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Sodium L-Ascorbyl-2-Phosphate CAS 66170-10-3

Molecular Formula: C6H10NaO9P

Formula Weight: 280.1

ZSpharmac: Sodium L-Ascorbyl-2-Phosphate Supplement

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Product Name: Sodium L-Ascorbyl-2-Phosphate
CAS No: 66170-10-3
Purity: 99%

Basic Info

Product Name:Sodium L-Ascorbyl-2-Phosphate
Other Names:2-Phospho-L-Ascorbic Acid Trisodium Salt
CAS:66170-10-3
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Solid
EINECS No.:1308068-626-2
Storage:Inert Atmosphere,Room Temperature
Provide:Sodium L-Ascorbyl-2-Phosphate MSDS;
Sodium L-Ascorbyl-2-Phosphate COA

What is Sodium L-Ascorbyl-2-Phosphate?

Sodium L-Ascorbyl-2-Phosphate trisodium salt Chinese alias vitamin C sodium phosphate, SAP, Sodium L-Ascorbyl-2-Phosphate sodium salt. Sodium L-Ascorbyl-2-Phosphate trisodium salt can be used as intermediate in pharmaceutical and chemical synthesis. If inhaled Sodium L-Ascorbyl-2-Phosphate trisodium salt, move patient to fresh air; in case of skin contact, remove contaminated clothing, rinse skin thoroughly with soap and water, seek medical attention if discomfort occurs; In case of contact with eyes, look for clinical interest if pain happens; In case of contact with eyes, different eyelids, rinse with running water or typical saline, as well as look for medical attention instantly; if consumed, wash mouth promptly, do not generate vomiting, as well as look for medical focus immediately.

Sodium L-Ascorbyl-2-Phosphate Properties:

Melting point 260 °C
storage temp. Inert atmosphere,Room Temperature
solubility Acidic DMSO (Slightly), Water (Slightly)
form Solid
color White to Off-White

 

Application of Sodium L-Ascorbyl-2-Phosphate

Sodium L-Ascorbyl-2-Phosphate trisodium salt can be used as alkaline phosphatase catalytic substrate. Alkaline phosphatase (ALP) is an essential biomarker whose uncommon expression is associated with different illness such as breast cancer cells, prostate cancer cells, bone condition, diabetic issues, and liver disorder. Quantitative discovery of ALP in lotion can aid in the medical diagnosis of relevant diseases. Spooky evaluation has been commonly utilized in ALP detection due to its simpleness as well as rapid feedback.However, conventional spectroscopic methods based on a single material and with a single colorimetric or fluorescent output signal have poor anti-interference ability and low accuracy, and are difficult to detect targets in complex samples. With the advancement of nanotechnology, a variety of ALP colorimetric sensing methods based on nano-gold and nano-silver have been developed, but the sensitivity of such methods needs to be improved; the weak shell changes of core-shell nanoparticles can cause significant Spectral and color variations, which appear to offer the possibility to further increase the sensitivity of colorimetric detection. Some studies have provided a dual-channel detection method for alkaline phosphatase activity. The principle is that alkaline phosphatase catalyzes the hydrolysis of its substrate Sodium L-Ascorbyl-2-Phosphate trisodium salt (AAP) to generate reducing ascorbic acid, which reduces ascorbic acid. Tollen’s reagent generates silver element and deposits on the surface of gold nanoparticles to form Au@AgNPs, which leads to the change of solution color and absorption spectrum; in addition, the generated Au@AgNPs can effectively quench the fluorescence of graphene quantum dots (GQDs), resulting in the change of solution color and absorption spectrum. Changes in fluorescence intensity. Thus, colorimetric and fluorescent dual-channel determination of alkaline phosphatase activity can be achieved through simultaneous changes in solution color, absorbance, and fluorescence intensity.

Sodium L-Ascorbyl-2-Phosphate trisodium salt can also be used for the preparation of a photoelectrochemical parathion sensor. It belongs to the technical field of novel nanometer functional materials and biosensors. First, a new two-dimensional nanophotosensitive material Mn-MoO3/TiO2@g-C3N4 was prepared. Taking advantage of the good biocompatibility and large specific surface area of ​​the material, parathion antibody was loaded, and then the glutaraldehyde Alkaline phosphatase is immobilized by cross-linking. During detection, since alkaline phosphatase can catalyze Sodium L-Ascorbyl-2-Phosphate trisodium salt AAP to generate L-ascorbic acid AA in situ, and then provide electron donors for photoelectric detection, The effect of the specific quantitative binding of antibody and antigen on the electron transport ability is used to reduce the photocurrent intensity accordingly. Finally, a label-free detection of parathion with low cost, high sensitivity, good specificity, rapid detection and simple preparation is obtained. photoelectrochemical biosensors.

Interaction Between Retinoic Acid andSodium L-Ascorbyl-2-Phosphate Trisodium Salt

Abstract: Although both retinoic acid (RA) and Sodium L-Ascorbyl-2-Phosphate trisodium salt (AscPNa) can promote the induction of mouse embryonic fibroblasts (MEFs) into induced pluripotent stem cells (iPS), in the coexistence of The inductive ability of both decreased. Zheng Hui’s team from the Guangzhou Institute of Biomedicine and Health of the Chinese Academy of Sciences proposed the following hypothesis, that is, RA and AscPNa may share some downstream signaling pathways, resulting in mutual “restraint”. Their study confirmed by RNA-seq that RA highly overlaps with the downstream activated genes of AscPNa during reprogramming. In addition, RA can help L-ascorbic acid membrane (Asc) transfer by regulating Glut1/3, promote and maintain its long-term high level of intracellular oxidation state, on the other hand, AscPNa is mainly in the process of promoting MET, down-regulation Zeb1 and Twist1, thereby inhibiting the expression of Cyp26a1/b1, thereby maintaining the level of intracellular RA. The two have different abilities and functions in somatic cell reprogramming. The conclusion of this study is that there is some kind of positive feedback effect between RA and AscPNa (vitamins A and C) during induced reprogramming. The specific results are as follows.

The authors found that as long as AscPNa was present, Oct4-positive clones could appear in MEF cells for about 12 days in different media, but AscPNa could inhibit the induction efficiency of RA. Next, the authors performed RNA-seq on induced reprogrammed cells cultured in N2B27 medium for 6 days. The overlapping genes regulated by RA and AscPNa were identified from the differential genes. The up-regulated genes were mainly related to cell cycle, neurogenesis, and cell adhesion; the down-regulated genes were related to extracellular matrix, cell migration and chemotaxis.
The authors speculate that a possible explanation is that RA and AscPNa conflict in the process of participating in the synthesis and degradation of Asc, so they found the SVCT and GLUT families because they play the role of transporting and maintaining Asc. The results showed that the RARA elements in the promoter regions of Glut1 and Glut3 were activated on day 6 during RA-induced reprogramming, the expression increased, and the corresponding intracellular level of Asc was also increased. Next, the authors tested the effect of AscPNa on Glut1 and Glut3 in MEF cells in the early stage of drug induction (also used dehydroascorbate DHAA for comparison, but found that DHAA is not as stable as AscPNa), and the results showed that RA can maintain the initial intracellular level of induction. The level of Asc and prevent the decline of intracellular Asc in the later stage. In conclusion, RA helps maintain intracellular Asc levels.
In turn, what is the effect of AscPNa on RA? Along the same lines, RA is degraded by CYP26A1 and CYP26B1 in vivo. Now under the action of AscPNa, these two enzymes are inhibited. Then the authors constructed a GFP reporter plasmid containing three RARA elements plus TK promoter, and transfected it into MEF cells. When RA was treated, GFP was expressed, and when RA was withdrawn, GFP expression gradually decreased. When RA was removed and AscPNa was added, GFP was still expressed, and the promoters of CYP26A1 and CYP26B1 were replaced by the same reason. Next, the author thought that a downstream transcription factor regulated by AscPNa could bind to these promoters to play a role. From the perspective of EMT, the author used TGF-β and TGF-β inhibitors to also achieve the transcription of CYP26A1 and CYP26B1. The authors thought of some transcription factors that are more important in the M state in EMT, such as ZEB1, TWIST1, etc., and predicted by Pscan software that they can indeed bind to the CYP26A1 and CYP26B1 promoters, and have been verified. It is concluded here that AscPNa inhibits CYP26A1 and CYP26B1 expression by inducing MET, thereby causing the accumulation of RA in cells.
Finally, it is summarized as follows. In the process of iPS-induced reprogramming, RA up-regulates Glut1, Glut3, etc., maintaining a high level of intracellular Asc, and then promoting reprogramming; while AscPNa causes MET to occur, thereby inhibiting the expression of CYP26A1 and CYP26B1, and ultimately destroying RA degradation. This regulatory mechanism is conserved in other cellular and biological behaviors, so this molecular mechanism is of great importance.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOSPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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