Sodium Hyaluronic Acid CAS 9067-32-7

Molecular Formula: C14H22NNaO11

Formula Weight: 403.31

ZSpharmac: Sodium Hyaluronic Acid Supplement

Product Name: Sodium Hyaluronic Acid

CAS No: 9067-32-7

Purity: 99%

Basic Info

Product Name:	Sodium Hyaluronic Acid
Other Names:	Sodium Hyaluronate
CAS:	9067-32-7
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Daily Chemical Raw Materials
Appearance:	White to Cream Powder
EINECS No.:	618-620-0
Storage:	-20°C
Provide:	Sodium Hyaluronic Acid MSDS； Sodium Hyaluronic Acid COA

What is Sodium Hyaluronic Acid ?

Sodium Hyaluronic Acid is a non-drug neutral medium. Salt Hyaluronic Acid shot is a colorless as well as clear thick liquid. Sodium Hyaluronic Acid is the primary element of joint synovial liquid and among the components of cartilage matrix. It plays a lubricating duty in the joint tooth cavity, decreases friction in between cells, as well as at the same time applies its elastic effect to buffer the effect of tension on articular cartilage. carry out proper physical functions. Sodium Hyaluronic Acid with high molecular weight, high concentration and also high viscoelasticity in the joint cavity can dramatically improve the inflammatory feedback of the joint, improve the viscosity and lubricating feature of the synovial liquid, protect the articular cartilage, advertise the healing and also regrowth of the articular cartilage, alleviate Pain, raised joint movement. The general dosage of salt hyaluronate for joints is: 1ml (10mg) for temporomandibular joint, 2ml (20mg) for shoulder joint, as well as 2.5 ml (25mg) for hip and also knee joint. Primarily made use of for the therapy of degenerative osteoarthritis, chronic terrible joint inflammation, rheumatoid or rheumatoid joint inflammation, temporomandibular joint inflammation, aseptic necrosis of the femoral head, etc.

Sodium Hyaluronic Acid Properties:

alpha	D25 -74° (c = 0.25 in water): Rapport et al., J. Am. Chem. Soc. 73, 2416 (1951)
storage temp.	-20°C
solubility	H₂O: 5 mg/mL, clear, colorless
form	Powder
color	White to cream
PH	pH(2g/l,25℃) : 5.5～7.5
Water Solubility	SOLUBLE

Sodium Hyaluronic Acid Uses

Hyaluronic acid (HA), likewise known as hyaluronic acid, is a straight polymer acidic mucopolysaccharide composed of D-glucuronic acid (GlcA) and N-acetylglucosamine (GlcNAc) alternately linked by disaccharide systems. Business HA is normally its sodium salt, namely salt hyaluronate (sodium hyaluronate).

Sodium Hyaluronic Acid is widely present in the body, with high material in joint tooth cavity, skin, glasslike body, cartilage, umbilical cable as well as rooster comb. A a great deal of researches have actually found that Sodium Hyaluronic Acid has lots of physical features, such as managing cell-to-cell adhesion, positioning, differentiation, promoting cell expansion as well as activity, as well as joining hydrating, lubrication, wound recovery, cells fixing as well as regeneration, inflammatory feedback, embryonic organic procedures such as growth and tumor.

Presently, the application areas of Salt Hyaluronic Acid in my country are mostly concentrated in the pharmaceutical, scientific diagnosis and therapy as well as cosmetic markets, accounting for more than 98% of the complete consumption. In the field of medicine, it is extensively used in different sensory surgical treatments, such as lens implantation, corneal transplantation as well as anti-glaucoma surgical procedure. The skin function can maintain the skin moist and also smooth, delicate as well as tender, elastic, as well as has the features of anti-wrinkle, anti-wrinkle, beauty care and restoring the physical function of the skin. Sodium hyaluronate is seen in other items.

However, in the “Announcement of the Ministry of Health on the Approval of 7 New Resource Foods including Lactobacillus acidophilus” (Announcement of the Ministry of Health, No. 12, 2008), the Ministry of Health approved Sodium Hyaluronic Acid as a new resource food, and now it is renamed as a new food. resource. The so-called new food raw materials refer to the following items that have no traditional eating habits in my country: animals, plants and microorganisms; ingredients separated from animals, plants and microorganisms; food ingredients whose original structure has been changed; other newly developed food raw materials.

Sodium Hyaluronic Acid is a constituent substance of the body, so it has a high biological safety. In recent years, there are more and more studies on the absorption, metabolism and efficacy of oral sodium hyaluronate at home and abroad, and a large number of scientific evidences affirm the efficacy of oral Sodium Hyaluronic Acid .

Physiological Function of Sodium Hyaluronic Acid

Sodium Hyaluronic Acid is the main component of the intercellular and extracellular matrix, which maintains the normal structure and function of cells. Sodium Hyaluronic Acid can bind 1000 times its weight of water, and its water retention performance is positively related to its concentration and molecular weight. It is currently recognized as the natural moisturizing agent with the strongest water retention capacity, and is widely used in the cosmetics industry; HA is a synovial fluid in the joint cavity of organisms Its good viscoelasticity and lubricity can reduce the pressure and wear of joints when the body moves; sodium hyaluronate can form a clot with fibrin to play a structural function in the process of wound healing, and can promote the formation of granulocytes. Phagocytosis activity, regulates inflammatory response, and low molecular weight sodium hyaluronate produced by local degradation can promote angiogenesis; we currently know that sodium hyaluronate can protect cells, affect cell movement, proliferation and differentiation, and affect cell phagocytosis.

Second, The Health Effect Of Oral Sodium Hyaluronic Acid

Sodium Hyaluronic Acid, as a natural constituent of living organisms, has only 15 g in the normal human body, but it plays a huge role in maintaining the normal function of the human body and delaying aging. Humans have the highest HA content in the embryonic period and gradually decrease with age. If the relative content of HA in the body is set at 100% at the age of 20, it will drop to 65%, 45% and 25% at the age of 30, 50 and 60, respectively. The HA content in people of the same age is also different. People with progeria have significantly lower HA content in their bodies, showing many symptoms of aging. The reduction of HA can lead to many problems such as arthritis, skin aging, increased wrinkles, presbyopia, etc. Therefore, the content of sodium hyaluronate in the body can be regarded as the scale of human aging. At present, oral Sodium Hyaluronic Acid supplementation with endogenous hyaluronic acid is considered to be an effective way for beauty care and longevity.

In the late 1980s, oral Sodium Hyaluronic Acid beauty and health food appeared in Japan. The theoretical basis is: after oral digestion and absorption of sodium hyaluronate, it increases the precursor of hyaluronic acid synthesis in the body, so that the content of hyaluronic acid in the body increases and is concentrated in the skin tissue, thereby enhancing the skin’s water retention capacity and softening the skin keratin. layer to improve skin elasticity and reduce wrinkles. Cosmetics containing sodium hyaluronate only act on the surface of the skin for local moisturizing, while oral sodium hyaluronate increases the content of endogenous hyaluronic acid through the degradation, absorption and resynthesis of exogenous hyaluronic acid, and activates Cells in the whole body, play an overall beauty and health care effect.

Toxicological Study on Oral Administration of Sodium Hyaluronic Acid

From the early animal tissue extraction method to the current mainstream of industrial production – fermentation method, the production of Sodium Hyaluronic Acid has experienced a series of changes from raw materials to technology. The development of production has further broadened the application field of Sodium Hyaluronic Acid, and related research on the oral properties of Sodium Hyaluronic Acid has also been widely carried out. It has been reported in the literature that there is no species difference between different sources of sodium hyaluronate, which is the difference between Sodium Hyaluronic Acid and other polysaccharides. Animal experiments have shown that sodium hyaluronate is not an antigen, and it has been confirmed that the potential allergic reaction of hyaluronic acid in humans is negative. The acute toxicity test of rats shows that oral administration of sodium hyaluronate 500mg/kg body weight has no antigenicity, no allergic reaction, no teratogenic, mutagenic and carcinogenic effects. The oral LD50 of bovine hyaluronate to mice is greater than 10 g/kg body weight, and it is of low toxicity according to the acute toxicity grading standard. Oral experiments show that Sodium Hyaluronic Acid is an actual non-toxic substance. Since sodium hyaluronate is a natural component in the human body, and sodium hyaluronate prepared by different processes has no species difference, oral sodium hyaluronate has high safety.

There are many examples of the application of Sodium Hyaluronic Acid in the beauty industry at home and abroad, and subcutaneous injection is generally used to eliminate facial wrinkles and increase skin elasticity. Some consumers who pay attention to beauty and health care have found that oral sodium hyaluronate products on the market can easily achieve similar results. Because oral administration is the most convenient and comfortable way of administration, countries all over the world, especially Western countries, are racing to develop oral medicines or health foods containing sodium hyaluronate. Today, oral sodium hyaluronate is used as an anti-aging product in addition to joint health.

The Role and Efficacy of Sodium Hyaluronic Acid in Cosmetics

Method/Step
First, what is Sodium Hyaluronic Acid? Hyaluronic acid is an acidic mucopolysaccharide. In 1934, Meyer, a professor of ophthalmology at Columbia University, first isolated the substance from the vitreous body of the bovine eye. With its unique molecular structure and physicochemical properties, hyaluronic acid shows a variety of important physiological functions in the body, such as lubricating joints, regulating the permeability of blood vessel walls, regulating proteins, water and electrolyte diffusion and operation, and promoting wound healing.
Second, the role and efficacy of Sodium Hyaluronic Acid in cosmetics,
1. Moisturizing effect, the hyaluronic acid of the skin starts to lose after the age of 25. At the age of 30, only 65% of the infancy is left, and only 25% at the age of 60. The moisture of the skin will also be lost along with the hyaluronic acid. Loss of elasticity and luster, aging phenomenon of wrinkles will appear for a long time. The use of cosmetics containing hyaluronic acid can supplement and store the skin’s moisture, restore and maintain the youthful luster of the skin.
2. Repair damaged skin. After the skin is exposed to the sun, the ultraviolet rays in the sun can cause erythema, dermatitis, peeling and other phenomena caused by skin burns. Sodium hyaluronate can promote the proliferation and division of epidermal cells and scavenge oxygen free radicals. It can promote the regeneration of the skin in the injured area.
3. Skin care after acid brushing. After brushing acid, the skin is dehydrated, sensitive and bursting. The use of functional cosmetics will aggravate the sensitive skin care reaction. Hyaluronic acid can quickly replenish the skin. Therefore, after acid brushing, you can only choose hyaluronic Acid skin care.
4. Thickening, Sodium Hyaluronic Acid has high viscosity in aqueous solution, its 1% aqueous solution is gel-like, and it can thicken and stabilize when added to cosmetics.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

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FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

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You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

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Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

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1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.