Zhishang Chemical

Welcome to Zhishang Chemical      +86-176 5311 3209     Simon@sdzschem.com

Zhishang Chemical
Close this search box.

Sodium L-ascorbyl-2-Phosphate CAS 66170-10-3

Molecular Formula: C6H10NaO9P

Formula Weight: 280.1

ZSpharmac: Sodium L-ascorbyl-2-Phosphate Supplier

Product Name: Sodium L-ascorbyl-2-Phosphate
CAS No: 66170-10-3
Purity: 99%

Navigation Bar

Basic Info

Product Name:Sodium L-ascorbyl-2-Phosphate
Other Names:L-Ascorbic Acid-2-Phosphate Sodium
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White to Off-White Solid
EINECS No.:425-180-1
Storage:Room Temperature
Provide:Sodium L-ascorbyl-2-Phosphate MSDS;
Sodium L-ascorbyl-2-Phosphate COA

What is Sodium L-ascorbyl-2-Phosphate?

L-ascorbic acid (vitamin C, hereinafter referred to as Vc) is a vital vitamin for people and pets, and it exists normally in fresh veggies and fruits. Vc has actually been extensively utilized in medicine, food, cosmetics and pet reproduction as well as various other fields. Nonetheless, the hydrogen of the enol hydroxyl group in Vc is simple to dissociate, easily oxidized as well as damaged by air and also various other oxidizing agents, and also soon undergoes an irreversible decay reaction and loses the decreasing capability of Vc. If any one of the hydroxyl groups is esterified with inorganic acid, the security to warmth, acid and oxygen will be greatly improved. Salt L-ascorbyl-2-Phosphate is a by-product of L-ascorbic acid, its buildings are white or somewhat yellow powder, odorless, unappetizing; reasonably secure in light, heat and air.

Sodium L-ascorbyl-2-Phosphate Property

Melting point 260 °C
density 1.94[at 20℃]
storage temp. Inert atmosphere,Room Temperature
solubility Acidic DMSO (Slightly), Water (Slightly)
form Solid
color White to Off-White
PH9.0-9.5 (25℃, 30g/L in H2O)
Water Solubility 789g/L at 20℃


Sodium L-Ascorbyl-2-Phosphate Application

Sodium L-Ascorbyl-2-Phosphate can be used as a catalytic substrate for alkaline phosphatase. Alkaline phosphatase (ALP) is an important biomarker whose abnormal expression is associated with various diseases such as breast cancer, prostate cancer, bone disease, diabetes and liver dysfunction. Quantitative detection of ALP in serum can assist in the diagnosis of related diseases. Spectroscopic analysis has been widely used in ALP detection due to its simplicity and fast response. However, conventional spectroscopic methods based on a single material with a single colorimetric or fluorescent output signal have poor anti-interference ability and low accuracy, making it difficult to detect targets in complex samples. With the advancement of nanotechnology, a variety of ALP colorimetric sensing methods based on nano-gold and nano-silver have been developed, but the sensitivity of these methods needs to be improved; weak shell changes of core-shell nanoparticles can cause significant changes. Spectral and color changes, the occurrence of which offer the possibility to further increase the sensitivity of colorimetric detection. Some studies have provided a dual-channel detection method for alkaline phosphatase activity. The principle is that alkaline phosphatase catalyzes the hydrolysis of its substrate Sodium L-Ascorbyl-2-Phosphate to generate reducing ascorbic acid, and ascorbic acid reduces Tollen’s reagent to generate silver Au@AgNPs are deposited on the surface of gold nanoparticles to form Au@AgNPs, resulting in changes in the solution color and absorption spectrum; in addition, the generated Au@AgNPs can effectively quench the fluorescence of graphene quantum dots (GQDs), resulting in changes in the fluorescence intensity of the solution. Thus, the colorimetric and fluorescent dual-channel measurement of alkaline phosphatase activity can be realized through simultaneous changes in solution color, absorbance and fluorescence intensity.

Sodium L-Ascorbyl-2-Phosphate can also be used in the preparation of a photoelectrochemical parathion sensor. It belongs to the technical field of new nanometer functional materials and biosensors. First, a new type of two-dimensional nano-photosensitive material Mn-MoO3/TiO2@g-C3N4 was prepared. Taking advantage of the good biocompatibility and large specific surface area of this material, parathion antibody was loaded, and then the Cross-linking immobilizes alkaline phosphatase. During detection, alkaline phosphatase can catalyze Sodium L-Ascorbyl-2-PhosphateAAP to generate L-ascorbic acid AA in situ, and then provide electron donors for photoelectric detection, and then use antibodies The influence of the specific quantitative combination with the antigen on the electron transport ability makes the photocurrent intensity decrease accordingly, and finally a label-free photoelectrochemical photoelectrochemical method for detecting parathion with low cost, high sensitivity, good specificity, rapid detection and simple preparation is produced. biological sensor.

The preparation Method of Sodium L-Ascorbyl-2-Phosphate

A preparation method of feed grade Sodium L-Ascorbyl-2-Phosphate is characterized in that it comprises the steps:

a. Add water, L-ascorbic acid, and L-sodium ascorbate to the reaction kettle in a ratio of 0.5 to 2:1:0.2 to 1.0 in parts by weight and stir for 0.5 to 1 hour;

b. Slowly add 20% to 60% calcium hydroxide suspension or calcium carbonate suspension to the above solution, and adjust the pH value of the solution to 5 to 12;

c. Add sodium trimetaphosphate 0.6-1.8 times of L-ascorbic acid into the solution of step b under stirring and then carry out phosphorylation reaction. During the reaction process, use 20%-60% calcium hydroxide suspension or calcium carbonate Adjust the pH value of the reaction solution to 8-10 with the suspension;

d. After 20 minutes to 1 hour of the above phosphorylation reaction, let the reactant stand at room temperature and solidify for 2 to 10 hours, chop it up, and flash dry to obtain off-white or light yellow L-ascorbic acid-2-phosphate The product, the content of Sodium L-Ascorbyl-2-Phosphate in this product is more than 35% in terms of ascorbic acid, and the total amount of phosphorylated L-ascorbic acid is more than 37%.

Biological Activity of Sodium L-Ascorbyl-2-Phosphate

2-Phosphate-L-ascorbic acid trisodium salt serves as an antioxidant as well as additionally a stimulator of hepatocyte advancement component (HGF) manufacturing.
Artificial insemination looks into 2-Phospho-L-ascorbic acid (Asc2-P) runs as an antioxidant as well as also a stimulant of hepatocyte growth variable (HGF) manufacturing.2-Phospho-L-ascorbic acid is a safeguarded by-product of L-ascorbic acid (AA) with similar natural house or business buildings to AA. AA as well as furthermore Asc-2P control a number of organic procedures. When 2-phospho-L-ascorbic acid was finished with DHT, DHT-induced DKK-1 mRNA expression was considerably attenuated in DPC. DHT therapy was additionally situated to boost DKK-1 marketer task. When 2-phospho-L-ascorbic acid was incorporated with DHT, the DHT-induced activation of luciferase work was significantly prevented.

About Products:
If you need Sodium L-Ascorbyl-2-Phosphate as a cosmetic raw material, please contact our service staff directly, and we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Sodium L-Ascorbyl-2-Phosphate, ZSpharmac will provide Sodium L-Ascorbyl-2-Phosphate raw materials for customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Sodium L-ascorbyl-2-Phosphate Quotation