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Sodium Cyclamate CAS 139-05-9

Molecular Formula: C6H14NNaO3S

Formula Weight: 203.23

ZSpharmac: Sodium Cyclamate Supplier

Product Name: Sodium Cyclamate
CAS No: 139-05-9
Purity: 99%

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Basic Info

Product Name:Sodium Cyclamate
Other Names:Sodium N-Cyclohexylsulfamate
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:White Powder
EINECS No.:205-348-9
Storage:Room Temp
Provide:Sodium Cyclamate MSDS;
Sodium Cyclamate COA

What is Sodium Cyclamate?

Sodium Cyclamate is a synthetic artificial sweetener that’s 30 to 50 times sweeter than sugar– the least sweet of all artificial sweeteners. Sodium Cyclamate does leave an aftertaste, though not as much as various other artificial sweeteners like saccharin. Sodium Cyclamate is warmth secure as well as is typically utilized in baked items where other artificial sweeteners can not be used. Sodium Cyclamate is likewise used in mix with other sugar, specifically saccharin, to enhance palatability.

Sodium Cyclamate Property

Melting point >300 °C (lit.)
density 1.58[at 20℃]
vapor pressure 0.002Pa at 150℃
storage temp. room temp
solubility 200g/l
form Powder
color White
PH5.5-7.5 (100g/l, H2O, 20℃)
Water Solubility >=10 g/100 mL at 20 ºC


Sodium Cyclamate Uses

  1. Sodium Cyclamate is taken advantage of as a sweetener in food processing, as an additive in medications, cosmetics, and feed.
  2. Sodium Cyclamate pertains to 30 times sweeter than sucrose. Thin down 1:10000 (sucrose 1:140, saccharin 1:50000) can still feel the sweetness. Utilized as a non-nutritive sugar in various applications. The concentration needs to not go beyond 0.4%, in order to alleviate the rage. According to my nation’s GB2760-86 plans, it can be utilized for renewing drinks, gelato, breads as well as wonderful fruit. Furthermore, according to the supporting plans of GB2760-89, it can additionally be utilized as an additive for pickles, flavoring sauces, ready white wine, cakes, biscuits, skin tone, and so on.
  3. Sodium Cyclamate is a much more frequently utilized non-nutritive artificial sugar. It is not absorbed in the body, does not produce warm, as well as does not develop cavities. The preference is close to sucrose, and it is normally combined with sodium saccharin (10:1) to mask the anger of salt saccharin. It can be used in tangerine peel, managed plum, dried bayberry, and also plum, with a maximum use of 8.0 g/kg; in candied fruit, with a maximum use of 1.0 g/kg; in pickles, seasoning sauces, prepared white wine, beverages, popsicles, gelato, as well as gelato, cakes, biscuits in addition to bread optimum use of 0.65 g/kg.
  4. Sodium Cyclamate is a non-nutritive sweetener. Can be utilized in various facets, mostly for diabetics. The concentration needs to not surpass 0.4%, in order to decrease the anger.

Production Method of Sodium Cyclamate

Synthesis technique of cyclohexylamine and sulfur trioxide
This is the manufacturing technique of Baldwin-Montrose Chemical Firm in the United States.
( CH3) 3N+ SO3 →( CH3) 3NSO3 [C6H11NH2] → [NaOH] → C6H11NHSO3Na.
To start with, trimethylamine as well as sulfur trioxide are respectively liquified in tetrachlorethylene solvent, and afterwards combined and also responded to form a suspension of trimethylamine-sulfur trioxide complex. Then include this suspension to the aqueous option of cyclohexylamine as well as sodium hydroxide, and respond at 60 ~ 70 ° C to develop Sodium Cyclamate.
It is also possible to liquify 40g of liquid SO3 in 200mLCH2C12, and also include it dropwise to 150mL of an option having 56g of triethylamine at -10 ° C, and then react at a continuous temperature level for 15 mins to create a triethylamine sulfur trioxide complex. At 20 ° C, equimolar cyclohexylamine was added dropwise, and reacted for 1 hour. After the reaction was full, 250 mL of 10% NaOH solution was added, and also responded at 60 ° C for 1 hr. The liquid layer was divided and concentrated, cooled down, taken shape, filtered with suction and also dried to acquire the product with a yield of regarding 95%.
In addition, Nitto Chemical Company of Japan takes on the process path of gas stage response of sulfur trioxide and also cyclohexylamine.
Synthesis approach of cyclohexylamine and sulfamic acid (or salt).
Japan Jifu Pharmaceutical Co., Ltd. makes use of cyclohexylamine and salt sulfamate as raw materials to produce cyclamate at 180 ~ 200 ° C in a light oil solvent. After the response, the completed product is acquired through formation as well as recrystallization, and the mother alcohol is returned to the activator for reuse. The raw material of this method is simple to get, the procedure is basic, the solvent is simple to recover, and also the yield is high.
According to domestic study records on the optimization of the procedure problems, add 25g of cyclohexylamine dropwise to a mixture of 10g of sulfamic acid and also 35g of light oil, react at 165 ° C for 3h, then cool down to below 130 ° C, and add 41g of 10% sodium bicarbonate solution The item was dissolved, and then distilled to recoup light oil and also cyclohexylamine, as well as finally the crude item was recrystallized, with a return of 97.5%.
C6H11NH2+ NH2SO3Na → C6H11NHSO3Na+ NH3 ↑.
Japan Toyo Chemical Co., Ltd. makes use of cyclohexylamine and sulfamic acid as basic materials to produce cyclamate at 160 ~ 179 ° C in o-dichlorobenzene, as well as the response temperature level of the second step is managed listed below 130 ° C. The unreacted cyclohexylamine as well as o-dichlorobenzene are distilled out with water vapor as well as recycled, and the reactant is crystallized and also recrystallized to acquire the completed product. The raw materials of this approach are cheap and very easy to get, the solvent is easy to recover, the response time is short, and the yield is high.
2CaH11NH2+ NH2SO3H → C6H11NHSO3NH3C6H11 [NaOH] → C6H11NHSO3Na.
Synthesis method of cyclohexylamine as well as chlorosulfonic acid This is the manufacturing method of a Japanese firm.
2C6H11NH2+ ClSO3H [< 5 ℃ = → C6H11NHSO3NH3C6H11 [NaOH] → C6H11NHSO3Na After response, 95% of the finished product is acquired by splitting up, focus as well as extraction. The raw materials of this approach are cheap as well as the reaction is fast, yet there are many side reactions and the tools is seriously corroded.

Effects of Sodium Cyclamate and Sodium Saccharin on Extravesical Effects in Rats

The tumor-promoting task of Sodium Cyclamate and salt saccharin was checked out in an assay based on the induction of epithelial emphases showing improved growth capacity in a rat bladder explant society system. A beginning, non-focal induction dose was specified for the carcinogen N-methyl-N-nitrosourea (MNU) to allow facilitation research studies. Saccharin induces epithelial emphases when included in cultures pretreated with a beginning dosage of MNU and also raises the occurrence of foci in cultures treated with a transforming dose of MNU. When Sodium Cyclamate was included alone to the cultures, cyclamate was located to generate a high incidence of sores. An additive effect could be discovered when MNU and Sodium Cyclamate therapies were incorporated. These outcomes suggest that both cyclamate and also saccharin can promote epithelial cell change in this system.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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