Zhishang Chemical

Welcome to Zhishang Chemical      +86-176 5311 3209     Simon@sdzschem.com

Zhishang Chemical
Close this search box.

Sodium Acetylated Hyaluronate CAS 158254-23-0

Molecular Formula: N/A

Formula Weight: 0

ZSpharmac: Sodium Acetylated Hyaluronate Supplier

Product Name: Sodium Acetylated Hyaluronate
CAS No: 158254-23-0
Purity: 99%

Navigation Bar

Basic Info

Product Name:Sodium Acetylated Hyaluronate
Other Names:Sodium Acetylated Hyaluronate in Skin Care
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Colorless Viscous Liquid
Provide:Sodium Acetylated Hyaluronate MSDS;
Sodium Acetylated Hyaluronate COA

What is Sodium Acetylated Hyaluronate?

Hyaluronic acid (HA), also known as hyaluronic acid, is composed of (1-3)-2-N-acetylamino-2-deoxy-D-glucose-(1-4)-O-β-D-glucose It is an acidic straight-chain polymucopolysaccharide formed by the repeated arrangement of the disaccharide of uronic acid. It has strong hydrophilicity and very good moisturizing properties. It is widely present in the cytoplasm of animal tissue cells and the membrane of some bacteria. In medicine, cosmetics and food, it is also recognized as the most ideal natural moisturizing factor by the international cosmetics industry.

With the continuous improvement of life, the quality of products required in life is rising, and there is no doubt about the moisturizing properties of HA. But the moisturizing time is not so ideal. In a high-paced life, it is impossible for people to touch up makeup and moisturize the skin frequently. So Sodium Acetylated Hyaluronate can solve this problem. Sodium Acetylated Hyaluronate not only has good hydrophilicity, but also has good lipophilic effect. Sodium Acetylated Hyaluronate exists in the skin in the form of a semi-mosaic structure, and the lipophilic section is attached to the epidermis section, which can be firmly attached to the skin due to its lipophilicity. At the same time, acetylated HA with small molecular weight can act on the human epidermis, and has a significant effect on skin moisturizing, skin repairing and increasing skin elasticity.

Sodium Acetylated Hyaluronate Efficacy and Action

Sodium Acetylated Hyaluronate is an acidic mucopolysaccharide that naturally exists in the corneal epidermis and can absorb 1,000 times its own weight in water to achieve skin moisture retention, prevention of water loss through the epidermis, and barrier repair when the skin is damaged. After use, the skin will certainly not feel completely dry and rise radiance. It can boost skin nutrition metabolic rate, make skin soft, smooth, wrinkle-free, boost flexibility, prevent aging, and is an excellent transdermal absorption booster while hydrating. Made use of in conjunction with various other nutrients, it can play a much more optimal result of promoting nutrition absorption.


Preparation Method of Sodium Acetylated Hyaluronate

A prep work technique of Salt Acetylated Hyaluronate, making up the complying with steps:
( 1) hyaluronic acid or its salt in acetic acid and acetic anhydride blended solvent, carry out acylation response under the catalysis of vitriol oil;
( 2) after the reaction is ended up, the response fluid is added into water for precipitation, the coarse precipitation is collected, as well as the acetylated hyaluronic acid is obtained after washing with water;

( 3) The pH worth of the acetylated hyaluronic acid in step (2) is adapted to be nearly neutral with alkaline remedy, as well as after being diluted with water, filteringed system and also spray-dried to get the acetylated salt hyaluronate.

Wherein, the hyaluronic acid salt is sodium salt, potassium salt, magnesium salt, calcium salt, zinc salt or ammonium salt of hyaluronic acid, and the molecular weight is 50-3000kDa.

Wherein, the proportion of acetic acid as well as acetic anhydride blended solvent in the blended solvent in the described action (1) is 1:1 ~ 4(v/v); the proportion of hyaluronic acid or its salt to the blended solvent is 1:10 ~ 50 (w/v); the quantity of concentrated sulfuric acid made use of make up 1% to 5% of the complete quantity of the reaction solution.

Wherein, the acylation response temperature of the step (1) is 5-40 ° C., and also the response is finished when the response solution is transparent.

Wherein, the amount of water made use of in the precipitation as well as washing in step (2) is respectively 2 to 20 times the complete quantity of the reaction solution.

Wherein, in step (3 ), the lye service is a remedy consisting of salt hydroxide, sodium carbonate, sodium bicarbonate, sodium phosphate or disodium hydrogen phosphate, and the changed pH worth is 4-8, preferably 5-7.

Wherein, symphonious (3 ), the proportion of the total volume of the Sodium Acetylated Hyaluronate remedy to the hyaluronic acid or its salt after being weakened with water is 5-50 mL:1 g.

Wherein, symphonious (3 ), the inlet air temperature of the spray drying out devices is 100-200 ° C, and the outlet air temperature is 70-120 ° C.

The Sodium Acetylated Hyaluronate prepared by the above technique has an average replacement level of acetyl team of 2.5 to 3.7, preferably 2.8 to 3.5, ideally 2.9 to 3.4, a lot more ideally 3.0 to 3.3; inherent viscosity is 0.1 to 2.3 dL/g, preferably 0.3 to 1.5 dL/g, more ideally 0.5 to 1.2 dL/g. Extensively utilized in the preparation of medications, cosmetics, clinical materials and feed ingredients.

Preparation Method of High Degree of Substitution Sodium Acetylated Hyaluronate

At present, the acetylation reaction is also described in detail in various textbooks. Among them, the active methylene compound is C-acylated at the α-position, and a strong base or strong acid is often used as a catalyst, and then reacted with an acylating agent, and acid chloride and acid anhydride are commonly used. As acylating reagents, carboxylic acids, acyl imidazoles, etc. are also used.

The invention discloses a preparation method of acetylated sodium hyaluronate with high substitution degree, which is characterized in that hyaluronic acid is prepared through I activation separation, II dehydration reaction and III acylation reaction, and I activation separation adopts triethylamine Ⅱ dehydration reaction is carried out with acetic anhydride under low temperature conditions with cobalt 60 radiation-assisted dehydration; described Ⅲ acylation reaction is carried out with catalyst and acylation enhancer; the beneficial effects of the present invention are: Ⅰ activation separation operation improves The degree of acetylation is improved, and the introduction of impurities is reduced while activating; low temperature and cobalt 60 radiation are used to assist dehydration to reduce the dehydration reaction temperature, and acetic anhydride is used as a dehydrating agent, and the material generated after acetic anhydride absorbs water can participate in the subsequent process. In the acylation reaction of III, the introduction of impurities is reduced, and acetic anhydride avoids the environmental pollution caused by acid gas when adding materials in the subsequent process; the catalyst and enhancer are added to the acylation reaction of III, which greatly improves the degree of acetylation.

About Products:
If you need Sodium Acetylated Hyaluronate, a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
Our company, as an experienced Sodium Acetylated Hyaluronate manufacturer and supplier, ZSpharmac will provide Sodium Acetylated Hyaluronate raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, and customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Sodium Acetylated Hyaluronate Quotation