Sodium Ferulic CAS 24276-84-4

1. Antiplatelet effect
(1) Anti-platelet aggregation effect
(2) Inhibition of platelet release response
(3) Inhibition of platelet adhesion reaction Sodium Ferulate is a cyclooxygenase inhibitor, which inhibits platelet aggregation by reducing platelet TXA2 production, which is similar to aspirin, but the effect is not as strong and long-lasting as aspirin. However, angelica can increase platelet cAMP content, which is different from aspirin. Therefore, when the two drugs are administered in vivo to inhibit platelet aggregation to the same extent, angelica has no obvious effect on the generation of PGI2 in the blood vessel wall, while aspirin has an inhibitory effect on the generation of PGI2 in the blood vessel. This may be related to the fact that Sodium Ferulate inhibits platelet aggregation through cAMP metabolism in addition to AA metabolism.
2. Antithrombotic effect
(1) Anti-thrombotic effect Angelica element has obvious inhibitory effect on arteriovenous bypass thrombosis in rats.
(2) Anticoagulant effect Sodium Ferulate has mild anticoagulant effect.
3. Analgesic effect
Sodium Ferulate has an obvious pain-relieving effect on migraine patients, and its mechanism may be related to its mild analgesic effect in addition to inhibiting platelet AA metabolism and platelet 5-HT release.
4. Antispasmodic effect on vascular smooth muscle
Sodium Ferulate has antispasmodic effect on norepinephrine-induced spasm of isolated rabbit aortic strips. Angelica (10-4mol/L) has a mild antagonism effect on the spasm induced by norepinephrine, but has no effect on the vasoconstriction response induced by serotonin. Angelica’s mild vascular smooth muscle decomposing effect may be related to its relief of migraine symptoms, but it is not the main link of angelica’s efficacy.
5. Gallbladder-protecting and liver-protecting effect
6. Antioxidation and membrane stabilization
(1) Antioxidant and free radical scavenging effect
Sodium Ferulate has a mild inhibitory effect on erythrocyte membranes induced by oxygen free radicals, reducing the membrane lipid peroxidation product malondialdehyde. Angelica’s anti-lipid peroxidation mechanism has two aspects. On the one hand, it directly removes free radicals and reduces the damage of free radicals to the cell membrane; on the other hand, the combination of angelica and membrane phosphatidylethanolamine makes the membrane less susceptible to oxygen free radicals And peroxidation occurs. Phosphatidylethanolamine is richer in polyunsaturated fatty acids than other membrane phospholipids, and is most easily oxidized to produce malondialdehyde. The combination of angelica and phosphatidylethanolamine reduces the production of malondialdehyde.
(2) Membrane stabilization
Cell membrane stability is associated with membrane lipid peroxidation. Lipid peroxide can invade the red blood cell membrane and cause hemolysis. Angelica’s inhibition of lipid oxidation may have an effect on erythrocyte membrane stabilization. Sodium Ferulate has a stabilizing effect on red blood cell membranes and may be beneficial in paroxysmal nocturnal hemoglobinuria and hemolytic disease of the newborn.
7. Regulatory effect on immune function
Sodium Ferulate can enhance the function of phagocyte system. Angelica is the active ingredient of Angelica sinensis, a traditional Chinese medicine for nourishing blood. It is speculated that the nourishing blood of traditional Chinese medicine may be related to enhancing the immune function of the body. The enhanced phagocytosis function of angelica is beneficial to remove foreign antigens and maintain the stability of the body itself.
8. Other functions
Sodium Ferulate also has anti-inflammatory effect, which can inhibit the inflammatory reaction caused by various inflammatory agents, such as increased capillary permeability and tissue edema. It has antifertility effects on female or male animals. Angelica can also reduce the incidence of tongue cancer and precancerous lesions in rats with experimental tongue cancer; it can inhibit the pathogenic infection of HIV cells, and may provide clues for the treatment of AIDS.