Zhishang Chemical

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Zhishang Chemical

Sodium Ferulic CAS 24276-84-4

Molecular Formula: C10H9NaO4

Formula Weight: 216.17

ZSpharmac: Sodium Ferulic Supplier

Product Name: Sodium Ferulic
CAS No: 24276-84-4
Purity: 99%

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Basic Info

Product Name:Sodium Ferulic
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:1806241-263-5
Storage:Under Inert Gas (Nitrogen or Argon) at 2-8°C
Provide:Sodium Ferulic MSDS;
Sodium Ferulic COA

What is Sodium Ferulic?

Sodium Ferulate (SF), trademark name Angelica, is the sodium salt of Ferulic acid,The reliable monomer components shared by Chuanxiong are regularly found in Chinese clinical products such as angelica, Chuanxiong, propolis, and likewise jujube seed. Membrane layer stability, in addition to medical impacts such as anti-inflammatory, analgesic, anti-fertility, immune function law, liver benefit along with hydrating. It is generally used clinically to deal with different cerebrovascular illness, such as logical infarction, sequelae of analytical hemorrhage, short-term logical ischemia; in addition to cerebral arteriosclerosis, migraine, faintness, sleeping disorders, amnesia; to deal with coronary heart disease, expand coronary arteries, increase numerous other Blood flow, increasing myocardial nourishment; likewise taken advantage of for leukopenia, vasculitis and additionally benzene poisoning.

Sodium Ferulic Property

storage temp. under inert gas (nitrogen or Argon) at 2-8°C


Sodium Ferulic Uses

Sodium Ferulate is used for the therapy of coronary heart disease, ischemic encephalopathy, leukopenia as well as thrombocytopenia.

Pharmacological Effects of Sodium Ferulate

1. Antiplatelet effect
(1) Anti-platelet aggregation effect
(2) Inhibition of platelet release response
(3) Inhibition of platelet adhesion reaction Sodium Ferulate is a cyclooxygenase inhibitor, which inhibits platelet aggregation by reducing platelet TXA2 production, which is similar to aspirin, but the effect is not as strong and long-lasting as aspirin. However, angelica can increase platelet cAMP content, which is different from aspirin. Therefore, when the two drugs are administered in vivo to inhibit platelet aggregation to the same extent, angelica has no obvious effect on the generation of PGI2 in the blood vessel wall, while aspirin has an inhibitory effect on the generation of PGI2 in the blood vessel. This may be related to the fact that Sodium Ferulate inhibits platelet aggregation through cAMP metabolism in addition to AA metabolism.
2. Antithrombotic effect
(1) Anti-thrombotic effect Angelica element has obvious inhibitory effect on arteriovenous bypass thrombosis in rats.
(2) Anticoagulant effect Sodium Ferulate has mild anticoagulant effect.
3. Analgesic effect
Sodium Ferulate has an obvious pain-relieving effect on migraine patients, and its mechanism may be related to its mild analgesic effect in addition to inhibiting platelet AA metabolism and platelet 5-HT release.
4. Antispasmodic effect on vascular smooth muscle
Sodium Ferulate has antispasmodic effect on norepinephrine-induced spasm of isolated rabbit aortic strips. Angelica (10-4mol/L) has a mild antagonism effect on the spasm induced by norepinephrine, but has no effect on the vasoconstriction response induced by serotonin. Angelica’s mild vascular smooth muscle decomposing effect may be related to its relief of migraine symptoms, but it is not the main link of angelica’s efficacy.
5. Gallbladder-protecting and liver-protecting effect
6. Antioxidation and membrane stabilization
(1) Antioxidant and free radical scavenging effect
Sodium Ferulate has a mild inhibitory effect on erythrocyte membranes induced by oxygen free radicals, reducing the membrane lipid peroxidation product malondialdehyde. Angelica’s anti-lipid peroxidation mechanism has two aspects. On the one hand, it directly removes free radicals and reduces the damage of free radicals to the cell membrane; on the other hand, the combination of angelica and membrane phosphatidylethanolamine makes the membrane less susceptible to oxygen free radicals And peroxidation occurs. Phosphatidylethanolamine is richer in polyunsaturated fatty acids than other membrane phospholipids, and is most easily oxidized to produce malondialdehyde. The combination of angelica and phosphatidylethanolamine reduces the production of malondialdehyde.
(2) Membrane stabilization
Cell membrane stability is associated with membrane lipid peroxidation. Lipid peroxide can invade the red blood cell membrane and cause hemolysis. Angelica’s inhibition of lipid oxidation may have an effect on erythrocyte membrane stabilization. Sodium Ferulate has a stabilizing effect on red blood cell membranes and may be beneficial in paroxysmal nocturnal hemoglobinuria and hemolytic disease of the newborn.
7. Regulatory effect on immune function
Sodium Ferulate can enhance the function of phagocyte system. Angelica is the active ingredient of Angelica sinensis, a traditional Chinese medicine for nourishing blood. It is speculated that the nourishing blood of traditional Chinese medicine may be related to enhancing the immune function of the body. The enhanced phagocytosis function of angelica is beneficial to remove foreign antigens and maintain the stability of the body itself.
8. Other functions
Sodium Ferulate also has anti-inflammatory effect, which can inhibit the inflammatory reaction caused by various inflammatory agents, such as increased capillary permeability and tissue edema. It has antifertility effects on female or male animals. Angelica can also reduce the incidence of tongue cancer and precancerous lesions in rats with experimental tongue cancer; it can inhibit the pathogenic infection of HIV cells, and may provide clues for the treatment of AIDS.

The Preparation Method of Sodium Ferulate

The synthesis of sodium ferulate 53 grams of sodium carbonate (0.5 mol) is dissolved in 1000 milliliters of water, add 205 grams of ferulic acid (1.05 mol), stir rapidly on a boiling water bath until dissolved, filter while it is hot, let the filtrate cool, Precipitate flaky sodium ferulate crystals, filter, wash with ethanol, suck dry, and dry below 50°C. The reaction formula is shown in Figure 1.


About Products:
If you need Sodium Ferulate as a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced manufacturer and supplier of Sodium Ferulate, ZSpharmac will provide Sodium Ferulate raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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