified cosmetic. Changing the internet material of salt pyroglutamate can transform the water content.

In powder cosmetics, Salt L-Pyroglutamate can change mineral oil, animal oil, manufactured oil as well as additionally various other oils as well as also glycerin, propylene glycol water-soluble polymer moisturizers, in addition to the impact is better. A visual powder that can be saved for an extended period of time in addition to furthermore has exceptional dispersibility in water is produced as abide by: (A) Phosphatidylphthalein Choline 8% (by weight), Cholesterol 2%, Propylene Glycol 4%; (B) Salt Pyroglutamate 6 5%; (C) Dextrin 20%. Heat and additionally mix (A) energetic elements, progressively consist of 3 times the amount of comfortable water to establish an oil-in-water solution, consist of (B) parts to the solution, after mixing carefully, include (C) components 3 times water dilution, spray Dry to get self-emulsifying powder cosmetics.

2. Soap
The soap made by including tinting associates, scents in addition to in addition various other energised parts to the average soap space will most definitely cause adjustments in the weight along with dimension of the soap as a result of the slow-moving evaporation of water. The surface of the soap is prone to separates along with the value of the product will absolutely lower. After the soap is taken in water throughout use, it requires to undertake repeated drying out treatment, as well as additionally divides will definitely turn up externally of the soap, which not simply influences the look, yet in addition typically divides right into blocks. If 0.5-15% sodium pyroglutamate is included in the soap base, the absolute best enhancement is about 5%, along with the conservation of the soap made will absolutely be substantially boosted. After usage, as a result of the result of salt pyroglutamate on the skin, the skin There is a moist experience on it.

The production treatment is as stick to: Include 5 parts of salt pyroglutamate to 10 parts of soap locations, blend well as well as additionally knead in a little soap rolling manufacturer, and likewise squeeze out the obtained flake soap integrate with an extruder, The temperature level degree of the sleeve as well as nozzle of the extruder is maintained a specific temperature, extruded right into a bar kind, as well as also afterwards the gotten soap bar is squared away into a finished item in a molding maker. Compared to conveniently supplied aesthetic soaps, this soap has the advantages of high frictional solubility, exceptional formability, no splitting after copied cleansing as well as also drying out, as well as also remarkable skin feeling after usage. In different other clear soaps as well as aesthetic soaps, salt pyroglutamate can moreover be added to enhance the excellent quality.

3. Food
Including hygroscopic Salt L-Pyroglutamate to cakes, toffee in addition to various other products can significantly decrease water loss and expand the life expectancy of points. Include 5% salt pyroglutamate per of both energetic ingredients of bread along with delicious chocolate toffee, together with the numerous other manufacturing conditions synchronize. The surface of the bread is still smooth along with has an outstanding appearance, while the control sample has numerous deep cracks in the center; the toffee with salt pyroglutamate is extremely soft in addition to has a smooth surface area, while the control toffee is difficult as well as also the surface gradually comes to be fine-grained.

4. Softgels
The soft tablet matrix normally used in medication in addition to food (such as jelly is water-soluble, if the filler is an aqueous remedy or suspension, it is challenging to develop a soft pill, in order to conquer this imperfection, the water-in-oil kind with consisted of oil and so forth has in truth continuously been utilized The emulsification approach, or the strategy of strengthening the jelly covering itself. However, consisting of oil is not ideal for all events. Improper use the hardener for increasing the jelly coating will trigger issues that are testing to liquify. If you contain scorched grains to the water-based active components Sodium amino acid (or taken advantage of in mix with added sugar alcohols, salt lactate, and so forth) humectant to develop a water-in-oil solution, making it testing for water to transfer to the matrix jelly movie, quiting the jelly film from straight talking with the water-based tablet computer oral dental filling. Soft tablet has really removed previous shortage, is a kind of extremely optimum soft tablet point.

A kind of beef juice capsule preparation task strategy is as stick to: in 50 parts of beef juice (having wetness 40%), mix 50 parts of D-sorbitol, 50 parts of salt lactate, 50 parts of Salt L-Pyroglutamate, 30 parts of L-lysine or kept Amino acid was used to get the mix, along with the mix was constructed right into a 2 5 mm round tablet (full weight 10.8 grams, material weight 10 grams, motion picture density 0. sm m ), dried at 20 ℃ till the movie moisture gets to 1 0 %. The beef juice pills were saved in a consistent temperature degree in addition to also dampness container at 40 ° C and 60% wetness for 120 days. The jelly membrane layer layers of all tablets were not harmed, in addition to these tablet computers were taken into comfortable water at 80 ° C. Dissolved completely within 30 secs, causing an outstanding flavorful fluid with beef taste.

5. Medications
Consisting of Salt L-Pyroglutamate to medical creams and also creams can raise security in addition to desire to the skin; the principle of the prep work method synchronizes as food soft pills, adding water-based medical soft tablets constructed from salt pyroglutamate, It boosts the absorption and also utilize cost of medications, in addition to can use water-based medicine energised components without blending oil; salt pyroglutamate can additionally be used as a stabilizer for solid-phase immune reagents and also liquid medications. A type of Xiaoke, 1.7 grams of 3-butanediol, 10 grams of methyl ethyl ketone, 30 grams of isobutanol, 5 grams of 2% salt pyroglutamate choice, consist of 2 grams of mefenamic acid after mixing, and afterwards thin down with ethanol to l 00 ml.

6. Textile
Salt L-Pyroglutamate can endow fibers with exceptional versatility, in addition to will absolutely not develop staining of plenty of dyeings during the therapy procedure. It can be made use of stably with fluorescent dyes, in addition to it is simple to dissolve or spread in water to develop a steady as well as consistent water-based system. As a result, it is extremely ideal as a fiber conditioner. When made use of, it is prepared as a 5-10% fluid remedy, diffusion or remedy (proper emulsifiers can be contained) to fertilize silk or woven towel. Therapy by dip-dyeing, spray-dyeing along with many various other approaches. It can soften in addition to end up all fibers such as woollen, cotton, rayon, nylon, polyester, and so on.

The situations of the therapy is as stick to: In 1 litre of 2% Salt L-Pyroglutamate liquid solution, the pre-desized wonderful degree towel (cotton textile) was filled at 40 ° C for half a hr, afterwards dehydrated as well as likewise dried out. The handled material had exceptional Superb Newmery homes (rubbing efficiency of woollen textile), gentleness and in addition versatility, when used as clothing product, it has a damp feeling and also likewise superior warmth retention.

7. Ink
Salt L-Pyroglutamate could be included in a liquid ink cosmetics for inkjet recording that does not block nozzles as well as has high printing premium quality. Inkjet tape-recording essentially papers individualities as well as additionally graphics by expeling ink grains from little inkjet nozzles (usually 10s to hundreds of microns in measurement). The ink made use of for inkjet recording is required to quit obstructing of the ink nozzle, to have phenomenal printing dry skin, not to hemorrhage, along with have an appropriate conductivity. Because sodium pyroglutamate, which has the quality of controling conductivity, has incredibly high water absorption, the ink comprised of including 2-10% salt pyroglutamate along with a certain quantity of polyol to the water-soluble color ink formula can To satisfy the above needs, generally, antifungal agents, pH regulatory authorities, surface stress and anxiety modifiers (surfactants), ultraviolet absorbers, anti-oxidants, etc can similarly be contributed to the ink solution.

An ink formula is as comply with: straight black 19, 1.5% (by weight), Salt L-Pyroglutamate 2.5%, polyethylene glycol (typical molecular weight 300) 5%, water 90.95%, 1.2-benzene And also isosialin-3-one 0.05%. After these components are integrated, they are penetrated a filter 2 times to make an ink. Tests have in fact confirmed that this ink is a water-based ink that does not block the nozzles and also has superior printing premium.

8. Pipeline cleaning
The pipe cleanser that can tidy up the sewer includes the reaction product of pyroglutamic acid in addition to additionally salt hydroxide as well as steel aluminum. It can in addition have specific not natural salts such as potassium nitrate, sodium nitrate, and so forth. They chemically react with aluminum in the existence of water, presenting heat. This comfy, in addition to Salt L-Pyroglutamate and also totally free salt hydroxide, has a collaborating result on raising the solvency of organics, so there define cleansing benefits.

Preparation of Salt L-Pyroglutamate

Add 200 grams of NaOH to 200 grams of water, then add 60 grams of pyroglutamic acid, stir, and dry the resulting solid at 100°C for 100-120 hours to obtain Salt L-Pyroglutamate.

About Products:
If you need the cosmetic raw material Salt L-Pyroglutamate, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Salt L-Pyroglutamate, ZSpharmac will provide Salt L-Pyroglutamate raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Sodium L-Pyroglutamate Quotation