Soapnut Extract CAS 223748-41-2

Molecular Formula: NULL

Formula Weight: 0

ZSpharmac: Soapnut Extract Supplement

Product Name: Soapnut Extract

CAS No: 223748-41-2

Purity: 99%

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Basic Info

Product Name:	Soapnut Extract
Other Names:	Genistein
CAS:	223748-41-2
Place of Origin:	Shandong, China
Brand Name:	ZSpharmac
Type:	Cosmetic Raw Materials
Appearance:	White Powder
EINECS No.:	0
Storage:	-20°C
Provide:	Soapnut Extract MSDS； Soapnut Extract COA

What is Soapnut Extract ?

Sapindus Mukorossi Gaertn SMG (Sapindus Mukorossi Gaertn SMG). Sapindus japonica generally consists of saponin, fatty oil, protein as well as other elements. Sapindus mucous is created in hill forests, and all districts southern of the Yangtze River are produced. Sapindus sinensis is level in nature as well as bitter in preference. It has the functions of clearing warmth, expectorating phlegm, getting rid of build-up and also eliminating insects. Researches have actually revealed that Sapindus japonica has a good healing result on viral liver disease, Sapindus japonica has the impact of decreasing mouse liver microsomal cytochrome P-450, and also Sapindus japonica has antihypertensive and also cardioprotective effects. Current research studies have revealed that complete saponins from Sapindus japonica have antibacterial, antioxidant, anti-myocardial anemia and safety effects on ischemia-reperfusion injury.

Sapindus saponin and aglycone have solid surface task, these actives are neutral, easy to biodegrade, non-irritating to the skin, non-toxic and also safe to the body, as well as likewise have particular purification capability and also foaming. It is a natural non-ionic surfactant, which can minimize the surface area tension of water, has excellent frothing buildings, and has the qualities of strong detergency, sterilization, antipruritic, pure scent, and so on. It can be utilized as an all-natural energetic substance for It can likewise be utilized to deal with professional athlete’s foot and ringworm in natural hair shampoos and various cleaning skin treatment cosmetics. Sapindus saponin is additionally an excellent pesticide emulsifier, and it has an excellent murder impact on cotton aphids, red crawlers and sweet potato jinhua insects. In addition, Sapindus includes numerous compounds that are beneficial to the body, such as lowering sugars, fatty acids, oils, oleic acid, carotenoids, niacin, riboflavin, protein, vitamin C, vitamin A, vitamin B as well as lysine, More than 10 amino acids such as tyrosine, phenylalanine, glutamic acid, glycine and histidine. It can be made use of as an active component to prevent the task of butyrate in the whitening cream, and it is also made use of as an energetic ingredient of all-natural energetic materials in natural hair shampoos and different skin care cosmetics. With the enhancement of individuals’s understanding of environmental management, the natural active substances extracted from Soapnut have actually restored interest, and also many brand-new cleaning items made from the combination of Sapindus japonica and synthetic energetic substances are deeply enjoyed by individuals. In addition to excellent lathering and also decontamination residential or commercial properties, Sapindus japonica triterpenoid saponins have been verified to have antibacterial, bactericidal and also anti-inflammatory effects on human skin, in addition to dandruff as well as antipruritic effects.

Soapnut Extract Market Outlook

Sapindus japonica is a new type of comprehensive resource with great development and utilization value, and its application value is very broad. However, due to the late start of the research on Sapindus japonica in my country, compared with foreign countries, there is a large gap. It is still in its infancy and needs to be further researched, developed and utilized. At present, there are some key problems in the development of Sapindus mucus that need to be solved urgently.
(1) Accelerate the research on the selection of the best strains of Sapindus japonica and the rapid vegetative propagation technology research With the improvement of the comprehensive development and utilization value of Soapnut Extract, the demand for Sapindus japonica is also increasing. At present, most of Sapindus japonicas are directly planted from seedlings cultivated by seed sowing, resulting in poor performance, large inter-individual differences, and unstable traits, resulting in low yield, poor fruit quality, and low production efficiency, restricting the The development of Sapindus industry. Therefore, the lack of high-quality and high-yield fruit-type Sapindus japonica varieties, supporting seedling clonal rapid propagation technology and high-yield and high-efficiency cultivation technology have become the technical bottleneck of the development of the Soapnut Extract industry and the technical problem that needs to be solved urgently. Therefore, accelerating the collection, evaluation and identification of Sapindus japonica germplasm resources, the selection of fruit-type Sapindus japonica varieties and the research and promotion of asexual rapid propagation technology are the necessary technical guarantees for the rapid, sustainable and healthy development of the Soapnut Extract industry.
(2) Strengthening the research on the molecular biology of Sapindus japonica Sapindus saponins at home and abroad The research on Sapindus japonica saponins mainly focuses on cultivation management, biology, saponin structure, improvement of component extraction process, determination of active ingredient content and function (pharmacological action) Research. Although the scientific community has reached a consensus on the basic framework and related enzymes in the process of saponin synthesis, the research on the specific genes related to saponin synthesis is rarely reported. In the future, we will further study the biosynthetic pathway of triterpenoid saponin, the main component of Soapnut Extract, and its possible molecular regulation mechanism by cloning and isolating the key enzyme genes of Sapindus saponin synthesis pathway. Many research reports indicate that saponins can have antifungal, antimicrobial, and allelopathic effects, etc. However, the molecular mechanisms of resistance and toxicity behind them have not been fully elucidated, and further research is needed.

Soapnut Extract App

1. Drug area

Sapindus is a traditional Chinese organic medication in my nation. Its medicinal value was recorded as early as in the Compendium of Materia Medica by Li Shizhen in the Ming Empire. Its origins and also fruits can be utilized as medication, which can clear warmth and also cleanse, fix phlegm and also alleviate coughing; flowers can treat eye diseases; seeds can avoid foul breath; peels can be utilized for Aching throat, coughing and also asthma, food stagnation, leucorrhea, chancre build-up, aching ringworm, swollen toxin, as well as avoid dandruff. Medicinal research studies in recent times have actually shown that the fruit of Sapindus japonica is rich in saponins as well as has different physiological activities such as antibacterial, antifungal, and antitumor.

1) Anti-bacterial. The ethanol essence of Sapindus japonica has inhibitory impacts on Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Proteus vulgaris and also Helicobacter pylori (H. pylori), specifically for gastric ulcer, duodenal ulcer and also stomach cancer. The inhibitory result of related Helicobacter pylori is evident, and also it will not trigger medicine resistance. Pet experiments have revealed that dental ethanol remove of Sapindus japonica has anti-inflammatory and also anti-ulcer impacts, which is useful for the prevention and also treatment of stomach ulcer.

2) Antifungal. The research study located that the combination of Sapindus japonica mono-saponin as well as di-saponin has a substantial anti-dermatophyte impact, of which mono-saponin has a more powerful inhibitory effect, while di-saponin has no effect.

3) Anti-tumor. The methanol essence of Sapindus japonica has inhibitory effect on the spreading of mouse melanoma and also gastric cancer cells in human beings, of which monosaponins have tumor-inhibiting activity, while double saponins have no activity in all. The research study also revealed that 10 monosaponins with helexin as aglycon were cytotoxic to 6 human tumor cells.

4) Other physiological tasks. In addition to the a number of physiological tasks provided above, Sapindus japonica saponins additionally have antiviral, hepatoprotective, spermicidal, promotion of antibiotic absorption, antiplatelet gathering, and also hypotensive impacts. For that reason, Sapindus has fantastic prospective in the avoidance and treatment of stomach ulcers, arteriosclerosis, hypertension, cancer, AIDS and also various other diseases and also the growth of contraceptives.

2. Daily chemical area (hair shampoo).

Soapnut Remove (saponin) has strong surface activity and also is an all-natural non-ionic surfactant. Its degreasing ability is much better than that of industrial detergents, and also Sapindus saponin is easily weakened and also has no hazardous deposits, causing water bodies after use. Environmental pollution troubles such as contamination and ecological hormone deposits. Furthermore, Sapindus saponin has a broad-spectrum elution result on heavy metals, and also the elution price of lead, manganese, chromium, arsenic, mercury, and so on is greater than 90%. Along with its excellent purification effect, Sapindus japonica additionally consists of amino acids, vitamins and also various other natural nutritional conditioning substances, which have anti-bacterial, anti-inflammatory, anti-dandruff as well as antipruritic effects, as well as are less annoying to the skin, secure and also trusted. Including Soapnut Remove The cleaning impact of the hair shampoo without the enhancement of artificial conditioner, the hair is soft as well as shiny. Superior washing efficiency, excellent biodegradability, broad-spectrum anti-bacterial ability, and also rich dietary conditioning ingredients make Sapindus an invaluable capacity in the growth of environmentally friendly day-to-day chemical products such as organic cleaning agents and natural cosmetics.

Genivida Genistein Pharmacological Actions

1. Genivida Genistein and Cardiovascular Disease
Genivida Genistein plays a very important role in reducing the incidence of cardiovascular disease. Low-density lipoprotein cholesterol in the blood is high and easily oxidized, which can cause atherosclerosis. Genistein can effectively reduce cholesterol through its antioxidant effect, inhibit the oxidation of low-density lipoprotein cholesterol (LDL), and make LDL in the blood. Maintain a low level, improve the abnormal state of peroxidation in the body caused by high fat, and relieve the peroxidative damage to the body. Genistein can up-regulate LDL receptors and increase LDL receptor activity, thereby promoting cholesterol clearance. Genistein also has the effect of inhibiting the proliferation of smooth muscle cells and angiogenesis and inhibiting cell adhesion, thereby reducing the incidence of cardiovascular disease.

2. The role of Genivida Genistein and cranial nerves
The latest literature reports that genistein has the effect of promoting brain nerve regeneration and cerebral coma. Modern medical theory holds that when stroke (cerebral hemorrhage) and stroke (cerebral infarction) occur, a series of pathophysiological changes such as ischemia, hypoxia, degeneration and necrosis of brain tissue cells are closely related to the influx of large amounts of extracellular calcium ions in brain tissue. relationship; the overload of calcium ions in brain cells is one of the main causes of degeneration and necrosis of brain cells. The latest research found that after changing the route of administration, genistein can pass through the blood-brain barrier, and by affecting the Ca++ receptors of the brain cell membrane, it can protect brain cells when stroke (cerebral hemorrhage) and stroke (cerebral infarction) occur.

3. Genivida Genistein and Cancer
Genivida Genistein has inhibitory and therapeutic effects on a variety of cancers through ①antioxidant effect ②inhibition of tyrosine kinase activity ③inhibition of topoisomerase activity ④estrogen and antiestrogen-like effect ⑤reduce tumor angiogenesis.

4. Genivida Genistein and Radiation Resistance
Genivida Genistein (genistein) is a potent inhibitor of protein tyrosine kinase activity, and also possesses antioxidant and estrogen-like effects, said landauer working in the laboratory of the United States Armed Forces Radiobiology Research Institute (AFRRI). et al demonstrated that it is a radioprotectant and that genistein significantly increased the dose of whole body radiation in patients with fatal traumatic brain injury, whether administered subcutaneously 24 hours before irradiation or by gavage 4 days before irradiation or 4 days after irradiation ( 30-day survival of mice at 9.5 Gy).

In the United States, some people use genistein for the prevention and treatment of side effects of tumor radiation therapy (Bio 300) using its anti-radiation effect. It is reported in the literature that genistein was taken before traumatic brain injury (7.75Gy) irradiation. Also reduces lung damage in long-lived animals.

5. Genivida Genistein and Women’s Menopause Syndrome
Genivida Genistein has weak estrogenic activity and has the effect of estrogen. Studies have shown that in women’s menopause, due to ovarian degeneration and the reduction of estrogen in the body, women will experience a series of symptoms of menopausal syndrome, while the intake of quantitative genistein during menopause It can supplement the lack of estrogen in the body and play a role in preventing and reducing women’s menopausal syndrome. Experiments suggest that estrogen-like effect may be the main mechanism of genistein to prevent osteoporosis.

Physiological Effects of Soapnut Extract

1. Bactericidal Effect

The study found that the ethanol and chloroform extracts of Sapindus japonica can inhibit the proliferation of Helicobacter pylori at very low concentrations (10 mg/mL in vitro and 2.5 mg/mL in vivo), and Helicobacter pylori was continuously cultured for 10 generations. The bacteria also did not develop resistance to Soapnut Extract. Methanol extract of Sapindus japonica peel has obvious antibacterial activity against two fungi (Rhizoctonia bataticola Briton Jones and Sclerotium rolfsii Sacc.) (ED50 ranges from 181 to 407 µg/mL), and they also found that sugar-free saponins have no antifungal activity. , the antifungal activity of disaccharide chain saponins was significantly stronger than that of monosaccharide chain saponins, indicating that sugar chain is a necessary condition for the antifungal activity of triterpenoid saponins. The in vitro antibacterial activity of the ethanol extract of Sapindus japonica fruit on Candida albicans found that it can cause cell wall deformation, cell lysis, and cytoplasmic membrane rupture within 60 minutes, thus playing a bactericidal function. The total saponins of Sapindus japonica have good antibacterial activity against gram-negative bacteria, and the inhibitory effect on fungal growth is stronger than that on bacteria, in a dose-dependent manner. A bactericide is formulated with Sapindus sapindis and citrus fruit extract, which can inhibit WHO gonococcus and clinically isolated Neisseria gonorrhoeae (including penicillin, tetracycline, nalidixic acid and ciprofloxacin-resistant bacteria) and prevent HIV and HPV infection.

2. Anti-Tumor Effect

The methanol extract of Sapindus japonica peel has inhibitory activity on the proliferation of mouse melanoma B16F10, human cervical cancer HeLa and human gastric cancer MK-1 cells. The three types of tumor cells have the same degree of inhibition of proliferation, but the two saponins have no inhibitory activity at all, and the degree of inhibition of the proliferation of tumor cells by saponins is enhanced when the acetyl group binds to the sugar chain. The ethanol and n-hexane extracts of Sapindus japonica had strong anti-proliferation activities on cervical cancer HeLa and lung cancer A549 cell lines (IC50 ranged from 214.7 to 298.5 µg/mL). Oleanolic acid-type saponins isolated from n-butanol extract of Sapindus japonica fruit have moderate cytotoxic activity against human lung cancer A549, human breast cancer MDA-231 and human prostate cancer PC-3 cell lines. The total saponins of Sapindus japonica down-regulated the expression of bcl-2 gene in human lung cancer A549 cells, and then it was concluded that the mechanism of total saponins of Sapindus japonicas inhibiting the proliferation of A549 cancer cells might be the induction of apoptosis.

3. Protect Stomach and Liver

In addition to being used as a soap substitute in the United States, Sapindus mucus fruit is also used to treat inflammatory conditions such as skin lesions and ulcers; studies have shown that the fruit extract can reduce the amount of gastric secretions in pylorus-ligated mice, researchers speculate It may be that substances such as saponins and tannins play a role in fighting gastric ulcers. Studies have shown that Soapnut Extract has the ability to protect hepatocytes in vitro, and has a repair function to carbon tetrachloride-induced liver damage in mice in vivo; Sapindus ethanol extract can also regulate blood lipid levels and improve liver tissue pathology in NAFLD rats. Variety. Triterpene saponin compounds, such as oleanolic acid derivatives and ivy saponins isolated from Sapindus genus, have activity in preventing and treating ulcers. In vivo experiments, 20 mg/kg Sapindoside B (Sapindoside B) reduced hepatic cytochrome P-450 in mice by 55%. 450, but this reduction basically disappeared after 3 d.

3. Protect Stomach and Liver

The antioxidant activity test of different solvent extracts of Sapindus japonicas showed that the water extract of Sapindus japonica fruit has the strongest antioxidant activity, and the methanol extract of Sapindus japonica leaves contains the highest total flavonoid content, and both observed To the high redox potential, showing the possibility of Soapnut Extract as health food and medicine. At the same time, Soapnut Extract and β-lactam antibiotics were given to experimental animals by oral or rectal administration. It was found that Soapnut Extract can enhance the absorption effect and pharmacological activity of antibiotics during oral and rectal administration, and can prolong the concentration of antibiotics in blood. Time to maintain above the minimum effective concentration. The acid-base hydrolyzate of sapindus saponin was studied in the laboratory on antifeeding and growth regulation of the pest Spodoptera litura. The results showed that the hydrolyzate of sapindusin can show significant antifeeding effect and toxicity to the third stage larvae. The study also showed that the saponin SMG-1 isolated from Sapindus muscaria could inhibit the binding of FMLP and the corresponding receptors, and it has the potential to be developed as a therapeutic agent for the treatment of neutrophilic inflammation.

Company Profile and Corporate Culture

Company Profile：

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture：

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info

Business Type: Manufacturer
Product Range: Additive , Chemical Auxiliary & Catalyst , Organic Chemicals
Products/Service: Organic Intermediate,Inorganic Chemistry, APIs, Dyestuffs And Pigments, Fragrance And Spices, Food Additives
Total Employees: 51~100
Capital (Million US $): 10000000RMB
Year Established: 2016

Production Capacity

No. of Production Lines : 8
No. of QC Staff : 5 -10 People
OEM Services Provided : yes
Factory Size (Sq.meters) : 3,000-5,000 square meters
Certificate: ISO9001 , CE , GMP , API , MSDS
Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.