Sinomenine has been confirmed to have a specific analgesic impact in experiments making use of mouse electric excitement, warmer method and photothermal excitement. Supplying iP sinomenine 50 mg/kg and 100 mg/kg to mice can significantly increase the pain limit to photothermal excitement, and the intensity of the result amounts 1/25 of morphine. The mix with morphine generates consistency, showing that the concept of its analgesic result resembles that of morphine. Anesthetics are various. Sinomenine can lengthen the time of discomfort activity to photothermal exhilaration, reaching the optimum 6 to 8 days after taking the drug. The strength of its analgesic result follows the reduction of histamine in pet skin. If it is combined with histamine, the influence vanishes; if it is combined with promethazine, the outcome is improved. In addition to the main effect, the factor may also be that promethazine irritates the launch of histamine from sinomenine. Furthermore, cortisone and salicylic acid can likewise enhance the analgesic outcome of sinomenine, because corticosteroids and antipyretic anesthetics have membrane layer maintaining influences, shielding against sinomenine from harmful pole cells, hence preventing the release of histamine.
Although the chemical framework of sinomenine is similar to that of morphine, the analgesic concept is various from that of morphine. Subsequently, some people think that there is an opposition between the major and outer aspects of the analgesic result of sinomenine. It is assumed that the histamine released by sinomenine Might compromise its extremely own analgesic influence. Nonetheless, with continued medicine, histamine in the cells is slowly depleted, and the contradiction between the central and external body organs gradually vanishes, activating analgesia to reach a peak with the deficiency of histamine. This complies with expert reports that the analgesic impact of continuous medicine in clients is enhanced.