Zhishang Chemical

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Zhishang Chemical

Sinomenine CAS 115-53-7

Molecular Formula: C19H23NO4

Formula Weight: 329.39

ZSpharmac: Sinomenine Supplier

Product Name: Sinomenine
CAS No: 115-53-7
Purity: 99%

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Basic Info

Product Name:Sinomenine
Other Names:8-Didehydro-4-Hydroxy-3
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Light Yellow Crystalline Powder
EINECS No.:204-094-6
Storage:Store at +4°C
Provide:Sinomenine MSDS;
Sinomenine COA

What is Sinomenine?

Sinomenine is an alkaloid extracted from the completely dry walking sticks of the deciduous winding vines Sinomeniumacutum (Thunb.) Rehd.etWils and also Sinomeniumacutum (Thunb.) Rehd.etWilsvarcinereumRehd.etwils. Sinomenine has analgesic, antitussive, anesthetic, antihypertensive, anti-inflammatory, and also can launch histamine to inhibit smooth muscle mass task. It is scientifically utilized to treat various intense as well as chronic arthritis, rheumatism and also rheumatoid joint inflammation, bone Joint inflammation, synovitis, frozen shoulder, aged low neck and back pain, soft cells injury, numerous neuropathic discomfort, etc.
[Beginning] Qingfengteng is primarily produced in Southwest, Central South as well as East China.
[Morphological attributes] This product is long cylindrical, frequently somewhat curved, with a size of 0.5 to 2 cm. The surface is greenish brownish to tan, and also some are taupe, with fine longitudinal lines and also lenticels. Nodes somewhat enlarged, with branches. Light body, tough as well as breakable, easy to break, uneven random sample, gray-yellow or light gray-brown, narrow bark, xylem rays set up radially, pith light yellow-white or yellow-brown.
[Gathering along with refining] Harvest the stems as well as also creeping plants in spring as well as summer, eliminate the slim stems as well as likewise leaves, completely dry them in the sunlight, or dampen them with water, cut into sections, and also dry them in the sunlight.
[Chemical Structure] The main part of S. sinomenine is sinomenine, and also it likewise contains sinomenine, bis-sinomenine, tetrandrine, magnolanine, sitosterol, stigmasterol, etc.

Sinomenine Property

Melting point 180 °C (dec.)(lit.)
alpha D26 -71° (c = 2.1 in alc)
Boiling point 466.98°C (rough estimate)
density 1.2012 (rough estimate)
refractive index 1.5000 (estimate)
storage temp. Store at +4°C
solubility Soluble to 65 mg/mL (197.33 mM) in DMSO
form neat


Sinomenine Uses

  1. Sinomenine has several organic effects such as sedative, anti-inflammatory, anti-bacterial, anti-diabetic, anti-ulcer, and also decreasing blood sugar level. Ursolic acid likewise has obvious anti-oxidation function, as well as is widely used as a basic material for medication as well as cosmetics.
  2. Sinomenine has the features of eliminating wind and moisture, advertising blood flow as well as digging up collaterals, diuresis and also swelling.
  3. Sinomenine has an anti-inflammatory analgesic as well as is made use of in the treatment of rheumatism as well as rheumatoid joint inflammation.

Pharmacological Effects of Sinomenine

Clinical Application of Sinomenine

In 1974, my country began to use the rhizome of Ivy teng to treat rheumatoid diseases. In 1981, it was made into hydrochloride tablets. In 1983, Capital Hospital, Anshan Tanggangzi Physiotherapy Hospital, Shanghai Guanghua Hospital, and Xi’an Fifth Hospital jointly used ivy total alkaloids for treatment. 172 cases of rheumatoid disease achieved good results, the total effective rate was 90.3%. Our group adopted a dose of 120 mg/day, which was gradually increased to 300 mg/day within two weeks and maintained at this level for a total of three months. After treatment, the patient’s morning stiffness, grip strength, joint tenderness and joint swelling were significantly improved compared with the control group (p<0.05), and the effective rate was 83.3%. The most common reaction during the course of treatment is skin rash, which occurs at different times, and generally occurs 1-2 weeks after taking the medicine, and is more likely to occur on exposed parts. The eruption rate was about 46.7%. Followed by neutropenia (2/30 cases) can be recovered after drug withdrawal or reduction. In addition to the analgesic and anti-inflammatory effects of sinovine total alkaloids in the treatment of rheumatoid diseases, whether it has immune function regulation effects still needs to be further explored. We believe that the analgesic effect of total alkaloids of sinovine appears later than that of Tripterygium wilfordii, about 20 days after taking the medicine, and the curative effect is longer after stopping the medicine.

About Products:
If you need Sinomenine, a cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Sinomenine manufacturer and supplier, ZSpharmac will provide Sinomenine raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

Help China Chemicals to benefit the happiness of human life
Become the most trusted chemical supplier in the world
Striver – oriented, enrich employees, customer first, deep service, seek development
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.


Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.


After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.


Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.



You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.


1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Sinomenine Quotation