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Sodium Bis(trimethylsilyl)Amide CAS 1070-89-9

Molecular Formula: C6H18NNaSi2

Formula Weight: 183.37

ZSpharmac: Sodium Bis(trimethylsilyl)Amide Supplement

Product Name: Sodium Bis(trimethylsilyl)Amide
CAS No: 1070-89-9  
Purity: 99%

Basic Info

Product Name:Sodium Bis(trimethylsilyl)Amide
Other Names:SodiuM Bis(triMethylsilyl)aMide, 2M soln. in THF
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Organic Chemical raw Materials
Appearance:Clear Orange to Brown Liquid
EINECS No.:213-983-8
Provide:Sodium Bis(trimethylsilyl)Amide MSDS;
Sodium Bis(trimethylsilyl)Amide COA

What is Sodium Bis(trimethylsilyl)Amide?

Sodium bis(trimethylsilyl)amide, commonly known as NaHMDS (sodium hexamethyldisilazide), is a strong base often used for deprotonation in reactions or as a catalyst in alkaline reactions. The advantage of this compound is that it can be a solid reagent and is soluble in a wide range of aprotic solvents, such as tetrahydrofuran, ether, benzene or toluene, and has a very strong basicity but poor nucleophilicity. Two bulky and lipophilic trimethylsilyl (TMS) groups prevent it from participating in nucleophilic substitution reactions.

Sodium Bis(trimethylsilyl)Amide Properties:

Melting point 171-175 °C (lit.)
Boiling point 67°C
density 0.904 g/mL at 25 °C
Fp 43 °F
storage temp. 2-8°C
solubility Soluble in hexane, toluene, ether,terahydrofuran, benzene and toluene.
form Liquid
color Clear orange to brown
Specific Gravity0.9
Water Solubility reacts


Sodium Bis(trimethylsilyl)Amide Uses

  1. Sodium bis(trimethylsilyl)amide is a non-nucleophilic strong base that can be used for the synthesis of pharmaceutical intermediates.
  2. Sodium bis(trimethylsilyl)amide (NaHMDS) is a representative of the homologous compound, as well as lithium bis(trimethylsilyl)amide (LiHMDS) and potassium bis(trimethylsilyl)amide (KHMDS). They are very widely used large sterically hindered strong base reagents in organic synthesis, and bis(trimethylsilyl)amino has pKa=29.5 in tetrahydrofuran. Compared with lithium diisopropylamide (LDA), it has weaker basicity, but it is very convenient to operate and use. It has good solubility in most organic solvents and can be used in a wide temperature range from –78°C to the reflux temperature of toluene to adjust its reactivity. Its chemical reactivity is very similar to LDA, and it is often used to generate carbanions and enolates.

Application of Sodium Bis(trimethylsilyl)Amide

NaHMDS is widely used to neutralize C-H acids. Some typical examples: deprotonation of ketones and esters to give their enol derivatives.
By dehydrohalogenation of CH2X2 (X=Br, I), halogenated carbene like CHBr and CHI forms are obtained. These carbene compounds can be added to olefins to obtain substituted cyclopropane compounds.
Georg Wittig reagents are prepared by deprotonation of quaternary ammonium salts.
Deprotonation of cyanohydrin.
NaHMDS can also be used as a neutralizing base for N-H type acids.

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
  • Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

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