Zhishang Chemical

Welcome to Zhishang Chemical      +86-176 5311 3209     Simon@sdzschem.com

Zhishang Chemical
Search
Close this search box.

Silybin A CAS 22888-70-6

Molecular Formula: C25H22O10

Formula Weight: 482.44

ZSpharmac: Silybin A Supplier

Facebook
Twitter
LinkedIn
Pinterest
WhatsApp
Email
Product Name: Silybin A
CAS No: 22888-70-6
Purity: 99%

Navigation Bar

Basic Info

Product Name:Silybin A
Other Names:Silibinin
CAS:22888-70-6
Place of Origin:Shandong, China
Brand Name:ZSpharmac
Type:Cosmetic Raw Materials
Appearance:Pale Yellow Solid
EINECS No.:245-302-5
Storage:-20°C
Provide:Silybin A MSDS;
Silybin A COA

What is Silybin A?

Silybin A is a flavonoid lignan compound separated from the seeds of silybin, the plant of Compositae. The major active ingredients are silybin, isosilibin, silybin and also silybin These four isomers can stop damages to the liver caused by chemical contaminants, food toxins and also medicines, and also advertise the regrowth and also repair of liver cells. They are called “natural liver defense medications”. It is beige crystalline powder at space temperature level, odorless, somewhat bitter taste, hygroscopic, quickly soluble in acetone, ethyl acetate, methanol, ethanol, somewhat soluble in chloroform, virtually insoluble in water. Silybin A is likewise referred to as Liheparin, Milk Thistle, Total Flavonoids of Milk Thistle, Silymarin, Yiganling, Silymarin, and Ligalon. As early as 2000 years back, the old Chinese utilized milk thistle to treat liver along with gallbladder diseases., it has the noticeable function of securing as well as preserving the liver cell membrane layer; it has various levels of liver damage set off by many kinds of liver poisonous substances such as carbon tetrachloride, thioacetamide, muscarine, phalloidin, hyosostigmine, and so on. It has protective and additionally recovery impacts, as well as has a particular repressive impact on the increase of alanine aminotransferase brought on by carbon tetrachloride. It is suitable for the therapy of chronic persistent liver disease, persistent energetic liver disease, extremely early liver cirrhosis, liver poisoning and also numerous other disease. Additionally, this product in addition has solid antioxidant property or commercial buildings, can do away with cost-free radicals in the body, and also delay aging. It has in fact been commonly made use of in the fields of medicine, medical care products, food along with cosmetics.

Silybin A Property

Melting point 164-174°C
alpha D20 +11° (c = 0.25 in acetone + alcohol)
Boiling point 793.0±60.0 °C(Predicted)
density 1.527±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility Acetone (Sparingly), DMSO, Methano (Sparingly)
form Solid
pkapKa 6.42±0.04 (Uncertain)
color Pale Yellow
Water Solubility 54mg/L(24.99 ºC)

 

Silybin A Pharmacological Actions

Application of Silybin A in Drug-Induced Liver Injury

1. Liver injury induced by antipsychotic drugs

In recent years, the number of patients with mental illness has gradually increased. The main treatment methods are long-term, uninterrupted oral antipsychotic drugs, and some patients even need to take drugs for life. Long-term use of antipsychotic drugs (mostly chlorpromazine) can lead to liver damage, mainly manifested as elevated serum ALT, and a few patients may develop jaundice. The mechanism of liver injury caused by antipsychotic drugs is not yet clear, and it may be caused by the toxic damage of drugs to liver cells or the allergic reaction of the liver to drugs. Studies have shown that the application of Silybin A in the treatment of liver injury caused by antipsychotic drugs can effectively reduce serum ALT levels. Another report pointed out that silibinin has a certain preventive effect on liver injury caused by HBV carriers taking antipsychotic drugs, and the safety is good.

2. Liver injury caused by anti-tuberculosis drugs

Drug-induced liver injury caused by anti-tuberculosis drugs accounts for 2% to 30% of all liver injuries in the world, and the data in my country is as high as 8% to 30%. The current tuberculosis control strategy emphasizes that in order to control tuberculosis, it is recommended to use isoniazid, rifampicin, pyrazinamide, ethambutol and (or) streptomycin for 6 to 9 months of standard anti-tuberculosis treatment. Medication will lead to drug resistance and may lead to varying degrees of liver damage.

Studies have shown that when isoniazid is used or combined with other anti-tuberculosis drugs, 10% to 30% of patients may experience liver failure, hepatic steatosis, and liver necrosis. Isoniazid is catalyzed by N-acetyltransaminase and amidohydrolase in vivo to directly or indirectly generate acetylhydrazide and hydrazine, which are important metabolites that cause liver damage. Rifampicin is an inducer of cytochrome P450 activation, which can increase the covalent binding of the activated metabolite of isoniazid to hepatocyte macromolecules, thereby causing liver cell membrane damage. At the same time, rifampicin is also a strong hepatic drug enzyme inducer, which can accelerate the metabolism of isoniazid into hepatotoxic metabolites and increase hepatotoxicity. In this regard, silibinin can antagonize liver cell necrosis, stabilize cell membrane structure and metabolism, and promote functional recovery. In addition, Silybin A has strong fat solubility, can effectively scavenge oxygen free radicals produced by isoniazid metabolites, prevent rifampicin from inducing metabolites, and thus play a good protective effect on the liver. Studies have shown that preventive hepatoprotective treatment with silibinin can reduce the interruption rate of drug action, improve patient compliance, and improve the effect of anti-tuberculosis treatment. However, other studies suggest that for people without liver damage, silibinin preventive hepatoprotective treatment is of little significance. At the same time, abnormal transaminases during anti-tuberculosis treatment are considered to be an adaptive performance of the liver.

3. Hepatic injury induced by acetaminophen

Acetaminophen is mainly used clinically for analgesia and antipyretic treatment, and it will not cause too much damage to the human body when applied according to the therapeutic dose. However, if acetaminophen accumulates acutely, it can lead to fatal hepatic or renal necrosis. Acute accumulation of acetaminophen in the body has become the main cause of acute liver failure in developed countries. For alcoholics, malnutrition, and dehydration patients, the dose threshold for acetaminophen to cause toxic effects is lower.

Acetaminophen drugs are mainly absorbed through the gastrointestinal tract and converted into non-toxic substances in the liver by combining glucuronic acid or sulfate. If the metabolic pathway is saturated, acetaminophen is transformed into a toxic metabolite – N-acetic acid-p-benzoquinone imine (NAPQI) combined with glutathione through the oxidase P450 system. When NAPQI is produced too much in the body Or when the content of glutathione is low, NAPQI will combine with proteins and lipids on the liver cell membrane, resulting in the death of liver cells.

Silybin A can inhibit liver injury caused by acetaminophen through direct anti-oxidation, cell membrane lipid scavenging free radicals or regulating oxidase P450 system. Studies have shown that silybin can increase the level of reduced glutathione in the body and destroy Acetaminophen-induced DNA islands play a role in inhibiting liver damage.

4. Liver injury induced by statins

Statins are mainly used to reduce the synthesis of cholesterol in the liver, thereby reducing the level of cholesterol in the blood, and can also exert anti-inflammatory and anti-fibrosis effects. Studies have shown that statins can delay the progression of non-alcoholic fatty liver disease through anti-inflammatory and anti-fibrosis effects. However, the use of statins also has a certain risk of liver damage. Although it is relatively rare in clinical practice, some patients still stop taking drugs because of this. At present, large doses and advanced age are considered to be the main risk factors for liver injury caused by statins, which often occurs after continuous statin therapy for 3 to 12 months, and the incubation period varies in different regions: the average is 155 days in the United States, and 155 days in Sweden. 3 months, 57 days in Spain and 56 days in Taiwan. Although silybin has anti-inflammation, anti-fibrosis, and immune regulation effects, there is no clear evidence that Silybin A is effective against statin-induced liver injury, so further research is still needed.

Silybin A Anticancer Mechanism

Silibinin can induce apoptosis and autophagy of cells by inducing the production of reactive oxygen species/reactive nitrogen. Can repair cancer cells damaged by chemotherapy drugs) protein plays an important role.

When the “p53 human tumor suppressor gene” protein is missing, silibinin can neither induce the production of active oxygen nor induce GSH (it can combine with free radicals, heavy metals, etc., and convert harmful poisons in the body into harmless substances. excreted from the body) depletion occurs, but silibinin can still induce an increase in nitric oxide levels, indicating that silibinin-induced production of reactive oxygen species depends on the normal function of the “p53 human tumor suppressor gene” and its induction of nitric oxide The ability to produce nitrogen was independent of the “p53 human tumor suppressor gene” protein.

Silibinin can induce apoptosis and autophagy in HeLa cells (a cervical cancer cell with abnormally rapid proliferation used in biological and medical research) no matter in the culture environment with serum or without serum.

The researchers investigated the mechanism by which silibinin-induced reactive oxygen species are generated. It was found that silibinin can kill cancer cells by causing intracellular oxidative damage and interfering with the normal respiratory function of mitochondria.

About Products:
If you need Silybin A, the cosmetic raw material, please contact our service staff directly, we will provide you with high-quality products at the best price.
As an experienced Silybin A manufacturer and supplier, ZSpharmac will provide Silybin A raw materials to customers all over the world for a long time.
Over the years, the company has been adhering to the spirit of “integrity management, strict quality control, customer first”, and has won unanimous praise from domestic and foreign customers.

Company Profile and Corporate Culture

Company Profile:

ZhiShang Chemical is owned by ZhiShang Group is a professional new-type chemicals enterprise combined into research and development, production and sales .

The company’s competitive product is pharmaceutical raw materials and intermediates (especially carbohydrate derivatives Series), In recent years, the company has made a major breakthrough in food and feed additives, plant extraction, industrial chemicals industry .

The company insists on the spirit of “sincere management, strict quality control, customer as god” , get consistent high praise from customers at home and abroad.

Corporate Culture:

OUR MISSION
Help China Chemicals to benefit the happiness of human life
OUR VISSION
Become the most trusted chemical supplier in the world
OUR BUSINESS PHILOSOPHY
Striver – oriented, enrich employees, customer first, deep service, seek development
OUR VALUES
Be prepared for danger in times of peace, forge ahead actively, unity and cooperation, and be brave to fight

About Us

The production base is located in Zhangqiu chemical industry park and Tai’an high-tech chemical industry park. laboratory and workshop in strict accordance with the GMP standard and the product fit national ISO9001 and ISO2000 standards.

“Zhishang” products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

Company Info
  • Business Type: Manufacturer
  • Product Range: Cosmetic raw materials
  • Products/Service:Cosmetic raw materials (flavors and fragrances,antioxidant products, moisturizing and hydrating, whitening agents, cosmetic additives)
  • Total Employees: 51~100
  • Capital (Million US $): 10000000RMB
  • Year Established: 2016
Production Capacity
  • No. of Production Lines : 8
  • No. of QC Staff : 5 -10 People
  • OEM Services Provided : yes
  • Factory Size (Sq.meters) : 3,000-5,000 square meters
  • Certificate: ISO9001 , CE , GMP , API , MSDS
  • Factory Location : Diao Town Industry Park, Zhangqiu City, Jinan City, Shandong Province, China.

Service

Pre-Sales Service

* Prompt reply and 24 hours online, professional team to provide best price and high quality product.

* Sample testing support.

* Every batch of products will be tested to ensureits quality.

*The packing also can be according the customers` requirment.

*Any inquiries will be replied within 24 hours.

*we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

 

After-Sales Service

*The fact of logistics information monitoring.

* Any questions about the product can be consulted at any time.

*Product has any problem can return.

FAQ

Do you accept sample order?

We will make samples before mass production, and after sample approved, we’ll begin mass production. Doing 100% inspection during production, then do random inspection before packing.

 

HOW TO CONFIRM THE PRODUCT QUALITY BEFORE PLACING ORDERS?

You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

What’s your MOQ?

Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Do you supply product report?

Yes. We’ll give you product analysis report before shipping.

  Is there a discount?

Different quantity has different discount.

Shipping

1. ≤50kg, Express delivery recommended, usually called as DDU service;

2. ≤500kg, Air shipping recommended, usually called as FOB, CFR, or CIF service;

3. >500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

4. For high value products, please select air shipping and express delivery for safe.

Get Silybin A Quotation