Sodium Isethionate CAS 1562-00-1

Molecular Formula: C2H5NaO4S

Formula Weight: 148.11

ZSpharmac: Sodium Isethionate Supplier

Product Name: Sodium Isethionate

CAS No: 1562-00-1

Purity: 99%

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Basic Info

Product Name:	Sodium Isethionate
Other Names:	Sodium Hydroxy Ethylene Sulfonate
CAS:	1562-00-1
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	White Fine Powder
EINECS No.:	216-343-6
Storage:	Store Below +30°C.
Provide:	Sodium Isethionate MSDS； Sodium Isethionate COA

What is Sodium Isethionate?

Sodium isethionate is a natural salt and also a crucial intermediate in drugs, cosmetics and everyday chemicals. Its synthesis concept is the condensation response of salt bisulfite and additionally ethylene oxide to create salt isethionate.

Sodium Isethionate Property

Melting point	191-194 °C(lit.)
density	1762.7[at 20℃]
storage temp.	Store below +30°C.
solubility	H₂O: 0.1 g/mL, clear, colorless
form	Fine Powder
color	White
PH	7.0-11.0 (20g/l, H2O, 20℃)
Water Solubility	SOLUBLE

Sodium Isethionate Uses

Sodium isethionate is made use of as surfactant intermediate, everyday chemical as well as additionally pharmaceutical intermediate, etc.
Sodium isethionate is an organic salt as well as an essential intermediate in pharmaceuticals, cosmetics, and everyday chemicals.
Salt isethionate is made use of as surfactant intermediate, everyday chemical as well as pharmaceutical intermediate, etc.

Sodium Isethionate Purification Method

At first the fresh sodium bisulfite qualified by analysis is added in the preparation still, under room temperature, normal pressure condition, be made into the aqueous solution of 35wt% with distilled water.

Send 2857Kg (concentration: 35wt%) of the prepared sodium bisulfite solution into the ethoxylation reactor. After nitrogen replacement and temperature rise operation, ethylene oxide is added at 90°C to start the reaction, and the temperature is controlled at 90-100°C. Pressure 0～0.1MPag (gauge pressure). After adding 500Kg of ethylene oxide, mature at 90-100°C for 30 minutes, and then unload.

The crude product (concentration 40-45wt%) synthesized in the previous step is sent to the double-effect continuous evaporating recrystallizer, operated in parallel, continuously fed, and intermittently discharged, that is, the dilute solution is advanced to the first-effect evaporator, and after preliminary After concentration, the concentration reaches 55-60wt%. The concentrated solution enters the second-effect evaporator, and after further concentration and evaporation to 72-75wt%, the concentrated solution enters the continuous crystallizer. The centrifuge centrifuges, the solid enters the next process, and the mother liquor returns to the second-effect evaporator to continue to participate in evaporation and concentration. When the content of ethylene glycol in the product reaches below 0.1%wt, it is regarded as qualified, and through analysis and detection, the product purity is greater than 99.5wt%.

A small amount of non-crystallizable raffinate is extracted with 3 times solvent, and the used extractant is dehydrated alcohol, and the sodium isethionate product is separated out in dehydrated alcohol, and a small amount of water and organic impurities, such as ethylene glycol, Polyethylene glycol and isethionate will enter the liquid phase ethanol, then enter the centrifuge for centrifugation, and finally dry the crystals in a disc dryer at 120°C to remove a small amount of residual solvent impurities in the product and moisture. The used extractant ethanol is recovered and reused. Extractant ethanol can be recovered by distillation.

Insulin Feedback Inhibition of Insulin Secretion in Isolated Pancreatic Islets

We have actually taken a look at the effect of exogenous insulin on secretory blister edges and also secretory blister lysis in isolated perifused rat islands. Employment of the somatostatin (SRIF) receptor to the plasma membrane layer is made use of as a marker of secretory blister marginalization, while insulin release mirrors the procedure of secretory vesicle lysis. A recently created perifusion protocol allows intermittent disruption of the secretory vesicle edge or secretory blister lysis. Islands were originally perfused with sugar (30, 100, 165, 200, or 300 mg/dl) in the existence of sodium isethionate. Sodium isethionate inhibits secretory blister lysis yet not the recruitment of SRIF receptors. Therefore, marginalization of secretory blisters to the surface membrane layer profits without lysis. Salt isethionate was after that removed, and also islands were challenged with 400 microM isobutylmethylxanthine (IBMX). In islands full of high concentrations of glucose, IBMX lysed more vesicles and led to improved insulin release. The existence of exogenous insulin throughout the first phase of secretory blister marginalization did not influence subsequent IBMX-induced insulin secretion from islets perfused with reduced sugar focus (30 as well as even 100 mg/dl). Insulin dramatically decreased IBMX-induced insulin release when glucose concentrations were increased to 165, 200, or 300 mg/dl. In different experiments, boosting insulin concentrations (50, 100 as well as 200 microU/ml) decreased glucose-induced SRIF receptor recruitment in a dose-dependent fashion. Our observations strongly recommend a healthy connection between ambient glucose and also insulin concentrations in terms of both favorable and adverse comments results on insulin release. Their results show up to operate at the level of the plasma membrane secretory blister boundary.

About Products:
If you need Sodium isethionate as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Sodium isethionate, ZSpharmac will provide Sodium isethionate raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Cosmetic raw materials
Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.