Sodium Dl Lactate CAS 312-85-6

Molecular Formula: C3H5NaO3

Formula Weight: 112.06

ZSpharmac: Sodium Dl Lactate Supplement

Product Name: Sodium Dl Lactate

CAS No: 312-85-6

Purity: 99%

Basic Info

Product Name:	Sodium Dl Lactate
Other Names:	Sodium Lactate
CAS:	312-85-6
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Organic Intermediate
Appearance:	Colorless or Slightly Yellow Syrupy Liquid
EINECS No.:	206-231-5
Storage:	Cool Dry Place
Provide:	Sodium Dl Lactate MSDS； Sodium Dl Lactate COA

What is Sodium Dl Lactate?

Sodium Dl Lactate is a colorless or slightly yellow transparent viscous liquid. The melting point is 17 ° C, and it is hygroscopic. Miscible with water, ethanol and glycerol. The aqueous solution has a neutral reaction. After inhalation, it can oxidize to generate carbonate ions and sodium ions to form sodium bicarbonate. The concentrated sodium hydroxide solution is added to the lactic acid solution of equal amount, boiled, and rapidly cooled to obtain it. It can also be used to alkalize urine required for acute urinary tract infections. But should prevent excessive alkalosis. It is commonly used in the preparation of Sodium Dl Lactate injection, compound Sodium Dl Lactate Ringer’s solution and various peritoneal dialysis solutions. As a weak organic acid salt, sodium lactate has not yet been included in the natural food preservatives. But as early as 2000, the United States Department of Agriculture allowed the addition of sodium lactate as a flavoring agent (addition <2%) and preservative (addition <4.8%) in food, and it is “generally regarded as safe” stipulated by the US Food and Drug Administration. (generally recognized as safe, GRAS) additives. Sodium lactate was first used in the field of food preservation around 1988. Adding Sodium Dl Lactate to unfrozen fresh pork has the effect of inhibiting bacterial growth. In 1989, Sodium Dl Lactate was added to other meat products, and it was found that sodium lactate could inhibit the growth of Streptococcus and Staphylococcus. As a natural flavoring agent, emulsifier, antifreeze, preservative, etc., Sodium Dl Lactate has gradually replaced chemical preservatives such as sodium benzoate in the foreign food industry.

Sodium Dl Lactate Properties:

Melting point	163-165 °C(lit.)
density	1.33
refractive index	1.422-1.425
storage temp.	2-8°C
form	syrup
color	50 APHA max.

Sodium Dl Lactate Uses

Sodium Dl Lactate is a brand-new type of antibacterial and also preservative, which is generally made use of in meat as well as poultry products, and has a strong repressive impact on meat food microorganisms, such as Escherichia coli, botulinum, Listeria monocytogenes, and so on. Inhibition of pathogenic bacteria, thus boosting food safety, improving as well as enhancing meat taste, as well as extending shelf life. Additionally, salt lactate also has a fresh-keeping impact on pasta items.
Sodium Dl Lactate is made use of as a medication to eliminate acidosis brought on by diarrhea, dehydration, diabetes mellitus, nephritis and also other illness.Also used as condiment, plasticizer of casein plastic, antifreeze, moisturizing agent, substitute for glycerin, corrosion inhibitor for alcohol antifreeze.

Preparation of Sodium Dl Lactate

The method for extracting Sodium Dl Lactate from calcium lactate-containing fermented liquor comprises the following steps:

(1) the calcium lactate-containing fermentation liquid is heated to 60～100 ℃, and the pH value is adjusted to 7～12, and the calcium lactate filtrate is obtained by filtration;

(2) Concentrate the calcium lactate solution until the lactate content is 200～500g/L, add sodium carbonate and/or sodium hydroxide, react at 40～100°C for 0.5～4 hours, make calcium ion precipitation completely, filter calcium carbonate or hydrogen calcium oxide to obtain sodium lactate solution;

(3) adding the activated carbon of 0.3wt%～3wt% to the Sodium Dl Lactate solution, decolorizing at 60～100 ℃ for 15～60 minutes, and filtering to obtain the sodium lactate filtrate;

(4) the Sodium Dl Lactate filtrate obtained by step (3) is processed by resin to remove impurities such as polyvalent metal ions; the Sodium Dl Lactate solution after resin purification can be selectively processed by membrane filtration;

(5) the Sodium Dl Lactate solution of preliminary purification is processed by electrodialysis, so that sodium lactate and impurities are effectively separated to obtain pure sodium lactate solution;

(6) The pure Sodium Dl Lactate solution is concentrated to obtain a qualified product with a mass fraction of 40% to 80%.

The Antibacterial Mechanism of Sodium Dl Lactate

At present, the understanding of the antibacterial mechanism of Sodium Dl Lactate is very limited. Based on the existing research, the components that play a bacteriostatic effect are explained as follows.
1) Sodium Dl Lactate molecule
It was observed by transmission electron microscope that when Salmonella was treated with 3200AU/mL cerein8A and 200mmol/L Sodium Dl Lactate, the cell wall was destroyed, protoplasts flowed out, and the substances inside and outside the membrane could not be transported normally. It is further proved that sodium lactate destroys the structural integrity of bacterial cell membrane and inhibits the normal synthesis of intracellular ATP. Sodium lactate enters bacterial cells and acts on the anaerobic respiration pathway, reducing intracellular energy synthesis and inhibiting bacterial growth and reproduction.
2) Lactic acid molecule
The large accumulation of intracellular anions is the main reason for inhibiting bacterial growth, and the concentration of intracellular anions is affected by the concentration of extracellular anions and pH value. Therefore, the effective antibacterial component in the Sodium Dl Lactate solution is the undissociated acid. After the cells are treated with Sodium Dl Lactate, the anions in the extracellular environment increase and the pH value decreases. Due to the permeability of the cell membrane, a large amount of intracellular anions are accumulated, the environment is acidified, and the metabolism is rapidly reduced, thereby inhibiting the growth of bacteria. Crist et al. believed that sodium lactate has a weak ability to be a fat-soluble acid. It enters the cell through the cell membrane in a non-dissociated form, and then dissociates in the cell to generate lactic acid molecules, acidify the cytoplasm, and rapidly reduce cell metabolism, resulting in slow bacterial growth. even death.
3) Lactate
Comparing Sodium Dl Lactate and sodium chloride, the results show that when the water activity is reduced to the same level with these two salts, Sodium Dl Lactate has a stronger inhibitory effect on the growth of Salmonella and Staphylococcus aureus, which indicates that lactate roots have a strong effect on the growth of microorganisms. Reproduction has a special inhibitory effect. Lactate ions affect the formation of electrochemical proton gradients in Salmonella and Staphylococcus aureus, and this formation plays an important role in microbial metabolism; due to the obstacles in the formation of electrochemical proton gradients, microorganisms need to consume more energy, making them energy-deficient. affect its growth and reproduction.

Sodium Dl Lactate precautions

1. Contraindications: Patients with heart failure and acute pulmonary edema, patients with cerebral edema, patients with severe lactic acidosis, patients with severe hepatic insufficiency, and severe renal failure.

2. Use with caution in patients with edema accompanied by sodium retention tendency, mild to moderate renal insufficiency, hypertensive patients, cardiac insufficiency, hepatic insufficiency, hypoxia and shock patients, patients with occult cardiac and renal insufficiency. Elderly patients, patients with beriberi, patients with alcoholism, salicylic acid poisoning or type I glycogen deposition disease, patients taking biguanides for diabetes or diabetic ketoacidosis, the elderly, pregnant women with pregnancy-induced hypertension syndrome.

3. After the application of this drug to correct acidosis in patients with hypocalcemia, symptoms such as numbness of hands and feet, pain, twitching and dyspnea often occur due to the decrease of serum calcium ion concentration. Others include increased heart rate, chest tightness, shortness of breath, increased blood pressure, weight gain, edema, hypokalemia, anxiety, panic, sweating, paresthesia, tremor, dizziness, etc.

4. Blood gas analysis or carbon dioxide binding capacity, serum sodium, potassium, calcium, and chloride concentrations, renal function, including serum creatinine, blood urea nitrogen, etc., should be checked or monitored. Blood pressure, cardiopulmonary function, venous or central venous pressure if necessary, liver function.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.